flexible, reliable, and configurable bioprocessing...

Flexible, reliable, and configurable bioprocessing solutions For process development and production operations

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HyPerforma G3Lite Controller

The Thermo Scientific™ HyPerforma™ G3Lite™ Controller is an open architecture control system that can be integrated with any single-use bioreactor such as the Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) (Available in sizes ranging from 50 L to 2,000 L). The system consists of a control tower that leverages intelligent transmitters, mass flow controllers (MFCs), pumps, sensors, and Thermo Scientific™ TruBio™ software that facilitates easy, reliable, and repeatable process development and commercial cell culture processes. HyPerforma G3Lite Controllers are fully self-contained, movable units that can be operated as stand-alone (for 1 vessel) or networked for multiple vessels. They are engineered to optimize capital cost for use in non-GMP and cGMP-certified production facilities.

Features• Stand-alone or networked (for multiple vessels)—

enabled by distributed control system (DCS)

• Includes up to six MFCs with air, O2, NS, CO2 for drilled-hole spargers (DHS); air for frit or open pipe spargers; air for overlays

• Probe configuration options—flexibility to connect electrochemical, single-use, or both for pH and dissolved

oxygen (DO) measurements

• Foam level, load cell, and TruTorr™ II pressure transmitters included in controller

• Scalability—transfer any process from 50 L to 2,000 L

• Modularity—predefined configurations available for 50, 100, 250, 500, 1,000, and 2,000 L bioreactors

• Scales and pumps available for multifeed purpose, including four peristaltic pumps for acid, alkali, antifoam, and feed

• Includes vent filter heater controller

• Touchscreen interface for easy data entry and control when necessary

• Temperature control unit (TCU) integration options available for implementing a temperature control strategy

Benefits• Open architecture capabilities to integrate and

communicate with vessels from other suppliers* (Sartorius, Millipore, and GE)

• Return on investment (ROI)—increase productivity and minimize downtime

G3Lite Controller specifications

Cart dimensions (H x W x D) 160 x 68 x 54 cm (63 x 27 x 21 in.)

Enclosure rating Cart: NEMA 12/IP52, HMI-NEMA 4X

Operating temperature 5°C to 40°C (41°F to 104°F)

Storage temperature –25°C to 70°C (–15°F to 158°F)

Relative humidity 5% to 95% (noncondensing)

Certifications CE specifications EN-60101 and EN-61325

Weight/shipping weight 68 kg/136 kg (150 lb/300 lb)

pH TruSens Transmitter (electrochemical), TruFluor pH Transmitter (single-use)

DO TruSens Transmitter (electrochemical), TruFluor DO Transmitter (single-use)

Temperature TruSens Transmitter (RTD)

Pressure TruTorr Transmitter

Load cells** Transmitter (vessel has built-in load cells)

Foam level Transmitter and cable assembly

Agitator Variable frequency drive (VFD) included to control agitator motor

* Depending on the vessel type and model, an engineered-to-order (ETO) product may be needed.

** Please refer to the HyPerforma S.U.B literature for more information on load cells.

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HyPerforma G3Lite Controller and S.U.B. specifi cations

S.U.B 50 L 100 L 250 L 500 L 1,000 L 2,000 L

Tank style Jacket Jacket Jacket Jacket Jacket Jacket

Vent fi lter heater (VFH)

VFH for Pall KA3 vent fi lter




VFH for Meissner 10 in. vent fi lter (quantity of 2)

VFH for Meissner 10 in. vent fi lter (quantity of 2)

Acid/alkali/antifoam/media feed control

3 ultralow-fl ow pumps (114 Watson Marlow head, 3 rollers, tubing with 1.6 mm wall thickness)

1 low-fl ow pump(313 Watson Marlow head, 3 rollers, tubing with 1.6 mm wall thickness)



3 ultralow-fl ow pumps (114 Watson Marlow head, 3 rollers, tubing with 1.6 mmwall thickness)



2 low-fl ow pumps(313 Watson Marlow head, 3 rollers, tubing with 1.6 mm wall thickness)

1 pump assembly(digital 520 standard, 2 rollers, tubing with 2.4 mm wall thickness)

1 ultralow-fl ow pumps(114 Watson Marlow head, 3 rollers, tubing with 1.6 mm wall thickness)

2 low-fl ow pumps(313 WM head, 3 rollers, tubing with 1.6 mm wall thickness)

1 pump assembly(digital 520 standard, 2 rollers, tubing with 2.4 mm wall thickness)

2 ultralow-fl ow pumps (114 WatsonMarlow head, 3 rollers, 1tubing with 1.6 mm wall thickness)

2 pump assemblies (digital 520 standard, 2 rollers, tubing with 2.4 mm wall thickness

TCU (air-cooled)

Lauda VC1200 D model (Cat. No. SV50239.80)





Lauda VC10000D model (Cat. No.SV50239.86)*

TCU (water-cooled)







Note: The controller is confi gured for additional scales and pumps, which are not included in the quote and need to be purchased separately. For more information on scale and additional pump model options, please contact your sales representative.* The standard model for the 2,000 L HyPerforma S.U.B. is the water-cooled version.

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Automation packages 1 2 3 4 5

Cat. No. F100-2697-001 F100-2697-002 F100-2698-001 F100-2699-001 F100-2700-001

Number of G3Lite controllers* 1 1–2 3 4 5–8**

TruLogic Base Cabinet (NEMA 12/IP54, stainless steel cabinet)

1 1 1 1

TruLogic Base Panel (inside G3Lite) 1

DeltaV MQ Controller, M-Series, VE3008 1 1 1

DeltaV MX Controller 1 1

Serial Card 1 1 2 2 3–4

TruBio Media Version 13, Release 5.0.X 1 1 1 1 1

DeltaV Software Media Pack 1 1 1 1 1

ProPlus 25 Device Signal Tag (DST) 1

Analog Control Output 25 DST 1

Guardian Support, 1 Year, 100 DST 1

Thermo Fisher Scientific remote support services (requires customer to be current on annual service contract; otherwise, daily rates will apply)

1 1 1 1 1

Microsoft Excel™ software, one license 1 1 1 1 1

ProPlus Workstation, Precision Minitower, No Monitor, DeltaV Dual and Quad Monitor, English or Non-English Microsoft™ Windows™ 10 Enterprise IoT 2016, RAID 1

1

Small Form Factor Tower, Single Monitor, Windows 10 Enterprise loT 2016; Quad-Core CPU, 1 x 500 GB SATA Drive (monitor not included)

1 2 3 4–7

Base Station License 1 2 3–6

Base Station Scale-Up License, 100 DST 1 2 3–6

Process History View License 1 2 3–6

TruBio Slave Dongle (or software key), Permanent 1 2 3 4–7

PlantWeb Experience 100 DST, v12.3 or Newer Software - one operator station/250pt OPC-DA on ProPlus/1 year foundation support included

1 1 1 1

ProPlus Workstation (PowerEdge tower server,RAID 1, Windows Server 2016 for DV 13.3)

1 1 1 1

Cable Assembly, cat5e, Yellow Boot, TruLogic, PRI Network, 20 ft (6 m)

2 3 4 8

Cable Assembly, cat5e, Black Boot, TruLogic, SEC Network, 20 ft (6 m)

2 3 4 8

22 in. Wide-Screen Monitor (required for TB 5.0 batch) 1 2 4 5 6–9

Application/Base Station License (250 DeltaV for OPC-DA plus 250 DeltaV Historian Parameters) (required for Application Station use)

1 1 1

Application Station/Historian License Scale-Up (1000 DeltaV Historian Parameters)

1 1 1

Application Station (PowerEdge tower server, RAID 10, Windows Server 2016)

1 1 1

DeltaV equipment crating/packaging (FSVR-CRA-DLV) 1 1 1 1

Audit Trail 1 1 1 1 1

Automation packages

* One G3Lite controller per bioreactor

** The quantity depends on the number of G3Lite controllers purchased.

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Thermo Scientifi c™ TruBio™ confi gurable upstream software provides easy-to-use process control. It can be confi gured by the user through a visual interface, eliminating the need to know process control programming. TruBio software is powered by an Emerson™ DeltaV™ system, has been developed according to GAMP™ 5 methods, and conforms to regulatory requirements for use in cGMP-compliant processes. Developed for use with HyPerforma controllers, TruBio software is designed to support easy-scaling tech transfer, reducing the time required for validation services. It enables the user to build sophisticated process control strategies without knowledge of DeltaV programming. It also provides the fl exibility to incorporate a wide range of cell culture, fermentor, or mixing vessels and manage multiple data streams from several unit operations.

TruBio software features and options• Calibration fl exibility, even for analog devices

• User interface provides ability to display pump and gas fl ow rate and total volume

• User interface provides display of set point (SP), outputs, and process value (PV) of all connected sensors

• Ability to defi ne default sensor as primarily for process control and redundant sensor (values) for display purposes

• Full record and display of the last vessel process information, including SPs

• Defi ne and set alarm notifi cations via email and integrate with building alarm*

• Option to save and load previously defi ned vessel process parameters

• Multi-feed scale function

• Up to four feeds on one scale to save cost and space

TruBio upstream softwareFlexible software

* Not a standard feature, and may require additional confi guration and module to enable it.

TruBio software capabilities

Basic operations• Key parameter display on

confi guration page

• Analyzer data entry pages

• Vessel settings

• Backup and restore procedures

• User access confi guration

• Online parameter updates

• 21 CFR Part 11 compliance

Controls and settings• pH control

• DO control

• Weight control

• Auxiliary input control

• Agitator speed control

• Gas fl ow control

• Pump control

• Foam and level control

• Vent heat control

Process data storage• Continuous historian

• Audit trail

• Alarm and events

Alarm management• Alarm confi guration • Alarm priorities

Calibration• pH sensor: one-point,

two-point (applicable only to electrochemical sensors; not for single-use sensors)

• DO sensor: one-point, two-point

• Temperature sensor: one-point, two-point

• Pressure sensor: one-point

• Pump

• Agitator speed: one-point, two-point

• Vessel weight: zero, tare

• Auxiliary input

Miscellaneous• Interlock confi guration

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Key advantages• The S.U.B works with single-use Thermo Scientifi c™

BioProcess Containers (BPCs) made with Thermo Scientifi c™ CX5-14 and Aegis™ 5-14 fi lms

• Films have been tested for leachable and extractable (L&E) according to BioPhorum Operations Groups (BPOG) guidelines

• Open architecture allows interoperability with any available control system

• S.U.B and BPC systems are designed using traditional stainless steel bioreactor principles to help ensure optimal cell culture performance

• 50, 100, 250, 500, 1,000 and 2,000 L sizes with 5:1 turndown ratio for consistent scalability for fi nal production

The HyPerforma S.U.B. is one of the most widely used S.U.B.s designed for mammalian cell culture. We fi rst launched the HyPerforma S.U.B. in 2006, and updated the design in 2013, while maintaining the robust, top-down, stirred-tank mixing system.

The S.U.B. has been widely adopted in process development and clinical trials as well as in bioproduction of cGMP cell culture. A superior solution, our bioreactors can be easily integrated withany controller available in the market today.

HyPerforma S.U.B.

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5:1 S.U.B. hardware dimensions and weights

Tank overall, including cable management tree: W x L x H

Jacketed tank weight: dry/wet at full working volume

50 L 94.2 x 84.3 x 198.6 cm (37.1 x 33.2 x 78.2 in.)

141.2 kg (311 lb) 191.2 kg (422 lb)

100 L 98.5 x 91.2 x 201.5 cm (38.8 x 35.9 x 79.3 in.)

219.09 kg (483 lb) 318.88 kg (703 lb)

250 L 112.8 x 102.2 x 215.5 cm (44.4 x 40.25 x 84.4 in.)

248.9 kg (5489 lb) 498.9 kg (1,100 lb)

500 L 125.2 x 124.4 x 251.1 cm (49.3 x 47.8 x 98.9 in.)

362.42 kg (799 lb) 862.28 kg (1,901 lb)

1,000 L 143.8 x 139.2 x 284 cm (56.6 x 54.8 x 111.8 in.)

655.01 kg (1,444 lb) 1,655.21 kg (3,649 lb)

2,000 L 179.7 x 171.4 x 355.5 cm (70.5 x 67.5 x 140 in.)

942.1 kg (2,078 lb) 2,938.1 kg (6,478 lb)

HyPerforma Single-Use Bioreactor specifications

5:1 S.U.B. hardware specifications

50 L 100 L 250 L 500 L 1,000 L 2,000 L

Liquid working volume 50 L 100 L 250 L 500 L 1,000 L 2,000 L

Minimum liquid working volume 10 L 20 L 50 L 100 L 200 L 400 L

Total reactor volume (not working volume) 65.5 L 120 L 316 L 660 L 1,320 L 2,575 L

Fluid geometry at working volume (height:diameter ratio) 1.5 1.5 1.5 1.5 1.5 1.5

Overall reactor geometry (height:diameter ratio) 1.9 1.9 1.9 1.9 1.9 1.9

Impeller (quantity x blade count) 1 x 3 1 x 3 1 x 3 1 x 3 1 x 3 1 x 3

Mixing rate range (rpm) 30–200 30–200 30–150 30–150 20–110 20–75

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The Thermo Scientifi c™ TruFlow™ gas MFC is designed to work with all of the HyPerforma control systems. Its compact assembly provides up to six standard mass fl ow controllers, three associated solenoid valves, and three gas outlet bulkheads from which to direct the gases. When connected, the TruFlow gas MFC is instantly recognized by TruBio software to provide precise control of gas fl ow, without requiring any confi guration, even at extremely low fl ow rates.

Features• Variety of fl ow rate options*

• Flow range confi gurability

TruFlow gas mass flow controller (MFC)

HyPerforma control systems. Its compact assembly provides up to six standard

MFC is instantly recognized by TruBio software to provide precise control of gas

TruFlow gas MFC specifi cations

Enclosure dimensions (H x W x D) Six mass fl ow controllers: 9.14 x 7.4 x 6.22 in.

Rating NEMA 5, IP 51 (liquid wipedown)

Maximum gas fl ow rate Confi gurable up to 30 slpm*

Weight/shipping weight 5.76 kg/9.1 kg (12.8 lb/20 lb)

Operating temp 5ºC to 40ºC (41ºF to 104ºF)

Storage temp –25ºC to 70ºC (–15ºF to 158ºF)

Relative humidity 5% to 95% (noncondensing)

Certifi cation CE (EN-61326 and EN-61010)

Inlet pressure 1.6 to 2.3 bar/25 to 35 psig

Outlet pressure 0 to 1.38 bar/0 to 20 psig

Accuracy ±0.8% of fl ow rate and ±0.3% full scale (Burkert)

Repeatability ±0.1% full scale (Burkert)

Mass fl ow controllers Up to six per vessel (standard)

Solenoid valves Three per gas

Outlet headers/spargers Three total

Cable assembly 2 m (6 ft) standard

Range of operating parameters

Volume 50 L 100 L 250 L 500 L 1,000 L 2,000 L

Recommended maximum gas fl ow rates (slpm) D

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fl ow

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DH

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Air 5 5 5 10 9 9 25 13 13 50 25 25 100 40 40 200 60 60

O2 5 – – 10 – – 25 – – 50 – – 100 – – 200 – –

CO2 1 – – 2 – – 2 – – 2 – – 5 – – 5 – –

N2 1 – – 2 – – 5 – – 5 – – 10 – – 10 – –

Total 5 5 5 10 9 9 25 13 13 50 25 25 100 40 40 200 60 60

Exhaust load 20 20 90 90 180 360

Note: MFCs greater than 50 L/min are mounted as individual units and are not part of the main MFC block.* May require additional confi guration for specifi c fl ow rate. Please consult with your local sales representative for more information.

• Plug-and-play connectivity

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Precision for dosing, feeding, mixing, transferring, and harvestingSuitable controller pumpheads are utilized to meet high-precision liquid delivery requirements in upstream (with controller) and downstream (external pumps) bioprocess applications. The pumps combine industry-known Watson Marlow™ pump heads with electronic boards. This pairing off ers optimized control of dosing, feeding, product transfer/harvest, buff er mixing (gradient or step), or general liquid management.

Features• Ability to easily switch the pump models for diff erent

fl ow rates

• Auto-detection for the pump by TruBio software

Superior, proprietary pump technology

Unleash your controllerThese pumps are standard in the HyPerforma G3 controllers and can be easily exchanged if the process fl ow rate requirements change. In HyPerforma G3 controllers, all of the pumps’ communications are aggregated by a master communication board; this board reads process values from and sends instructions to the pumps.

Pump specifi cations

Pump series 114 313 520

Power supply 24 V DC 24 V DC 24 V DC

Max current (at 25°C) 0.25 A 0.95 A 1.5 A

Average current (at 25°C) 0.2 A 0.75 A 1 A

Operating temperature 5°C to 50°C (41°F to 122°F)

Storage temperature –10°C to 70°C (14°F to 158°F)

Humidity 10% to 90% (noncondensing)

Speed 5 to 160 rpm 1 to 300 rpm 1 to 300 rpm

Accuracy ±2 rpm, or ±2% of set point ±1 rpm, or ±2% of set point ±1 rpm, or ±2% of set point

Certifi cations CE: EN-60101 and EN-61326 CE: EN-60101 and EN-61326 CE: EN-60101 and EN-61326

Tubing (thickness, ID) 0.8 mm, 4.8 mm 0.8 mm, 8.0 mm 1.6 mm, 9.6 mm

Pump speed Minimum/maximum fl ow rates

1 0.16 mL/3 min (5 rpm) 0.05 mL/3.1 min 0.4 mL/10.6 min

10 0.3 mL/6 min 0.5 mL/31.4 min 4.2 mL/106.8 min

50 1.7 mL/30 min 3.2 mL/179.8 min 21.2 mL/536.9 min

100 3.4 mL/57.5 min 6.3 mL/335.4 min 42.6 mL/1,102.6 min

160 5.5 mL/104 min NA NA

250 NA 15 mL/630 min 105.6 mL/2,879.7 min

300 NA 17.7 mL/808.1 min 123.2 mL/3,400.0 min

114 series

313 series

520 series

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We provide reusable sensors with high reliability and superior performance for cell culture and fermentation process monitoring. Thermo Scientifi c™ TruDO™ and TrupH™

sensors have been specifi cally designed to minimize drift in bioprocess environments, undergo sterilization cycles, and help ensure measurement consistency from batch to batch. We also provide material certifi cates and lot traceability for cGMP applications.

TruDO and TrupH sterilizable sensors

Sensor specifi cations

TrupH K8 TrupH VP6 TruDO Optical TruDO (12 mm, 25 mm)

Measurement Electrochemical Electrochemical Optical phase shift Polarographic

Range pH 0–14 pH 0–144 ppb to 300% saturation

10 ppb to 200% saturation

Maximum precision range pH 2–12 pH 2–12 – –

Temperature0°C to 135°C(32°F to 275°F)

0°C to 135°C(32°F to 275°F)

0°C to 130°C(32°F to 266°F)

0°C to 135°C(32°F to 275°F)

Pressure 6 bar (87 psi) max 6 bar (87 psi) max 12 bar (174 psi) max 4 bar (58 psi) max

Connection PG 13.5 PG 13.5 None None

Connector type K8 VP6 VP8 D4, VP6

Wetted material Glass Glass316L stainless steel,USP Class VI silicone

316L stainless steel

Temperature compensation NA NA 22 Kohm Thermistor 22 Kohm thermistor

Surface fi nish NA NA Electropolish RA12 Electropolish RA12

Cable length 6 m (20 ft) 6 m (20 ft) 6 m (20 ft) 6 m (20 ft)

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A range of single-use sensors have been designed specifically to optimize cell growth in single-use bioreactors. Thermo Scientific™ TruFluor™ and TruTorr™ sensors measure the four fundamental process parameters: pH, dissolved oxygen, temperature, and headspace pressure. Thermo Scientific sensors seal reliably into an insertion port, so that process sterility is guaranteed.

Thermo Scientific single-use sensors implement a patented optical design using only USP Class VI materials to optimize performance while maximizing reliability. All sensors are precalibrated and provide full traceability information using a gamma irradiation–resistant chip. The chip includes all calibration information, which is transferred to the transmitter when connected with a cable.

Using a HyPerforma G3 controller with TruFluor single-use sensors provides accurate measurements that enable the bioreactors to create a suitable cell culture environment.

Single-use sensorsMinimize contamination riskOur single-use sensors can be inserted in the S.U.B. BPC ports and irradiated with the bag in order to both preserve and guarantee the sterile barrier.

Biocompatibility test and gamma irradiation qualificationAll of our single-use sensor materials have undergone USP Class VI and gamma irradiation (up to 50 kGy) testing. The results are available by request for auditing purposes. Certificates are also available for all wetted materials.

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Blade transmittersThermo Scientifi c™ TruFluor pH and DO blades are panel-mounted instruments that have plug-and-play capabilities with any TruFluor pH or DO reader. The blades provide the output from the sensors to the controller in a digital format.

TruFluor and TruTorr blades are rail mounted in a controller and do not have a display or keypad. All blades require a 2-point calibration for accuracy specs and provide data from sheaths containing a chip, and detailed diagnostics to the bioreactor control system.

Single-use sensors, readers, and transmitters

TruTorr II single-use pressure sensorHigh-accuracy single-use headspace pressure sensorThe Thermo Scientifi c™ TruTorr™ II single-use pressure sensor is a single-use solution for measuring headspace pressure and preventing rupture of a BPC. A TruTorr II loop consists of a disposable pressure sensor, a cable, and a transmitter blade that are seamlessly integrated into a bioreactor controller.

TruFluor pH and TruFluor DO sensorsAccurate and reliable sensors for better process controlThermo Scientifi c™ TruFluor™ pH and TruFluor™ DO single-use measurement solutions each consist of an optical probe with an embedded temperature sensor. A TruFluor loop consists of a disposable sheath welded in the BPC, an optical reader, a cable, and a transmitter (blade).

Readers minimize drift and photodegradationThermo Scientifi c™ TruFluor pH and TruFluor DO optical smart readers utilize a patented design that minimizes photodegradation of the active sensing element. The design has been optimized to provide accurate in situmeasurement of pH and dissolved oxygen using phase fl uorometric detection in real time. The temperature measurement leverages a 316L stainless steel thermal plate embedded in the sheath, and provides accurate results that can also be used as a process variable. TruFluor DO sensors are based on oxygen quenching of fl uorescence, whereas TruFluor pH sensors are based on dual lifetime referencing. There is no detectable photoinduced drift for either of these sensors in a 3-week period of sampling at 2-second intervals.

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Single-use sensor specifications

Specifications TruTorr II TruFluor pH TruFluor DO

Environmental

Operating temperature 15°C to 45°C/59ºF to 113ºF 4°C to 45°C/39.2ºF to 113°F

Maximum operating pressure

7.0 psi 1 bar/14.7 psi

Storage temperature 0°C to 60°C/32°F to 140°F

Storage relative humidity 10 to 90% (noncondensing)

Maximum altitude 12,192 m/40,000 ft

Materials USP Class VI/ISO 10993 USP Class VI and 316L stainless steel

Performance

Sample rate settings 1 second 1 second to 30 minutes

Measuring range 0 to 0.48 barg (0 to 7 psig) pH 5.5 to 8.5 0 to 52.5% O2/0 to 250% air-sat

Limit of detection 0.7 mbarg (0.01 psig) NA 0.03% O2

Relative accuracy 3.5 mbarg (0.05 psig)±0.05 pH over calibration range after a 2-point calibration have0.3 to 0.8 pH units of separation

Accuracy±0.10 psig @ 0-1 psi±0.20 psig @ 1-3 psi±0.35 psig @ 3-7 psi

At 37.5°C: Depends on sampling method and off-line analyzer used for 1-point standardization

At 25°C: ±1% at 20.95% O2

Response time (T90 agitated)

<1 second <60 seconds <40 seconds

Drift (21 days) 13.6 mbarg (0.2 psig)<0.05 pH units for a standard process (5-second sampling rate)

CalibrationPrecalibrated (chip)1-point standardization optional

Precalibrated (chip) 2-point calibration required prior to operation. 1-point standardization available.

Precalibrated (chip) 1-point standardizationor 2-point calibration optional

Gamma irradiation 25–40 kGy is the standard range

Cross-sensitivity None IPA + water

Organic solvents (e.g., toluene, acetone, benzene, methylene chloride), sulfur dioxideand chlorine gases.

Certifications/warranty

Biocompatibility ISO10993-5, animal component–free; latex-, phthalate-, and BPA-free

Use case Warranty valid for one gamma sterilization cycle and use

Manufacturing environment

ISO 14644-1, Class 10,000 clean room (ISO 7)

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These transmitters can be used only with G3 Controller series

Blade transmitter specifications

Specifications TruTorr TruFluor pH TruFluor DO

Physical description

Case material Aluminum bracket

Rating NEMA 1 (when mounted has same rating as enclosure)

Dimensions (W x H x D) 35 x 130 x 128 mm/1.4 x 5.1 x 5 in.

Mounting Rack DIN

Display Virtual transmitter in TruBio software (GAMP 5)

Weight (shipping weight) 0.1 kg/0.2 lb (0.3 kg/0.6 lb) 0.2 kg/0.4 lb (0.4 kg/0.8 lb)

Specifications

Power supply 24 VDC at 150 mA

Signal outputs Isolated, 4–20 mA, 1x pressure Digital, 1x pH, 1x temperature Digital, 1x DO, 1x temperature

Output accuracy ±0.1 mA NA NA

Transmitter diagnosticsInternal diagnostics for sensor and loop

LED failure, 4–20 mA loop errors (for cases where blades are not used) or zeroing errors. Reported directly in TruBio control software

Calibration (Based on NIST traceable standards. Entered automatically using chip)

Optional 1-point standardization

Optional 1-point standardization or 2-point calibration (for improved accuracy spec). Can be transferred to TruBio software with file transfer or memory stick

RFI/EMI EN-61326

Operating temperature 5°C to 45°C/41°F to 113°F

Storage temperature 0°C to 65°C/32°F to 149°F

Relative humidity 10 to 90% (noncondensing)

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Lauda temperature control unit

We understand that environmental conditions of single-use bioreactors, fermentors, and media mixers need to be closely monitored and controlled in order to provide optimal growth conditions. One of the most important conditions is temperature, which must be accurately regulated to enable reliability and consistency of your processes.

Key featuresRecirculating chillers included in the Lauda™ temperature control unit (TCU) help meet endothermic (heating) and exothermic (cooling) reaction requirements. This product is compatible with single-use systems in a wide range of working volumes and off ers:

• Global voltage capability

• Confi gurable product platforms

• Customizable solutions and logistics

• Global service footprint

• Global compliance, including:

– Conformité Européenne (CE)

– Canadian Standards Association (CSA/UL)

– Restriction of Hazardous Substances (RoHS/WEEE)

Size Cat. No.

50 L, 100 L VC1200/D

200 L, 250 L VC2000/D

500 L VC5000/D

1,000 L, 2,000 L VC10000/D

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HyPerforma S.U.B.s

Volume Description Cat. No.

50 L

304 jacketed with 2:1 turndown ratio, AC motor, includes load cells, vent filter heater support, tool kit SUB0050.7000

304 jacketed with 2:1 turndown ratio, AC motor, includes load cells, vent filter heater support, tool kit, and cable management tree

SUB0050.7001



SUB0050.7003

100 L



SUB0100.7005



SUB0100.7007

250 L



SUB0250.7009



SUB0250.7011

500 L



SUB0500.7013



SUB0500.7015

1,000 L



SUB1000.7017



SUB1000.7019

2,000 L304 jacketed with 2:1 turndown ratio, AC motor, includes load cells, vent filter heater support, tool kit SUB2000.7020


Ordering information

17

HyPerforma G3Lite Controller Cat. No.

Description Non-GMP GMP

HyPerforma G3Lite Controller (120/240 V) for the 50 L S.U.B. (Configured to optionally connect: Two 15 kg scales and two WM 313 external pumps, one 6 in. VFH)

F100-2701-001 F100-2701-002

• Licenses: Delta VV (latest version), TruBio (non-GMP and GMP versions available)

• 6x3 TruFlow gas MFCs

• 4 pumps (WM three 114 and one 313)

• Transmitter for TruFluor sensor, TruSens transmitter, RTD, and all necessary cables

• HMI and foam level cable assemblies

• NEMA 4X

• 22 in. touchscreen monitor with KVM with keyboard/pointing devices

• One 6 in. vent filter heater (Cat. No. SV50191.62)

HyPerforma G3Lite Controller (120/240 V) for the 100 L S.U.B (Configured to optionally connect: Two 30 kg scales and two WM 313 external pumps, one 6 in. VFH)

F100-2702-001 F100-2702-002



• 4 pumps (WM three 114 and one 313)



• NEMA 4X




F100-2703-001 F100-2703-002



• 4 pumps (WM two 114 and two 313)



• NEMA 4X




F100-2704-001 F100-2704-002



• 4 pumps (WM one 114, two 313 and one 520)



• NEMA 4X



HyPerforma G3Lite Controller (120/240 V) for the 1,000 L S.U.B. (Configured to optionally connect: Two 60 kg scales and two WM 313 external pumps, one 10 in. VFH)

F100-2705-001 F100-2705-002


• 4x3 and two 1x1 TruFlow gas MFCs

• 4 pumps (WM one 114, two 313 and one 520)



• NEMA 4X



HyPerforma G3Lite Controller (120/240 V) for the 2,000 L S.U.B. (Configured to optionally connect: Two 150 kg scales and two WM 313 external pumps, two 10 in. VFH Programmable SV50191.33)

F100-2706-001 F100-2706-002


• 4x3 and 2, 1x1 TruFlow gas MFCs

• 4 pumps (2 x 313 and 2 X 520)



• NEMA 4X


• Two 10 in. vent filter heaters (Cat. No. SV50191.64)

Contact your BioProduction account manager to learn more.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals. © 2019 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. DeltaV is a trademark of DeltaV Emerson Process Management. GAMP is a trademark of the International Society for Pharmaceutical Engineering, Inc. Lauda is a trademark of Lauda Dr. R. Wobser GmbH & Co. COL08749 0319

Lauda TCU

Description Cooling/heating output Working temperature range Voltage Cat. No.

Lauda VC 1200/D 1.1 kW cooling, 1.8 kW heating –20 to 80°C, air-cooled 200–230 VAC, 50/60 Hz SV50239.80

Lauda VC 1200/D 1.1 kW cooling, 1.8 kW heating –20 to 80°C, water-cooled 200–230 VAC, 50/60 Hz SV50239.81







TCU hose kits and ball valves

TCU Cat. No. TCU hose kit TCU ball valve

Air-cooled Water-cooled Description Cat. No. Description Cat. No.

SV50239.80 SV50239.813/4 in. ID, 10 ft, 1 1/2 in. tri-clamp

SV50239.31 Right angle, 1/2 in. NPT, ball valve SV50239.34





SV50239.86 SV50239.871 in. ID, 10 ft, 1 1/2 in. tri-clamp

SV50239.37 Right angle, 1 in. NPT, ball valve SV50239.41

flexible, reliable, and configurable bioprocessing...

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