Is the optic disc cupping or Is the optic disc cupping or sinking in glaucoma?sinking in glaucoma?

Syed S. Hasnain M.D.Syed S. Hasnain M.D.560 W. Putman Ave # 6560 W. Putman Ave # 6

Porterville CA 93257, U.S.A.Porterville CA 93257, U.S.A.www.hasnaineye.comwww.hasnaineye.com

hasnain40@sbcglobal.nethasnain40@sbcglobal.net

Hasnain ss. Scleral edge , not optic disc or retina, is the primary site of injury in chronic glaucoma. Medical Hypotheses (2006) 67, 1320-1325

Reference:

Abstract Abstract

The term The term cuppingcupping implies that the physiological cup starts implies that the physiological cup starts enlarging in glaucoma. enlarging in glaucoma.

The terms The terms cuppingcupping and and simple glaucomasimple glaucoma have been have been synonymous since 1850’s.synonymous since 1850’s.

This presentation is designed to determine whether the This presentation is designed to determine whether the cuppingcupping is occurring or not. If not, then what may be is occurring or not. If not, then what may be occurring to the physiological cup.occurring to the physiological cup.

This presentation will discuss three puzzling questions and This presentation will discuss three puzzling questions and how their answers, by deductive reasoning and how their answers, by deductive reasoning and photographic evidence, led to the conclusion that the optic photographic evidence, led to the conclusion that the optic disc may not be disc may not be cupping cupping but instead but instead sinking in its entirety. sinking in its entirety.

Puzzling Questions in Puzzling Questions in GlaucomaGlaucoma

Q 1.Q 1. Why do some people develop glaucoma at a Why do some people develop glaucoma at a normal IOP such as 15mmHg, while others don’t at a normal IOP such as 15mmHg, while others don’t at a high IOP such as 30mmHg ?high IOP such as 30mmHg ?

Q 2.Q 2. Why are the arcuate fibers selectively Why are the arcuate fibers selectively destroyed first, whereas the macular fibers last until destroyed first, whereas the macular fibers last until the end stage of glaucoma?the end stage of glaucoma?

Q 3.Q 3. Why can’t we halt glaucoma in spite of Why can’t we halt glaucoma in spite of maximally lowering of IOP with treatment?maximally lowering of IOP with treatment?

This presentation would discuss above questions This presentation would discuss above questions and their possible answers.and their possible answers.

Puzzling Question 1Puzzling Question 1 Q. Why do some develop glaucoma at a normal IOP such Q. Why do some develop glaucoma at a normal IOP such

as 15mmHg (NTG), while others not at a high IOP such as as 15mmHg (NTG), while others not at a high IOP such as 30mmHg (Ocular Hypertension)?30mmHg (Ocular Hypertension)?

History revealed that HTG patients were usually in good History revealed that HTG patients were usually in good health whereas the NTG patients had cardio-pulmonary health whereas the NTG patients had cardio-pulmonary and circulatory problems. Interestingly, about 70% of NTG and circulatory problems. Interestingly, about 70% of NTG patients were long-term smokers. Thus, glaucoma may be patients were long-term smokers. Thus, glaucoma may be a multifactorial disease. More the risk factors present, a multifactorial disease. More the risk factors present, higher the likelihood of glaucoma akin to ischemic heart higher the likelihood of glaucoma akin to ischemic heart disease. disease. This may be the answer to puzzling Q 1.This may be the answer to puzzling Q 1.

Above raises another question: If HTG is an ocular disease Above raises another question: If HTG is an ocular disease and NTG a systemic disease then why are there similar and NTG a systemic disease then why are there similar arcuate field defects in both HTG and NTG ? arcuate field defects in both HTG and NTG ?

In order to answer the above question we have to find out In order to answer the above question we have to find out why and how the arcuate fibers are being why and how the arcuate fibers are being selectivelyselectively destroyed destroyed first.first. We will now discuss the puzzling Q 2. We will now discuss the puzzling Q 2.

Can arcuate fibers be selectively Can arcuate fibers be selectively destroyed if ‘cupping’ is occurring?destroyed if ‘cupping’ is occurring?

Not likely.Not likely. Physiological cup is the Physiological cup is the base left over after the atrophy of base left over after the atrophy of the Bergmeister’s papilla and is the Bergmeister’s papilla and is made of fibrous tissue, not elastic. made of fibrous tissue, not elastic. First why should raised IOP enlarge First why should raised IOP enlarge physiological cup concentrically? physiological cup concentrically? However, if cupping ( enlargement However, if cupping ( enlargement of the cup) is due to high IOP then of the cup) is due to high IOP then why is there no cupping in acute why is there no cupping in acute glaucoma whereas present in NTG?glaucoma whereas present in NTG?

How is it possible that How is it possible that glaucomatous cupping involving glaucomatous cupping involving 360 degrees of disc would 360 degrees of disc would selectivelyselectively destroy the arcuate destroy the arcuate fibers and not encompass the rest? fibers and not encompass the rest? If the above is not possible then If the above is not possible then cupping cupping may not be occurring.may not be occurring.

Outer dotted circle depicting enlargement of the physiological cup.

Puzzling Q 2. Puzzling Q 2. Can the arcuate fibers while in the Can the arcuate fibers while in the

optic disc be selectively destroyed by optic disc be selectively destroyed by any cause?any cause?

Unlikely.Unlikely. How is it possible that high IOP, or in fact any How is it possible that high IOP, or in fact any pathology, can pathology, can selectively and precisely selectively and precisely destroy the destroy the arcuate fibers among the million or so densely packed arcuate fibers among the million or so densely packed nerve fibers in the 1.5mm size optic disc?nerve fibers in the 1.5mm size optic disc?

If above is not possible, then the optic disc may not be If above is not possible, then the optic disc may not be the primary site of injury. the primary site of injury.

If the optic disc is not the primary site of injury then the If the optic disc is not the primary site of injury then the terms terms cuppingcupping and and cup/disc ratiocup/disc ratio would become invalid would become invalid and misleading in evaluation of glaucoma.and misleading in evaluation of glaucoma.

Can the arcuate fibers while in the Can the arcuate fibers while in the retina be selectively destroyed by any retina be selectively destroyed by any

pathology?pathology? Unlikely. How is it possible that IOP or in fact any pathology Unlikely. How is it possible that IOP or in fact any pathology

can can selectively and preciselyselectively and precisely destroy the arcuate fibers destroy the arcuate fibers while they are in the retina?while they are in the retina?

Regarding apoptosis: How is it possible that apoptosis would Regarding apoptosis: How is it possible that apoptosis would initiate initiate selectively and preciselyselectively and precisely only with those ganglion only with those ganglion cells of the retina which serve the arcuate nerve fibers? cells of the retina which serve the arcuate nerve fibers?

If the above scenarios are not possible then the retina may not If the above scenarios are not possible then the retina may not be the primary site of injury. be the primary site of injury.

Based on arcuate field defects, if the optic disc or retina Based on arcuate field defects, if the optic disc or retina cannot be the primary site of injury then what may be the site cannot be the primary site of injury then what may be the site of injury? of injury? we are left with the circular border tissue.we are left with the circular border tissue.

Can border tissue be the site of Can border tissue be the site of injury?injury?

Circular border tissue cushions between the optic disc and Circular border tissue cushions between the optic disc and scleral edge (rim), and secures the optic disc in place.scleral edge (rim), and secures the optic disc in place.

Border tissue is exclusively supplied by short posterior ciliary Border tissue is exclusively supplied by short posterior ciliary arteries directly or via circle of Zinn-Haller.arteries directly or via circle of Zinn-Haller.

Normally, the IOP should be lower than the arterial pressure Normally, the IOP should be lower than the arterial pressure of the border tissue for its healthy maintenance and survival.of the border tissue for its healthy maintenance and survival.

This delicate balance would be reversed either by increase in This delicate balance would be reversed either by increase in IOP or due to decrease in arterial pressure of the border IOP or due to decrease in arterial pressure of the border tissue as a result of poor systemic circulatory problems. In tissue as a result of poor systemic circulatory problems. In the latter scenario, even the normal IOP would become high the latter scenario, even the normal IOP would become high for that poorly perfused and reduced arterial pressure of the for that poorly perfused and reduced arterial pressure of the border tissue. border tissue.

Simulation: Border Tissue of Simulation: Border Tissue of ElschnigElschnig

Circular Border tissue (green) lies between the optic disc and the scleral edge (rim). Border tissue acts as a cushion and also secures the optic disc in the scleral opening

What happens if the border tissue What happens if the border tissue atrophies?atrophies?

Optic disc would become loose and begin to sink in the scleral Optic disc would become loose and begin to sink in the scleral foramen.foramen.

AnalogyAnalogy: A road made of nerve fibers which converge on the : A road made of nerve fibers which converge on the manhole cover in a road as the retinal nerve fibers converge manhole cover in a road as the retinal nerve fibers converge on the optic disc.on the optic disc.

If the manhole cover begins sinking in its entirety due to If the manhole cover begins sinking in its entirety due to deterioration of adherent material circumferentially , the ‘road deterioration of adherent material circumferentially , the ‘road nerve fibers’ would be stretched and severed at the edge.nerve fibers’ would be stretched and severed at the edge.

Likewise process of sinking and severing of the RNF’s may be Likewise process of sinking and severing of the RNF’s may be occurring to the optic disc in glaucoma. occurring to the optic disc in glaucoma.

Analogy: Sinking Manhole Cover to Analogy: Sinking Manhole Cover to glaucomatous optic discglaucomatous optic disc

Normal: Manhole cover flush with the road. If the course of blood vessels crossing disc margin is straight then there is no sinking or no glaucoma.

Early Stage glaucoma : Kinking of the blood vessels at the margin due to sinking

Middle Stage: Loss of temporal fibers and more kinking of the bl. vessels

Final Stage: Total loss of optic disc. Optic disc area becomes an empty crater. Only larger blood vessels remain at the rim.

We come back to puzzling question We come back to puzzling question No. 2: No. 2: Can the arcuate fibers be Can the arcuate fibers be

selectively destroyed if the optic disc is selectively destroyed if the optic disc is sinking? sinking? Likely:Likely: As As hypothesized in hypothesized in

following diagram.following diagram.

Double arcuate field defects. This may be the answer to the puzzling question number 2. Why are the arcuate fibers selectively destroyed first in glaucoma?

Due to temporal sinking (green arrows) all the temporal fibers which include sup. and inf. arcuate and macular fibers would be severed simultaneously. However, arcuate fibers being fewer in number, therefore they would be depleted earlier giving rise to double arcuate field defects whereas the macular fibers being abundant would last till the end stage of glaucoma. Concurrent severing of the macular fibers is revealed by loss of ganglion cells of the macular area by OCT.

Macular fibers

Macular fibers

Arcuate fibers

Arcuate fibers

What may happen as the sinking of What may happen as the sinking of the disc continues?the disc continues?

Retinal nerve fibers anchor the optic disc in place Retinal nerve fibers anchor the optic disc in place as as roots anchor a tree.roots anchor a tree.

As the nerve fibers are being severed and depleted, As the nerve fibers are being severed and depleted, the optic disc becomes more loose and sinks further the optic disc becomes more loose and sinks further resulting in severing of more nerve fibers. resulting in severing of more nerve fibers.

This creates a self-propagating cascade of loosening This creates a self-propagating cascade of loosening and sinking which would continue until all the nerve and sinking which would continue until all the nerve fibers are severed at the edge. Glaucoma can’t be fibers are severed at the edge. Glaucoma can’t be halted; akin to a sinking ship. halted; akin to a sinking ship. This may be the answer This may be the answer to the puzzling Q 3. that once the glaucoma is initiated to the puzzling Q 3. that once the glaucoma is initiated it can’t be haltedit can’t be halted..

Optic disc area becomes an empty crater after Optic disc area becomes an empty crater after severance of all the axons (axotomy) of the optic disc.severance of all the axons (axotomy) of the optic disc.

Analogy: Analogy: Sinking manhole cover to a glaucomatous Sinking manhole cover to a glaucomatous

discdisc

Normal: Manhole cover flush with the road. Blood vessels are straight at the margin of the disc. If there is no sloping or kinking of blood vessel at the margin, then there is no sinking of the optic disc therefore no glaucoma.

Early stage glaucoma: Splinter hemorrhage at 7 o’clock. Kinking and sloping of the blood vessels at the margin. Physiological cup is still intact. Arcuate field defect present. Temporal part pale and sunken due to thinning of RNFL.

Late stage glaucoma: Physiological cup is broken ( de-cupping ) due to confluence of cup’s usual pallor with pallor produced by the destruction of nerve fibers in the peripheral part. Nasal shifting of vessels from loss of anchorage due to loss of temporal nerve fibers.

End stage glaucoma: Total loss of the optic disc due to axotomy of the axons. Disc area becomes an empty crater. Only the larger blood vessels remain at the rim of the scleral opening.

Points against cupping of optic discPoints against cupping of optic disc Cupping implies that the physiological cup starts enlarging Cupping implies that the physiological cup starts enlarging

concentrically. Cupping, occurring concentrically, cannot concentrically. Cupping, occurring concentrically, cannot selectivelyselectively andand preciselyprecisely destroy only the arcuate fibers destroy only the arcuate fibers among the million or so densely packed nerve fibers in among the million or so densely packed nerve fibers in

1.5 mm size optic disc. 1.5 mm size optic disc.

If cupping is indeed occurring then those born with large If cupping is indeed occurring then those born with large cups (e.g. 0.8) would become blind sooner than those born cups (e.g. 0.8) would become blind sooner than those born with 0.2 cups. with 0.2 cups. But this is not the case.But this is not the case.

Fibers for the central vision are located in the central part of Fibers for the central vision are located in the central part of the disc and also superficial (closer to the vitreous). If the disc and also superficial (closer to the vitreous). If cuppingcupping were occurring then these fibers should be were occurring then these fibers should be destroyed first but opposite is the case since the deeper destroyed first but opposite is the case since the deeper peripheral vision fibers are destroyed first in glaucoma.peripheral vision fibers are destroyed first in glaucoma.

Cupping occurring concentrically can’t explain the nasal Cupping occurring concentrically can’t explain the nasal shifting of the central vessels.shifting of the central vessels.

Points in favor of sinking of the optic Points in favor of sinking of the optic disc.disc.

Sinking may explain the severing of the peripheral vision fibers earlier since Sinking may explain the severing of the peripheral vision fibers earlier since they are located deeper and closer to the scleral edge (rim)they are located deeper and closer to the scleral edge (rim)

Sinking may explain double arcuate field defects.Sinking may explain double arcuate field defects.

Sinking of the optic disc may explain the nasal shifting of the blood vessels Sinking of the optic disc may explain the nasal shifting of the blood vessels due to loss of anchorage from severance of temporal fibers.due to loss of anchorage from severance of temporal fibers.

Sinking may explain the splinter hemorrhage due to severing of the smaller Sinking may explain the splinter hemorrhage due to severing of the smaller

blood vessels at the scleral rim.blood vessels at the scleral rim.

Sinking may explain progressive thinning of RNFL as revealed by OCT due to Sinking may explain progressive thinning of RNFL as revealed by OCT due to continuous severing of the nerve fibers. continuous severing of the nerve fibers.

Sinking may explain sloping and kinking of the blood vessels at the entire disc Sinking may explain sloping and kinking of the blood vessels at the entire disc margin occurring prior to any change in the contour of the physiological cup. margin occurring prior to any change in the contour of the physiological cup.

Sinking would become self-propagating resulting in severing of the nerve Sinking would become self-propagating resulting in severing of the nerve fibers (axotomy) until all the axons are finished and the disc area becomes an fibers (axotomy) until all the axons are finished and the disc area becomes an empty crater—this is what revealed by its histology.empty crater—this is what revealed by its histology.

Simulation: Normal & Sinking DiscSimulation: Normal & Sinking Disc

Upper DiagramUpper Diagram: Normal disc. : Normal disc. Arrangement of nerve fibers in Arrangement of nerve fibers in the retina & optic disc.the retina & optic disc.

Lower DiagramLower Diagram: Glaucomatous.: Glaucomatous. As the disc (yellow) sinks, the As the disc (yellow) sinks, the

deeper peripheral fibers are deeper peripheral fibers are stretched and severed at the stretched and severed at the edge and thus the central edge and thus the central fibers move closer to the fibers move closer to the edge. Therefore, the peripheral edge. Therefore, the peripheral fibers are severed first and the fibers are severed first and the central fibers at the last. central fibers at the last.

Scleral

Sclera

Border TissueScleral edge

Border Tissue

Scleral Edge

Arcuate

MacularArcuateArcuateArcuateAArcuate

Macular( Black)

Macular Nasal

Nasal

Black arrows showing central fibers moving closer to the edge as the peripheral fibers are being severed and depleted.

Normal arrangement of nerve in the optic disc.

Patient A: Early Stage Sinking DiscPatient A: Early Stage Sinking Disc

No change in size of No change in size of physiological cup.physiological cup.

Prominent temporal scleral Prominent temporal scleral rim due to thinning of RNFL. rim due to thinning of RNFL. Temporal area sunken and Temporal area sunken and pale due to destruction of pale due to destruction of nerve fibers and its nerve fibers and its vasculature.vasculature.

Sloping of vessels due to Sloping of vessels due to sinking and splinter sinking and splinter hemorrhage at 7 o’clock due hemorrhage at 7 o’clock due to severing of smaller blood to severing of smaller blood vessels. vessels.

Middle Stage: Sinking DiscMiddle Stage: Sinking Disc

Original cup is broken (de-Original cup is broken (de-cupping) due to merging of cupping) due to merging of its usual pallor with the its usual pallor with the pallor produced by pallor produced by destruction of nerve fibers destruction of nerve fibers and its vasculature.and its vasculature.

Prominent scleral edge due Prominent scleral edge due to thinning of RNFL. to thinning of RNFL.

Absence of smaller blood Absence of smaller blood vessels between 7 to 9 vessels between 7 to 9 o’clock after being severed.o’clock after being severed.

Arcuate field defect present Arcuate field defect present in this case.in this case.

Final Stage: Sinking DiscFinal Stage: Sinking Disc

Optic disc area is pale and Optic disc area is pale and shallow ( crater formation) shallow ( crater formation) due to loss of nerves and due to loss of nerves and vasculature.vasculature.

Entire scleral opening is Entire scleral opening is visible due to loss of disc.visible due to loss of disc.

Nasal shifting of vessels due Nasal shifting of vessels due to loss of anchorage from to loss of anchorage from temporal fibers.temporal fibers.

Marked kinking of vessels at Marked kinking of vessels at the edge due to loss of the edge due to loss of underlying nerve fibers. underlying nerve fibers.

Final Stage: Uniform SinkingFinal Stage: Uniform Sinking

Right Eye: unusual Right Eye: unusual case.case.

No nasal shifting of No nasal shifting of central vessels due to central vessels due to uniform loss of uniform loss of anchorage provided by anchorage provided by RNF’s 360 degrees as RNF’s 360 degrees as a result of flat insertion a result of flat insertion of the optic disc in the of the optic disc in the scleral foramen. scleral foramen. Unusual scenario.Unusual scenario.

Conclusion Based on SinkingConclusion Based on Sinking Optic disc may Optic disc may notnot be cupping in glaucoma. be cupping in glaucoma.

Optic disc may be sinking in its entirety in glaucoma.Optic disc may be sinking in its entirety in glaucoma.

Normal tension glaucoma may be a systemic disease.Normal tension glaucoma may be a systemic disease.

Glaucoma is a multifactorial disease. More the risk factors Glaucoma is a multifactorial disease. More the risk factors present, higher the likelihood of development of glaucoma present, higher the likelihood of development of glaucoma akin to ischemic heart disease.akin to ischemic heart disease.

The nerve fibers are not being atrophied but severed The nerve fibers are not being atrophied but severed (axotomy) and depleted. At the end stage, entire disc is (axotomy) and depleted. At the end stage, entire disc is perished. This is what the histology of the end-stage perished. This is what the histology of the end-stage glaucomatous disc revealing– an empty crater without disc.glaucomatous disc revealing– an empty crater without disc.

Glaucoma a mechanical disease (herniation of the optic Glaucoma a mechanical disease (herniation of the optic disc)? Treatment? Find ways to stabilize the sinking disc.disc)? Treatment? Find ways to stabilize the sinking disc.