María Carolina Portela FernándezUPB’s School of Health Sciences, Faculty of

MedicineIII Semester Student

Chaperone enzyme Rad18

Escorts the DNA polymerase Pol eta

Repairs sunlight induced damage propperly

Pol eta

Other DNA polymerases may take its place

The repair mechanisms are not accurate

e.g.: Xeroderma Pigmentosum

Essential to prevent mutations in the most vulnerable cell cycle phase

Cancer cells have high Cdc7

levels

Increases Pol eta+Rad18

BLOCK CHEMOTHERAPY AGENTS’ ACTION SUCH AS CIS-PLATINUM

The team looked for DNA structural changes with

advanced sequencing techologies

Most cells go into apoptosis

Few ones try to fix the mistake, causing cancer.

Most human cells may suffer one of these

catastrophes

It would be interesting to do some research on the mechanisms

that cause these catastrophes as a contribution in the prevention of the cancer disease.

Cancer epidemic, humankind has to

fight against it

Great interest in investigations about

its mechanisms.

Science must discover how to

attack them

Cancer’s downfall D

ow

nfa

ll – Jam

es M

urp

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Medical utility comes to

1. MARTINEZ SÁNCHEZ, Lina María [y otros]. Biología molecular. 6 ed. Medellín: UPB. Fac. de Medicina, 2011. 292 p.

2. “Chaperone enzyme provides new target for cancer treatments” on ScienceDaily.com [available online at http://www.sciencedaily.com/releases/2011/01/110118143220.htm (January 30, 2011)] 

3. “Cancer in a single catastrophe: Chromosome crisis common in cancer causation” on ScienceDaily.com [available online at http://www.sciencedaily.com/releases/2011/01/110106144735.htm (January 30, 2011)]