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CG2010 CytogardCytotoxic Drug Safety Cabinets

www.thermoline.com.au

https://www.thermoline.com.au/products/fume-cabinets/


Cytotoxic drug safety cabinets are

defined in Australian Standard AS2252.5

as the primary barrier against exposure to

aerosolsthatareproducedinthepreparation,

manipulation and dispensing of cytotoxic

drugs. Many of these drugs are known to

be mutagens and are suspected of being

carcinogens and teratogens. Recent work

involving prions has proven that exposure

may result in effects that are insidious and

maynotmanifestthemselvesforsomeyears.

The requirements for protection involve the

following:

› Protection of cabinet users and other

staff from exposure to aerosols or

vapourswhichmay be generated in the

preparation,manipulation,anddispensing

ofcytotoxicdrugs;

› Protectionofdrugproducts,so that they

maybepreparedinanenvironmentwhich

is essentially free from particulate and

biologicalcontamination;

› Protectionofcabinetmaintenance

personnelfromtheresidueofdrug

particleswhichcancontaminatefilters,

fansandothermechanicalcomponents.

Applications

CG2010 CytogardTM drug safety

cabinets are designed and manufactured in

Australiainthreenominalwidths –a900mm,

1200mm and 1800mm – and fully comply

with all requirements of Australian Standard

AS2252.5.

Cytotoxic cabinets are necessary for

operator and product protection, in addition

tothesafeguardsprovidedbyaneffectiveair

barrierandClyde-ApacMicrosealTMHEPAfilter

technology,CG2010 series is also equipped

withacarbonfiltertoremoveharmfulvapours

thatmaybereleasedduringthecompounding

process. CG2010 series are essential for

the protection of personnel, product and the

environment.

Description

AESEnvironmentalmaintainsanISO

9001:2015qualitymanagementsystemto

ensureprocessandproductconformance.




CG2010 CytogardTM drug safety

cabinets are designed and manufactured to

comply with all requirements of Australian

StandardAS2252.5.

Each cabinet is factory-certified by

a NATA Accredited laboratory to meet the

specified performance requirements. These

cabinetsmayalsobeusedwherethehandling

of other drugs and chemical requires both

containmentandasepticmanipulation.

Cytotoxic safety cabinets are part-

recirculating laminar air flow enclosureswith

highefficiencyparticulateair(HEPA)filtration

of exhaust air andanair barrier at thework

opening.

HEPA-filtered vertical laminar airflow

whichisrecirculatedintheworkzonecreates

an ultra-clean work environment for product

protection.Anairbarrierbetweentheoperator

and the work zone is maintained by a flow

of roomair intoa fullwidthgrille in thework

opening.

The barrier air mixes with the

recirculated laminar flow air in a sump

underneaththeworksurfaceandisexhausted

from the cabinet via a HEPA filter which is

locateddirectlyundertheworktray.

Australian Standards

All positive pressure zones and filter

seals are surrounded by negative pressure

zones,soastocontainpotentiallyhazardous

aerosols.Cabinetsareavailablewiththework

zone width of 90cm, 120cm or 180cm and

arefreestandingunitsthatincorporateafloor

stand.

Standard cabinets have exhaust

dischargeontheright-handsidewithoptional

left-hand side or top exhaust available. Top

exhaust is typically specified where cabinet

exhaust air is to be entrained into the room

exhaustinaccordancewithAS2252.5.

These cabinets provide advanced

systemmonitoring technologyandanumber

ofuniquedesignfeaturesintendedtoenhance

safetyandeaseofuse.




Construction

CabinetConstructed in electro-galvanised steel

withjointsweldedusingagasshieldedarcprocess.

Thismethodproducesarobust,leakfreehousing

that is able to withstand the rigours of transport

and handling. The exterior is finished in a high-

qualitypowdercoatwhichhasbeendevelopedfor

laboratoryequipment.

Work ZoneConstructed in grade 304 stainless steel

with2Bfinish.Cornersareradiusedandcrevice-

free for ease of cleaning and all surfaces are

carefully dressed to remove sharp edges. The

removableworktrayisdesignedtoallowcleaning

access to its undersidewithout removing it from

thecabinet.

A pneumatic mechanism opens and

closes the viewing window without the need for

externalfastenersorcatches.Thewindowisself-

supporting in the fully open position to facilitate

cleaningandaccessforlargeitems.Openingthe

window with the cabinet running automatically

engagesaboostmodeforenhancedcontainment

byactivatingamaximumexhaustairflowandthe

alarmsystems.

Hepa FiltersClydeApacMicrosealTMHEPAfilters,are

manufactured to meet requirements of AS4260.

Eachfilterisindividuallycertifiedtobeleakfreein

accordancewithAS1807.6.

Amanufacturerendorsed test label fittedwithan

extractofthetestreportisaffixedtoeachfilter.

Aprefilterextendsthelifeof theexhaust

HEPA filter and protects it from mechanical

damageduringcleaningoftheworkzone.

FansSeparatedirectdrivefansareprovidedfor

theexhaustand laminar flowHEPA filters.Fans

arefittedwithspeedcontrollerstoenableairflows

tobemaintainedthroughfilterlife.

Thefancontrolcircuitsareinterlockedso

thatthelaminarflowsystemwillnotoperateuntil

theexhaustsystemhasachievedacontainment

condition.

Audible and visible alarms with

rechargeablebatteryback-upsignifyanyreduction

inbarriercontainmentorlaminarairflow.

ElectricalCabinets operate on single-phase 240V,

50Hzpowerviaa10Aoutlet.Theelectricalsystem

complieswithAustralianStandardAS3100.

Alowvoltagetouchcontrolpanelislocated

on the frontof thecabinet.TheOptima2000TM

microprocessor-controlled control and diagnostic

systemprovidescontinuousmonitoringofcritical

cabinet functionswith a digital display indicating

thenatureofanymalfunction.




Features

Standard

Features

› Optima2000TMprorammablecontrolanddiagnosticsystemwithdigitaldisplay

› Lowvoltagetouchcontrols

› Alarmsandboostmodeautomaticallyengagedwhenviewingwindowisopen

› Boostmodeselectableatcontrolpanel

› Selectablepost-useover-runtimer

› Hourmetertorecordoperatingtime

› Provisionforinterfacewithbuildingenergymanagementsystems

› Pneumaticallyassistedviewingwindow

› Magnahelicgaugetomonitorfansystems

› Fully-sealedworkopeningcoverfortestingprocedures

› Comprehensiveoperationandmaintenancemanual

Options

› Activatedcharcoalexhaustfilter

› Workareapoweroutlet

› Ultra-violetgermicidallamp

› Gastap(solenoid-interlocked)

› Servicetaps(vac,air,CO2,etc.)

› Hangingrailinworkarea

Exhaustfan

LaminarflowHEPAfilter

Exhaustfanplenum

Prefilter

ExhaustHEPAfilter

Kneespace

Airbarrier

Positivepressureplenum

Negativepressureplenum

Laminarflowfan



Personnel Protection

Cytotoxic drugs and prions are

hazardoustohumanhealth. It isnecessary

toprotectbothusersandservicepersonnel.

Forthoseapplicationswherepersonneland

environmentalprotectionisrequired,Clyde-

Apac Class I or Class II biological safety

cabinets, or cytotoxic drug safety cabinets

(asapplicable)shouldbeconsidered.

ModelOverall

Dimensions (mm)Work Zone

Dimensions (mm)Weight

(kg)

W D H W D H

CGA90SIDEEXHAUST 1135 770 2310 880 560 610 326

CGA90TOPEXHAUST 1035 770 2410 880 560 610 326

CGA120SIDEEXHAUST

1440 770 2310 1180 560 610 372

CGA120TOPEXHAUST 1340 770 2410 1180 560 610 372

CGA180SIDEEXHAUST

2050 770 2310 1790 560 610 487

CGA180TOPEXHAUST 1950 770 2410 1790 560 610 487

ModelRHS

exhaustLHS

exhaustTop

exhaust

CGA90 2030021 2030022 2030023

CGA120 2030201 2030202 2030203

CGA180 2031201 2031202 2031203

WARNING




Operation

ControlPanel

1. Fan/post-useover-runswitch2. Poweroutletswitch3. Gasresetswitch*4. Fluorescentlightswitch5. UVlampswitch*6. Boostmodeswitch7. Displaypanel8. Mainspowerindicator9. Alarmindicator

*optionalfunction

1 2 3 8 9

4 5 6 7

High-efficiency filters and fans

deliver quiet operation and safety.

Negative pressure zones surround all

positive pressure areas, eliminating the

possibility of contaminated air bypassing

thefilterorescapingfromthecabinet.

Inoperation,verticallaminarairflow

gently passes from the Laminar HEPA

filter to the sumpHEPA filter to createa

biologicallycleanworkarea.

In Cytotoxic cabinets:

An air barrier across the work

access opening, into the sump, reduces

potential risks topersonnel fromairborne

contaminantsintheworkzone.

In Cytotoxic models, the airflows

combine in the sump area beneath the

work floor and pass through an extra

HEPAfilterbeforerecirculationviaareturn

airplenum,tothetophousing.

Separate fan/filter arrangements

allowindependentadjustmenttomaintain

aneffectiveairbarrier.

A microprocessor is used to

control the speed of the blower motors.

Thismicroprocessor also allows fingertip

controloffunctionsandstatusincluding:

› Cabinetperformanceandstatusclearly

displayedinplainEnglish.

› Boostmode.

› Built-instopwatch.




© 2019 AES Environmental | Bulletin No. 14N.11.17 AES114 REV3In keeping with our policy of continuing product improvement, we reserve the right to alter specifications without notice.

THE COMPANY AESEnvironmentalisanAustralianownedmanufacturingbusinessproducingproductsunderClyde-Apac,EmailAirHandlingandVokesbrandnamesforindustriesthatareasvariedasindustrialplants,commercialbuildings,powerstations,foodprocessing,healthcare,scienceandelectronics.AESEnvironmentalconsiderstheAustralianStandardsasacorecomponentofitsproductmixandhasdevelopedanexportmarketin25countries,promotingAustralianStandards,engineeringandmanufacturingsolutions.AESEnvironmental,atrustedmanufacturercapableofdeliveringreliableproductsolutionstohighly-criticalapplications,wherethecontrolofhazardousairbornecontaminationisoftencriticaltoprocessandpersonnel.

› HWSSeriesTMhorizontallaminarflowcabinets.

› VWSSeriesTMverticallaminarflowcabinets.

› BSC2000TMClassIbiologicalsafetycabinets.

› BH2000TMClassIIbiologicalsafetycabinets.

› PCRlaminarflowcabinets.

› Recirculatingfumecabinets.

› TFPTMSeriesHEPAfiltercleanroommodules.

› ExhaustCaptureHoodforCytotoxicSuite.

› Passthroughhatches.

Other Products On-Site Testing

Cytotoxicdrugsafetycabinetsare

factorytestedandcertifiedbyaNATA-

Accreditedlaboratory.Additionaltestingand

certificationisrecommendedasfollows:

› Onsitepriortouse

› Aftermaintenance

› Afterfilterreplacement

› Afterre-location

› Atleastannually

› Inspecialcircumstances,e.g.iffaulty

operationissuspected.




cg2010 cytogard - thermoline › content › cytotoxic-drug...laminar airflow which is recirculated...

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