THE BUSINESS MAGAZINE OF PHARMA

APRIL 2011

— HBA’s 2011 Woman of the Year —

— Pfizer’s Dr. Freda Lewis-Hall —— Pfizer’s Dr. Freda Lewis-Hall —

ASilver LiningASilverLining

TRANSLATIONAL MEDSA COMING-OF-AGE STORY

GSK’S TRUSTUS TEST

CANADIAN PHARMAWILLIAMS OF RX&D

VOLUME 31, NUMBER 4

John

Hal

pern

Pho

togr

aphy

The determination of Pfizer’s Dr. Freda Lewis-Hall has enabled her to find a ray of hope in every situation she’s encountered, from glass ceilings, to patients’ bedsides, to the challenges facing pharma today

by Jennifer Ringler, Associate Editor

— HBA’s 2011 Woman of the Year —

ASilver LiningLining

PHARMACEUTICAL EXECUTIVEPHARMACEUTICAL EXECUTIVE2

Mother. Daughter. Mentor. Advo-cate. Leader. And friend. All these words describe the Healthcare

Businesswomen’s Association’s (HBA) 2011 Woman of The Year, Dr. Freda Lewis-Hall. Yet none is enough to explain the keen observational skills and engagement as-sets that have placed her squarely on the path to where she sits today: A key member of the “C suite” at the world’s largest biomedicines company.

Recently, Pharm Exec had the opportunity to sit down with Lewis-Hall to learn about the experiences, both professional and per-sonal, which brought her the HBA award and built her career in linking the profession of medicine to the larger politics of public health.

Seeds of SuccessA “can-do” attitude and the natural inclina-tion to help others are traits that Lewis-Hall says were literally seared into the fabric of her childhood from day one. Besides hav-ing supportive, encouraging parents who she says “actually believed [she] could fly,” Lewis-Hall also had an uncle who moved in with her family when she was a toddler. Her uncle, a paraplegic, spent a great deal of time fashioning everyday tools for him-self to use for chores so that he was able to maintain his self-sufficiency. Years before the Americans with Disabilities Act (ADA) came to fruition in 1990, Lewis-Hall grew up with a role model in the house whose motto—which he practiced literally and philosophically every day—was, “When things seem out of reach, move closer.”

If her uncle’s adaptability to his own condition instilled in Lewis-Hall an enter-prising attitude, then the rest of her fam-ily’s reaction taught her selflessness, coop-eration, and generosity of spirit: “In our house, there were stairs that led up to the bedrooms. My uncle would wait [there] in the evenings if he was too tired to walk up with his crutches. My dad would be out late driving a cab … and I would hear him come in and literally carry my uncle up the stairs. It was the idea that we were always there for each other and literally carried each other on our backs to make things hap-

pen,” she recalls. “It was profound learn-ing about being part of a community, and for me, now, being part of a workplace.”

One other person became a crucial part of the family unit that Lewis-Hall observed in her early years—Dr. Settles, the fam-ily physician. “I saw my uncle treated and moved along not just by the love and atten-tion of the family, but by the medical care he received,” she explains. “By age six, I was hooked. I really knew that some way, some how, I was going to be a physician.”

The Concrete CeilingLewis-Hall grew up during a time when the glass ceiling around female advancement in the professional world was so firmly in place that many never bothered looking up, if they were even aware it was there at all. For example, despite Lewis-Hall’s excellent grades and demonstrated leadership abili-ties in high school in Annapolis, Maryland, her guidance counselor suggested that being a Navy officer’s wife would be an excellent “career” choice. “I was absolutely stunned,” says Lewis-Hall.

When asked about her views on the glass ceiling today, Lewis-Hall says, “Well, first of all, I never thought it was glass. I thought it was concrete and lead-lined, so Superwoman couldn’t even see through it with her X-ray vision. I don’t know who was nice enough to call it glass, but it wasn’t me.” But even this experience was something her supportive family, with its mantra of positivity, spun into gold from straw: “I went home that evening and told my mother,” recalls Lewis-Hall, “and she said, ‘We’re going to take the best colleges list and start at the top and apply until the money runs out.’” And so the two women sat down together and applied to the most prestigious schools out there—Harvard, Yale, Brown, Johns Hopkins—shunning soci-ety’s expectations for women to accomplish the very least, defiantly aiming instead for the very best. Lewis-Hall ended up earning her undergraduate degree in Natural Sciences from The Johns Hopkins University in large part because it was close to her Maryland home, and because, “I wanted to be a doctor, so where else but Johns Hopkins?”

Currently, says Lewis-Hall, that concrete

ceiling “is being chipped away. Now around our [industry’s] tables as part of our lead-ership teams are people who look different from each other—we come from different backgrounds, we have different perspectives that allow for robust decision-making and sharing. I don’t think it’s gone by any stretch of the imagination, but it’s coming down; it’s more porous. The value of complemen-tary leadership is being seen by women who have gotten through the cracks in the con-crete ceiling and by men who have realized that this is much better in a lot of ways.”

After college, Lewis-Hall was faced with another choice that would become a step-ping stone on her journey to becoming a doctor: getting into medical school. She was working at the time for the Federal Power Commission in Washington, DC, when she told her mother she wanted to attend How-ard University Hospital and College of Med-icine. Her mother replied, “Isn’t that right up the street from where you’re working? You should go over there and ask them if you can be in their medical school.”

“I said to my mother, ‘That’s not how it works; you don’t just walk in and ask some-one if you can be in their medical school,’” recalls Lewis-Hall. Nevertheless, she walked over on her lunch break one day and filled out the application, and was accepted for the upcoming school year. Was the decision to become a doctor based on it being a lu-crative career? A way to provide solutions to public health challenges? The draw of the mix of policy and medicine? “That all sounds so profound,” says Lewis-Hall. “I just … wanted to help people.”

Memorable MomentsOne such opportunity for Lewis-Hall to help people occurred after her residency, when she worked for the National Health Services Corps in the Virgin Islands. “I was in a health manpower shortage area, help-ing people that wouldn’t have otherwise had psychiatric care at that point,” she says.

During this time, psychiatry was undergo-ing a major shift towards taking patients out of hospitals and mainstreaming them back into their communities, and places like the Virgin Islands had no provisions in place for

such a shift. “I was in Washington, DC, do-ing work at St. Elizabeth’s Hospital, and I realized that the people hospitalized there were likely going to be deinstitutionalized and sent back to the Virgin Islands, and there wasn’t anyone or anything that was going to provide care,” says Lewis-Hall.

Eventually, she went on to serve as acting medical director for the US Virgin Islands Department of Health. “I went down to try and help evolve the system so it could meet the needs of those chronically mentally ill patients, and it was a very, very profound experience,” she says. “Going to the Virgin Islands, where there was just little or nothing, was a really shocking learning experience.”

After leaving the Virgin Islands, Lewis-Hall returned to Howard, where she learned even more about psychiatry while counsel-ing patients and serving as vice chair and assistant professor. “I loved what was hap-pening in psychiatry, and I was drawn to it,” she says. “Psychiatry at that time was still grounded in understanding people, in listen-ing. It was really a listening profession at that time, and I loved the idea of being taught to professionally listen.” That skill—the capac-ity to evaluate carefully what others are say-ing—is often missing in the conventional list of leadership traits, but Lewis-Hall has been careful to cultivate it in making her way up the professional ladder.

Lewis-Hall’s work at Howard also got her interested in the biology behind psychiatry. “I became fascinated with brain biology and learning—learning what was being learned.

I think it’s also part of what got me ready to come into the [pharma] industry,” she says.

Diversity, Biology, and Eli LillyLewis-Hall’s first foray into the pharma in-dustry was at Eli Lilly, where she began as clinical research physician and, over a pe-riod of eight years, moved her way up the ranks, creating and directing the Lilly Cen-ter for Women’s Health and then serving as product team leader.

While we all recognize that diversity can play a role in our lives in cultural and philo-sophical ways—from civil rights to work-place equality—Lewis-Hall began to under-stand during her time at Lilly that diversity may have biological and physiological roles to play as well. “I spent some time on gen-der-based health, gender-based biology, and ethnopsychopharmacology—looking at the differences that race and ethnicity made and how these things affect the way that drugs are metabolized in different people,” she ex-plains.

Such interests led to Lewis-Hall develop-ing and directing the Lilly Center for Wom-en’s Heath, aimed at incorporating science-based, gender-related advantages into all life-cycle stages of Lilly’s neuroscience, car-diovascular, and women’s health therapies. “That was a time when there wasn’t a lot of thought about gender-based research,” she says. “So my first few years in the indus-try were really great in that they confirmed the power of science for bringing benefit to patients and provided me with an opportu-

nity to really connect with the community around a health issue.”

In fact, diversity issues played a role in Lewis-Hall’s career not only in the research she was working on at Lilly, but—through-out her life—in her personal development as well. “Sometimes I have a hard time teas-ing apart what my ethnicity and my gender bring to the table, although I am not at all confused about the fact that there is a sig-nificant impact,” she says. “I think there were times when I felt that maybe my cred-ibility was challenged in a way that it might not have been … As a young, female, Af-rican-American physician, I had to wonder if I carried the same weight—had the same gravitas—that someone else might have.”

Thankfully, Lewis-Hall had a mentor to look to at Lilly, Dr. August “Gus” Wata-nabe, who oversaw Lilly’s research labs. “He reminded me over and over that at the end of the day, I am a physician, trained in the art of healing,” she recalls. “He told me to never forget that my grounding at the company was that I brought patient-centeredness into the room with me—that when I walk into the room, someone who has touched a patient, treated a patient, and understands the patient is now here repre-senting that; the patient walks in with me.”

Pfizer “has a lot of experience [in global health],” says Lewis-Hall, pictured here in Uganda, and “would love personally to become more involved in that and to appply the medical community of Pfizer to this work in a bigger way.”

Get

ty Im

ages

/ A

lani

e/Li

fe F

ile

APRIL 2011 www.pharmexec.com 4

Sound advice like this is what helped Lew-is-Hall realize that diversity in the workplace was not just something that might or might not bring her credibility into question, but something to be celebrated and leveraged, using each person’s strengths and differences to contribute to the greater good of the com-pany.

Sidney Taurel, former CEO of Lilly, had this to say about Lewis-Hall: “Freda is one of the most energetic, communicative, and driven people I’ve worked with. She com-bines competence as a physician with a pas-sion to make a difference in peoples’ lives as a leader, a mentor, and an advocate. With her infectious enthusiasm, she is good fun to be around.”

Patient Focus at PfizerThat patient-centeredness and respect for diversity has transferred to Lewis-Hall’s cur-rent role as chief medical officer (CMO) of Pfizer. “At the end of the day, I believe we as a company are accountable for the safe, effective, and appropriate use of our medi-cines,” she says. “This is a really good op-portunity for us to live our word that the patients are at the center of what we do.”

Being at Pfizer—where she administers a division budget of more than $600 million annually—has given Lewis-Hall time to re-flect on why she transitioned from direct patient care into the private sector and the pharma industry: “What attracted me to it and what ultimately won me and kept me is the idea that probably the most incredible science ever happens in this environment,” she says. “It’s a data-rich environment where

you have the ability to help not just one pa-tient at a time, but millions of patients at a time. I would never, ever have guessed that this was what I’d be doing now.”

Part of the way Lewis-Hall keeps her fo-cus on the patients through her work at Pfiz-er is by stressing the importance of clinical trials. “If medicines are going to be evolved so that they properly serve the people that are going to use them, then the globaliza-tion of our clinical trial effort is critical,” she explains. Pfizer is the only pharmaceu-tical company to be accredited by the As-sociation for the Accreditation of Human Research Protection Programs (AAHRPP) for ensuring the protection of human sub-jects taking part in early-stage clinical trials.

Finally, Lewis-Hall notes how important her role is as industry representative on the new federal Patient Centered Outcomes Re-search Institute’s (PCORI) governing board, which will fund studies to evaluate the clini-cal effectiveness among the patient popula-tion of drugs and other medical treatments. “It is a striking opportunity to really be able to focus on patient-centered outcomes with a group of people that are dedicated to that task. And I’m especially excited because pharma’s there at the table.”

As CMO of Pfizer, as well as being an Exec-utive Officer and member of the senior lead-ership team, Lewis-Hall is one of the highest-ranking women in the industry. (And best paid, with a $4.5 million total pay package last year.) Lewis-Hall has tackled the highly sensitive issue of increasing the effectiveness of internal systems for collection and report-ing of adverse events, particularly through

the integration of Wyeth’s safety reporting system with Pfizer’s—a complicated process that was completed ahead of schedule.

Reflecting on her own leadership role at Pfizer, Lewis-Hall recognizes that a certain skill set and leadership style is necessary in dealing with the uncertainty in the industry going forward. “I think the more mature you are as a leader, the better able you are to manage uncertain or ambiguous environ-ments, because that’s what’s required,” she says. She believes that a new form of lead-ership—quite the opposite of the old “com-mand and control” model—is required now, “which isn’t, ‘Do what I told you to do,’ but ‘Do what you think you should do.’”

Looking beyond her current role, to what else she’d like to accomplish professionally, Lewis-Hall says, “Introducing new treat-ments and new preventions is part of it, but I think that our ability to serve in a broader way and to really change the face of global health is really profound.

“I think Pfizer has a lot of experience, and we’re doing a lot of good work in this space,” she says. “I would love personally to become more involved in that and to ap-ply the medical community of Pfizer to this work in a bigger way.”

Industry PerspectiveLewis-Hall’s many years as a physician and industry expert have given her the multi-

Trips such as this to Ethiopia helped Lewis-Hall begin to shape her thoughts on the future, where she sees an opportunity to “serve in a broader way and to really change the face of global health.”

55 PHARMACEUTICAL EXECUTIVE APRIL 2011 www.pharmexec.com

faceted perspective she needs to understand the complicated changes facing the industry today, from health reform to patent cliffs to R&D cost concerns. “We deal with this uncertainty every day, and I like to think that we do it well,” she says. “We strive for the right amount of information to support our decisions. And for me, that’s the trick in senior leadership—making sure that you’ve asked all the right questions and that you’ve pushed to acquire as much of the informa-tion as you need to make a good decision.”

From her vantage point at Pfizer, Lewis-Hall can see the industry shifting, and rec-ognizes collaboration as the only possible solution to the new problems it’s faced with. “When I look at what I came into in 1994 [at Lilly] and what we look like as an indus-try now in 2011, I feel that we’ve changed in a very profound way,” she explains. “It used to be that we went down in the basement by ourselves with our best scientists and had a ‘eureka!’ moment—finding something that was going to cure something—and then came to the light of day and sold it. That’s not happening anymore. Now it’s all hands on deck. It’s partnerships with other big companies, with small companies, with academic institutions, with nonprofit orga-nizations. This is an ecosystem for problem-solving around the still vexing issues that face us.” Lewis-Hall told Pharm Exec that being able to reach out to a range of new stakeholders is going to be a critical skill for

the next generation of industry leaders. “We are already seeing it in the actions of indi-vidual company CEOs.”

Advice for Future LeadersMentoring has always been a natural part of Lewis-Hall’s personal and professional life, and in that way she is well suited for the role of HBA Woman of the Year, to offer advice to the future female leaders of pharma.

In addition to leadership through listening, one piece of advice that Lewis-Hall received from Sandro Franchi, a former HR employee at Lilly, has stayed with her, and she often passes it on to others: Think of your career in terms of your pinnacle role. “When I men-tor people I always ask, ‘What do you want your last job, your pinnacle role, to be—the place from which you will be able to make the greatest impact?’” she says. Once you can figure that out, she says, all the career moves you make from then on should be stepping stones that will lead to your pinnacle role. “This isn’t about where you will have the greatest glory, the biggest title, or the most money. People should tag where they believe

they can have the greatest impact and then begin to accumulate the skills, behaviors, and experience that will allow them to have that impact.”

Lewis-Hall’s mentoring and leadership skills—along with her patient care and indus-try experiences—make her ideal to represent the HBA in a more turbulent era of transition from the traditional business model. “I think women leaders already have a running start on the kind of leadership that’s required to run such a complicated ecosystem of differ-ent interests,” she says. “We’re collaborative leaders, we are motivational leaders, we’re about relationships. These are all the kinds of things that are perfectly positioned to advance women to solve the problems that are facing us—the ones that are facing us as businesses, but also as a global community around healthcare.” Is there a next step in this record of success? “I intend to stay com-mitted to the path of public health and to do what I can to ensure the private sector is there in full, to meet the needs of all patients worldwide through better access and more treatments.”

“What attracted me to [pharma] and what ultimately won me and kept me is the idea that probably the most incredible science happens in this environment. It’s a data-rich environment where you have the ability to help not just one patient at a time, but millions of patients at a time.”

Posted with permission from Pharmaceutical Executive. Copyright ©2011, an Advanstar publication. All rights reserved.www.pharmexec.com

#1-28855018 Managed by The YGS Group, 717.505.9701. For more information visit www.theYGSgroup.com/reprints.

373 Route 46 West • Building E • Suite 215 Fairfield, NJ 07004

973.575.0606 • www.hbanet.org

66PHARMACEUTICAL EXECUTIVEAPRIL 2011 www.pharmexec.com