cience · issn0036-8075 24june1994 volume264 number5167 american associationforthe advancementof...

ISSN 0036-8075 24 JUNE 1994 VOLUME 264 NUMBER 5167 AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE 1836 New look for South Pole? 1891 & 1930 DNA polymerase P structure and mechanism NEWS & COMMENT NSF Eyes New South Pole Station A Design for Life in the Freezer 1836 AIDS Vaccine Research: U.S. Panel 1839 Votes to Delay Real-World Vaccine Trials French Science: In Midst of a Freeze, Science Minister Calls for Expansion 1840 Quantity No Longer Counts in Britain 1840 Misconduct Panel Sets Ambitious Agenda 1841 Crane Experiment Finally Perches in Washington State 1842 RESEARCH NEWS The Inner Sanctum of the Proton 1843 Lucky Break for Kidney Disease Gene 1844 A Dark Matter Recipe Is Tested-And 1845 Found Wanting A Challenge to p16 Gene as a Major 1846 Tumor Suppressor Cancer Research: A New Test Gives 1847 Early Warning of a Growing Killer Genome Initiatives Tackle C 1848 Developing World's Big Killers Board of Reviewing Editors Frederick W. Alt Don L. Anderson Michael Ashburner Stephen J. Benkovic David E. Bloom Floyd E. Bloom Piet Borst Henry R. Bourne Michael S. Brown James J. Bull Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Paul J. Crutzen Robert Desimone Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Klaus Friedrich Theodore H. Geballe John C. Gerhart Roger 1. M. Glass Stephen P. Goff Peter N. Goodfellow Corey S. Goodman Ira Herskowitz Eric F. Johnson Stephen M. Kosslyn Michael LaBarbera Nicole Le Douarin Charles S. Levings Ill Alexander Levitzki Harvey F. Lodish Richard Losick Diane Mathis Anthony R. Means Shigetada Nakanishi Roger A. Nicoll Stuart L. Pimm Yeshayau Pocker Dennis A. Powers Ralph S. Quatrano V. Ramanathan Douglas C. Rees T. M. Rice David C. Rubie Erkki Ruoslahti Gottfried Schatz Jozef Schell Ronald H. Schwartz Terrence J. Sejnowski Ellen Solomon Thomas A. Steitz Michael P. Stryker Robert T. N. Tjian Emil R. Unanue Geerat J. Vermeij Bert Vogelstein Harold Weintraub Arthur Weiss Zena Werb George M. Whitesides Owen N. Witte William A. Wuif Keith Yamamoto SCIENCE * VOL. 264 * 24 JUNE 1994 CI ENCE L PARASITOLOGY a NEWS REPORTS Fighting Parasites on a Shoestring 1857 Finding 'Sustainable' Ways to Prevent 1859 Parasitic Diseases Taking the Human Factor Into Account Models Aid Understanding, 1862 Help Control Parasites POLICY FORUMS Fighting the Parasites of Poverty: Public 1864 Research, Private Industry, and Tropical Diseases T. Godal Economics and the Argument for 1866 Parasitic Disease Control D. B. Evans and D. T. Jamison PERSPECTIVES Unusual Strategies of Gene 1868 Expression and Control in Parasites T. W. Nilsen RNA Editing and the Evolution of Parasites 1870 L. Simpson and D. A. Maslov Antigenic Variation in African Trypanosomes 1872 P. Borst and G. Rudenko Vector Biology and the Control of Malaria 1874 in Africa F. H. Collins and N. J. Besansky Immunoglobulin E and Effector Cells 1876 in Schistosomiasis M. Capron and A. Capron ARTICLES Malaria Pathogenesis 1878 L. H. Miller, M. F. Good, G. Milon Mathematical Studies of Parasitic 1884 Infection and Immunity R. M. Anderson DEPARTMENTS THIS WEEK IN SCIENCE 1825 RANDOM SAMPLES 1850 EDITORIAL 1827 BOOK REVIEWS 1952 Progress in Parasitology Conceptual Foundations of Modern Particle Physics, LETTERS 1829 reviewed by C. Quigg * e: The Story of a Number, Sedimentology of the K-T Boundary: H. E. Clifton P. Borwein * Morphological Change in Quaternary and R. H. Dott Jr. * Dioxin Effects: G. M. Reggiani Mammals of North America, E. L. Lundelius Jr. * Quantum Uncertainty Principle: No Loopholes: Reverse Transcriptase, R. A. Weiss * Vignettes, etc. J. Schwinger * History Lesson: C. A. Carr PRODUCTS & MATERIALS 1961 SCIENCESCOPE 1835 INSIDE AAAS 1962 1 822

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ISSN 0036-807524 JUNE 1994VOLUME 264NUMBER 5167

AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE

1836New look forSouth Pole?

1891 & 1930DNA polymerase Pstructure and mechanism

NEWS & COMMENTNSF Eyes New South Pole StationA Design for Life in the Freezer

1836

AIDS Vaccine Research: U.S. Panel 1839Votes to Delay Real-World Vaccine Trials

French Science: In Midst of a Freeze,Science Minister Calls for Expansion

1840

Quantity No Longer Counts in Britain 1840

Misconduct Panel Sets Ambitious Agenda 1841

Crane Experiment Finally Perchesin Washington State

1842

RESEARCH NEWSThe Inner Sanctum of the Proton 1843

Lucky Break for Kidney Disease Gene 1844

A Dark Matter Recipe Is Tested-And 1845Found Wanting

A Challenge to p16 Gene as a Major 1846Tumor Suppressor

Cancer Research: A New Test Gives 1847Early Warning of a Growing Killer

Genome Initiatives Tackle C 1848Developing World's Big Killers

Board of Reviewing EditorsFrederick W. AltDon L. AndersonMichael AshburnerStephen J. BenkovicDavid E. BloomFloyd E. BloomPiet BorstHenry R. BourneMichael S. BrownJames J. Bull

Kathryn CalameC. Thomas CaskeyDennis W. ChoiJohn M. CoffinPaul J. CrutzenRobert DesimoneBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. Fearon

Harry A. FozzardKlaus FriedrichTheodore H. GeballeJohn C. GerhartRoger 1. M. GlassStephen P. GoffPeter N. GoodfellowCorey S. GoodmanIra HerskowitzEric F. Johnson

Stephen M. KosslynMichael LaBarberaNicole Le DouarinCharles S. Levings Ill

Alexander LevitzkiHarvey F. LodishRichard LosickDiane MathisAnthony R. MeansShigetada Nakanishi

Roger A. NicollStuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanDouglas C. ReesT. M. RiceDavid C. RubieErkki Ruoslahti

Gottfried SchatzJozef SchellRonald H. SchwartzTerrence J. SejnowskiEllen SolomonThomas A. SteitzMichael P. StrykerRobert T. N. TjianEmil R. UnanueGeerat J. Vermeij

Bert VogelsteinHarold WeintraubArthur WeissZena WerbGeorge M. WhitesidesOwen N. WitteWilliam A. WuifKeith Yamamoto

SCIENCE * VOL. 264 * 24 JUNE 1994

CIENCEL

PARASITOLOGY aNEWS REPORTS

Fighting Parasites on a Shoestring 1857Finding 'Sustainable' Ways to Prevent 1859Parasitic Diseases

Taking the Human Factor Into AccountModels Aid Understanding, 1862Help Control Parasites

POLICY FORUMSFighting the Parasites of Poverty: Public 1864Research, Private Industry, and Tropical Diseases

T. GodalEconomics and the Argument for 1866Parasitic Disease Control

D. B. Evans and D. T. JamisonPERSPECTIVES

Unusual Strategies of Gene 1868Expression and Control in Parasites

T. W. NilsenRNA Editing and the Evolution of Parasites 1870

L. Simpson and D. A. MaslovAntigenic Variation in African Trypanosomes 1872

P. Borst and G. RudenkoVector Biology and the Control of Malaria 1874in Africa

F. H. Collins and N. J. BesanskyImmunoglobulin E and Effector Cells 1876in Schistosomiasis

M. Capron and A. CapronARTICLES

Malaria Pathogenesis 1878L. H. Miller, M. F. Good, G. Milon

Mathematical Studies of Parasitic 1884Infection and Immunity

R. M. Anderson

DEPARTMENTSTHIS WEEK IN SCIENCE 1825 RANDOM SAMPLES 1850EDITORIAL 1827 BOOK REVIEWS 1952Progress in Parasitology Conceptual Foundations of Modern Particle Physics,LETTERS 1829 reviewed by C. Quigg * e: The Story of a Number,Sedimentology of the K-T Boundary: H. E. Clifton P. Borwein * Morphological Change in Quaternaryand R. H. Dott Jr. * Dioxin Effects: G. M. Reggiani Mammals of North America, E. L. Lundelius Jr.* Quantum Uncertainty Principle: No Loopholes: Reverse Transcriptase, R. A. Weiss * Vignettes, etc.J. Schwinger * History Lesson: C. A. Carr PRODUCTS & MATERIALS 1961SCIENCESCOPE 1835 INSIDE AAAS 1962

1 822

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