clusters of differentiation
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8/8/2019 Clusters of Differentiation
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Clusters of Differentiation
Molecule Cell Sources Principal Actions Notes
CD1 APCs (Dendritic cells,
macrophages)
1. Nonclassical MHC involved in presentation of lipid
antigens to T cells
2. Associated with β2-macroglobulin
CD2 T cells Adhesion molecule
CD3 T cells 1. Part of the T-cell receptor complex
2. Participates in transport of the newly synthesized
TCR to the cell surface
3. Participates in signal transduction to the cell's
interior after the TCR has bound antigen
CD3γ, δ, ε, and the ζ cha
CD4 Helper T cells Helper T-cell co-receptor
CD5 1. B-1 cells
2. T cells
1. Marker on B-1 cells
2. Also expressed by T cells
CD8 Cytotoxic T cells Cytotoxic T-cell co-receptor
CD11+CD18 1. Naïve T cells
2. Effector T cells
Binds to ICAM-1 on T cells, resulting in strong adhesion LFA-1 (β2 integrin)
CD141. Macrophages2. Monocytes
Lipopolysaccharide (LPS) binding protein that acts as aco-receptor to TLR 4
CD15 Neutrophils Mediates phagocytosis and chemotaxis Sialyl-Lewisx
CD16 NK cells Recognition site for activation of NK cells by Fc regions
of IgG
FcγRIII
CD19+CD21 Tissue cells CD19 & 21 (CCL19 & CCL21) lead naïve T-cells into Both bind to CCR7 on ce
secon ary ymp e mmune sys em
CD20 B cells Cell surface protein that is the target of monoclonal
antibodies in the treatment of all B cell lymphomas
and leukemias
CD25 T cells α subunit of IL-2 receptor
CD28 Th1 cells 1. Binds to B7 on APC to co-stimulate T-cell response
to antigen binding
2. Without CD28/B7, T-cells become anergic on
binding antigen
CD29+CD49 Effector T cells Binds to VCAM-1 on endothelium, resulting in strong
adhesion
VLA-4
CD31 1. Endothelial cells
2. Naïve T cells
3. Effector cells
Facilitates diapedesis (the migration of inflammatory
cells out of the venules and into the interstitial space)
PECAM-1
CD34 Hematopoietic stem cells Marker on hematopoietic stem cell
CD40 1. Macrophages
2. B cells
1. For macrophages to become activated, they first
require a signal from INFγ, and then binding of CD40
to the CD40 ligand on the Th1 cell
2. Resting B-cells are activated when bound to CD40L
on T cells
CD44 Hematopoeitic stem cells Highly potent L- & E-selectin ligand Directs migration of
hematopoietic stem cell
bone marrow
CD45 1. Naïve T cells
2. Memory T cells
Regulator of T- and B-cell antigen receptor signaling
(suppressed JAK kinases & thus interferes with
CD45RA is found on naïv
cells and CD45RO is foun
intracellular signaling) on memory T cells
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Clusters of Differentiation
Molecule Cell Sources Principal Actions Notes
CD54 Endothelial cells ICAM-1 is a ligand for LFA-1, involved in strong
adhesion
ICAM-1
CD56 NK cells 1. Adhesion molecule expressed by NK cells
2. CD56high
NK cells are poorly cytotoxic but strong
secretors of cytokines
3. CD56low
are the opposite
CD59 All "self" cells Inhibits the complement membrane attack complex by
binding C5b678 and preventing C9 from binding and
polymerizing
Protectin
CD62E Endothelial cells Loosly bind to leukocytes (Sialyl-Lewisx) in venules,
resulting in a rolling adhesion
E-Selectin
CD62L Naïve T cells Loosly bind to GlyCAM-1 in venules of lymphoid
tissues, resulting in a rolling adhesion
L-Selectin
CD62P 1. Endothelial cells
2. Platelets
1. Stored in granules Weibel-Palade bodies
2. Loosly bind to leukocytes (Sialyl-Lewisx) in venules,
resulting in a rolling adhesion
P-Selectin
CD69 T cells Earliest inducible cell surface glycoprotein acquired
during T cell activation
CD80+CD86 APC (Dendritic cells,
macrophages)
1. Binds to CD28 on T-cell to co-stimulate T-cell
response to antigen binding
2. Without CD28/B7, T-cells become anergic on
bindin to anti en
B7.1 & B7.2
CD95 Endothelial cells VCAM-1 is a ligand for VLA-4, involved in strong
adhesion
Fas
CD106 Endothelial cells VCAM-1 is a ligand for VLA-4, involved in strong
adhesion
VCAM-1
CD127 IL-7 receptor α chain