Dr.ir. Maurice van der Beek, Dr. Eduard Pelssers

Philips Applied Technologies

January 21, 2009

Bringing microFluidics to Life

Micro Technology Innovation Forum

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum2

A leading technology center

Founded in 1968

Sales 2007

EUR 149 Million

Worldwide representation

North America: San José (USA), Andover (USA)

Europe: Eindhoven (NL), Redhill (UK)

Asia: Bangalore (India), Singapore

Philips Applied Technologies

University degree / Ph.D.s

± 390Other type of education

± 140 A multinational highly qualified workforce of about

845 people (+ 150 temporary employees)

Bachelors & Engineers

± 315

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

Contract R&D services

3

Innovation through turnkey solutions and specialist support

Technology

• Home and Building

Automation & Security

• Instrumentation & Stages

• Opto-electronic modules

• RFID

• Energy

Lifestyle

• Multimedia Experience

• Personal Care, Wellness &

Beauty

• Robotics

• Information, Storage &

Streaming & Retrieval

Healthcare

• Medical devices & implants

• Patient monitoring &

connected care

• Medical imaging & therapy

systems

• Molecular healthcare devices

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum4

R&D for every phase of the innovation process

Concept Design Engineering Industrialization Ramp-up

• Product design

• Process design

• Equipment design

• Technical Product Docu-mentation (TPD)

• Functional models

• Quality and reliability

• Prototypes

• Industry consulting

• Research

• Innovation consulting

• Manufacturing support

• Small volume production

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum5

Customers

Philips Consumer Lifestyle

Philips Lighting

Philips Healthcare

Philips Research

Philips Incubators

Philips IP&S

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

Magnotech - Cozart and Philips

Rapid Drug Screen with

Cozart (a wholly owned subsidiary of Concateno plc) and Philips are engaged to develop

and commercialize an innovative new handheld drugs-of-abuse testing product based on

Magnotech™ technology

6

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, Reference

Magnotech - Platform Elements

Disposable• Sample taking unit

• Pre-treatment

• Detection

Analyser• Magnetic actuation

• Signal processing

• No moving parts

• Embedded software

Bio-chemistry• Magnetic beads

• Printed spots

• Dry reagents

Software• Host software

• Integration with clinical

IT infrastructure

7Philips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, Reference

What is needed: system architecture approach

Disposable• Sample taking unit

• Pre-treatment

• Detection

Reaction vessel enabling all processes

for the detection of drugs from saliva

Pre-treatment Labeling Enabling label detectionSample taking Sample transport

functional

architecture

Capillary force

Pressure difference

Electrowetting

etc.

Immuno-magnetic

Fluorescent

None

etc.

SPR

Optical

Magnetic

Etc.

Filtering

Chemical

Enzymatic

etc.

Cotton swab

Paper

Pipette

etc.

architecture

options

Low cost / mass manufacturableproduct requirements

Product conceptssystem

architecture

8Philips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

What is needed: a multidisciplinary team

Biochemistry

Transport

phenomena

Optics

(Colloid)

Chemistry

Mechanics

Physics

9

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

Concept Design Engineering Industrialization Ramp-up

• ?

Stargate – a lifecycle model for business creation

What is needed: a structured way-of-working

10

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

What is needed: access to techniques for integration

Bio spotting

Plastics molding

Joining / laser welding

Surface modification

Assay development

Microfluidic design

Pre-pilot Assembly

Pilot Production

11

Microfluidic functional testing

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

CHALLENGE

• Realization of microfluidic fluid

handling steps realized without

user actuation (autonomous flow)

RESULT

• Sample treatment, aliquoting, and

rapid transport based on capillary

flow

• Realization of an evaluation tool

BENEFITS

• Fully autonomous

• Cost effective implementation in

disposables

• General use – Microfluidic Platform

Microfluidic design and functional testing

12

0

5

10

15

20

25

30

35

40

45

0 0.5 1 1.5 2 2.5 3

time (s)

Sp

ot

nr.

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

CHALLENGE

• Mass manufacturing of plastics featuring

submillimeter structures for use in

microfluidic applications

RESULT

• Mold insert creation using various

techniques, i.e. micro-milling, micro-EDM,

laser ablation, focused ion beam,

diamond tip milling

• Replication of micrometer-sized features

into plastics using the process of injection

molding

BENEFITS

• Design freedom

• Dimensional accuracy

• High degree of automation

Micro injection molding

picture

13

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

CHALLENGE

• Hermetic sealing of (transparent) polymer cartridges for

biomedical applications

RESULT

• Thermal joining of parts using standard IR fiberlasers.

• Absorption of laser light by addition of carbon black or by

polymer itself dependent on wavelength.

BENEFITS

• High quality joint for polymer parts

• No addition of chemicals is required

• Accurate and flexible technique.

• Small heat affected zone; no adverse

effect to pre-immobilized antibodies

Laser welding of biomedical cartridges

fluid inlet

channel

filled with

fluid

laser weld

Top view of cartridge

14

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, Reference 15

Deposition and localization of protein activated magnetic

particles

CHALLENGE

• Deposition of small volumes (typical 100 nl)

of a liquid with relative high viscosity

containing protein coated magnetic

particles with high precision of both

volume and location

RESULT

• Selection and modification of existing

dosing system by extending both hardware

(vision) and software of the instrument

BENEFITS

• Cost effective development of equipment

for small scale production with a clear open

route towards larger scale production

Philips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

Confidential Philips Applied Technologies, Author, MMMM dd, yyyy, ReferencePhilips Applied Technologies, Maurice van der Beek, January 21 2009, Micro Technology Innovation Forum

CHALLENGE

• Bio-compatible assembly of plastic micro-fluidic

products

RESULT

• Micro-biological clean manufacturing:

• Cross-flow and down-flow boxes

• Clean room class 10000

• Fixed instructions, product tracking

• Automated visual inspection

BENEFITS

• Scalable production

16

Pilot-line production in clean room