combination of drugs dr. shabana ali. combination of drugs two or > two drugs = effect modified...
TRANSCRIPT
COMBINATION OF COMBINATION OF DRUGSDRUGS
COMBINATION OF COMBINATION OF DRUGSDRUGS
DR. SHABANA ALIDR. SHABANA ALI
Combination of drugs• Two or > two drugs = effect
modified
EffectAction of drug Or Interaction at PK or PD level
SynergismDrug A + Drug B = action
synergistic
Both Drugs may have same actions or one drug may be inactive (given alone)
Types of Synergisma) Summation (addition)b) Potentiation (supra-additive)
a) SummationCombined effect of two drugs = sum
of effects (drugs given separately) cont.
Drugs acting on same receptors or having same mechanisms
e.g. combination of antacids, chemotherapeutic agents, diuretics; Ad + NA
Summation 1+1 = 2
b) Potentiation (supra-additive)
• Combined effects of two drugs = > sum of effects (drugs given separately)
• 1+1=>2E.g., sulphamethoxazole & trimethoprim =
bacteriostaticCo-trimaxozole= bactericidalAntihypertensive (captopril & diuretic);
tyramine + MAOI