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Page 1: CIENCE · ISSN0036-8075 24JUNE1994 VOLUME264 NUMBER5167 AMERICAN ASSOCIATIONFORTHE ADVANCEMENTOF SCIENCE 1836 Newlookfor South Pole? 1891 &1930 DNApolymeraseP structure and mechanism

ISSN 0036-807524 JUNE 1994VOLUME 264NUMBER 5167

AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE

1836New look forSouth Pole?

1891 & 1930DNA polymerase Pstructure and mechanism

NEWS & COMMENTNSF Eyes New South Pole StationA Design for Life in the Freezer

1836

AIDS Vaccine Research: U.S. Panel 1839Votes to Delay Real-World Vaccine Trials

French Science: In Midst of a Freeze,Science Minister Calls for Expansion

1840

Quantity No Longer Counts in Britain 1840

Misconduct Panel Sets Ambitious Agenda 1841

Crane Experiment Finally Perchesin Washington State

1842

RESEARCH NEWSThe Inner Sanctum of the Proton 1843

Lucky Break for Kidney Disease Gene 1844

A Dark Matter Recipe Is Tested-And 1845Found Wanting

A Challenge to p16 Gene as a Major 1846Tumor Suppressor

Cancer Research: A New Test Gives 1847Early Warning of a Growing Killer

Genome Initiatives Tackle C 1848Developing World's Big Killers

Board of Reviewing EditorsFrederick W. AltDon L. AndersonMichael AshburnerStephen J. BenkovicDavid E. BloomFloyd E. BloomPiet BorstHenry R. BourneMichael S. BrownJames J. Bull

Kathryn CalameC. Thomas CaskeyDennis W. ChoiJohn M. CoffinPaul J. CrutzenRobert DesimoneBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. Fearon

Harry A. FozzardKlaus FriedrichTheodore H. GeballeJohn C. GerhartRoger 1. M. GlassStephen P. GoffPeter N. GoodfellowCorey S. GoodmanIra HerskowitzEric F. Johnson

Stephen M. KosslynMichael LaBarberaNicole Le DouarinCharles S. Levings Ill

Alexander LevitzkiHarvey F. LodishRichard LosickDiane MathisAnthony R. MeansShigetada Nakanishi

Roger A. NicollStuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanDouglas C. ReesT. M. RiceDavid C. RubieErkki Ruoslahti

Gottfried SchatzJozef SchellRonald H. SchwartzTerrence J. SejnowskiEllen SolomonThomas A. SteitzMichael P. StrykerRobert T. N. TjianEmil R. UnanueGeerat J. Vermeij

Bert VogelsteinHarold WeintraubArthur WeissZena WerbGeorge M. WhitesidesOwen N. WitteWilliam A. WuifKeith Yamamoto

SCIENCE * VOL. 264 * 24 JUNE 1994

CIENCEL

PARASITOLOGY aNEWS REPORTS

Fighting Parasites on a Shoestring 1857Finding 'Sustainable' Ways to Prevent 1859Parasitic Diseases

Taking the Human Factor Into AccountModels Aid Understanding, 1862Help Control Parasites

POLICY FORUMSFighting the Parasites of Poverty: Public 1864Research, Private Industry, and Tropical Diseases

T. GodalEconomics and the Argument for 1866Parasitic Disease Control

D. B. Evans and D. T. JamisonPERSPECTIVES

Unusual Strategies of Gene 1868Expression and Control in Parasites

T. W. NilsenRNA Editing and the Evolution of Parasites 1870

L. Simpson and D. A. MaslovAntigenic Variation in African Trypanosomes 1872

P. Borst and G. RudenkoVector Biology and the Control of Malaria 1874in Africa

F. H. Collins and N. J. BesanskyImmunoglobulin E and Effector Cells 1876in Schistosomiasis

M. Capron and A. CapronARTICLES

Malaria Pathogenesis 1878L. H. Miller, M. F. Good, G. Milon

Mathematical Studies of Parasitic 1884Infection and Immunity

R. M. Anderson

DEPARTMENTSTHIS WEEK IN SCIENCE 1825 RANDOM SAMPLES 1850EDITORIAL 1827 BOOK REVIEWS 1952Progress in Parasitology Conceptual Foundations of Modern Particle Physics,LETTERS 1829 reviewed by C. Quigg * e: The Story of a Number,Sedimentology of the K-T Boundary: H. E. Clifton P. Borwein * Morphological Change in Quaternaryand R. H. Dott Jr. * Dioxin Effects: G. M. Reggiani Mammals of North America, E. L. Lundelius Jr.* Quantum Uncertainty Principle: No Loopholes: Reverse Transcriptase, R. A. Weiss * Vignettes, etc.J. Schwinger * History Lesson: C. A. Carr PRODUCTS & MATERIALS 1961SCIENCESCOPE 1835 INSIDE AAAS 1962

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