crossing the bridge from microfluidics to connected health ... · digital health funding hit a new...
TRANSCRIPT
Crossing the Bridge from Microfluidics to Connected Health & Blended Reality for Life
Dr. Ali Tinazli – Head of Healthcare Strategy CTO Office – Vision, Strategy & IncubationDecember 13th 2016
©2016 HP, Inc. | HP Confidential1
© Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.2
Our heritage:• Founded in 1939 by engineers
Bill Hewlett and Dave Packard• Start-up capital: $538• First product: Model 200A audio oscillator• Earliest customer: Walt Disney Studios
History of innovation
3
*Source: Guinness World Record for fastest time to print 500 sheets by an office color desktop printer, April 2012. Record set on HP X576dw models.© Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.
HP Model 200A audio oscillator
used to test sound equipment
Launch of LaserJet and
thermal, miniaturized
inkjet printing technology
HP invented the first scientific
hand-held calculator,the HP-35
The HP 9100A, the world’s first
desktop computer
HP launches the world's
fastest desktop printer*
HP unveils the future of 3D printing and immersive computing
HP reinvents printing
delivering Ink, Laser, and PageWide,
technologies
HP launches the world’s
thinnest laptop
The Compaq Portable, one
of the first laptops
Jet Fusion 3D
1939 1968 2014 20161972 20131984201
51983 2016
HPtoday
© Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.4
1 Total net revenue is based on non-GAAP segment reporting for fiscal year 2015. Total net revenue is calculated based on total segment revenue, which does not include intercompany eliminations.
Fortune 100company
$52.7B revenuerevenue in FY15 1
Operations in 170 countries
~50,000employees
Fortune Most Admired#7 in technology
250,000+channel partners
18,000+patents
©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. | HP Confidential5
Technology Convergence
©2016 HP, Inc. 6
We are in the Age of Technology Convergence
7
Healthcare has been undergoing a transformation similar to manufacturing
8
From a 1-to-1 art to digital mass industrialization & scale, transforming to personalized and democratized applied science
Leve
l of T
echn
olog
y
Ancient times
• Healthcare 1.0– Rudimentary
– Highly personal 1-to-1
– Access: Exclusive
Pre 20th Century
• Healthcare 2.0– Foundation of modern
medicine
– Shift to scientifically-based medicine
– Access: Limited
20th Century
• Healthcare 3.0– Industrialization,
centralization & standardization
– Rise of complexity & specialization
– Technologies challenge healthcare economics
– Access: Benefit
Next
• Healthcare 4.0– Decentralization
enabled by microfluidics
– Focus on prevention
– Personalized treatments
– Big data, AI and machine learning
– Access: Democratized
Healthcare Timeline Key trends shaping Healthcare
Shift towarddecentralized,
connected,preventive, and
personalizedtreatment
models
Convergence ofTechnologies
Empoweredand engaged customers
Regulatorychanges
Digital Revolution: Internet-of-Things
71627243
73247404
74847562
2013 2014 2015 2016 2017 2018
Total world population
Shortage of doctors and nursing staff put pressure on healthcare system
699,100 709,700 735,600 759,800
706,500 723,400798,500
851,300
2008 2010 2015 2020
Supply Demand
Projected Supply & Demand of Physicians in the US
90kshortage
European health professionals or other health workers Estimated shortage by 2020
Physicians 230,000
Dentists, pharmacists, and physiotherapists 150,000
Nurse 59000
Total 970,000
Doctors (per 1,000 population) as compared with the total world population (millions)
1.7 1.7
Doctors per 1,000
Popu
latio
n (m
illio
n)
Doctors
6
5
4
3
2
1
Source: European Commission
Pressure to contain costs and demonstrate value is coming from all sides
Cost Increase Factors
Higher premiums Affordable Care Act Overuse of services Coverage expansion Austerity measures
Life sciences companiesHealth plansProvidersGovernments Consumers
Expanding healthcare and lowering costs requires eliminating waste of resources & adding value
Medical advances — Unraveling the human genome, emergence of precision medicineCase in point — Cures for diseases like hepatitis C, but costs are substantialPersonalized care — Shifting clinical offerings from mass generalization to mass customization
Telemedicine mHealth EMR Wearable
Combining big data, analytics, and machine learning can create efficiencies and increase speed of care
Source: Deloitte, 2016
With doctors and healthcare workers now using machines to provide efficiency, better care and take on more complex tasks
Source: Accenture, 2015
Today
• Phone apps are helping doctors and patients calculate the risk of heart surgery
• Mental patients in the U.K. are using social media to anonymously interact
• A software-based Alzheimer’s diagnostic test can detect impairments on the hippocampus (the first area of the brain to be affected) by evaluating your eye movement
• Ingestible or implantable devices collect newfound levels of data that can better inform a doctor’s care plan
• Develop caregiving teams/connect with peers using social media• Surgeons using wearables have real-time access to data from
monitoring equipment, so they can make more informed decisions about the patient during a procedure
Tomorrow
SocialMedia
Alzheimer’s Diagnostic test
Phone apps Caregiving team Implantable
device
Real-time data
Technology Trigger
Peak of Inflated Expectations
Plateau of Productivity
Many of the emerging digital health technologies are at the beginning of the hype cycle which is not surprising given digital health is still in its infancy
Slope of Enlightenment
Trough of Disillusionment
Source: Digital Health Hype Cycle by Bionicly (not Gartner), 2014
Digital Health
Digital health funding hit a new high in 2015, reaching nearly $6B
Growing healthcare challenges from rise in patients with chronic diseases,
healthcare cost and doctor shortage
Source: Partnership to Fight Chronic Disease and A.D. Little
190M
$42T
90,000 U.S. Doctor shortfall by 2025
Total cost of chronic disease from 2016-2030 in U.S.
Number of Americans affected by 1 or more chronic diseases
Digital healthcare a large and growing market
Source: A.D. Little, 2016
60.8
135.9
233.3
2013 2017 2020
Predictive
Preventative
Personalized
Participatory
4Ps of Healthcare
Digital Health Market 2013-2020 ($bn)
Prevention to elimination is plausible thanks to exponential
technology growth
Sources: Sparks & Honey, Millennial Branding, Salt
Faster, Cheaper Genomics
Sequence a genome in a day @ $1000
Managing Big Data
Healthcare data doubles every
24 months
Increasing Connectivity
Sensors increase data accuracy & frequency
for improved care
Reduced Drug Development Time
Data analysis reduced from 2 days to 1 min
Healthcare 2.0:Computing + AI + Machine Learning
+ Big Data+ Sensors
Precision Medicine
©2016 HP, Inc. 14
15
Today’s Reality - Imprecision Medicine
Towards Precision Medicine
Precision Medicine © InnVentis
16
Needed: Blood to Personal Molecular Profile
Personal Molecular ProfileMachine learningbased on
longitudinal, multi-omic data
Blood sample
17
PRECISION MEDICINE: Integrating multi-omics, clinical and real world data
Creation of topological mapsof health/disease
Eric Topol, CELL,Volume 157, Issue 1, 27 March 2014, Pages 241–253 Precision Medicine © InnVentis
18
Precision Medicine causes Paradigm Shift
Symptom-based Cohort-based Algorithm-based
Yesterday
Intuition Medicine
Today
Evidence-based Medicine
Tomorrow
Precision Medicine
DAT
AAC
TIO
NS
Application of rules, algorithms and reference databases enables ACTIONABLE clinical decision support & PRECISE/EFFICIENT care
Reference Databases
(Rules & Algorithms)
PersonalMolecular Profiles
(PMP, multi-omics)
Molecular Imaging
Non-molecular content (waveforms)
Precision Medicine(prevention,
diagnosis, treatment)
MobileInformation
CommunicationTechnologies
Big DataAnalytics
Precision Medicine © InnVentis
19
Pattern Diagnostics:• Is independent from baselines
• Reveals “hidden” disturbances
• The more data the better the analysis; i.e. precise patter recognition from “different angles”
• Machine learning recognizes “fragments” of a pattern
Molecular patterns are like memorable “skylines“
Pattern discovery, Machine Learning in Precision Medicine:FDA calls this “complementary“ diagnostics
Precision Medicine © InnVentis
©2016 HP, Inc. | HP Confidential20
Personal Molecular Profiles (PMP) will assess patients with unprecedented precision
Personal Molecular Profile
Accurate and actionable diagnostics Disease and patient
stratification Prevention and early
intervention Complementary Diagnostics Personalized products
(pharma, neutraceutical)
Health/Disease management Personalized health/disease
status monitoring Compliance management Disease stage classification Disease vs. non‐disease
events Medication dosage and
timing
! Value creation For patients For pharma and biotech
industry For payers/providers For society
+
Machine learningbased on longitudinal, multi-omic data
Blood sample
Adapted from Precision Medicine © InnVentis
Precision Fluidics for Precision Medicine
©2016 HP, Inc. 21
22
The Hype Cycle
23
History & Trajectories of Microfluidics Chip Markets
HP’s Technology Framework addresses unmet Needs in the Industry
Reliable, cost-effective microfluidic solutions at scale to enable a wide use point-of-care testing.
Microfluidics consumables
HP is the world’s largest microfluidics company
Stable, contractual supply of microfluidic consumables business with long lifecycle.
Razor/Blade consumables business
Print business is a supplies businessof prefilled microfluidic cartridges
Mobile Compute, processing, communication and data capture for telemedicine and digital health.
Computing and mobility
Computing, commercial mobility, dataprocessing & connectivity is in our DNA
The One Device
©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. |24
Mar
ket
Nee
dH
P Co
re E
xper
tise
& IP
Emerging needs in healthcare for decentralization/democratization of diagnostics will drive the “Medical Office of the Future”
© Copyright 2015 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.25
Building Blocks for the Tools in Precision MedicinePrecision dispense, microfluidics, novel sensing combine with supply chain, manufacturing & compute
Microfluidics MEMS Scale
© Copyright 2015 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.26
High Precision Microfluidics Hardware and Consumables Solutions
HP MEMS Microaccuracy Manufacturing Scale
Ink jet print heads are the ultimate success of integrating electronics with microfluidics(!)Embedding electronics in microfluidics (or vice versa) is a key step to extracting the data from the ‘wet stuff’…
Application: Consumables
Application + Device:Consumables +
Mobile Platform
Application + Solution:Consumables +
Mobile Platform +
Cloud Storage & Analytics
HP’s modular Platform Technology Architecture
27
From application-specific consumables to a fully-integrated Cloud Solution
©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. l
Next Dimension: A mobile Communications Platform for PoC Diagnostics
28
• Addresses immediate market needs as expressed by pharma companies and government organizations: seeking for a mobile MS Windows platform which is state-of-the-art.
• Security advantages of a Win 10 platform vs. other devices (i.e. Android and iOS)
Smart Phone are revolutionizing the ways of how patients and healthcare professionals engage – establishing standards are needed for safety and security reasons.
©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. l
Liquid Biopsy: An emerging market for radically improved cancer management and more…A cancer diagnosis to being about as eventful as having the flu!
Data are getting as important as actual clinical chemistry in diagnostics!
New value creation: DNA analysis will become a • cloud-based node in the • Internet of Things, • with subscription software, for both control and processing.
©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. l
Connected Health
©2016 HP, Inc. 30
© Copyright 2015 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.31
HP’s Microfluidics & Machine learning capabilities for predictive cancer diagnostics
Big Data
Decentralized data capture units
Mobile Point-of-Care (PoC) Platform
CloudAnalyticsData Processing
© Copyright 2015 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.32
A healthcare-IoT system which connects, combines and integrates healthcare data
Healthcare subscription models + IoT will form a new category
WearableDevice
TelehealthDevice
GatewayDevice
CloudPlatform
Micro Services
• Platform• Patient• Provider• System• Specialists
© Copyright 2015 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.33
Everything imbued with intelligence
Anticipates our needs
Deliver information, products and services when needed
AI assistants and friends
Enabling new experiences
Becoming a utility
Omni intelligence
ThankYou
34 © Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.
@DrTinazli
https://www.linkedin.com/in/alitinazli