exercise and fatigue
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Exercise and fatigue. Chapter 9 pages 263 - 277. Contraction types. Isometric contraction – maintain same length in presence of load Example: arm wrestling, yoga plank pose Isotonic contraction – maintain same force while contracting Example: arm curl with fixed weight - PowerPoint PPT PresentationTRANSCRIPT
Exercise and fatigue
Chapter 9
pages 263 - 277
Contraction types
Isometric contraction – maintain same length in presence of load Example: arm wrestling, yoga plank pose
Isotonic contraction – maintain same force while contracting Example: arm curl with fixed weight
Lengthening contraction – muscle provides resistance while load extends muscle Example: quadriceps during knee bend
Isometric tension time course Brief latent period for AP to initiate the isometric contraction Tension rises and falls with Ca2+ levels Tension due to contracted myosin cross-bridges and stretched actin
filaments
Single Muscle Fiber Isometric and Isotonic Twitch Contraction
Muscle length and tension
Isotonic contraction time course Tension rises and falls with Ca2+ levels Muscle cannot shorten until tension exceeds load
Muscle length time course for isotonic contraction Fastest shortening occurs when tension >> load Isometric when tension = load Lengthening when tension < load Shortening does not begin until enough cross bridges
have been formed and the muscle tension just exceeds
the load on the fiber, also eventually a load is reached
that the fiber is unable to lift
Isotonic Twitch Contractions with Different Loads
Velocity of skeletal muscle shortening and lengthening
Muscle length and tension
Muscle tension changes with length Tension depends on overlap of actin and myosin
filaments Relaxed muscle fibers typically have optimal length
for force generation Tension drops off when muscles contract or when
they are stretched by external load
Variation in muscle tension at different lengths of muscle fiber
At what length do skeletal muscles generate the most force?
1 2 3 4 5
20% 20% 20%20%20%1. Fully contracted
2. Partially contracted
3. Relaxed
4. Partially stretched
5. Fully stretched
Frequency and tension
Contraction in response to single AP is called a twitch Nervous system controls contraction intensity and duration
via repetitive APs Repetitive APs will produce individual twitches at low
frequency (< 5 Hz) Repetitive APs > 10 Hz prevent complete recovery of
normal Ca2+ levels, leads to constant contraction known as tetanus
Higher frequency APs increase level of basal contraction AP frequency controls contraction strength Fused tetanus – APs at such high frequency that Ca2+ levels
never fall below level that saturates troponin
Isometric contractions produced by multiple stimuli
How does the nervous system control the tension produced by a single muscle fiber?
1 2 3 4
25% 25%25%25%1. Alter level of muscle [Ca2+]i during single AP
2. Alter level of muscle [Ca2+]i with multiple APs
3. All of the above
4. None of the above
Metabolism and fatigue
Most tissues that have a relatively constant rate of ATP consumption
Rate of ATP consumption in muscle drastically increases during contraction
Muscle tissue has specialized mechanisms for ATP production to account for variable consumption rate
Also requires constant ATP production during sustained activity
Muscle fatigue occurs when ATP production and reserves cannot sustain consumption
The three sources of ATP production during muscle contraction:1) Creatine phosphate 2) oxidatgive phosphorylation 3) glycolysis
Sources of ATP in muscle
Creatine Phosphate (CP) is initial source of ATP during contraction
ATP subsequently produced by glycolysis and oxidative phosphorylation of glucose
Glycolysis becomes more important during intense activity, rapid but inefficient!
Glucose comes from glycogen stored in muscle or from blood
Fatty acids are metabolized during sustained exercise CP and glycogen levels must be restored following activity
Requires ATP energy from oxidative phosphorylation Oxygen debt – sustained hyperventilation after cessation of
activity to provide O2 for restoring CP and glycogen
Fatigue
Involuntary decline and cessation of muscle contraction during tetanic stimulation is known as fatigue
Muscle must recover during quiescent period before subsequent stimuli can elicit contraction
High-frequency fatigue due to brief intense activity (fast recovery) Conduction failure from buildup of extracellular K+ in transverse
tubules, effect is to depolarize membrane potential Lactic acid buildup following glycolysis lowers pH Elevated ADP prevents dissociation of ADP from myosin
Low-frequency fatigue due to sustained moderate activity and decrease in energy sources (slow recovery) Hypoglycemia or low blood glucose Reduced glycogen in muscles Brain may sense hypoglycemia and prevent presynaptic APs
Muscle fatigue during a maintained isometric tetanus
Which of the following is NOT responsible for muscle fatigue?
1 2 3 4
25% 25%25%25%1. ADP increase inhibits cross bridge cycling
2. Conduction failure due to elevated [K+]o
3. Sudden decrease in [Ca2+]i levels
4. Decreased pH due to lactic acid buildup
Types of skeletal muscle fibers
Classified by major source of ATP Oxidative fibers consume high levels of O2
Tend to be smaller to improve O2 diffusion Surrounded by many blood vessels Contain many mitochondria Contain O2 carrier known as myoglobin that gives red color Fatigue resistant due to low glycogen consumption and low lactic acid
production
Glycolytic muscle fibers Don’t need high O2, can be larger to generate more force Also require more glycogen storage, white muscle fibers Fatigue rapidly due to high glycogen consumption and high lactic acid
production
Types of skeletal muscle fibers
Also classified by contraction velocity Fast vs. slow contraction determined by rate at
which myosin ATPase hydrolyzes ATP to during contraction cycling Fast fibers generate force faster for bursts of activity Slow fibers needed for sustained activity
Four possible combinations, slow-oxidative, fast-oxidative-glycolytic, fast-glycol
Slow -glycolytic fibers not found
Rate of fatigue development in the 3 types of muscle fibers
Fiber recruitment
Whole muscles consist of a mix of fiber types Control tension and velocity through order in which fiber
types begin contracting Process known as fiber recruitment Thinner oxidative fibers are recruited first Larger glycolytic fibers are recruited later Fiber size determines response to presynaptic APs and
postsynaptic AChR activation Therefore a larger fiber may require higher frequency of
presynaptic APs to be recruited
Recruitment of Muscle Fibers
Fiber recruitment
Recruitment provides a large range of forces and shortening velocities that muscles can produce
Tension is controlled by the number of contracting myofibrils acting in parallel Remember forces in parallel add
Velocity is controlled by fast/slow fiber type Velocity also controlled with total force generated
by muscle relative to applied load This is how muscles can produce motion or force
that ranges from delicate to powerful
Which muscle fibers are recruited first by the nervous system during muscle contraction?
1 2 3 4
25% 25%25%25%1. Fast glycolytic
2. Fast oxidative
3. Slow glycolytic
4. Slow oxidative
Adaptation to exercise
Muscle fibers can change size after disuse or excessive use Atrophy – reduction in muscle fiber size Hypertrophy – increase in muscle fiber size
Number of muscle fibers stays relative constant through adult life
Muscles can also change their capacity for ATP production Repetitive exercise of high intensity short-duration exercise
hypertrophies fast glycolytic muscle and increases glycolytic enzymes Increase in glycolytic enzymes also occurs in oxidative fibers and
can convert these to glycolytic This leads to big, bulky muscles in body builders
Adaptation to exercise
Low intensity sustained exercise (aerobic exercise) increases mitochondria and blood vessels in oxidative fibers These fibers may even atrophy slightly to reduce ATP consumption
and increase resistance to fatigue Can reduce glycolytic enzymes to convert some glycolytic fibers into
oxidative fibers This leads to trim, toned muscles in aerobic athletes
Not clear what signals initiate these changes in muscle Anabolic steroids accelerate myofibril growth in response to
exercise by increasing rate of protein synthesis Training regimens have gotten very specialized to increase
strength and endurance where needed Muscle soreness is inflammatory response due to myofibril
damage Excessive stress or repetitive lengthening contractions