PURPOSE

ToevaluatewhetherthepresenceofperitumoraledemainFSET2-

weightedIDEALsequencesinMagneticResonanceImaging(MRI)is

correlatedwithspeciDicbiologicalsubtypesofbreastcancer.

METHODS

FromAugust 2017 toMarch 2018, 68 patientswith biopsy-proven

breast cancer underwent bilateral contrast-enhanced breast MRI,

performedona3Tscanner(GEDiscoveryMR730)usingadedicated

coilandprotocol,inproneposition.

30patients(meanageof52)withperitumoraledema,detectableas

FSET2-weightedIDEALhyperintensity,wereenrolledinthisstudy.

Thepatientswere divided into 3 groups characterizedby different

prognosticphenotypes: LuminalA, LuminalB andTripleNegative/

Basal-like, according to molecular proDiling (Ki-67, hormone

receptorsstatusandHer-2expression).

RESULTS

On histological examination 23 unifocal and 7 multifocal/

multicentrictumorsweredetected:25(83.3%)wereinvasiveductal

carcinoma (IDC) and 5 (16.7%) were invasive lobular carcinoma

(ILC).Tumormeansizewas29.3mm(SD16.4).

The prognostic phenotype of patients was: Luminal A in 6 (20%),

LuminalBin16(53.3%)andTripleNegativein8(26.7%).

Perilesional edema was signiDicantly correlated with breast cancer

withworse prognosis (Luminal B andTripleNegative) rather than

with those with better prognosis (Luminal A) (p < 0.0001 – Chi

squaredtest).

CONCLUSION

In spite of its limits (small population, preliminary results to be conDirmed), our study showed that perilesional edema is

signiDicantlyassociatedwithmoreaggressivebreastcancer.

Therefore, surrounding edemadetectedonFSET2-weightedIDEALsequencesmaybeusefulintheevaluationofbreastcancer

andcouldbeconsideredanadditionalprognosticindicator.

CANPERILESIONALEDEMADETECTEDINMRIBECONSIDEREDASABIOMARKERFORBREASTCANCER?

ROLEOFFSET2-WEIGHTEDIDEALSEQUENCES

MoffaG,Gala?F,MarzoccaF,PanzironiG,PediconiFSapienza,UniversityofRome–DepartmentofRadiological,OncologicalandAnatomo-pathologicalSciences

moffa.giuliana@gmail.com

LuminalA LuminalB TripleNegative

6(20%) 16(53.3%) 8(26.7%)

CASE1Singlelesion(19mm),IDC,G3,TripleNegative

CASE2Biggernodule(16mm),IDC,G3,LuminalB

FSET2-weightedIDEAL

T1-weightedDISCO3D

post-contrast

Post-processingsubtraction

TheBREASTMRIPROTOCOL

includes

•  Pre-contrastFSET2-

weightedIDEAL

•  DWIandADCmaps

•  Dynamic3DT1-

weightedDISCO,

acquiredbeforeand

aftercontrastagent

administration(0,2

ml/kgProHance®–

Gadoteridol279.3mg/

ml,BraccoImaging

S.p.A.)

83%

17%

HISTOLOGY

IDCILC

p<0.0001–Chisquaredtest