can perilesional edema detected in mri be …
TRANSCRIPT
PURPOSE
ToevaluatewhetherthepresenceofperitumoraledemainFSET2-
weightedIDEALsequencesinMagneticResonanceImaging(MRI)is
correlatedwithspeciDicbiologicalsubtypesofbreastcancer.
METHODS
FromAugust 2017 toMarch 2018, 68 patientswith biopsy-proven
breast cancer underwent bilateral contrast-enhanced breast MRI,
performedona3Tscanner(GEDiscoveryMR730)usingadedicated
coilandprotocol,inproneposition.
30patients(meanageof52)withperitumoraledema,detectableas
FSET2-weightedIDEALhyperintensity,wereenrolledinthisstudy.
Thepatientswere divided into 3 groups characterizedby different
prognosticphenotypes: LuminalA, LuminalB andTripleNegative/
Basal-like, according to molecular proDiling (Ki-67, hormone
receptorsstatusandHer-2expression).
RESULTS
On histological examination 23 unifocal and 7 multifocal/
multicentrictumorsweredetected:25(83.3%)wereinvasiveductal
carcinoma (IDC) and 5 (16.7%) were invasive lobular carcinoma
(ILC).Tumormeansizewas29.3mm(SD16.4).
The prognostic phenotype of patients was: Luminal A in 6 (20%),
LuminalBin16(53.3%)andTripleNegativein8(26.7%).
Perilesional edema was signiDicantly correlated with breast cancer
withworse prognosis (Luminal B andTripleNegative) rather than
with those with better prognosis (Luminal A) (p < 0.0001 – Chi
squaredtest).
CONCLUSION
In spite of its limits (small population, preliminary results to be conDirmed), our study showed that perilesional edema is
signiDicantlyassociatedwithmoreaggressivebreastcancer.
Therefore, surrounding edemadetectedonFSET2-weightedIDEALsequencesmaybeusefulintheevaluationofbreastcancer
andcouldbeconsideredanadditionalprognosticindicator.
CANPERILESIONALEDEMADETECTEDINMRIBECONSIDEREDASABIOMARKERFORBREASTCANCER?
ROLEOFFSET2-WEIGHTEDIDEALSEQUENCES
MoffaG,Gala?F,MarzoccaF,PanzironiG,PediconiFSapienza,UniversityofRome–DepartmentofRadiological,OncologicalandAnatomo-pathologicalSciences
LuminalA LuminalB TripleNegative
6(20%) 16(53.3%) 8(26.7%)
CASE1Singlelesion(19mm),IDC,G3,TripleNegative
CASE2Biggernodule(16mm),IDC,G3,LuminalB
FSET2-weightedIDEAL
T1-weightedDISCO3D
post-contrast
Post-processingsubtraction
TheBREASTMRIPROTOCOL
includes
• Pre-contrastFSET2-
weightedIDEAL
• DWIandADCmaps
• Dynamic3DT1-
weightedDISCO,
acquiredbeforeand
aftercontrastagent
administration(0,2
ml/kgProHance®–
Gadoteridol279.3mg/
ml,BraccoImaging
S.p.A.)
83%
17%
HISTOLOGY
IDCILC
p<0.0001–Chisquaredtest