Founders

With the support of

2

Letters of intent

Individual quotation, then selection by the SAB Validation by the Bureau

Full Application

Individual quotation, then selection by the SAB

Proposal to the bureau

Selection and validation by Executive Comittee

Selection process

40

15

10

3

Selected Projects

Comparison of bioassay, Scrapie Cell-Assay and Protein Misfolding Cycle Assay performances for detection of endogenous Prion in sheep blood

Principal Investigator: O. Andreoletti (INRA-ENVT, Toulouse, France)

4

Selected Projects

Probing the chemistry and conformational change underlying autocatalytic self-propagation of misfolded prion protein

Principal Investigator: M. Beekes (Robert Koch Institute, Berlin, Germany)

5

Selected Projects

Optimisation, evaluation and validation of a PMCA-based confirmatory screening assay to detect prions in human blood. A French and British Collaborative Study

Principal Investigators: J. Coste (EFS-PM, Montpellier, France) M. Jones (SNBTS, Edinburgh, UK)

6

Selected Projects

Assessment of prion infectivity in blood in primate and sheep models, and evaluation of removal processes (extension 2009)

Principal Investigator: D. Dernis (EFS-Nord, Lille, France)

7

Selected Projects

Infectivity titrations of blood components from chimpanzees infected with the agent of Gerstmann-Sträussler-Scheinker Syndrome in mice and comparison of sensitivity of mouse bioassays

Principal Investigator: L. Gregori (FDA, USA)

8

Selected Projects

Evaluation of cold atmospheric plasma to decontaminate surgical instrument surfaces and eliminate prion infectivity

Principal Investigators: C. W. Keevil (Southampton University, UK) R. Hervé (Southampton University, UK)

9

Selected Projects

An assessment of the relevancy of sheep and mice animal model for blood safety investigation

Principal Investigator: C. Lacroux (INRA-ENVT, Toulouse, France)

10

Selected Projects

Detection of PrPSc (a biomarker for TSE infection) in blood using QUIC shake technology: validation of in vitro studies with infectivity models

Principal Investigators: J. C. Manson (The Roslin Institute, UK) S. MacCutcheon (The Roslin Institute, UK)

11

Selected Projects

Elucidation of the misfolding process… Insights into a preamyloid state by selectively trapping prion proteins in oligomeric forms

Principal Investigator: J. Torrent (INSERM, Montpellier, France)

12

Selected Projects

Risk assessment of Insoluble PrP from normal human brains

Principal Investigator: W.Q. Zou (Case Western Reserve University, Cleveland, USA)