garlic benefit
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Of the many beneficial actions of garlic, inhibition of thegrowth of cancer is perhaps the
most remarkable. Our previousanimal studies demonstrated that aged garlic extract was
highlyeffective, and unlike the approved immunotherapy for human bladdercancer,bacillus Calmette-Gurin (BCG), garlic was effectivewhen added to the diet. To
elucidate the mechanism of this antitumoreffect, the literature describing antitumor and
immune-enhancing
effects of garlic is reviewed. Garlic can detoxify carcinogens
bystimulation of cytochrome P450 enzymes, antioxidant activityor sulfur compound binding.
Studies demonstrate a direct toxiceffect of garlic to sarcoma and gastric, colon, bladder
andprostate cancer cells in tissue culture, but these effects cannotexplain the inhibition ofgrowth of transplanted cancer in animalmodels. The most likely explanation of this effect
is immunestimulation. Comparison of the effects of garlic to BCG immunotherapy
reveals many similarities. Both stimulate proliferation of lymphocytesand macrophage
phagocytosis, induce the infiltration of macrophagesand lymphocytes in transplantedtumors, induce splenic hypertrophy,stimulate release of interleukin-2, tumor necrosis
factor- andinterferon- , enhance natural killer cell, killer cell and lymphokine-activated
killer cell activity. These activities represent effective stimulationof the immune
response. Studies suggest that garlic may be useful
in preventing the suppression ofimmune response that is associatedwith increased risk of malignancy. Data suggest that
maintenanceof immune stimulation can significantly reduce the risk of cancer.Clinicaltrials should be initiated to test the hypothesis that the immune stimulation and other
beneficial effects of garlicare able to reduce the incidence of cancer.
KEY WORDS: immunocopetence garlic cancer bladder mouse
\E Transitional cell carcinoma of the bladder is highly susceptible toimmunotherapy and
is one of a very few human malignancies forwhich immunotherapy is the current
treatment of choice. Immunotherapy
with bacillus Calmette-Gurin (BCG)
3
is superior tochemotherapy in the treatment of carcinoma in situ of the bladder;unlike chemotherapy,
it provides long-term protection from tumorrecurrence and disease progression. Clinicalefficacy in the treatmentof bladder cancer has also been reported with other
immunotherapies,including Keyhole limpet hemocyanin (KLH), interleukin-2 (IL-2),
interferon- (INF- ) and the interferon inducer, bropirimine.
Previous studies have demonstrated that BCG immunotherapy is superior tochemotherapy with thiotepa, doxorubicin or mitomycinin clinical trials, and laboratory
studies have suggested thesuperiority of BCG over alternative immunotherapies. We
were,therefore, surprised by the report of Lau et al. (1990) thatintralesional aged garlic
extract (AGE) was more effective than
BCG in the treatment of transplanted transitionalcell carcinomain the mouse model. In an effort to develop improved treatments for
bladder cancer, we evaluated AGE in the murine model. Theseresults and the data that
suggest that the antitumor activityof garlic may be related at least in part to immunestimulationwill be reviewed.
Antitumor activity of garlic
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The recorded use of garlic in the treatment of tumors dates all the way back to 1550 BC
when ancient Egyptians administered itorally and topically; the modern era, however,
begins in the1950s when Weisberger and Pensky (1958) demonstrated in vitro andinvivo that thiosulfinate extracts of garlic inhibited thegrowth of malignant cells and
prevented growth of sarcoma 180ascites tumor. Since that time, garlic has been
demonstrated
in epidemiologic studies to be associated with a reduced risk
of stomachcancer (You et al. 1989 ) and, in animal models,to have antitumor activity in sarcoma,
mammary carcinoma, hepatoma,colon cancer, and squamous cell carcinoma of the skin
and esophagus(Lau et al. 1990 ). These effects appear to be mediated by variousmechanisms. Prevention of malignant transformation after theadministration of chemical
carcinogens may result from inhibitionof the activation of procarcinogens by garlics
effecton cytochrome P450 enzymes (Dion and Milner 1997 ), antioxidantactivity, or
detoxification by binding to sulfur compounds ingarlic (Abdullah et al. 1988 ). Directinhibition of cancercell growth in tissue culture has been documented in sarcoma as well
as gastric, colon, bladder and prostate carcinoma celllines (Knowles and Milner 1997 ,
Pan et al. 1985 , Weisbergerand Pensky 1958 ). The mechanism of direct tumor cell
inhibition
has not yet been determined. Perhaps the most important action
of garlic in theinhibition of cancer and the topic of thisreview is potentiation of the immune system.
Aged garlic extract as an immunotherapy for bladder cancer
Lau et al. (1986) compared intralesional and intraperitonealgarlic extract therapy with
effective immunotherapies for bladdercancer, BCG, Corynebacterium parvum (CP) andKLH in the transplantablemurine bladder tumor model MBT2. These experiments
demonstratedthat intralesional immunotherapy with each of these agents significantly
inhibited tumor growth (P< 0.05). Maximal inhibition oftumor growth was seen with CP(250g) and garlic extract(25 mg). Significant reduction in tumor growth was observed
with intraperitoneal CP treatment. Intraperitoneal garlic appeared
to reduce tumor growth,although not to the level of statistical significance, and intraperitoneal BCG had no effect.
Examination of hematoxylin and eosinstained sectionsof the transplanted tumorsdemonstrated necrosis and infiltrationwith macrophages and lymphocytes. Intralesional
BCG and CP inducedgranuloma formation as well, but no granuloma were seen after
treatment with garlic extract. Intraperitoneal garlic treatmentproduced tumor necrosis and
infiltration with macrophages andsmall lymphocytes, suggesting an immune response.
This group (Marsh et al. 1987 ) evaluated these same treatmentsintravesically after
intravesical tumor transplantation. The efficacyof CP, garlic and BCG, but not KLH, was
confirmed. Maximal inhibition
of tumor growth was again observed with CP and garlic.Comparingtreatment schedules of 1, 6, or both 1 and 6 d after tumor transplantation,only
garlic treatment achieved statistical significance whengiven as a single treatment 6 d
after transplantation.
Microscopic examination of the bladders revealed infiltrationof macrophages and smalllymphocytes in animals treated withCP, BCG and, to a lesser extent, KLH. Topical garlic
treatmentresulted in extensive macrophage and neutrophil infiltration,with few
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lymphocytes. Splenic weights were significantly increasedin all treatment groups relative
to untreated controls. Splenicphagocytic function and natural killer (NK) cell cytotoxicity
were reported to be significantly increased with both CP andgarlic immunotherapy.
These experiments suggested that garlic treatment effectivelyinhibited growth of
transitional cell carcinoma in vivo. In
view of the recognized toxicity of BCG therapy andthe absenceof observed toxicity with garlic treatment in these studies,garlic therapy
could be an effective treatment alternative forpatients with bladder cancer. Datasuggested that immune mechanismsmight be responsible for the observed beneficial
response togarlic.
To further establish garlic as a safe and effective treatmentfor bladder cancer, weevaluated intralesional and oral AGEtreatment of transitional cell carcinoma in the
murine model(Riggs et al. 1997 ). We confirmed that intralesional garlicextract was
highly effective in the treatment of subcutaneously transplanted MBT2 bladder cancer.
Inhibition of tumor growthwas highly significant (P< 0.001) and similar to that ofBCG
(Table 1 ). Unfortunately, in contrast to the previous investigators,
we observed thatrepeated intralesional garlic injection wastoxic, resulting in death of up to 42% of treated
mice. Reductionin the dose and frequency of intralesional garlic injectionreduced thetoxicity, but our enthusiasm for a clinical trial of intravesical garlic was diminished in
view of the newly discoveredrisk. Because oral garlic has been used for thousands of
years,we sought to evaluate oral garlic in the treatment of transplantedbladder cancer.Remarkably, oral AGE when added to drinkingwater in doses of 5, 50 and 500 mg/100
mL inhibited the growthof transitional cell carcinoma in a dose-dependent manner (Table
2 ). Significant inhibition of tumor growth was seen at the50 and 500 mg/mL dose (P=
0.023 andP< 0.001, respectively),and significant improvement in survival (10 of 20,50% vs. 4of 20, 20% control,P= 0.048) was seen with the 500 mg/mL dose.No adverse
effect of oral garlic administration was seen. Animal
weights did not differ among groupsand water intake was highestin the group with the highest concentration of AGE.Becauseno toxicity was observed and antitumor effect was highest inthe group with the
highest oral garlic intake, it is possiblethat higher doses may be even more effective.
Studies to identifythe optimal oral dose of garlic in the treatment of bladdercancer are inprogress.
Evidence for immunologic antitumor action of garlic
We observed that garlic has direct dose-dependent toxicity to cultured transitional cell
carcinoma cells, but only at doses 15 mg/mL,concentrations that are not practical with
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systemic administration(Riggs et al. 1997 ). The remarkable efficacy of oral,
intravesicaland intralesional AGE is therefore clearly not related to direct cytotoxicity
alone. The alternative antitumor mechanisms ofdetoxification of carcinogens, antioxidantactivity and inhibitionof procarcinogens similarly cannot explain the inhibition ofgrowth
of transplanted cancer. Of the currently recognized effectsof garlic, only immune
stimulation can logically explain the
observed inhibition of growth of transplanted cancer.
What evidence supports immune stimulation as an important antitumor effect of garlic?One approach to answer this question is to compare thereported effects of garlic with a
recognized, Food and Drug Administrationapproved,clinically useful cancer
immunotherapy such as BCG.
The effects of garlic on murine transitional cell carcinomaare remarkably similar to those
of BCG. Both inhibit tumor growth,and microscopic examination of the site of tumor
transplantationreveals infiltration with macrophages and lymphocytes. BCG,but not
garlic, induces granuloma formation. In animal models,both BCG and garlic induce
hypertrophy of the reticuloendothelial
system as measured by splenic hypertrophy. Garlic,like BCG,increases NK cell activity.
Intravesical BCG administration results in the release of cytokinesin the urine, and
elevation of urinary cytokines, particularlyIL-2, tumor necrosis factor- (TNF- ), andINF- , is associatedwith antitumor activity. In animal studies, AGE is reportedto induce
the release of IL-2, TNF- , and INF- (Kyo et al. 1998 ). Enhancedphagocytosis, one of
the first immunostimulatory actions reportedwith BCG, is seen with garlic administration(Kyo et al. 1998 ).Additional activities seen with both BCG and garlic includeenhanced
killer cell activity and immunoproliferation of lymphocytesin response to mitogen
stimulation (Kyo et al. 1998 ). Theseeffects, particularly the pattern of cytokine release,
suggest
that garlic, like BCG, stimulates a Th1 cellular immune response
that ischaracteristic of effective antitumor immunotherapies.
The component in garlic that is responsible for the effective immune stimulation is not
known conclusively, and it is likelythat multiple ingredients are immunologically active.A proteinfraction from garlic is known to augment in vitro macrophagecytotoxicity and
phagocytosis as well as stimulate lymphocyteproliferation (Hirao et al. 1987 ). The
protein fraction 4 (F4)from garlic has been demonstrated to enhance the cytotoxicityofhuman peripheral blood lymphocytes against NK-sensitive (K562) and NK-resistant
(M14) cell lines (Morioka et al. 1993 ). Theseeffects were markedly augmented by the
addition of low dosesof IL-2. The combination was also more effective in inducing
lymphokine-activatedkiller cell activity. F4 enhanced IL-2 or conconavalin Ainducedproliferation of lymphocytes and IL-2 receptor expression. Theenhanced cytotoxicity
induced by F4 and F4 plus IL-2 was abolishedby anti-IL-2 antibody, suggesting that the
activity of F4 ismediated by IL-2 (Morioka et al. 1993 ). These data suggestthat the F4fraction of garlic is an efficient immunopotentiatorthat may be effective in cancer
immunotherapy.
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Although the F4 fraction of garlic is clearly an immune stimulant,it is not the only
immunologically active ingredient in garlic.Therefore, F4 may not be entirely
responsible for the observedbeneficial response in transplanted tumors. In studies of theeffect of diallyl disulfide on the growth of transplanted humancolon carcinoma cell lines
in immunologically compromised nudemice, Sundaram and Milner (1996) found diallyl
disulfide to
be as effective as 5-fluorouracil (5-FU) in inhibiting tumor
growth.Combining the diallyl disulfide and 5-FU did not increasethe effect, but concurrent
diallyl disulfide treatment did significantlyreduce the depression of leukocyte counts and
splenic weightassociated with chemotherapy administration (Sundaram and Milner1996). In another study, Geng et al. (1997) examined the effectsofS-allyl cysteine, a water-
soluble constituent of garlic thatinhibits chemical carcinogen-induced colon and
mammary tumors inanimals and inhibits the growth of neuroblastoma and melanoma in
vitro. In studies of human T cells, S-allyl cysteine was foundto inhibit activation of thenuclear protein of the Rel oncogene family(nuclear factor- B). This protein, which is
induced by TNF- orH2O2, regulates immune function, inflammation and cellular growth
(Geng et al. 1997 ). These studies suggest that low-molecular-weight compoundsas well
as proteins found in garlic have antitumor and immune effects.
Prevention of immune suppression
Immune surveillance offers protection from cancer and from impairmentof immune
defenses, as occurs with conditions ranging from abnormalitiessuch as acquired
immunodeficiency syndrome (AIDS) to the normal aging process. In addition toenhancing NK function in AIDS patients, garlic is reported to improve age-related
deterioration of learningbehavior and impairment of immune response in a mouse model
(Zhanget al. 1997 ). The most common carcinogen, ultraviolet irradiation,appears to beinhibited by garlic. UV irradiation damages DNA and induces a specific defect in T-cell
immunity, impairing
the recognition of UV-induced malignancy. Most interestingly,
oralgarlic administration is found to protect from photoimmunosuppression(Reeve et al.
1997 ). Induction of an impaired immune responseby the tumor itself is an effectivemeans to escape destructionby host surveillance mechanisms. It is not known whether
garliccan reduce the inhibition of immune response induced by tumor,but the observed
responses are certainly compatible with this hypothesis.Protection from immunesuppression is potentially an importantmechanism in preventing the development of
malignancy. For example,in our experience with maintenance BCG immunotherapy in
patientswith superficial bladder cancer, stimulation of the immune systemfor a period of3 y not only protects from recurrence of bladdercancer, but significantly reduces the
incidence of other malignanciesas well (Lamm et al. 1999 ). Additional evidence that
garlic
potentiates immune responses is provided from other studies
as well. In a study ofthe effect of garlic on the neuroendocrineand immunomodulation network, Zhang et al.(1997) reportedthat AGE improves age-related deterioration of learning behavioras
well as impaired immune response in a mouse model. Garlic increased not only
lymphocyte proliferation, as seen in otherstudies, but antibody production as well (Zhanget al. 1997 ).
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Further study will be required to identify the active ingredients in garlic that are
responsible for the observed antitumor activityand immune stimulation. Data now
suggest that low-molecular-weightsulfur compounds and F4 have immune-stimulatingproperties andalso that garlic can detoxify chemical carcinogens to prevent
carcinogenesis and directly inhibit the growth of cancer cells. Garlic appears to stimulate
immunity including macrophage activity,
NK and killer cells, and lymphokine activatedkiller cells,and it increases production of IL-2,TNF, and INF- . These cytokinesare
associated with the beneficial Th1 antitumor response, whichis characteristic of effective
cancer immunotherapies. LikeBCG, garlic stimulates proliferation of macrophages andlymphocytes,and also protects against suppression of immunity by chemotherapy and UV
radiation. Garlic is clearly not a panacea for cancer,but its broad range of beneficial
effects warrants serious considerationin clinical trials for the prevention and treatment of
cancer.
Fighting Infection without Antibiotics
We have been putting out the slogan, "say no to drugs, say yes to herbs" for several years
now. One of the drugs I'd like to see people start saying "NO" to is antibiotics. However,
people are scared not to take antibiotics when they are sick. They are even more scarednot to give them to their kids. I am no stranger to antibiotics, I was raised on them. For
the first twenty years of my life my sinuses were always stuffed and I had to breathe
through my mouth. I was always getting sick (colds, coughs, sore throats, sinusheadaches, etc.) and I was always taken to the doctor, who always gave me antibiotics. I
was probably taking penicillin an average of two to three months each year. Starting atabout 14 the doctor gave me penicillin every day for a period of about two years. Thiswas supposed to clear up my sinusitis. It only made it worse. By age 19, I was getting
sick all the time. I wound up with walking pneumonia and had to take both tetracyclin
and ampicillin, since penicillin did not do anything for me anymore.
It was shortly after this I got into natural health and quit using the antibiotics. As far as I
can remember I have used an antibiotic three times in the last 15-20 years and I am not
certain I would use one again, if I had the same problems. Most of you probably knowthat antibiotics contribute to yeast infections, which weaken the immune system. You
probably know that they kill the friendly bacteria in your colon, too. I have always felt
that antibiotics make the body lazy because they are doing something for the body that itshould be doing for itself. However, I think there may even be deeper problems here.
At the American Herbalist Guild 1997 symposium, Paul Bergner, N.D. and editor ofMedical Herbalism, said something about antibiotics which really set me to thinking. He
said that he has not been able to find any convincing proof that antibiotics kill bacteria in
living tissue. They do so in the test tube, but that does not mean they are doing it inside
the human body. He suggested that antibiotics might just be suppressing symptoms of
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infection.
Let me elaborate. Most of you know that I have been teaching for years that "the cold isthe cure." That is to say, symptoms of acute illness are produced by the body's immune
system fighting the disease. Fever, coughing, etc. are all signs that the body's immune
response is working to fight the illness. Dr. Bergner said that Herring's Law of Cure wasdeveloped from observations made at a homeopathic hospital. It appears that smallpox
went through one wing of the hospital and all the patients came down with the disease.
When they got the smallpox, the symptoms of their original illness, mumps, fever, etc.disappeared. After successfully treating the patients homeopathically for smallpox,
however, the original disease they had returned. What Dr. Herring hypothesized was this:
When the body is fighting off one disease, and another more serious threat is presented to
the body, the body will quit fighting off the first disease and tackle the more seriousproblem. Once the system has rid itself of the more serious threat, it will go back to work
on the less serious illness. This is why Herring's law tells us that the body heals "in
reverse order of symptoms suppressed." In his lecture, Paul Bergner, said that when
people have infections they are manifesting good symptoms of a healing crisis, fever,inflammation, etc. Then, we introduce an antibiotic, a concentrated mold toxin, into the
system. The body takes a look at the mold toxin and says, "Wo! We have a serious threathere." So, it quits fighting the infection and starts working to get rid of the mold toxin.
Thus, the symptoms of infection disappear.
However, shortly after the person quits taking the antibiotic (often in about two to four
weeks) the person gets sick again. You see, now that the body has successfully fought the
invasion of mold toxin, it goes back to fighting the original illness. This means that the
antibiotic has not cured anything, it has merely replaced one disease with another. It alsoexplains why people who constantly take antibiotics (like I used to) keep getting sicker
and sicker. They are merely suppressing the body's efforts to get well. I am too chicken to
tell you never to use an antibiotic. In fact, even since I decided antibiotics were not goodfor the body about fifteen years ago, I've broken down on three occasions and gotten one
myself. Twice I got them for my ears - once when my eardrum ruptured and once when I
could not seem to get rid of an ear infection. In both of these cases I do not think theantibiotic helped one bit. The third time was an infection on my finger that I could not
seem to heal. That time the antibiotic seemed to help. So, maybe sometimes the body
does need a little suppression of symptoms. However, most of the time, I feel the natural
alternatives are so superior in their effectiveness, that I am seldom tempted to evenconsider antibiotics from the doctor.
Here are some of my favorite infection fighting remedies.
Garlic
In my opinion, garlic is the king of natural infection fighters. Although it is useful foralmost any type of infection, bacterial, yeast or viral, it excels at fighting infection in the
respiratory and lymphatic systems. When I'm really serious about knocking something
out I use raw garlic. I've taken one or two cloves, chopped them finely and swallowed the
pieces with some water and a little bread or crackers (to reduce stomach upset).
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I've also used the garlic oil orgarlic oil capsules, both topically and internally. Lately,
I've taken to using theHigh Potency Garlic from NSP. I have been given to understandthat each of these tablets is equivalent to about four cloves of raw garlic in potency. This
form of garlic is nice, since it doesn't produce the odor or the stomach upset of raw garlic.
I am not timid about using garlic for infection. I have taken as much as two cloves or onehigh potency garlic tablet every two hours fora couple of days to clear up a problem.
I've rubbed garlic oil on my children's chests two or three times per day and I have given
them a half dropperful or the contents of a soft gel capsule every 30 minutes for a coupleof hours.
Silver Shield (Colloidal Silver)
Next to garlic, my favorite antibiotic has become colloidal silver. A colloid is a microfinesuspension of something in a solution. Silver has long been known to have a preserving
and anti-bacterial action. A few years ago I learned that one of the ways to purify water is
to put some silver coins in it. This is what the pioneers did to preserve their water in their
barrels while traveling across the plains. Silver coins also used to be put into milk toprevent it from spoiling. Colloidal silver seems to work very well in fighting bacterial
infection. I used it on our son, Joshua, because of his weak immune system. I have used itin both his ears and my ears to help fight infection. It has an antiinflammatory quality to
it.
Goldenseal or Oregon grape
Goldenseal has long been used to fight infection. However, as I mentioned before, I am
trying to steer people in the direction of using Oregon grape as an alternative in order to
preserve our wild populations of goldenseal.
Oregon grape is also cheaper and does not lower blood sugar levels like goldenseal.
All of these herbs contain berberine, an alkaloid known to help the body destroy anumber of harmful bacteria. These herbs also tone the mucous membranes, stimulate the
liver and help to cleanse the lymphatics. Goldenseal has its strongest affinity for the
digestive tract, while Oregon grape is more for the lymphatics and barberry for the liver.These herbs combine well with immune stimulants likeechinacea and astragalus. They
help the body fight off bacterial infection without promoting yeast overgrowth.
Once, when I had an abscess on a tooth and the dentist wanted me to take an antibiotic, Iwent home and took 4 capsules of goldenseal and two raw garlic cloves every two hours
for two or three days. Not only did I clear the infection naturally, I also had a healing
crisis doing this. My body passed a residue of tetracycline and ampicillin from mysinuses. It had been over fifteen years since I had taken these antibiotics for pneumonia
and they had lodged in my body all those years. Do you see why I am not so hot on
antibiotics?
Volatile Oils
For some serious infections, I hae found that blends of volatile oils work wonders. Tea
Tree oil, of course, is a classic. It is a wonderful topical antiseptic. Unlike it's
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pharmaceutical counterparts which damage healthy tissue and slow healing, tea tree oil
actually stimulates growth of healthy tissue and speeds healing. It can be applied
externally to cuts, scrapes, wounds, bruises, burns, etc. You can also gargle with it if youdilute a few drops to a couple of ounces of water. You have to be very careful when
taking volatile oils internally, since they are very potent substances. Tea tree oil can be
used internally when diluted to a strength of one to five drops per pint of water.However, I have often mixed more potent volatile oil blends and diluted them with olive
oil (ten to one) to fight serious infections. My favorite oils for this purpose, besides tea
tree oil, of course, are: lemon,lavender, thyme, myrrhandcloves. You'll need to domore research on your own, however, before you start experimenting with volatile oils
internally.
Another useful infection fighter is IN-X.
IN-X contains goldenseal, parthenium, black walnut, plantain, althea and bugleweed.
Black walnut has antiseptic properties and supplies natural iodine to the body, which is a
powerful infection fighter. Althea has been used for respiratory problems. Plantain is an
anti-poison herb, and bugleweed has been used for respiratory and circulatory problems.IN-X works well in combination with extra garlic for fighting low grade infections in the
body.
Most of the time, these herbal remedies will actually work better at fighting infection
than antibiotics will. Just remember not to be timid about using them. I typically takesome of these herbs about every two hours when infection is present. Also remember that
these remedies are not necessarily the best for viral infections like colds and flu. Frankly,
no one should take an antibiotic for a cold or the flu anyway, since antibiotics don't
have any affect on viruses. Doctors know this, they just prescribe the antibiotic for peoplebecause that's what they think people want.
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7/29/2019 Garlic Benefit
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Garlic has been used for centuries as a medicinal herb. It has been cultivated in the
Middle East for more than 5,000 years and has been an important part of Traditional
Chinese Medicine. The bulb is used medicinally. It has been traditionally used for manyconditions, including parasites, respiratory problems, poor digestion, and low energy.
It has these constituents:
Highest sulphur content of any plant in the Allium genus.
Trace elements: germanium, selenium
Volatile oil containing sulphur compounds
Amino acids allin and allicin.
Benefits of Garlic
Dosage
Side Effects
Benefits of Garlic
Clinical Applications include:
Antioxidant protection
Atherosclerosis
Prevention of thrombosis
Hypertension
Acute rhinitis Influenza
Infectious bronchitis
Benign prostate hyperplasia
Colon cancer
High cholesterol
High triglycerides
Intermittent claudication
Warts (used topically).
Our review of the medical literature reveals the following information about the use of
garlic extracts.
Antioxidant Protection
Allicin increases blood levels of two antioxidant enzymes: catalase andglutathione peroxidase.
Acts as an effective antioxidants against the oxidative damage caused by nicotine.
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Protects vascular endothelial cells from oxidant injury.
Prevents LDL oxidation.
Inhibits lipid peroxidation in the liver, retarding the aging process in liver cells.
Oxygen free radicals are involved in the genesis and maintenance of
hypercholesterolemic atherosclerosis it can be useful in preventing the
development of hypercholesterolemic atherosclerosis.
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Anti-Atherogenic
Helps in preventing the development of hypercholesterolemic atherosclerosis.
Reduces lipid content in arterial cells and prevents intracellular lipidaccumulation.
Counteracts the effects of a high-sucrose diet in lab animals, minimizing
elevations in triglycerides and cholesterol.
Minimizes or prevents elevations in blood lipids in humans after consumption of ahigh-fat / cholesterol meal.
The organic disulphides in garlic can inactivate the thiol groups in the enzyme
HMG CoA reductase , thereby inhibiting cholesterol synthesis by the liver.
Not only a preventive but possibly also a curative role in arteriosclerosis therapy
(plaque regression) may be ascribed to garlic remedies.
Lowers total cholesterol by 10%; lowers LDL-cholesterol by 15%; lowerstriglycerides by 13%; increases HDL-cholesterol by 31%.
Anti-Thrombotic
The constituent ajoene inhibits platelet aggregation regardless of mechanism of
induction.
Serves as beneficial agent in the prevention of thrombosis.
Inhibits thrombosis due to vascular damage.
Increases fibrolytic activity.
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Anti-hypertensive (high blood pressure)
Lowers systolic pressure by 20-30 mm Hg and diastolic by 10-20 mm Hg. Inhibits in vitro the enzyme cyclo-oxygenase, which can produce pro-
inflammatory and hypertensive prostaglandins.
Anti-Microbial
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1 mg garlic = 15 Oxford units of penicillin. Garlic has 1% of the potency of
penicillin.
Inhibits Candida albicans in animal studies and Cryptococcal meningitis in humantrials.
Exhibits broad-spectrum antimicrobial activity:
o
Gram-positive bacteria: Bacillus cereus, Bacillus subtilis, Mycobacteriumsmegmatis, Streptomyces griseus, Staphylococcus aureus, Lactobacillus
plantarum.
o Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, and
Xanthomonas maltophilia.
Demonstrates in vitro virucidal activity against herpes simplex virus type 1,
herpes simplex virus type 2, parainfluenza virus type 3, vaccinia virus, vesicularstomatitis virus, and human rhinovirus type 2.
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Dosage
Cardiovascular preventive intervention - Commercial preparation to provide at
least 4,000 mcg of allicin daily which is equivalent to 2-4 cloves of fresh garlic.
Immune support - 4,000 mcg of allicin 3 times daily.
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Side Effects
Be cautious if you are taking anticoagulant drugs. Some people experience gastricirritation even at moderate doses. Other people have difficulty metabolizing allicin
effectively.
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