bioengineering & biotechnology

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Bioengineering &Biotechnology

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CONTENTS

Biosignals and Systems............................................3

Biomechanics ..........................................................6

BioMEMS, BioNEMS, and Biomaterials ..................8

Biomedical Imaging ..............................................13

Biotechnology ......................................................18

General Textbooks ................................................22

Page 3 Page 6

Page 8 Page 12

Page 15 Page 18

GTN01 TMC

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3

Biosignals and Systems

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Bestseller!

Basic TransportPhenomena inBiomedicalEngineeringThird EditionRonald L. FournierUniversity of Toledo, Ohio, USA

Bringing together funda-mental engineering and lifescience principles, this highlyaccessible text provides a focused coverage of keymomentum and mass transport concepts in biomed-ical engineering. It offers a basic review of units anddimensions, material balances, and problem-solvingtips, and emphasizes those chemical and physicaltransport processes that have applications in thedevelopment of artificial and bioartificial organs, con-trolled drug delivery systems, and tissue engineering.

The book also includes a discussion of thermodynam-ic concepts and covers topics such as body fluids,osmosis and membrane filtration, physical and flowproperties of blood, solute and oxygen transport, andpharmacokinetic analysis. It concludes with the appli-cation of these principles to extracorporeal devices aswell as tissue engineering and bioartificial organs.

Designed for the beginning student, the book pro-vides a quantitative understanding of the underlyingphysical, chemical, and biological phenomenainvolved. It offers mathematical models using the“shell balance” or compartmental approaches, alongwith numerous examples and end-of-chapter prob-lems based on these mathematical models. In manycases these models are compared with actual experi-mental data. Encouraging students to work exampleswith the mathematical software package of theirchoice, this text provides them the opportunity toexplore various aspects of the solution on their own,or apply these techniques as starting points for thesolution to their own problems.

Selected Contents:

Introduction. A Review of Thermodynamic Concepts.Physical Properties of the Body Fluids and the CellMembrane. The Physical and Flow Properties ofBlood. Solute Transport in Biological Systems.Pharmacokinetic Analysis. Extracorporeal Devices.Tissue Engineering. Bioartificial Organs. Index.

Catalog no. K11304, August 2011, 483 pp.ISBN: 978-1-4398-2670-6, $109.95 / £55.99Also available as an eBook

Systems BiologyMathematicalModeling and Model AnalysisAndreas KremlingTechnical University Munich,Germany

Series: Chapman & Hall/CRCMathematical andComputational Biology

“Computational modelingof biological circuits, net-works, and pathways is one of the most excitingareas in biology today, and Andreas Kremling'sSystems Biology: Mathematical Modeling andModel Analysis is a meticulous and far-reachingtreatment of this critically important subject. Thisbook clearly aims to be comprehensive without sac-rificing depth, and the result is an exhaustive surveyof modeling approaches. Each chapter is thought-fully crafted to draw in novices to the field while stillengaging experts. Additionally, a number of well-designed exercises complement each chapter. I foundthe sections on model analysis and control theoryparticularly useful and relevant.”

—Markus Covert, Stanford University

Drawing on the latest research in the field, this textpresents various methods for modeling and analyzingbiological systems, in particular cellular systems. Itshows how to use predictive mathematical models toacquire and analyze knowledge about cellular sys-tems. It also explores how the models are systemati-cally applied in biotechnology. The book includesmany analytical and numerical examples as well asexercises and a bibliography at the end of each chap-ter. MATLAB® code is available on the book’s CRCPress web page.

Selected Contents:

Fundamentals: Introduction. Biological Basics.Fundamentals of Mathematical Modeling. ModelCalibration and Experimental Design. Modeling ofCellular Processes: Enzymatic Conversion.Polymerization Processes. Signal Transduction andGenetically Regulated Systems. Analysis of Modulesand Motifs: General Methods of Model Analysis.Aspects of Control Theory. Motifs in CellularNetworks. Analysis of Cellular Networks: MetabolicEngineering. Topological Characteristics. Appendix.Index.

Catalog no. K16367, November 2013, 379 pp.ISBN: 978-1-4665-6789-4, $79.95 / £49.99Also available as an eBook

http://www.crcpress.com/product/isbn/9781439826706


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Introduction toBiomedicalEngineeringTechnologySecond EditionLaurence StreetRosedale, British Colombia,Canada

Medical devices are oftencomplex, but while there aredifferences in design fromone manufacturer to anoth-er, the principles of operation and the physiologicaland anatomical characteristics on which they operateare universal. This book explains the uses and applica-tions of medical technology as well as the principles ofmedical equipment management to familiarize read-ers with their prospective work environment.

Written by an experienced biomedical engineeringtechnologist, the book describes technologicaldevices, tools, and test equipment used in today’shealth care arena. Photographs of representativeequipment as well as the technical, physiological, andanatomical basis for their function is detailed for awide range of biomedical devices—from defibrillatorsto electrosurgery units. Also discussed are the loca-tions where the equipment is commonly found inhospitals.

Thoroughly revised and updated, this second editioncovers a wider range of devices and includes anexpanded section on equipment management. Theauthor’s practical approach and organization, outlin-ing everyday functions and applications of the med-ical devices, prepares readers for situations they willencounter on the job. Appendices supply useful infor-mation such as normal medical values, a list of regu-latory bodies, Internet resources, and information ontraining programs. The revised second editionincludes more examples and illustrations as well asend-of-chapter questions to test the reader’s under-standing. The book also contains more than 360 illus-trations.

Selected Contents:

Introduction. Diagnostic Devices: Part One, PartTwo, and Part Three. Diagnostic Imaging. TreatmentDevices: Part One, Part Two, and Part Three.Biomedical Engineering Technologist (BMET) Work.Testers and Tools. Batteries, Radiation, andComputers. Technology Management. Appendices:Normal Values, Regulations and Standards,Biomedical Engineering Technology Programs in theUnited States and Canada, Biomedical Associations,Devices and Manufacturers, Test EquipmentManufacturers, Bibliography and Internet Resources.

Catalog no. K12781, October 2011, 391 pp.ISBN: 978-1-4398-6058-8, $98.95 / £62.99Also available as an eBook

Analysis andApplication ofAnalogElectronicCircuits toBiomedicalInstrumentationSecond EditionRobert B. NorthropUniversity of Connecticut, Storrs,USA

Series: Biomedical Engineering

This book helps biomedical engineers understand anddesign signal conditioning systems using analog inte-grated circuits. It explains the electronic componentsand subsystems—the “building blocks”—that are usedin ECG, EEG, EMG, ERG, tomographic images, bio-chemical spectrograms, and other crucial medicalapplications. This updated second edition features aglossary, new end-of-chapter problems, and three newchapters that address wireless patient monitoringusing UHF telemetry, power amplifiers and their appli-cations to biomedical instruments, and RFID, GPS, andultrasonic tags used in ecological research. The bookprovides end-of-chapter problems as well as examplesthat emphasize biomedical electronic applications.

Catalog no. K12982, March 2012, 578 pp.ISBN: 978-1-4398-6669-6, $125.95 / £81.00Also available as an eBook

New!

AmbientDiagnosticsYang CaiCarnegie Mellon University,Pittsburgh, Pennsylvania, USA

This text addresses innova-tive methods for discoveringpatterns from affordabledevices, such as mobilephones, watches, cameras,and game interfaces to inter-pret multimedia data for personal health monitoringand diagnosis. This is the first comprehensive text-book for studying multidisciplinary innovations inaffordable health care—from sensory fusion to patterndetection to classification. The book includes 171exercise problems and 45 case studies.

Catalog no. K14779, July 2014, c. 394 pp.ISBN: 978-1-4665-1041-8, $99.95 / £63.99Also available as an eBook




5



BiomedicalEngineeringPrinciplesSecond EditionArthur B. Ritter, Vikki Hazelwood, Antonio Valdevit, andAlfred N. Ascione

Praise for the Previous Edition:

“For practicing engineers without biomedical engi-neering background, the book provides an excellentresource to explain the many intricacies of biomed-ical engineering and provides sufficient backgroundmaterial to make the subject understandable.”

—Richard C. Fries, PE, CRE, Baxter Healthcare, Inc., in IEEE Engineering in Medicine and Biology Magazine,

December 2006

“[Provides] not only an in-breadth overview on cur-rent BME fields, but also an in-depth analysis of spe-cific selected topics that are supported by appropri-ate mathematical models, equations, quantitativedata charts and tables.”

—Biomedical Engineering Online, 2005

Integrating engineering, medicine, biology, and physics,this book clearly defines basic principles in image pro-cessing, biomechanics, modeling physiological process-es, and bioelectric signal analysis to build a solid under-standing of devices and designs for improved function-ing of the human body. It includes cutting-edge discus-sions on tissue engineering, cardiovascular components,bone regrowth, and nerve regeneration. Other topicscovered include technologies at the forefront of cardiaccare—such as total artificial hearts, left ventricular assistdevices, and stents—and issues related to minimallyinvasive and robotic surgery, next-generation imagingdevices, and nanodevices.

Selected Contents:

Introduction: Modeling of Physiological Processes.Cell Physiology and Transport. Principles andBiomedical Applications of Hemodynamics. ASystems Approach to Physiology. The CardiovascularSystem. Biomedical Signal Processing. SignalAcquisition and Processing. Techniques forPhysiological Signal Processing. Examples ofPhysiological Signal Processing. Principles ofBiomechanics. Practical Applications ofBiomechanics. Biomaterials. Principles of BiomedicalCapstone Design. Unmet Clinical Needs.Entrepreneurship: Reasons why Most Good DesignsNever Get to Market. An Engineering Solution inSearch of a Biomedical Problem to Solve. TissueEngineering. Future Trends in BME.

Catalog no. K10621, May 2011, 540 pp.ISBN: 978-1-4398-1232-7, $109.95 / £69.99Also available as an eBook

Signals andSystems AnalysisIn BiomedicalEngineeringSecond EditionRobert B. NorthropUniversity of Connecticut, Storrs,USA


This book focuses on themathematical tools requiredto analyze and describe biomedical signals and sys-tems. Based on the author's 30 years of experience inteaching as well as his personal research on neurosen-sory systems, this book, now in its second edition,provides a ready source of information on the special-ized mathematical techniques most useful in describ-ing and analyzing biomedical signals. It discusses theanalysis of nonlinear systems, nonlinear oscillators,and biological clocks. It also explores the mathemat-ics of tomographic imaging, covers joint time-fre-quency analysis of nonstationary biomedical signals,and describes the Hilbert transform.


Biology forEngineersArthur T. JohnsonUniversity of Maryland, CollegePark, USA

Biology is a critical applica-tion area for engineeringanalysis and design.Engineering students insome programs must be wellversed in the fundamentalsof biology as they relate totheir field. This is an intro-ductory text that minimizes unnecessary memoriza-tion of connections and classifications and insteademphasizes concepts, technology, and the utilizationof living things. Emphasizing the ever-present interac-tions between a biological unit and its physical, chem-ical, and biological environments, the book providesample instruction on the basics of physics, chemistry,mathematics, and engineering. It brings together allthe concepts needed to understand the role of biolo-gy in modern technology.

Catalog no. 77635, September 2010, 775 pp.ISBN: 978-1-4200-7763-6, $115.95 / £72.99Also available as an eBook




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Biomechanics

BiofluidMechanicsThe HumanCirculation, Second EditionKrishnan B. Chandran,Stanley E. Rittgers, andAjit P. Yoganathan

“... the book provides agood platform in fluidmechanics prior to pro-gressing to the physiologi-cal applications which make it an appropriate text-book for BME students.”

—Professor Tim McGloughlin, Centre for AppliedBiomedical Engineering Research and Department of

Mechanical Aeronautical and Biomedical Engineering,University of Limerick

This classroom-tested text teaches students how fluidmechanics is applied to the study of the human circu-latory system. Reflecting changes in the field since thepublication of its predecessor, this second editionincludes improved figures, additional examples, andmore problems at the end of each chapter. It alsopresents a new chapter on the computational fluiddynamic analysis of the human circulation, whichreflects the rapidly increasing use of computationalsimulations in research and clinical arenas.

• Reviews fluid and solid mechanics and normalcardiovascular physiology

• Explains how to model steady and unsteadyflows

• Evaluates the design and development of artificial heart valves, stent implants, and vascular grafts

• Describes various approaches for modeling cardiovascular diseases and therapies

• Includes end-of-chapter references and problemsas well as numerous figures throughout

Selected Contents:

Fluid And Solid Mechanics And CardiovascularPhysiology: Fundamentals of Fluid Mechanics.Introduction to Solid Mechanics. CardiovascularPhysiology. Biomechanics Of The Human Circulation:Rheology of Blood and Vascular Mechanics. Staticand Steady Flow Models. Unsteady Flow andNonuniform Geometric Models. Native Heart Valves.Cardiovascular Implants, BiomechanicalMeasurements, And Computational Simulations:Prosthetic Heart Valve Dynamics. VascularTherapeutic Techniques. Fluid DynamicMeasurement Techniques. Computational FluidDynamic Analysis of the Human Circulation. Index.

Catalog no. K12006, February 2012, 451 pp.ISBN: 978-1-4398-4516-5, $109.95 / £69.99Also available as an eBook

Fundamentals ofBiomechanicsRonald L. HustonUniversity of Cincinnati, Ohio,USA

“This biomechanics bookdoes indeed lay the groundfor learning the fundamen-tals in biomechanics, whichhave been lacking for somany years. The book getsaway from the statics con-cepts that are quite abundant and dominant topicsin previous published biomechanics books andinstead focuses on motion, dynamics, and currentpractical problems that are relevant to gait analysisand human joint dynamics. The examples are vivid,intuitive, [and] interesting.”

—Farid Amirouche, University of Illinois at Chicago

This textbook provides a comprehensive survey ofhow principles of mechanics are applied to humansystems and organs. After a review of terminology, asummary of human anatomy, and a presentation ofanthropometric data, the text discusses methods forbiomechanical analyses including essential mathemat-ics, mechanics, and modeling techniques. It then cov-ers tissue biomechanics, kinematics, and dynamics ofhuman body models as well as applications such aslifting, walking, swimming, and accident victim simu-lation. Each chapter contains reference lists for morein-depth study and problems sets with solutions.

Selected Contents:

Introduction. Review of Human Anatomy and SomeBasic Terminology. Methods of Analysis I: Review ofVectors, Dyadics, Matrices, and Determinants.Methods of Analysis II: Forces and Force Systems.Methods of Analysis III: Mechanics of Materials.Methods of Analysis IV: Modeling of Biosystems.Tissue Biomechanics. Kinematical Preliminaries:Fundamental Equations. Kinematic Preliminaries:Inertia Force Considerations. Human Body InertiaProperties. Kinematics of Human Body Models.Kinetics of Human Body Models. Dynamics ofHuman Body Models. Numerical Methods.Simulations and Applications.

Catalog no. K14776, April 2013, 470 pp.ISBN: 978-1-4665-1037-1, $99.95 / £63.99Also available as an eBook



7

Biomechanics


Biomechanics ofthe Upper LimbsMechanics, Modelingand MusculoskeletalInjuries, Second EditionAndris FreivaldsThe Pennsylvania StateUniversity, University Park, USA

There already is a wealth ofliterature covering cumula-tive trauma disorders, med-ical management, and lower back problems.However, despite a spike in the number of work-relat-ed musculoskeletal disorders of the upper limbs dueto an increase in the number of computer-relatedjobs, few if any books have focused exclusively onsuch disorders, until now.

In its second edition, this comprehensive text isexpanded to include recent findings regarding jobstressors and ergonomic solutions. It provides up-to-date research on the biomechanics of the upper limbsand the mechanics of neuromuscular systems. It cov-ers risk factors for various disorders and tools used toidentify their causes. The book provides numerousexamples in each chapter and also features down-loadable PowerPoint slides, sample exams, and otherbackground material on a supporting website.

This comprehensive text explores:

• Biomechanics of the upper limbs and the motorcontrol system

• The structure and physiology of the humanmusculoskeletal and neuromuscular systems

• Recent research findings and solutions to variousergonomic problems

• Risk factors for disorders and tools used to identify their causes

Selected Contents:

Introduction to Biomechanics. Structure of theMusculoskeletal System. Neuromuscular Physiologyand Motor Control. Modeling of Muscle Mechanics.Models of the Upper Limbs. MusculoskeletalDisorders and Risk Factors. Instrumentation. Job andWorksite Analysis. Hand Tools. The OfficeEnvironment.

Catalog no. 91190, February 2011, 564 pp.ISBN: 978-1-4200-9119-9, $129.95 / £84.00Also available as an eBook

BiofluidDynamicsPrinciples andSelected ApplicationsClement KleinstreuerNorth Carolina State University,Raleigh, USA

Biofluid Dynamics builds asolid understanding of med-ical implants and devicesfrom a bioengineeringstandpoint. The text featuresextensive worked examples and mathematical appen-dices; exercises and project assignments to stimulatecritical thinking and build problem-solving skills;numerous illustrations, including a 16-page colorinsert; computer simulations of biofluid dynamicsprocesses and medical device operations; tools forsolving basic biofluid problems; and a glossary ofterms. The text can be used as a primary selection fora comprehensive course, as a two-course sequence, oras a reference for professionals in biomedical engi-neering and medicine.

• Presents the first comprehensive textbook onbiofluid dynamics

• Provides extensive worked examples, homeworkproblems, and illustrations

• Contains project assignments to stimulate criticalthinking and build students’ problem-solvingskills

• Develops the necessary tools for solving basicbiofluid problems analytically, approximately,and numerically

• Offers computer simulations of biofluid dynamics processes and medical device operations

Selected Contents:

Elements of Continuum Mechanics. BiofluidDynamics Concepts. Analyses of Arterial Diseases.Biofluid Mechanics of Organ Systems. Case Studiesin Biofluid Dynamics. Appendices. Index.

Catalog no. 2221, April 2006, 528 pp.ISBN: 978-0-8493-2221-1, $125.95 / £82.00Also available as an eBook



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BioMEMS, BioNEMS, and Biomaterials

Introduction toBioMEMSAlbert FolchUniversity of Washington, Seattle,USA

“Dr. Folch’s book is a monu-mental achievement whichbrings an authoritative andcomprehensive account tothe rapidly growing, multi-disciplinary field ofBioMEMS. Many workingscientists and engineers as well as students will findthis book fascinating.”

—Mehmet Toner, Helen Andrus Benedict Professor ofBioengineering, Harvard Medical School

“With extensive citations of the current literature,explanations that really put the technology in con-text, clear enunciation of the motivations for minia-turization, and historical perspective, the author hasmade the material very accessible and clear … . Idefinitely recommend this textbook for bioengineer-ing students.”

—Professor Karen C. Cheung, University of BritishColumbia

This classroom-tested book covers the whole breadthof the field, including classical microfabrication,microfluidics, tissue engineering, implantable systems,and cell- and noncell-based devices. It gives readers areal sense of how the field has grown by providing his-torical perspectives and covering the state of the art.The text contains problem sets, design challenges, keyreferences, and more than 400 color figures—mostfrom the original researcher. DownloadablePowerPoint slides are available for instructors.

• Focuses on the essentials of microfabrication

• Presents in-depth coverage of the techniques ofcell/protein micropatterning

• Provides a thorough presentation of microfluidics

• Discusses how BioMEMS devices can improvefluid handling

• Provides a good overall vision of the evolution ofimplantable microdevices

Selected Contents:

How Do We Make Small Things? Micropatterning ofSubstrates and Cells. Microfluidics. Molecular Biologyon a Chip. Cell-Based Chips for Biotechnology.BioMEMS for Cell Biology. Tissue Microengineering.Implantable Microdevices. Appendix. Index.

Catalog no. K10966, August 2012, 528 pp.ISBN: 978-1-4398-1839-8, $93.95 / £59.99Also available as an eBook

MolecularMotors inBionano-technologyKeith Firman and James YouellUniversity of Portsmouth, UK

Biological molecular motorsprovide most cells with thedynamic systems requiredfor their day-to-day exis-tence. Examples occur ineven the simplest organism (e.g. a bacteria virus) andthe range of tasks that they carry out is vast. Over thelast few years there has been a large increase in thestudy of these motors, and it is becoming apparentthat many motors will find uses in either bionan-otechnology or synthetic biology.

Molecular Motors in Bionanotechnology describesa wide range of molecular motors, ranging fromchemical to biological motors, in a manner thatupdates, or reviews, both classification of the type ofmotor and their grouping into families. Many tech-niques have evolved to study and characterize molec-ular motors at the single-molecule level (e.g. use ofmolecular tweezer devices for single-molecule stud-ies). The text introduces the reader to the conceptsand benefits of these techniques. In addition, thebook discusses motors that are being used or may beused in the future as part of a synthetic biologyapproach to building devices and sensors.

• Illustrates examples of major groupings ofmotors

• Provides a coherent review of groupings andfamilies of molecular motors

• Discusses various uses in synthetic biology andbionanotechnology

Catalog no. N10568, March 2013, 212 pp.ISBN: 978-981-4267-02-1, $149.95 / £95.00Also available as an eBook



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RegenerativeEngineering Edited by

Cato T. LaurencinUniversity of Connecticut HealthCenter, Farmington, USA

Yusuf KhanUniversity of Connecticut HealthCenter, Farmington, USA

“The text is well written andsuccinct. The references areup to date. Given the back-ground of the senior editor as an orthopaedic sur-geon, clinical details are provided in most of thechapters in a highly readable manner, and this canbe useful for the non-clinician user.”

—The Journal of Histotechnology, March 2014

Regenerative engineering is the intersection of regen-erative medicine and tissue engineering. Regenerativemedicine focuses on the biological aspects of tissueregeneration via stem cells, factors, and cytokines.Tissue engineering focuses on the integration of mate-rials science and life sciences. This book integratesthese two areas, presenting each concept in theframework of regenerative engineering. Through thecombination of fundamental lecture-based teachingand problem-based learning approaches, the text-book aims to develop students into future researcherscapable of completing the translation of their workfrom the benchtop to the bedside.

Selected Contents:

Regenerative Engineering: The Future of Medicine.Cell Biology. Stem Cells and Tissue Regeneration.Introduction to Materials Science. Biomaterials. InVitro Assessment of Cell–Biomaterial Interactions.Host Response to Biomaterials and Its Implications inRegenerative Engineering. Organ RegenerativeEngineering: Cell Sources, Considerations, andStrategies. Cardiovascular Regenerative Engineering.Bone Regenerative Engineering. Engineering Tissue-to-Tissue Interfaces. Neural RegenerativeEngineering. Ligament Regenerative Engineering.Skeletal Muscle Regenerative Engineering.Engineering Limb Regeneration: Lessons fromAnimals That Can Regenerate. Index.

Catalog no. K10724, June 2013, 435 pp.ISBN: 978-1-4398-1412-3, $99.95 / £63.99Also available as an eBook

An Introductionto BiomaterialsSecond EditionEdited by

Jeffrey O. HollingerCarnegie Mellon University,Pittsburgh, Pennsylvania, USA


The second edition of thispopular text includes ninenew chapters that provide acomprehensive and up-to-date educational frame-work for biomaterials education. A new chapter onthe biology of wound healing sets the stage for thebasic requirements of standardized biomaterials test-ing and explains the reactions between biomaterialsand the living system into which they are implanted.The book explains in vitro and in vivo testing para-digms and provides numerous examples on experi-mental design, laboratory assays, and animal models.Emphasizing the importance of the regulatoryprocess, it describes how innovation in the biomateri-als process relates to patentability and inventorship.

• Covers wound healing biology and hostresponse to implanted biomaterials

• Examines the regulatory process, including standardized product testing

• Reviews the innovativeness of biomaterials, with inventorship and patents in mind

• Considers experimental design, basic scientificmethods, and statistics

• Includes extensive references for further study

• Contains end-of-chapter questions and answers

Selected Contents:

Biology, Biomechanics, Biomaterial Interactions:Wound Healing Biology; Cellular Mechanics;Materials–Host Interactions. Biomaterials Testing,Statistics, Regulatory Considerations, IntellectualProperty: Standardized Materials Testing; Statistics.Biomaterials Compositions. Biomaterials Applications.Index.

Catalog no. K10637, November 2011, 644 pp.ISBN: 978-1-4398-1256-3, $125.95 / £51.99Also available as an eBook



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UnderstandingNanomedicineAn IntroductoryTextbookRob BurgessMedical NanotechnologiesIncorporated, Richardson, Texas,USA

This book addresses the lat-est findings and intriguingpossibilities in nanomedi-cine, drawing on real dataand published research from the medical sciences. Itcomprehensively covers a broad range of therapeuticand diagnostic applications of nanotechnology, pro-viding descriptions of cutting-edge discoveries alongwith historical perspectives. The text focuses on nano-materials and nanoparticles—the sectors that hold themost promise for the future of medicine. The bookpresents the impact of nanotechnology in major med-ical areas including cancer treatment, clinical neuro-science, tissue engineering, and drug delivery. Alsocovered is the worldwide governmental regulatoryimpact on nanomedicine.

Catalog no. N10477, June 2012, 524 pp.ISBN: 978-981-4316-38-5, $149.95 / £95.00Also available as an eBook

From MEMS toBio-MEMS andBio-NEMSManufacturingTechniques andApplicationsMarc J. MadouUniversity of California, Irvine,USA

This book details manufac-turing techniques applicableto bio-nanotechnology. Thebook first reviews MEMS techniques, materials, andmodeling. It then covers nanofabrication, geneticallyengineered proteins, artificial cells, nanochemistry,and self-assembly. The book also discusses scalinglaws in MEMS and NEMS, actuators, fluidics, andpower and brains in miniature devices. It concludeswith coverage of various MEMS and NEMS applica-tions. This color text offers end-of-chapter problems,worked examples throughout, extensive references,and PowerPoint slides for download.

Catalog no. 5516X, June 2011, 650 pp.ISBN: 978-1-4200-5516-0, $109.95 / £69.99Also available as an eBook

BiomedicalMicrosystemsEllis MengUniversity of Southern California,Los Angeles, USA

The book begins with anintroduction on the benefitsof miniaturization. It thenpresents a rigorous and in-depth treatment of biomed-ical microelectromechanicalsystems (BioMEMS) includ-ing materials, methods,processes, and concepts. The author covers funda-mental principles and building blocks, includingmicrofluidic concepts, lab-on-a-chip systems, andsensing and detection methods. The book thenexplores several important applications of BioMEMSsuch as microdialysis, catheter-based sensors, MEMSimplants, neural probes, and tissue engineering. Italso describes research and commercialized BioMEMSdevices as well as emerging applications. Detailedexamples, exercises, and illustrations help clarify theconcepts included.

Catalog no. 51229, September 2010, 408 pp.ISBN: 978-1-4200-5122-3, $104.95 / £65.99Also available as an eBook

A LaboratoryCourse inBiomaterialsWujing XianUniversity of Illinois at Urbana-Champaign, USA

A teaching tool for instruc-tors in biomaterials and bio-engineering, this volume is acomprehensive laboratorytextbook with detailed, step-by-step descriptions of labprocedures and explanations. It trains readers in labo-ratory skills, data analysis, problem solving, and scien-tific writing. The book integrates principles frommaterials science, chemistry, biochemistry, cell biolo-gy, and engineering. Many of the experiments pre-sented are adapted from research papers to reflectrecent progress in biomaterials and bioengineering.The text includes text boxes with in-depth informa-tion, case studies, and lab tips as well as informationon equipment, reagents, and supplies.

Catalog no. 75829, June 2009, 216 pp., Soft CoverISBN: 978-1-4200-7582-3, $74.95 / £45.99Also available as an eBook





11



A LaboratoryCourse in TissueEngineeringMelissa Kurtis MicouUniversity of California, SanDiego, USA

Dawn KilkennyUniversity of Toronto, Ontario,Canada

This book contains 15 stand-alone experiments based onboth classic and modernapproaches. Experiments encompass a set of widelyapplicable techniques including cell culture,microscopy, histology, immunohistochemistry,mechanical testing, soft lithography, and commonbiochemical assays. The book presents experimentsusing equipment commonly found in labs equippedfor tissue culture thus minimizing the cost of reagents.In addition to teaching specific techniques, the exper-iments emphasize engineering analysis, mathematicalmodeling, and statistical experimental design. It alsodescribes multiple formats useful for the presentationof results, including technical posters, extendedabstracts, and technical reports. The book includespre- and post-lab questions for each experiment.

Catalog no. K13694, August 2012, 304 pp., Soft CoverISBN: 978-1-4398-7893-4, $62.95 / £40.99Also available as an eBook

BioMEMSScience andEngineeringPerspectivesSimona BadilescuConcordia University, Montreal,Quebec, Canada

MuthukumaranPackirisamyConcordia University, Montreal,Quebec, Canada

This books supports the multidisciplinary learninginvolved in the development of biomicrosystems. Itpresents a balanced introduction of the biological,engineering, application, and commercializationaspects of the field. With a focus on molecules of bio-logical interest, the book explores the building blocksof cells and viruses as well as linkers, molecules thatform the self-assembled monolayers (SAMs), andhydrogels used for making different surfaces biocom-patible through functionalization. The book coversfabrication techniques and includes problems in eachchapter in addition to real-life examples.

Catalog no. K10877, April 2011, 368 pp.ISBN: 978-1-4398-1699-8, $109.95 / £69.99Also available as an eBook

Ultrasonic andElectromagneticNDE for Structureand MaterialCharacterizationEngineering andBiomedicalApplicationsEdited by

Tribikram KunduThe University of Arizona,Tucson, USA

Most books on nondestructive evaluation (NDE) focuseither on the theoretical background or on advancedapplications. Bridging the gap between the two, thisbook brings together the principles, equations, andapplications of ultrasonic and electromagnetic NDE ina single, authoritative resource. It begins with the fun-damentals of mechanics and electromagnetic theoryand then covers state-of-the-art topics and applica-tions. These include structural health monitoring,acoustic microscopy, terahertz imaging, and more.The book includes questions, problems, and worked-out examples as well as hundreds of illustrations.

Catalog no. K11655, June 2012, 890 pp.ISBN: 978-1-4398-3663-7, $139.95 / £80.00Also available as an eBook

Forthcoming!

BiomaterialsA Basic IntroductionQizhi ChenMonash University, Clayton,Australia

George Thouas

The multidisciplinary field ofbiomaterials incorporatesprinciples from fields asdiverse as materials science,engineering, cell biology,and medicine. This textbook provides an appropriatebalance between depth and broadness of coverage toenable understanding of the most important con-cepts and principles at the right level by students froma wide academic spectrum. The book introduces thefundamental science relevant to biomaterials andpresents the properties and principles of biomaterialsfrom the point of view of clinical applications. Thebook includes learning objectives, chapter highlights,laboratory practices, problems, and references.

Catalog no. K22550, November 2014, c. 736 pp.ISBN: 978-1-4822-2769-7, $119.95 / £76.99Also available as an eBook





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New!

Design of Biomedical Devices and SystemsThird EditionPaul H. King, Richard C. Fries, and Arthur T. Johnson

A substantial revision of a solid text, the third editionincludes information on bioprocessing and devotesmore instruction to integrating medical and biologicalconsiderations with engineering. It features updatesto all chapters as well as new problems, examples,and case studies throughout.

Selected Contents:

Introduction to Biomedical Engineering Design.Fundamental Design Tools. Design TeamManagement, Reporting, and Documentation.Product Definition. Product Documentation. ProductDevelopment. Hardware Development Methods andTools. Software Development Methods and Tools.Human Factors. Industrial Design. Biomaterials andMaterial Testing. Risk Analysis—Devices andProcesses. Testing. Analysis of Test Data. ProductLiability and Accident Investigations. The FDA andDevices. Food and Drug Administration History andRelevant Nondevice Regulations. BiologicalEngineering Designs. International Regulations andStandards. Intellectual Property: Patents, Copyrights,Trade Secrets, and Licensing Patents. Manufacturingand Quality Control. Miscellaneous Issues.Professional Issues. Concept to Product? SuggestedReading. Appendices.

Visit www.crcpress.com for complete contents

“This book is a comprehensive overview of all thepieces that need to come together to bring a medicaldevice from an idea to approved device. It is animpressive compilation of information that is noteasily found elsewhere, and includes extensive refer-ences for every chapter. The writing is clear, yet suc-cinct. The book is well organized with labeled sub-sections that let the reader find exactly what contenthe/she may want to explore. Each chapter has exer-cises that can be used as a self-assessment or to sup-plement a class.”

—Anna Iwaniec Hickerson, Keck Graduate Institute ofApplied Life Sciences, Claremont, California, USA

Design of Biomedical Devices and Systems, ThirdEdition covers the design of biomedical engineeringdevices and systems. The book strongly emphasizesand clarifies the standards of design procedure.Following best practices for conducting and complet-ing a design project, it outlines the various steps in thedesign process in a basic, flexible, and logical order.

What’s New in the Third Edition:

This latest edition contains a new chapters on biolog-ical engineering design, product development, andFDA regulations for items other than devices such asdrugs. It adds mathematical modeling tools and pro-vides new information on clinical trials and steriliza-tion methods. This new edition:

• Familiarizes the reader with medical devices,their design, regulation, and use

• Emphasizes a practical, hands-on approach todevice design

• Provides an overview of basic design issues

• Considers device safety aspects

• Discusses the need for documentation

• Provides a summary of key ways to protect intellectual property

• Discusses the legal ramifications of medicaldevice development and failure

Catalog no. K16421, August 2014, c. 505 pp.ISBN: 978-1-4665-6913-3, $129.95 / £82.00Also available as an eBook


13

Biomedical Imaging


Introduction toNuclear ScienceSecond EditionJeff C. BryanUniversity of Wisconsin–LaCrosse, USA

This introductory textbookprovides a clear and com-plete introduction to nuclearchemistry and physics—from basic concepts tonuclear power and medicalapplications. The book covers energetics, nuclear sta-bility, radioactive decay, nuclear reactions, interactionsof radiation with matter, detection methods, and safe-ty measures such as monitoring and regulations. Itexplores applications in medicine, power generation,food safety, waste, and weapons.

This second edition of a bestseller contains 60 percentmore material and includes new chapters on dosime-try as well as new sections on nuclear forensics, radi-ology, gamma cameras, and decay through proton orneutron emission. This expanded edition provides amuch-needed textbook and resource for undergradu-ate students in science and engineering as well asthose studying nuclear medicine and radiation thera-py. It also serves as a general introduction to nuclearscience for all interested readers. All chapters areupdated and contain additional end-of-chapter prob-lems. A new appendix provides nuclear data for allnuclides mentioned.

New to This Edition:

• More in-depth coverage of nuclear reactors andrecent accidents such as the one in Fukushima,Japan

• A chapter on dosimetry of radiation fields

• Expanded discussion of applications

• More detailed explanations of the necessarymathematics

Selected Contents:

Introduction. Mathematics of Radioactive Decay.Energy and the Nucleus. Applications of NuclearScience I: Power and Weapons. Radioactive Decay:The Gory Details. Interactions of Ionizing Radiationwith Matter. Detection of Ionizing Radiation.Applications of Nuclear Science II: Medicine andFood. Nuclear Reactions. Fission and Fusion.Applications of Nuclear Science III: More aboutNuclear Reactors. Radiation Protection. X-rayProduction. Dosimetry of Radiation Fields.Appendices. Bibliography. Index.


PracticalUltrasoundAn Illustrated Guide,Second EditionJane AltyConsultant Neurologist, LeedsTeaching Hospitals NHS Trustand Honorary Senior Lecturer,University of Leeds, UK

Edward HoeyConsultant Radiologist, Heart ofEngland NHS Foundation Trust,UK and Honorary Senior Lecturer,University of Birmingham, UK

“The authors are to be congratulated for theirefforts. … Not only are you on the brink of discover-ing a wonderful world of non-invasive imaging, butalso your pathway to achieving the competence thatyou desire will be made considerably easier by thisbook.”

—Henry C Irving FRCR, Consultant Radiologist, St James’s University Hospital, Leeds, UK; Ex-Treasurer of

The Royal College of Radiologists

Commended by the British Medical Association, thisvolume focuses on the scans regularly encountered ina busy ultrasound department and provides every-thing practitioners need to know to become compe-tent and skilled in scanning. Each chapter containsexamples of common and clinically relevant patholo-gies and discusses the salient features of these condi-tions. This second edition includes new chapters onbreast, musculoskeletal, and Focused Assessment withSonography in Trauma (FAST) ultrasonography.Beginning with the general principles of ultrasoundscanning and a guide to using the ultrasoundmachine, the book provides step-by-step instructionson how to perform scans and is supplemented byhigh-quality images and handy tips.

• Covers everything a trainee needs to know tobecome competent in ultrasound scanning

• Presents a practical guide, using simple illustrations, accurate images, and uncomplicated language

• Provides step-by-step instructions on how toperform ultrasound scans

Selected Contents:

General Principles of Ultrasound Scanning. Guide toUsing the Ultrasound Machine. Abdomen. Renal,Including Renal Transplant. Abdominal Aorta. LiverTransplant. Testes. Lower Limb Veins. Carotid DopplerExamination. Female Pelvis. Early Pregnancy. Thyroid.Focused Assessment with Sonography in Trauma(FAST). Breast. Musculoskeletal Ultrasound. Index.

Catalog no. K17225, August 2013, 295 pp.Soft CoverISBN: 978-1-4441-6829-7, $79.95 / £49.99Also available as an eBook



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Biomedical Imaging

New!

Applied MedicalImageProcessingSecond Edition, A Basic CourseWolfgang BirkfellnerMedical University of Vienna,Austria

“I mention the book everytime I meet someone whoasks what the best way is to get into this field.”

—Professor Leo Joskowicz, Head of Computer-AssistedSurgery and Medical Image Processing Laboratory, The

Hebrew University of Jerusalem, Israel

Praise for the First Edition:

“This is a lucid, well-written, and hands-on textbookthat explains in simple terms—and with examples—the basic issues of medical image processing. It con-tains many examples and useful programs.”

—Professor Leo Joskowicz, Head of Computer-AssistedSurgery and Medical Image Processing Laboratory, The

Hebrew University of Jerusalem, Israel

“The plethora of examples in each chapter … allowsthe reader to apply the theory and visually assess theoutcomes. This book is a perfect blend of theory andpractice. I highly recommend it.”

—Dr. Pascal Fallavollita, Technical University of Munich,Germany

Avoiding excessive mathematical formalisms, this sec-ond edition of a bestseller delivers an ideal introduc-tion to medical image processing, presenting keyprinciples and algorithms using simpleMATLAB®/Octave scripts. It discusses data storage,transformations, segmentation, rendering, registra-tion, and reconstruction and also has a chapter onclinical applications as well as an image-guided thera-py tutorial. Including examples from radiology, inter-nal medicine, surgery, and radiation therapy, the textis helpful to students of medical physics, biomedicalengineering, computer science, and applied mathe-matics as well as radiology professionals.

Selected Contents:

A Few Basics of Medical Image Sources. ImageProcessing in Clinical Practice. Image Representation.Operations in Intensity Space. Filtering andTransformations. Segmentation. Spatial Transforms.Rendering and Surface Models. Registration. CTReconstruction. A Tutorial on Image Guided Therapy.A Selection of MATLAB® Commands.


Biomedical Signaland ImageProcessingSecond EditionKayvan NajarianVirginia CommonwealthUniversity, Richmond, USA

Robert SplinterUniversity of North Carolina atCharlotte, USA

This book has received wideand welcome reception fromuniversities and industry research institutions alike. Itaddresses the application of standard and novel pro-cessing techniques to biomedical signals and images.The first section presents an introduction to digital sig-nal and image processing, including Fourier transform,image filtering, edge detection, and wavelet transform.The second section investigates specific biomedical sig-nals, such as ECG, EEG, and EMG. The third sectionfocuses on imaging using CT, x-ray, MRI, ultrasound,positron, and other biomedical imaging techniques.

Retaining all of the quality and precision of the first edi-tion, the book offers numerous additional examples—predominantly MATLAB®-based—to illustrate the con-cepts described in the text and to ensure a completeunderstanding of the material. The author takes greatcare to clarify ambiguities in some mathematical equa-tions and to further explain and justify the more com-plex signal and image processing concepts thus offer-ing a complete and understandable approach to com-plicated concepts.

• Includes updates for all chapters as well as many additional examples

• Employs understandable descriptions of mathematical techniques

• Provides a simple approach to complicated concepts

• Presents newly revised and expanded end-of-chapter problems

Selected Contents:

Introduction To Digital Signal And Image Processing:Signals and Biomedical Signal Processing. FourierTransform. Image Filtering, Enhancement, andRestoration. Edge Detection and Segmentation ofImages. Wavelet Transform. Other Signal and ImageProcessing Methods. Clustering and Classification.Processing Of Biomedical Signals: Electrical Activities ofCell. Electrocardiogram. Electroencephalogram.Electromyogram. Other Biomedical Signals. ProcessingOf Biomedical Images: Principles of ComputedTomography. X-Ray Imaging and ComputedTomography. Magnetic Resonance Imaging.Ultrasound Imaging. Positron Emission Tomography.Other Biomedical Imaging Techniques. Related Titles.

Catalog no. K13235, May 2012, 411 pp.ISBN: 978-1-4398-7033-4, $119.95 / £70.99Also available as an eBook



15

Biomedical Imaging


Biosignal andMedical ImageProcessingThird EditionJohn L. SemmlowRobert Wood Johnson MedicalSchool, New Brunswick, NewJersey, USA

Benjamin Griffel

This third edition of a best-seller offers comprehensivecoverage of the major approaches in biomedical signaland image processing. It provides a complete set ofsignal processing tools, including diagnostic decision-making tools and classification methods. Thoroughlyrevised and updated, it supplies important new mate-rial on nonlinear methods for describing and classify-ing signals, including entropy-based methods andscaling methods. This edition covers data “cleaning”methods commonly used in areas such as heart ratevariability studies along with actual examples. It alsoincludes new end-of-chapter problems.

This is the first and only textbook to supply a hands-on tutorial in biomedical signal and image processingand offers a unique and proven approach to signalprocessing instruction, unlike any other competingsource on the topic. The book also showcases valuableimplementation procedures, common pitfalls, andessential application concepts. The text is accompa-nied by a CD with support data files and all MATLAB®

examples and figures found in the text.

• Offers a substantial revision to a well-establishedtextbook

• Adds new material on nonlinear methods fordescribing and classifying signals

• Supplies new end-of-chapter problems andexamples

• Includes studies dealing with heart rate variabili-ty as actual examples

• Incorporates MATLAB® throughout the text

Selected Contents:

Introduction. Basic Concepts. Spectral Analysis:Classical Methods. Digital Filters. Spectral Analysis:Modern Techniques. Time–Frequency Analysis.Wavelet Analysis. Advanced Signal ProcessingTechniques: Optimal and Adaptive Filters. MultivariateAnalyses: Principal Component Analysis andIndependent Component Analysis. Fundamentals ofImaging Processing: MATLAB® Image ProcessingToolbox. Spectral Analysis: The Fourier Transform.Image Segmentation. Image Reconstruction.Classification I: Linear Discriminant Analysis andSupport Vector Machines. Adaptive Neural Nets.

Catalog no. K16329, February 2014, 630 pp.ISBN: 978-1-4665-6736-8, $119.95 / £76.99Also available as an eBook

Physics forDiagnosticRadiologyThird EditionP. P. DendyAddenbrookes NHS Trust,Cambridge, UK

B. HeatonAberdeen Radiation ProtectionServices, UK

“This is the third edition of awell-established and popular textbook on physics ofdiagnostic radiology… The textbook describes recentstate-of-the-art advances in medical imaging in a wayradiologists, radiographers, and medical physicistswill find easy to understand. It is internationally rec-ognized as one of the key textbooks in its field.”—Dr. Keith Faulkner, North East Strategic Health Authority, UK

Praise for the Second Edition:

“One of the most useful features is the amount of reviewmaterial. A series of discussion questions are given atthe end of each chapter and six to fourteen multiple-choice questions per chapter are listed in an appendix,with an answer key for all questions and explanatoryfootnotes for some … On the whole, I found the mate-rial to be authoritative, comprehensive, and accurate.”

—Doody Online Reviews

Fully revised and updated, this bestseller helps readersunderstand how various imaging techniques work. Thisedition includes new chapters on PET and PACS as wellas new material on digital receptors, radiation doses, andrisks to patients as well as special radiographic techniquesincluding subtraction techniques and interventional radi-ology. It also emphasizes the differences between analogand digital images and covers other topics includingmulti-slice CT and three-dimensional resolution, dualenergy applications, and cone beam CT. The bookincludes exercises, multiple choice questions, extensivereferences, and suggestions for further reading.

Selected Contents:

Fundamentals of Radiation Physics and Radioactivity.Production of X-Rays. Interaction of X-Rays and GammaRays with Matter. Radiation Measurement. The ImageReceptor. The Radiological Image. Assessment of ImageQuality and Optimisation. Tomographic Imaging withX-Rays. Special Radiographic Techniques. DiagnosticImaging with Radioactive Materials. Positron EmissionTomographic Imaging (PET). Radiobiology and GenericRadiation Risks. Radiation Doses and Risks to Patients.Practical Radiation Protection and Legislation.Diagnostic Ultrasound. Magnetic Resonance Imaging.Digital Image Storage and Handling. Multiple ChoiceQuestions. Index.

Catalog no. 83155, August 2011, 720 pp.ISBN: 978-1-4200-8315-6, $83.95 / £51.99Also available as an eBook



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Biomedical Imaging

Webb's Physicsof MedicalImagingSecond EditionEdited by

M. A. FlowerInstitute of CancerResearch/Royal Marsden NHSFoundation Trust, UK

Series: Series in MedicalPhysics and BiomedicalEngineering

“Possibly the most comprehensive book on the sub-ject currently on the market.”

—Dr. Sandro Olivo, University College London

Praise for the First Edition:

“Steve Webb has produced a first-class book.Because The Physics of Medical Imaging is up todate in a rapidly changing field, it is the text ofchoice for teaching graduate research students inthis new and exciting subspecialty of physics.”

—Physics Today

“… a worthwhile addition to the personal library ofanyone connected with this field.”

—Journal of Clinical Physics and Physiological Measurement

Since the publication of the best-selling first edition,the technology and clinical applications of medicalimaging have changed significantly. Gathering thesedevelopments into one volume, this comprehensivesecond edition presents the basic physics, moderntechnology, and up-to-date examples of clinical appli-cation across all the modalities of medical imaging. Itnow covers state-of-the-art detector technology andcomputer processing used in medical imaging. Alongwith many new examples and figures, this editionincludes new chapters on medical image processingand multimodality imaging.

Selected Contents:

In the Beginning: The Origins of Medical Imaging.Diagnostic Radiology with X-Rays. X-RayTransmission Computed Tomography. ClinicalApplications of X-Ray Computed Tomography inRadiotherapy Planning. Radioisotope Imaging.Diagnostic Ultrasound. Spatially Localised MagneticResonance. Physical Aspects of Infrared Imaging.Imaging of Tissue Electrical Impedance. OpticalImaging. Mathematics of Image Formation andImage Processing. Medical Image Processing.Perception and Interpretation of Images. ComputerRequirements of Imaging Systems. MultimodalityImaging. Epilogue. Index.

Catalog no. IP743, June 2012, 864 pp.ISBN: 978-0-7503-0573-0, $93.95 / £51.99Also available as an eBook

Rapid Review ofRadiologyShahid Hussain, Sherif Aaron Abdel Latif,and Adrian David Hall

Series: Medical Rapid ReviewSeries

“Despite its small size, thiscase-based review of diagnostic radiology isremarkably comprehen-sive... Overall, this book is ofvery high quality and would be quite useful for sen-ior radiology trainees in the U.K. and radiology res-idents preparing for American Board of Radiologyexams.” (5 stars)

—Dana Smetherman, MD, Ochsner Clinic Foundation,Doody's Review Service

As in all specialties, learning in radiology is a life-longprocess. But for radiologists in training, there are vastamounts of information to assimilate. In this book, theauthors have compiled 191 cases to help the readerwith practical aspects of image recognition and differ-ential diagnosis.

The selection of cases is broad enough to provide anintroduction to some readers, but also includes moretesting cases for those in the later stages of training.Each self-test case is presented with one or moreimages, along with pertinent clinical details. The solu-tion and explanation is also presented along with dif-ferential diagnoses that logically derive from theimages and history. The correct diagnosis is followedby discussion of the underlying problem, strategypoints, and main imaging findings.

The book contains 500 images including x-rays, ultra-sound, CT, MRI, interventional techniques, andnuclear medicine imaging. It is of value to radiologistsin training and other health professionals wishing toimprove their radiological skills and is the first book forthe FRCR Part 2B exam.

Selected Contents:

General Introduction. Chest Imaging. AbdominalImaging. Central Nervous System Head and NeckImaging. Musculoskeletal Imaging. PediatricImaging. Breast Imaging.

Catalog no. K21978, May 2010, 352 pp., Soft CoverISBN: 978-1-84076-120-7, $75.95 / £46.99



17

Biomedical Imaging


New!

MagneticResonanceImagingThe BasicsChristakis ConstantinidesUniversity of Cyprus, Nicosia

This book provides a solidintroduction to the funda-mentals of MRI technology.Based on courses taught atThe Johns Hopkins University, the book provides anoverview of magnetic resonance and examines theprinciples of physics for nuclear magnetic resonance(NMR) signal formation and image construction. Itexplains the mathematical formulation of MRI anddiscusses image quantitative indices. Additional topicsinclude Fourier transformations, hardware and elec-tronics of an MRI scanner, magnetic fields, and NMRspectroscopy and spectral acquisition and imagingtechniques. The book includes worked examples andproblem sets to explain the concepts taught.

Catalog no. K22099, March 2014, 235 pp.Soft CoverISBN: 978-1-4822-1731-5, $69.95 / £44.99Also available as an eBook

ImageProcessing withMATLAB®

Applications inMedicine andBiology, Second EditionOmer Demirkaya, Musa H. Asyali, andPrasanna K. Sahoo

Image Processing withMATLAB®: Applications in Medicine and Biologyexplains complex, theory-laden topics through exam-ples and MATLAB® algorithms. It describes classical aswell emerging areas in image processing and analysis.Reducing the need for the trial-and-error way of solv-ing problems, this book helps readers understandadvanced concepts by applying algorithms to real-world problems in medicine and biology.

Each chapter has been revised and updated with newchapters added in morphological operations, valida-tion of image analysis methods, and image registra-tion. Substantial updates have been given to chapterson medical imaging systems, image segmentationmethods, and deformation models. The book alsoincludes new modalities such as ultrasound, andmore.

• Includes several new contributors as experts intheir respective fields

• Contains new questions and examples

• Adds new chapters on image registration, morphological operations, and validation ofimage analysis methods

• Features a solutions manual available for instructors wishing to convert this reference toclassroom use

Catalog no. K22900, March 2015, c. 475 pp.ISBN: 978-1-4822-3246-2, $99.95 / £63.99Also available as an eBook

Clark's EssentialPhysics inImaging forRadiographersKen Holmes, Marcus Elkington, andPhil Harris

An invaluable tool for stu-dents, assistant practitioners,and radiographers, this easy-to-understand pocket guideprovides an accessible intro-duction to the study of physics in imaging for radiog-raphers in a reader-friendly format. With diagramsand photographs to support the text, each chapterprovides clear learning objectives and a series ofMCQs to test reader assimilation of the material. Thebook opens with overviews of image production,basic mathematics and physics relevant to medicalimaging, and follows with detailed chapters on thephysics relevant to producing diagnostic images usingx-rays. Features diagrams and photographs to sup-port the text.

Catalog no. K18088, October 2013, 214 pp.Soft CoverISBN: 978-1-4441-4561-8, $31.95 / £19.99Also available as an eBook




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Biotechnology

Algorithms inBioinformaticsA PracticalIntroductionWing-Kin SungNational University of Singapore

“This aptly titled book is atimely publication thatdetails several algorithmswidely used in bioinformat-ics. … This work can serveas a reference guide for stu-dents and researchers attempting to implement orlearn algorithms relevant to bioinformatics.Although some concepts referenced in the bookspecifically target advanced bioinformatics experts,general users should not be discouraged from read-ing this work. …Summing Up: Recommended.”

—CHOICE, June 2010

“… an excellent guide. The book is appropriate foradvanced undergraduates and graduates in mathe-matics or CS. … The 27-page introduction is themost efficient concept-building summary and expli-cation of molecular biology that I have encountered.… Section 1.8 sets a new, high standard for science-history exposition, covering Gregor Mendel to thepresent. …This self-contained, well-designed, andwell-written book, with its many good exercises, bib-liographic references, and photo-quality figures, isan ideal introduction to bioinformatics.”

—George Hacken, Computing Reviews, March 2010

This classroom-tested text provides an in-depth intro-duction to the algorithmic techniques applied inbioinformatics. For each topic the author clearlydetails the biological motivation, precisely defines thecorresponding computational problems, and includesdetailed examples to illustrate each algorithm. Thetext covers basic molecular biology concepts,sequence similarity, the suffix tree, sequence databas-es, sequence and genome alignment, the phyloge-netic tree, genome rearrangement, motif finding, thesecondary structure of RNA, peptide sequencing, andpopulation genetics. Supplementary material is pro-vided on the author’s website and a solutions manualis available for qualifying instructors.

Selected Contents:

Introduction to Molecular Biology. SequenceSimilarity. Suffix Tree. Database Search. MultipleSequence Alignment. Genome Alignment.Phylogeny Reconstruction. Phylogeny Comparison.Genome Rearrangement. Motif Finding. RNASecondary Structure Prediction. Peptide Sequencing.Population Genetics. References. Index.

Catalog no. C7033, November 2009, 407 pp.Pack - Book and EbookISBN: 978-1-4200-7033-0, $91.95 / £43.99Also available as an eBook

New!

Robotic SurgeryWith SmartMaterials, RoboticStructures, andArtificial MusclesMohsen ShahinpoorUniversity of Maine, Orono, USA

Siavash GheshmiUniversity of Maine, Orono, USA

In recent years robotic surgery has garnered a greatdeal of interest due to its non-invasive surgicalapproach. This book focuses on robotic surgery andbiomimetic artificial muscles and their possible engi-neering, industrial, medical, and science applications.It presents the fundamentals of surgical robots, includ-ing the design of their geometrical configurations,kinematics, dynamics, and control. It also describessystems that can be manufactured or fabricated to actlike biomimetic artificial muscles, sensors, and actua-tors.

This book is expected to include an introductory gen-eral chapter on the history of robotic surgery and bio-mimetic artificial muscles and their possible engineer-ing, industrial, medical, and science applications.Other chapters are expected to cover the fundamen-tals of surgical robots such as design of their geomet-rical configurations, kinematics, dynamics, and con-trol. Also discussed are the designs of ophthalmic sur-gical robots, general laparoscopic surgical robots, andapplications of a number of particular materials andsystems that are currently available.

• Serves as a textbook on robotic surgery education

• Addresses the applications of artificial muscles,smart materials, and sensors to robotic surgery

• Includes end-of-chapter homework problemsand MATLAB® codes for the diagrams in theappendix

Selected Contents:

Introduction to Surgical Robots GeneralConfigurations. Surgical Robots Kinematics andWorkspace. Intraocular Robotic Surgical Systems.Deployable Laparoscopic Robotic Surgical Systems.Applications of Intelligent Materials and ArtificialMuscles to Robotic Surgery. Summary andConclusions. References. Appendix. Index.

Catalog no. N11018, August 2014, c. 300 pp.ISBN: 978-981-4316-23-1, $179.95 / £114.00



19

Biotechnology


Learning Bio-Micro-NanotechnologyMel I. MendelsonLoyola Marymount University, LosAngeles, California, USA

“… a great combination oftwo key disciplines in thecoming quarter of this cen-tury, biotechnology andnanotechnology. This willbe a good guidebook for theacademic adventure as well as a bible for the pio-neer in the engineering and scientific field.”

—Hideyuki Kanematsu, Suzuka National College ofTechnology

“… provides an excellent, multi-dimensionalapproach to learning that I have not seen in othernanotechnology textbooks.”

—Kory Goldammer, Richland College

A primary text for undergraduate nanotechnologycourses, this book is designed for students who lack across-disciplinary background and knowledge ofmicro and nanotechnology. Clearly and conciselywritten, it contains many examples, questions, andproblems divided into three hierarchical learning skills:understanding, analyzing, and evaluating concepts.The author attempts to break down the boundariesbetween biology, chemistry, physics, engineering,and ethics. He accomplishes this by co-mingling thevocabulary and concepts of these disciplines aroundbio-applications. Copiously illustrated, this new textleans heavily towards biological and biomedical appli-cations and includes a comprehensive chapter onethics.

• Introduces micro/nanotechnology vocabulary,concepts, and applications from first principles

• Emphasizes learning with thinking exercises,analogies, and study questions

• Includes team assignments and assessment exercises

• Discusses nanotechnology and cancer, risks,ethics, and future predictions

Selected Contents:

Thinking Small and Big. Biomolecules and Cells.Molecular Chemistry. Bit of Physics. Engineering Bitsand Bytes. Seeing Small Things. Nanoelectronics.Microelectromechanical Systems. Nanotechnologyand Cancer. Risks: Nano or Mega? Ethics and SocialRelevance. Self-Assembled Future. Appendices.

Catalog no. 82035, January 2013, 611 pp.ISBN: 978-1-4200-8203-6, $89.95 / £57.99Also available as an eBook

BiotechnologyFundamentalsFirdos Alam KhanManipal University, Dubai, UAE

This textbook discusses thefundamentals of biotechnol-ogy as well as recent relateddevelopments such as stemcell research, cloning, biofu-el, transgenic plants, geneti-cally modified food, pharma-cogenomics, and nano-biotechnology. Incorporating extensive pedagogyinto the content, the authors provide examples, end-of-chapter problems case studies, and laboratory tuto-rials. The book also includes definitions, historical per-spectives, time lines, and major discoveries along withinformation on biotechnology products, currentresearch and development, career prospects, ethicalissues, and future trends.

• Includes information on current research trends

• Covers novel medical genetics topics such asintra-uterine insemination

• Discusses the process of biotech product development, with suitable examples

• Examines ethical issues within biotechnologyresearch and product development

Selected Contents:

Introduction to Biotechnology. Genes and Genomics.Proteins and Proteomics. Recombinant DNATechnology. Microbial Biotechnology. AgriculturalBiotechnology. Animal Biotechnology. EnvironmentalBiotechnology. Medical Biotechnology.Nanobiotechnology. Product Development inBiotechnology. Industrial Biotechnology. Ethics inBiotechnology. Careers in Biotechnology. LaboratoryTutorials. Glossary.

Catalog no. K11059, September 2011, 608 pp.ISBN: 978-1-4398-2009-4, $98.95 / £51.99Also available as an eBook



20 1-800-634-7064 • 1-859-727-5000 • +44 (0) 1235 400 524 • [email protected]

Biotechnology

Introduction toInstrumentationin Life SciencesPrakash Singh BisenDefense Research & DevelopmentEstablishment, Gwalior, India

Anjana SharmaRani Durgavati University,Jabalpur, India

“A comprehensive textbookon instrumentation meth-ods which covers all majortopics including practical exercises representing thesyllabi of various postgraduate and undergraduateprograms in life sciences.”

—Prof. Vinay Sharma, Prof. & Head, Dept. of Bioscience &Biotechnology, Banasthali University, India

“The proposed book is an excellent one for use ofstudents, research scholars and teachers of life sci-ences, biotechnology, biochemistry, biophysics andother related disciplines where such books exclusive-ly dedicated for life sciences are not available.”

—Prof. Sukh Mahendra Singh, Coordinator, School ofBiotechnology, Banaras Hindu University, India

Addressing aspects of instrumentation that hold thekey for cutting-edge research and innovative applica-tions, this book is designed to serve a wide range ofstudents and researchers in the diversified fields of lifesciences including pharmacy, biotechnology, microbi-ology, biochemistry, and environmental sciences. Thebook is unique in its broad subject coverage, incorpo-rating fundamental techniques as well as applicationsof modern molecular and proteomic tools that are thebasis for state-of-the-art research. It includes well-illus-trated diagrams to explain the principles and theoriesbehind the instruments described.

• Includes basic theoretical and practical details fornumerous types of chromatography

• Describes a broad range of spectroscopic techniques

• Contains unique in-depth coverage of fermentation processes

• Offers an excellent bench manual for researchers

Selected Contents:

Microscopy. Micrometry. ElectrochemicalTechniques. Chromatography. Spectroscopy.Centrifugation. Electrophoresis. X-Ray Microanalysis.Techniques with Radioisotopes. Fermentation.Conductivity Meters. Glossary. Index.

Catalog no. K14893, September 2012, 383 pp.Soft CoverISBN: 978-1-4665-1240-5, $83.95 / £51.99Also available as an eBook

BiotechnologyOperationsPrinciples andPracticesMichael J. RoyUniversity of Wisconsin-Madison,USA

Due to rapid developments inthe biotechnology industry—and the wide range of disci-plines that contribute to itscollective growth—there is aneed to more carefully plan and fully integrate biotechdevelopment projects. Despite the wealth of operationsexperience and associated literature available, no singlebook has yet offered a comprehensive, practical guide tofundamentals.

Filling this void, this book presents an integrative phi-losophy serving as a practical guide for students, pro-fessionals, or anyone else with interests in the biotechindustry. Using simple language and explanatory fig-ures, this book describes the functional areas thatmust be successfully integrated to safely and efficient-ly bring a biotechnology product to market.

Although many books emphasize specific technicalaspects of biotech, this is perhaps the first to integrateessential concepts of product development and scien-tific and management skills with the seven functionalareas of biotechnology:

• Biomanufacturing• Clinical trials• Nonclinical studies• Project management• Quality assurance• Quality control• Regulatory affairs

A practical roadmap to optimizing biotechnologyoperations, this reference illustrates how to use specif-ic product planning, design, and project manage-ment processes to seamlessly merge plans and effortsin key functional areas. Applying lessons learnedthroughout the nascent history of biotech, the authorhighlights developmental principles that could helpbring future products to market with increased safetyand efficiency. Drawing from his experiences workingin both industry and government, the author clarifiesbasic methodologies and practices to help reducerisks and resolve problems as future technological dis-coveries are developed into tangible products.

Selected Contents:

Introduction to Biotechnology Operations: Planningfor Success. Project Management. Regulatory Affairs.Regulatory Compliance. Quality Systems.Biomanufacture. Quality Control. Nonclinical Studies.Clinical Trials. Glossary. Additional Reading. PracticalProblems and Questions.




21

Biotechnology


Forthcoming!

NanotechnologyUnderstanding Small Systems, Third EditionBen Rogers, Jesse Adams, and Sumita Pennathur

Series: Mechanical and Aerospace Engineering Series

Catalog no. K21691, October 2014, c. 432 pp.ISBN: 978-1-4822-1172-6, $99.95 / £72.99Also available as an eBook

“The book is well written with lots of examples andhistoric perspectives that certainly make readingmore enjoyable and stimulating.”

—Dr. Prabhu Arumugam, Louisiana Tech University, Ruston, USA

Nanotechnology is a gigantic topic about smallthings. This book uncovers the most importantaspects of nanotechnology for the reader. It beginswith an overview of nanotechnology emphasizing itshistory, key personalities, and early milestones. Thebook then presents the issues, promises, and funda-mentals behind nanotechnology.

Also covered are a variety of topics including nano-materials, nanomechanics, nanoelectronics,nanoscale heat transfer, nanophotonics, nanoscalefluid mechanics, nanobiotechnology, and nanomedi-cine. In these “nano” chapters the authors discuss thespecific, fundamental differences between macroscaleand nanoscale phenomena and devices—using appli-cations to teach key concepts.

This is a substantial revision of one of the first true pri-mary texts in nanotechnology. The second editionwas a CHOICE Award winner in 2011. Each chapter inthe third edition has been thoroughly revised andupdated. It also includes a major chapter onnanomedicine. This edition:

• Includes new personality profiles and sidebars toemphasize the people and history of the field

• Provides the latest understanding of the humanhealth ramifications of nanomaterials

• Incorporates new problems, examples, and anexhaustive nanotech glossary

• Provides a list of recommended resources for further study

Selected Contents:

Big Picture and Principles of the Small World:Understanding the Atom: Ex Nihilo Nihil Fit.Nanotechnology Starts with a Dare: Feynman’s BigLittle Challenges. Why One-Billionth of a Meter Is aBig Deal. Thinking It Through: The BroadImplications of Nanotechnology. The Business ofNanotech: Plenty of Room at the Bottom Line Too.Introduction to Miniaturization: Background: TheSmaller, the Better. Scaling Laws. The Basics ofQuantum Mechanics. Summary. Introduction toNanoscale Physics: Background: Newton Never Sawa Nanotube. One Hundred Hours and Eight Minutesof Nanoscale Physics. The Basics of QuantumMechanics. Summary. Nanomaterials: Background:Matter Matters. Bonding Atoms to Make Moleculesand Solids. Crystal Structures. Structures SmallEnough to Be Different (and Useful). Summary.Nanomechanics: Background: The UniverseMechanism. A High-Speed Review of Motion:Displacement, Velocity, Acceleration, and Force.Nanomechanical Oscillators: A Tale of Beams andAtoms. Feeling Faint Forces. Summary.Nanoelectronics: Background: The Problem(Opportunity). Electron Energy Band. Electrons inSolids: Conductors, Insulators, and Semiconductors.Fermi Energy. Density of States for Solids. Turn Downthe Volume! (How to Make a Solid Act More Like anAtom). Quantum Confinement. Tunneling. SingleElectron Phenomena. Molecular Electronics.Summary. Nanoscale Heat Transfer: Background: HotTopic. All Heat Is Nanoscale Heat. Conduction.Convection. Radiation. Summary. Nanophotonics:Background: The Lycurgus Cup and the Birth of thePhoton. Photonic Properties of Nanomaterials. Near-Field Light. Optical Tweezers. Photonic Crystals: ABand Gap for Photons. Summary. Nanoscale FluidMechanics: Background: Becoming Fluent in Fluids.Fluids at the Nanoscale: Major Concepts. How FluidsFlow at the Nanoscale. Applications of Nanofluidics.Summary. Nanobiotechnology: Background: OurWorld in a Cell. Introduction: How Biology “Feels” atthe Nanometer Scale. The Machinery of the Cell.Applications of Nanobiotechnology. Summary.Nanomedicine: What Is Nanomedicine? MedicalNanoparticles. Nanomedicine and Cancer.Biomimicry in Nanomedicine. CommercialExploration. Summary. Glossary. Index.


22 1-800-634-7064 • 1-859-727-5000 • +44 (0) 1235 400 524 • [email protected]

General Textbooks

NumericalMethods forChemicalEngineers UsingExcel, VBA, andMATLAB®

Victor J. Law Tulane University, New Orleans,Louisiana, USA

While teaching a course forengineers over the last 15years, the author found the need for a new text-book—one that was less elementary and providedapplications better suited for chemical engineers. Sixyears’ worth of teaching notes were enhanced todevelop this book. Since many practical engineeringproblems must be solved numerically, this text showshow to use numerical methods and Excel®/VBA forchemical and biomolecular engineering problems.

Topics covered include nonlinear equations, VisualBasic, linear algebra, ordinary differential equations,regression analysis, partial differential equations, andmathematical programming methods. The book alsoincludes an introduction to MATLAB®, which becomeseasier to learn after studying the programming toolspresented in previous chapters.

Most of the examples and problems discussed in thetext are related to chemical and biomolecular engi-neering and cover a broad range of application areasincluding thermodynamics, fluid flow, heat transfer,mass transfer, reaction kinetics, reactor design,process design, and process control. The chapters fea-ture “Did You Know” boxes, which teach readers spe-cific Excel features. Each chapter contains examplesthat demonstrate how a particular numerical methodor programming methodology can be implemented.The book also contains end-of-chapter exercises.

Selected Contents:

Roots of a Single Nonlinear Equation. Visual Basic®

for Applications Programming. Linear Algebra andSystems of Linear Equations. NumericalDifferentiation and Integration. Ordinary DifferentialEquations (Initial Value Problems). OrdinaryDifferential Equations (Boundary Value Problems).Regression Analysis and Parameter Estimation. PartialDifferential Equations. Linear Programming,Nonlinear Programming, Nonlinear Equations, andNonlinear Regression Using Solver. Introduction toMATLAB®. Appendix A: Additional Features of VBA.Index.


TechnicalWritingA Practical Guide for Engineers andScientists Phillip A. Laplante The Pennsylvania StateUniversity, Malvern, USA

Series: What Every EngineerShould Know

“Concisely written, fast-paced, comprehensive, andwritten with workplace expectations in mind,Laplante hits the mark when he says his book isintended to complement reference books or othertechnical communication books… The language iseasy for students to understand; the design, graph-ics, and examples keep readers engaged; and it canbe a great supplement or primary text depending onhow much original material of your own you wouldlike to provide to your students.”

—Diane Martinez, Technical Communication, May 2012

Written by a renowned engineer and widely pub-lished technical author, this guide enables readers towrite, edit, and publish materials of a technical natureincluding books, articles, reports, and electronicmedia. Complementing the traditional writer’s refer-ence manuals and other books on technical writing,this text helps readers understand the practical con-siderations in writing technical content. Drawing onhis own work, the author presents many first-handexamples of writing, editing, and publishing technicalmaterials.

This book:

• Offers precise, hands-on coverage of technicalwriting

• Explains how to write for blogs, social networks,and other e-media

• Incorporates at least one figure, table, graphic,bullet list, or equation on most pages

Selected Contents:

The Nature of Technical Writing. Technical WritingBasics. The Writing Process. Scientific Writing.Business Communications. Technical Reporting.Using Graphical Elements. Publishing Your Work.Writing for E-Media. Writing with Collaborators.Glossary. Index.

Catalog no. K11106, July 2011, 250 pp., Soft CoverISBN: 978-1-4398-2085-8, $43.95 / £28.99Also available as an eBook



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CRC Press Virtual Textbook Fairweb: http://www.crcpress.com/textbookfair/engineering

for ENGINEERING FACULTY

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