ited clinical study impact trans - epidermal delivery for ......introduction: ited - trans-epidermal...

iTED Clinical StudyImpact Trans - Epidermal Delivery for Skin Enhancement

Multi-Site Clinical Results

Table of Contents

About Alma Lasers .......................................... 3

Introduction ..................................................4-5

Clinical Studies: Scars ...............................6-14

Clinical Studies: Acne Scars ....................15-23

Clinical Studies: Strech Marks ..................24-33

Clinical Studies: Skin Rejuvenation ............34-48

Clinical Studies: Melasma ........................49-56

]2[

About Alma Lasers

Alma Lasers is the leading supplier of innovative medical aesthetic technologies.

Alma Lasers is recognized by industry practitioners for its whole-hearted

commitment to providing complete solutions to professional practices.

Alma Lasers offers innovative technologies, dependable equipment and

years of industry expertise. Alma Lasers seeks the creation of a strong and

lasting relationship with our doctors and aesthetic clinics based on trust and

a genuine desire for the success of the practice.

For more information visit www.almalasers.com

Facebook: www.facebook.com/almalasers

Twitter: @almalasers

LinkedIn: http://www.linkedin.com/company/alma-lasers

]3[

Introduction:

iTED - Trans-Epidermal Delivery with Impact Technology

iTED is a skin barrier breakthrough solution developed to overcome

the challenge of introducing active ingredients to the deeper layers of the skin

without interference from the stratum corneum (outer layer of skin barrier).

iTED is a multi-step solution that combines fractional ablation and ultrasound

technologies with ProfoundPixel Smart Messengers. Treatment protocol

first calls for fractional skin ablation and the formation of microchannels in the

skin. iTED then harnesses the power of acoustic ultrasonic waves,pushing

the ProfoundPixel Smart Messengers into these microchannels,

which leads directly to the area that will most benefit from the active

ingredients. iTED is for the treatment of scars, stretch marks, melasma,

acne scars, skin whitening and skin rejuvenation - indications for which

there is mostly no effective solution which is not highly invasive.

iPixelRF and iPixelCO2

The first step in the iTED treatment is to create microchannels in the

skin. iTED uses the iPixelRF or iPixelCO2. The iPixelRF is a radio wave

generator that causes precise and controllable thermal damage and

fractional ablation, while the iPixelCO2 is the world’s fastest and most

powerful fractional ablative CO2 laser. Both iPixel modules pierce the

skin and cause fractional ablation - forming the microchannels. Each

microchannel is 80-120 microns in diameter and has a depth of 100-150

microns, depending on the power settings.

ProfoundPixel Smart Messengers

The advantage of Trans-Epidermal Delivery compared to topical, oral,

and hypodermic injections - is the ability to deliver the appropriate dose

of active ingredients directly to the location that will most benefit. When

active ingredients are introduced directly to biological tissue, they are

more deeply absorbed and provide a stronger therapeutic effect. Until

now, the main problem with effective delivery of skin care products/

cosmeceuticals, was the fact that the stratum corneum is an effective

barrier to outside elements.

ProfoundPixel Smart Messengers are applied to the skin following the

creation of the microchannels. The Smart Messengers are forced through

the microchannels by the Impact Ultrasound unit.

Impact

The acoustic vibrations of the Impact ultrasound module provides the

Smart Messengers greater mobility and reactivity. This increases the

amount of active ingredients that enter the body, thereby increasing the

effectiveness of the iTED treatment.

]4[

Treatment Settings

Face

Treated area iPixelRF Power [W] ipixel co2 Power [W]

Neck 30-40 20-30 High Mode

Chin 30-40 20-30 High Mode

Cheeks 35-45 20-30 High Mode

Periorbital 30-40 20-30 High Mode

Forehead 35-45 20-30 High Mode

Body

Treated area iPixelRF Power [W] ipixel co2 Power [W]

Hand 30-40 20-30 High Mode

Abdominals 35-45 20-30 High Mode

Waist 35-45 20-30 High Mode

Hip 30-40 20-30 High Mode

Buttocks 35-45 20-30 High Mode

Treatment

The pictures in this clinical bookare of treatments which have been performed in Brazil, Korea, Israel, Russia and Dubai. Patients underwent treatment for the removal of stretch marks and scars, skin rejuvenation, and skin whitening. Other noted changes in the appearance of the skin following the iTED procedure include a decrease in skin tension by the scar and the reduction in height or depth of the scar. In addition, using basal blood flow assessment with a Doppler flowmeter, the edema of the adjacent tissue decreased due to improvements of the blood circulation.

Conclusions

]5[

]5[

iTED treatment is designated for mature scars, post acne scars, stretch marks, skin whitening and skin rejuvenation.

Scars

iTED Treatment ResultsSkin Barrier Breakthrough Solution

Before

RF: 45 W, 3 passes Cosmeceutical: TriancinolonaImpact: 60 Hz, 80%, 1 min

1 week after 2 Tx

Scars

]7[Courtesy of: Maria Claudia Issa, MD, PhD, Rio de Janeiro, Brazil

Before

Courtesy of: Igor Pinson, MD, PhD, Dermatologist, Moscow, Russia

RF: 45 w Cosmeceutical: ContractubexImpact: 40 Hz, 50%, 1 min

After 2 Tx

Scars

]8[

Before

Courtesy of: Igor Pinson, MD, PhD, Dermatologist, Moscow, Russia

RF: 50 w 2-3 passes Cosmeceutical: Contractubex Impact: 40 Hz, 50%, 1 min

10 days after 4 Tx

Scars

]9[

Before

Courtesy of: Maria Claudia Issa, MD, PhD, Rio de Janeiro, Brazil

RF: 40W, 2 passes Cosmeceutical: Hyaluronic Acid + Vit CImpact: 60 Hz, 80%, 1 min

1 week after 2 Tx

Scars

]10[

Before After 4 Tx.

RF: 40W, 2 passes Cosmeceutical: Hyaluronic Acid + Vit CImpact: 60 Hz, 80%, 1 min

Scars


Before

RF: 45W, 3 passes Cosmeceutical: Triancinolona Acetonide Impact: 60 Hz, 80%, 2 min

After 1 Tx.

Scars


Courtesy of: Tania Meneghel, MD, DermatologistClínica Renaissance, São Paulo, Brazil

iPixel CO2: Medium, 70mJ/Pixel, 0, 2 passes Cosmeceutical: Quercetin Impact: 50Hz, 50%,

Scars

]14[

After 1 TxBefore

Acne Scars


Before

Acne Scars


After 2 Tx

RF: 45 W, 3 passes Cosmeceutical: Tretinoin 0.05% Impact: 60 Hz, 80%, 2 min ]16[

Before

Acne Scars

RF: 45 W, 3 passes Cosmeceutical: Tretinoin 0.05% Impact: 60 Hz, 80%, 2 min

After 3 Tx.


Before

Acne Scars

RF: 60 W, stationary and iPixelRF (In Motion), 6 passes Cosmeceutical: Dalacine (Clindamycin)

After 3 Tx

]18[Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

Before

Acne Scars

RF: 40-50 W (Treatments 1-5), 100 W (Treatment 6), iPixelRF (IN Motion), 7 passes Cosmeceutical: Locoid (hydrocortisone butyrate) Impact: 40 Hz, 50%, 2 min

After 6 Tx


Before

Acne Scars

RF: 55-65 W, 4-5 passes Cosmeceutical: PRPImpact: 60 Hz, 50%, 2 min

Courtesy of: Choi Jun, MD, PhD, MayLin Clinic, Seoul, Korea

1 week after 1 Tx

]20[

Before

Acne Scars

Courtesy of: Michael Shohat, MD, DermatologistAesthetic Laser Clinic , Tel Aviv, Israel

RF: 45-50 W, 2-3 passe Cosmeceutical: Meso anti Wrinkle,1% HA,MicroAcne kit Impact: 60 Hz, 80%, min

After 3 Tx

]21[

Before

Acne Scars

iPixel CO2: 60 W cheeks area - 50 mJ/Pixel, 2 passes, 30 mJ/Pixel, 1 passCosmeceutical: Retinoic acid Impact: 50 Hz, 80%

After 1 Tx


Before

Acne Scars

iPixel CO2: 60 W 50 mJ/Pixel , 2 passes Cosmeceutical: Retinoic acid Impact: 50 Hz, 80%

After 2 Tx


Strech Marks


After 4 Tx

RF: 45 W, 3 passes Cosmeceutical: Hyaluronic Acid + Vitamin CImpact: 60 Hz, 80%, 4 min

Before

Stretch Marks


Stretch Marks

Before After

RF: 45 W,3 passes Cosmeceutical: Hyaluronic Acid + Vitamin CImpact: 60 Hz, 80%, 4 min ]26[


Stretch Marks

RF: 45 W – 2 crosses (4passes) in motion tip Cosmeceutical: tretinoin 0,05% Impact: 60 Hz 80%

Before After 4 Tx


Stretch Marks

Before After 1 Tx

RF: 55W, 2 passes Cosmeceutical: Meso Striae kitImpact: 60 Hz, 50%, 5 min ]28[


Stretch Marks

Before After 3 Tx

RF: 55W, 3 passes Cosmeceutical: Meso Striae kitImpact: 80 Hz, 50%, 3 min

]29[Courtesy of: Michael Shohat, MD, DermatologistAesthetic Laser Clinic , Tel Aviv, Israel

Before 14 days after 2 Tx

RF: 45 W, 3 passes Cosmeceutical: Hyaluronic Acid + Vitamin C

Stretch Marks

Courtesy of: Igor Pinson, MD, PhD, Dermatologist, Moscow, Russia ]30[

Before After 2 Tx

RF: 45 W Cosmeceutical: Tretinoin 0.05% Impact: 50 Hz, 80%, 1 min

Stretch Marks

Courtesy of: Maria Claudia Issa, MD, PhD, Rio de Janeiro, Brazil ]31[

Before After 1 Tx

iPixel CO2: 60 W, 60 mJ/Pixel + 1 pass with the 7x7 tip

Stretch Marks

Courtesy of: Maria Claudia Issa, MD, PhD, Rio de Janeiro, Brazil ]32[

Before

Courtesy of: Dong-Hye Suh, MD, Dermatology, Arumdaun Nara Dermatologic Clinic, Korea

After 1 Tx

RF: 40-45 W Cosmeceutical: PRPImpact: 50 Hz, 50%

Stretch Marks

]33[

Skin Rejuvenation



Skin Rejuvenation

Before 1 week after 2 Tx

RF: 40 W, 3 passes Cosmeceutical: Retinoic Acid 0,05%Impact: 60 Hz, 80%, 60 sec periocular +120 sec-malar and mandibular ]35[

Skin Rejuvenation

After 4 Tx

RF: 40 W, 3 passes Cosmeceutical: Anti-Wrinkle+Retinoic Acid (RA) Impact: 60 Hz, 80%, 1 min

Before


Skin Rejuvenation

Before After 3 Tx

RF: 45 w Cosmeceutical: Tretinoin 0,05%+ HÁ 5% + VIT C 5%Impact: 60 Hz, 80%


Skin Rejuvenation

Before

RF: 40W, 2 passes Cosmeceutical: Vit C + Hyaluronic AcidImpact: 60 Hz, 80%, 1 min

After 2 Tx


Skin Rejuvenation

RF: 60 W, 2 stationary passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min

After 4 Tx

Before


Skin Rejuvenation

Before After 2 Tx

RF: 55 W, 3 passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min


Skin Rejuvenation

Before After 3 Tx

RF: 50W, 4 passes stationary Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min


Skin Rejuvenation

Before

RF: 40W, 3 passes Cosmeceutical: Meso DMAE Impact: 60 Hz, 80%, 2 min

1 week after 1 Tx


Skin Rejuvenation

RF: 60W, 3 stationary passes and 2 IN Motion passes Cosmeceutical: Vitamin C, Alphalipoic acid, Zinc, Silicium and Manganese Impact: 60 Hz, 60%, 2 min

Before After 3 Tx

Courtesy of: Maria Angelo-Khattar, PhD, Aesthetica Clinic, Dubai

]43[

Skin Rejuvenation

Before

iPixel CO2: Low mode 50 mJ/Pixel, 2 passes Cosmeceutical: ProfoundPixel SR kit Impact: 60 Hz, 60%, 1 min

After 2 Tx

Courtesy of: Yitzchak Ramon, MD, Elisha Hospital & Rambam Health Care Campus, Haifa, Israel ]44[

Skin Rejuvenation

Before

RF: 60 W, 4 passes Cosmeceutical: ProfoundPixel SR kit Impact: 60 Hz, 80%, 1 min

After 2 Tx

]45[Courtesy of: Yitzchak Ramon, MD, Elisha Hospital & Rambam Health Care Campus, Haifa, Israel

Skin Rejuvenation

Before


After 2 Tx


Skin Rejuvenation

Before

RF: iPIxel RF, 50 W, 4 passes Cosmeceutical: PRP Impact: 50 Hz, 50%, 4 min

After 7 Tx

Courtesy of: YoungSeung Jeon, MD, Dermatologist,Arumdaun Clinic Jeju, Korea ]48[

Melasma


Melasma

RF: 45-50 W Cosmeceutical: Melasma KitImpact: 45 Hz, 50%, 1 min

]50[Courtesy of: Igor Pinson, MD, PhD, Dermatologist, Moscow, Russia

Before After 3 Tx

Melasma

RF: 45-50 W Cosmeceutical: Melasma KitImpact: 45 Hz, 50%, 1 min

]51[Courtesy of: Igor Pinson, MD, PhD, Dermatologist, Moscow, Russia

Before After 2 Tx

Melasma

iPIxel CO2: High power, 15 mJ/Pixel, 2 passes Cosmeceutical: 4% Hydroquinone gel Impact: 50 Hz, 40%, 2 min ]52[


Before After 1 Tx

Melasma



Before After 1 Tx

Melasma

iPIxel CO2: High power, 10 mJ/Pixel, 2 passes Cosmeceutical: Bleaching gel Impact: 50 Hz, 20%, 2 min ]54[


Before After 1 Tx

Melasma



Before After 1 Tx

Melasma

iPIxel CO2: High power, 70 mJ/Pixel, 1 pass, Spacing 1 Cosmeceutical: Vitamin C, kojic acid, tranexamic acid, Mg Sulfate Impact: 50 Hz, 50%

]56[Courtesy of: Tania Meneghel, MD, DermatologistClínica Renaissance, São Paulo, Brazil

Before After 1 Tx

ited clinical study impact trans - epidermal delivery for ......introduction: ited - trans-epidermal...

Documents