Benu Brata Das, Ph.D.

Associate Professor and Wellcome Trust/ DBT India Alliance Fellow.Laboratory of Molecular BiologySchool of Biological SciencesIndian Association for The Cultivation Of ScienceJadavpur, Kolkata, 700032, India.Phone: +91 33 2473 4971/3372 (Ext 2108) Fax: +91 33 2473 2805E-mail: pcbbd@iacs.res.in ; benubrata@yahoo.com

Research Focus:

DNA, Topoisomerases, DNA repair, Post-translational regulation of DNA repair proteins, Chromosome Instability, Checkpoints, Molecular Pharmacology, Genetic Diseases and Cancer

2. Email(s) and contact number(s)E-mail: pcbbd@iacs.res.in ; benubrata@yahoo.comPhone: +91-891-022-9121 (Mobile)

+91 33 2473 4971/3372 (Ext 2108) Fax: +91 33 2473 2805

3. Institution: Indian Association for The Cultivation Of Science

4. Date of Birth: 24th December, 1975

5. Gender (M/F/T): Male

6. Whether differently abled (Yes/No): No7. Academic Qualification (Undergraduate Onwards)

S.No Degree Year Subject University/ Institute1. M.Sc. 1998 Zoology Burdwan University

2. Ph.D. 2006Molecular Biology and Biochemistry

CSIR-Indian Institute of Chemical Biology/ Jadavpur University (Degree Awarded)/

8. Ph.D thesis title: Molecular Characterization of the structure of DNA Topoisomerase 1 gene of Leishmania

donovani Guide Name, Dr. Hemanta K. Majumder Institute/Organization/University, CSIR-Indian Institute of Chemical Biology, KolkataYear of Award. 2006

9. Work experience:

1

S.No Positionsheld

Name of theInstitute

From To

1. Visiting Fellow(Post doctoral

Fellow)

National Cancer Institute, National Institute of Health,

USA

22nd July2006

22nd July2011

2. Full Time Federal Employee

Resaerch Fellow (FTE)

National Cancer Institute, National Institute of Health,

USA

22nd July2011

30th November, 2012

3. Assistant Professor Indian Association for the Cultivation of Science,

Kolkata, India

05th

December, 2012

5th Dec, 2012 to 25th

September, 2017

3. Associate Professor

Indian Association for the Cultivation of Science,

Kolkata, India

05th

December, 2012

26th September, 2017 to present

11. Details about no of Ph.D. and Postdoctoral fellows:

Postdoctoral fellows: 1 (DBT-RA)

Ph.D students: 7 (Current : Senior Research Fellow: 3, Junior Research Fellow: 3)

Student graduated: 2; Dr. Subhendu Kumar Das ( IACS Best thesis award 2019 out of all disciplines,

currently PDF at NIH, NCI, USA); Dr. Ishita Rehman (selected for PDF at MD Anderson Cancer

institute, USA)

Int MSc-Phd student: 1

12. Professional Recognition/ Award/ Prize/ Certificate, Fellowship received by the applicant.

S.No Name of Award Awarding Agency Year

18. S. Ramachandran- National Bioscience Awards for Career Development 

Department of Biotechnology, Government of India

2019

17. Elected Member of GuhaResaerch Conference 

GRC, India 2019

16. Elected fellow of West Bengal Academy of Science & Technology (FAScT)

West Bengal Academy of Science & Technology (WAST)

2019

15. Invited Speaker and travel award for ATW2019 internationalmeeting

International Ataxia-Telangiectasia Workshop 2019 (ATW2019), Houston Methodist Hospital, Houston,USA

2019

14. Gordon Conference Travel Award and selected speaker

DNA Topoisomerases in Biology and Medicine, Gordon Research Conference, South Hadley, MA, USA

2018

13. ISA-Senior Visiting Professor Fellow-2016

Department of Pharmacy and Biotechnology - FaBiT, University of Bologna, Italy

2016

12. Wellcome Trust/ DBT India Alliance Intermediate Fellowship

Wellcome Trust/ DBT India Alliance 2013

11. DST-Ramanujan Fellowship Department of Science and Technology, Government of India

2013

10. DBT-Ramaligaswami Retry Fellowship

Department of Biotechnology, Government of India

2013

2

9. NCI outstanding Postdoctoral Fellow award (among top five)

National Cancer Institute, NIH, USA 2012

8. Gordon Conference Travel Award and selected speaker

Gordon Conference, DNA repair and mutagenesis meeting, USA

2012

7. Cold Spring Harbor meeting Travel award and selected speaker

Cold Spring Harbor: DNA replication and repair meeting, USA

2011

6. Fellows Award for Research Excellence

NIH, USA 2011

5. Fellows Award for Research Excellence

NIH, USA 2010

4. NDDO Honorary Award Lecture 8th International Symposium on Targeted Anticancer Therapies 2010, March 4-6. Washington DC, USA.

2010

3. Postdoctoral visiting fellowship award

National Cancer Institute, NIH, USA 2006

2 Best Poster Award International Training and Research in Emerging Infectious Diseases, at New Delhi, India

2005

1. Junior Research Fellowship (NET/JRF)

National Eligibility Test (CSIR-UGC), India 2001

13. Publications (complete List of papers).

Publications arising from Dr. Das independent laboratory at IACS, Kolkata during last 5 years.

Total of 11 publications inclusive of 8 corresponding author papers have been published by Dr. Benu Brata Das since 2014 as an independent investigator at IACS, Kolkata. His total publications have received nearly 2183 citations with an H-Index of 20 (2014 onwards). The papers that are published in the last five years have been listed below.

(*Corresponding authors, # Joint first authors; IP: Journal Impact Factor; Ci: citations)

1. Gain, C., Malik, S., Bhattacharjee, S., Ghosh. A, Robertson, E.S, Das, B.B., Saha, A. Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. PLoS Pathog. 2020 16(2):e1008105 (IP: 6.15, Ci: Just published)

2. Ghosh, A., Bhattacharjee, S., Paul Chowdhuri, S., Mallick, A, Rehman, I., Basu, S., and Das, B.B*. 2019. SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy. SCIENCE ADVANCES, 5(11):eaax9778. (IP: 12.80, Ci: Just published)

3. Halder, D., Saha, S., Singh, R., Ghosh, I., Mallick, D., Dey, S., Ghosh. A., Das, B.B., Ghosh S and Jana SS. 2019. Non-muscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells, Mol Biol Cell. 30 (12): 1463-1476. ( IP: 3.90 ; Ci: 1 )

4. Kundu, B#., Das, S. K.#, Chowdhuri, S. P#., Pal, S., Sarkar, D., Ghosh, A., Mukherjee, A., Bhattacharya, D., Das, B.B.* Talukdar, A.* 2019. Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity. Journal of Medicinal Chemistry (ACS)., 62: 3428-3446. (IP: 6.56; Ci: 4)

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5. Rehman, I.; Basu, S.; Das, S.K.; Bhattacharjee, S.; Ghosh, A.; Pommier, Y*.; and Das, B.B * .  2018. PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes. Nucleic. Acids Research., 46: 5601-5617. (IP: 11.56; Ci: 9)

6. Das, S. K, Ghosh, A., Paul Chowdhuri, S, Halder, N., Rehman, I., Sengupta, S., Sahoo, K.C., Rath, H.*, and Das, B.B*. 2018. Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes.  Journal of Medicinal Chemistry (ACS)., 61 (3), 804–817. (IP: 6.56; Ci: 8)

7. Mallick, A., Kuman, M.M., Ghosh A, Das, B.B., and Basu, S. 2018. Cerberus Nanoparticles: Co targeting of Mitochondrial DNA and Mitochondrial Topoisomerase I in Breast Cancer Cells. ACS Applied Nano Materials , 1 (5), 2195-2205. (IP: --; Ci: 3)

8. Bhowal S, Ghosh, A.,Chowdhuri, S.P., Mondal, R.,*, Das, B.B . *. 2018. A Novel Metallogel Based Approach to Synthesize (Mn, Cu) Doped ZnS Quantum Dots and Labeling of MCF-7 Cancer Cells. Dalton Transactions, 47, 6557. (IP: 4.09; Ci: 4)

9. Maji S, Alam P, Kumar GS, Biswas S, Sarkar PK, Das B, Rehman I, Das, B.B . , Jana NR, Laskar IR, Acharya S. 2017. Induced Aggregation of AIE-Active Mono-Cyclometalated Ir(III) Complex into Supramolecular Branched Wires for Light-Emitting Diodes. Small. 15, 1603780-1603787. (IP: 10.85; Ci: 13)

10. Das, S. K., Rehman, I., Ghosh, A., Sengupta, S., Majumder, P., Jana, B and Das, B.B*. 2016. Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells. Nucleic. Acids Res., 44: 8363-75. (IP: 11.56; Ci: 28)

11. Majumdar, P, Bathula C, Basu S.M., Das, S.K., Agarwal R, Hati S, Singh A, Sen, S*, Das, B.B.*. 2015. Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. Eur J Med Chem. ;102:540-5. (IP: 4.81; Ci: 29)

12. Das, B.B*, Huang S.N., Murai J., Rehman I@., Amé J.-C., Sengupta S@., Das S.K.@.,Majumdar, P@., Zhang H., Biard D., Majumder H.K., Schreiber V., Pommier Y.*, 2014. PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage, Nucleic. Acids Res., 42:4435-49. 2014. (IP: 10.25; Ci: 121)

Publications arising from Dr. Das's post doctoral work at NCI/NIH/USA

1. Rui G¶., Das BB¶., Chatterjee R., Vinson C and Pommier Y., 2014. Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells. DNA Repair, 13:1-9. (¶ Joint first author).

2. Murai, J., Huang, S.Y., Das B.B . , Renaud, A., Zhang, Y., Doroshow J.H., Ji J.,Takeda S and Pommier Y. 2012. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Research ,   72: 5588-99.

3. Murai, J., Huang, S.Y., Das, B.B. , Dexheimer T.S., Takeda, S., and Pommier, Y. 2012. Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damages induced by topoisomerases I and II, and base alkylation in vertebrate cells. J. Biol. Chem, 287(16): 12848-57.

4. Douarre, C., Sourbier, C., Dalla Rosa I., Das, B.B ., Redon CE., Zhang H., Neckers L and Pommier Y. 2012. Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism. PLoS One.;7(7):e41094.

5. Das, B.B . , Dexheimer TS, Maddali K and Pommier Y. 2010. Role of Tyrosyl DNA Phosphodiesterase (TDP1) in mitochondria. Proc Natl Acad Sci U S A. 16;107(46):19790-19795.

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6. Das, B.B., Antony, S., Gupta, S., Dexheimer, T.S., Redon, C.E., Garfield S., Shiloh, Y. and Pommier Y. 2009. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO Journal . 28, 3667-3680.

7. Sordet, O., Redon, C, Guirouilh-Barbat J., Smith, S., Solier, S., Douarre, C., Conti, C, Nakamura, A, Das, B.B . , Nicolas E, Kohn, K.W., Bonner, W.M., Pommier, Y. 2009. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep . 10(8):887-93.

Publications arising from Dr. Das's PhD work at IICB, Kolkata

1. Roy A, Ganguly A, BoseDasgupta S, Das, B.B . , Pal, C., Jaisankar, P, Majumder, H.K. 2008. Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani. Mol Pharmacol. , 74, 1292-307.

2. BoseDasgupta S, Das, B.B . , Sengupta S, Ganguly A, Roy A., Dey S, Tripathi G, Dinda B, Majumder, H.K. 2008. The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA 'degradesome'. Cell Death Differ, 10, 1629-40.

3. Bosedasgupta S., Das B.B., Ganguly A., Roy A., and Majumder H.K. 2008. Amino acids 39-456 of the large subunit and 210-262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania. Biochem J. 15; 481-9.

4. Bosedasgupta, S., Ganguly A., Das, B.B., Roy A., Majumder, H.K. 2008. The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase. Molecular Microbiology. 67, 31-46.

5. Roy A., Das, B.B., Ganguly A., Bosedasgupta S., Khalko NV., Pal C., Dey S., Giri VS. and Majumder H.K. 2008. An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme. Biochem J. 409 , 611-22.

6. Ganguly A., Das B.B., Roy A., Sen N., Dasgupta SB., Mukhopadyay S., Majumder HK., 2007. Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer Res. 24: 11848-58.

7. Das B.B., Bosedasgupta S., Ganguly A., Majumder S., Roy A and Majumder HK Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function. FEBS J. 274:150-63. 2007.

8. Sen N., Banerjee B., Das, B.B., Ganguly A., Sen T., Pramanik S., Mukhopadhay S and Majumder, H.K. 2007. Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex. Cell Death Differ. 2. 358-67.

9. Sen N., Banerjee B., Gupta S.S., Das, B.B . , Ganguly A., Majumder H.K. 2007. Leishmania donovani: dyskinetoplastid cells survive and proliferate in the presence of pyruvate and uridine but do not undergo apoptosis after treatment with camptothecin. Exp Parasitol. 115. 215-9.

10. Ganguly A., Das B.B., Sen N., Roy A., Dasgupta SB and Majumder HK. 2006. LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani. Nucleic Acids Res. 34, 6286-97.

11. Das, B.B . , Sen N, Dasgupta S.B., Ganguly A, Majumder H.K. 2006. Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. Nucleic Acids Res. 34 , 1121-32.

12. Sen N., Das B.B . , Ganguly A., Banerjee B., Sen T. and Majumder H.K. 2006. Leishmania donovani: intracellular ATP level regulates apoptosis-like death in luteolin induced dyskinetoplastid cells. Exp Parasitol. 114(3):204-14.

13. Gosh S, Bandyopadhyay S, Pal S, Das, B.B . , Bhattacharya DK, Mandal C. 2005. Increased interferon gamma production by peripheral blood mononuclear cells in response to stimulation of overexpressed disease-

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specific 9-O-acetylated sialoglycoconjugates in children suffering from acute lymphoblastic leukaemia. Br J Haematol. 128, 35-41.

14. Das, B.B ., Sen N., Dasgupta S.B., Ganguly A., Majumder H.K. 2005.N-terminal region of the large subunit of Leishmania donovani bi-subunit topoisomerase I is involved in DNA relaxation and interaction with smaller subunit. J Biol Chem. 280, 16335-44.

15. Sen N., Das B.B . , Ganguly A., Mukherjee T., Bandyopadhyay S., Majumder H.K. Camptothecin-induced imbalance in intracellular cation homeostasis regulates programmed cell death in unicellular hemoflagellate Leishmania donovani. J Biol Chem . 279, 52366-75. 2004.

16. Sen N., Das B.B., Ganguly A., Mukherjee T., Tripathi G., Bandyopadhyay S., Rakshit S., Sen T., Majumder, H.K. 2004. Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ. 8, 924-36.

17. Das, B.B., Sen N., Ganguly A., Majumder H.K. 2004. Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani. FEBS Lett . 565 , 81-8.

Review article

1. Pommier, Y*, Huang S.Y., Gao, R., Das, B.B., Murai, J., Marchand, C. 2014. Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). DNA Repair; 19:114-29.

2. Das, B.B., Ganguly, A., Majumder, H.K. 2008. DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy. Adv Exp Med Biol.; 625:103-15.

3. Das, B.B., Sengupta T., Ganguly, A. and Majumder, H.K., 2006. Topoisomerases of kinetoplastid parasites: why so fascinating? Molecular Microbiology. 62, 917-27.

4. Das, B.B., Ganguly A, Majumder, H.K. 2006. Topoisomerase research of kinetoplasti parasite Leishmania, with special reference to development of therapeutics. Indian J Med Res. 123(3):221-32.

Complete list of book chapters etc.

1. Leishmania, the causative agent of Kala Azar: DNA transaction enzymes as possible drug targets. Recent Advances in Communicable and Non-communicable Diseases. Sengupta S, Das BB and Majumder HK. (ISBN 978-93-81891-31-5), Book: Asis Datta and V.P. Sharma Eds., The National Academy of Sciences, India, Publisher: Capital Publishing Company, New Delhi pp. 227-243. 2016

2. Tyrosyl-DNA phosphodiesterase 1. Dexhimer TS., Huang Shar-yin, Das, B.B. and Pommier Y. Book: DNA Topoisomerases and Cancer: Publisher: Springer, NY USA. 2011

3. DNA topoisomerases of Leishmania: the potential targets for anti-leishmanial therapy. Das BB, Ganguly A, Majumder HK. Book: Drug Targets in Kinetoplastid Parasites; Publisher: Springer, NY USA. 2008

14. Detail of patents. Indian Patent filed on dated 29.05.2018 with application No. 201811020003. Title: Bicyclic compounds as topoisomerase I inhibitors

16. Invited Presentations:

31. Invited lecture at the American Catholic University, Washington DC, USA, Department of Biological Sciences, September 10th, 2018. Title: New Challenges in personalized cancer Chemotherapy.

30. Invited Lecture at the Centre of Gene regulation in Health and Disease at Cleveland  State University (CSU), Cleveland, OH, USA  dated 28th August, 2018. Title: New regulators of DNA Topoisomerase 1-induced DNA damage and Repair.

29.Selected lecture at the DNA Topoisomerases in Biology and Medicine Gordon Research Conference July 29 - August 3, 2018, Mount Holyoke College, MA, USA, Title of the talk: “PRMT5-Mediated Arginine Methylation of TDP1 for the Repair of Topoisomerase I Covalent Complexes"

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28. Invited lecture at Indo-Israel meeting organized by INSA India. Recent Advances in Molcular genetics, Feb 12-13; 2018 Title of Talk: New regulators of DNA Topoisomerase I-induced DNA damage and repair.

27. IABS 2018 at IACS Kolkata, 1-3 rd Feb 2018; Title of Talk: New regulators of DNA Topoisomerase I-induced DNA damage and repair

26. Frontiers in Modern Biology, IISER, Kolkata dated January 19-21, 2018; Title of the lecture: New regulators of DNA Topoisomerase I-induced DNA damage and repair

25. Invited lecture at the Department of Molecular Genetics, ERASMUS MC medical school, Rotterdam,NETHERLANDS, Sept 21, 2017. Title of Talk: Role of PARP inhibitors in combination with Top1 inhibitors in cancer

24.EMBO Topoisomerase meeting at Les Diablerets, Switzerland, September 17-20, 2017: Presentation Title: Role of PARP inhibitors in combination with Top1 inhibitors in cancer

23. International meeting: Chromosome Stability 2016, between 15 – 18 December, 2016 in Trivandrum, Kerala, India.  Invited lecture :New regulators of DNA Topoisomerase I-induced DNA damage and repair".http://conference.iisertvm.ac.in/chromosome_stability/index.php/pages/speakers

22. ISA visiting professor honorary lecture, Institute of Advances Sciences, University of Bologna, Scuola Superiore di Studi Umanistici, via Marsala 26, Bologna, Italy NOV 08, 2016, FROM 05:30 PM TO 07:30 PM, Title: Targeting DNA topoisomerase in cancer: why so fascinating?" http://www.isa.unibo.it/en/lectures/lecture-by-benu-brata-das

21. University of Bologna, Department of Pharmacia and Biotechnology, Italy. Invited lecture on 28/10/2016 DALLE 14:30 ALLE 16:30, Dove Aula 1, Via Belmeloro 6. Title of The talk: DNA TOPOISOMERASE IN LIFE AND DEATH: NEW therapeutic opportunities ARE ON THE HORIZON" http://www.fabit.unibo.it/it/eventi/copy24_of_i-seminari-del-fabit-1

20: BITS-PILANI Conference on Gene and Genome Regulation (BCGGR-2016), BITS, PILANI, Rajasthan. 18th to 20th, February, 2016. Title of Talk: "DNA Topoisomerase in life and Death: New therapeutic opportunities are on the horizon".19: BITS, Goa Conference: New Frontiers in Chemistry- from Fundamentals to Applications (NFCFA 2015) during Dec 18th-19th 2015 in Goa. Title of Talk: "DNA Topoisomerase in life and Death: New therapeutic opportunities are on the horizon".

18. EMBO Meeting and workshop: DNA topoisomerases, DNA topology and human health, 13 th-17th September 2015, Les Diablerets, Switzerland. Presentation title: “Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells”

17. National Symposium: " Molecules to system" at Presidency University, Kolkata, 29 th-31st January, 2014.  Invited lecture: "Coupling PARP1 and TDP1 repair pathways: New therapeutic opportunities are on the horizon" .

16. Chromosome Instability 2014: JNCASR Bangalore, India, 14-18th December, 2014.  Invited lecture : "Coupling PARP1 and TDP1 repair pathways: New therapeutic opportunities are on the horizon".

15. Gordon Research Conference : DNA Topoisomerase in Biology and Medicine: 10-15 September, 2014 at Sunday River Resort in Newry ME United States.  Presentation title: Coupling of Poly(ADP-ribose) polymerase (PARP1) and Tyrosyl-DNA phosphodiesterase ( TDP1) for the repair of Topoisomerase I-induced DNA damage.

14. Gordon Research Conference : DNA, Damage, Mutation & Cancer: March 16-21st, 2014 at the Ventura Beach Marriott, Ventura, California. Presentation title: Coupling of Poly(ADP-ribose) polymerase (PARP1) and Tyrosyl-DNA phosphodiesterase ( TDP1) for the repair of Topoisomerase I-induced DNA damage.

13. UGC-DRS Sponsored National Seminar on “Bioprospecting of Natural Products” scheduled at the Department of Zoology, The University of Burdwan during December 05-06, 2013. Title of talk: DNA Topoisomerase in Life and Death.

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12. Gordon Research Conference: A Delicate Balance: Cellular Mutation Pathways in Genetic Stability and Disease at Newport, RI, USA Sep, 2012 Title of talk: “PARP1 is a critical cofactor for TDP1 repair function”.

11. National Cancer Institute Outstanding Postdoctoral Fellow award talk. January 2012, Selected among top five finalists for outstanding fellow at NCI/NIH. Title: “Novel role of TDP1 in the repair of Nuclear and Mitochondrial DNA: Implications in human diseases”.

10. Cold Spring Harbor meeting: Eukaryotic DNA Replication & Genome Maintenance meeting Cold Spring Harbor, NY, USA, September 2011. Title: “Coupling of Poly(ADP-ribose) polymerase (PARP1) and Tyrosyl-DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I (Top1)-mediated DNA damage.

9. Indian Institute of Science Education and Research, Mohali. Title: Novel role of DNA repair enzyme Tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria, India. November 2011.

8. Indian Institute of Technology-Bombay. Department of Biotechnology; Title: Novel role of DNA repair enzyme Tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria, India. November 2011.

7. Indian Institute of Science Education and Research, Kolkata. Title: Novel role of DNA repair enzyme Tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria, India. November 2011.

6. The Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India. Title: Novel role of DNA repair enzyme Tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria. Mohanpur, Nodia, India. November 2011.

5. 8th Young Investigator meeting Boston October, 2011 at the Stata Auditorium, MIT, Cambridge, MA, USA. Title: “A Novel Nuclear and Mitochondrial DNA repair enzyme Tyrosyl-DNA phosphodiesterase (TDP1): Insights into Topoisomerase1-induced DNA Damage and Human diseases”

4. 11th Annual Fellows and Young Investigators Colloquium at Williamsburg Marriott hotel from February 25, 2011. Title: Role of Tyrosyl-DNA phosphodiesterase (TDP1) in mitochondrial DNA repair.

3. Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Department of Carcinogenesis, Biomarker and Epidimology. Washington DC 20057. Title: ATM and/or DNA-PK facilitates repair of Topoisomerase I-associated DNA breaks by Novel phosphorylation of TDP1 at Serine 81. October 22, 2009.

2. NDDO Honorary Lecture: ATM and/or DNA-PK facilitates repair of Topoisomerase I-associated DNA breaks by Novel phosphorylation of TDP1 at Serine 81. 8th International Symposium on Targeted Anticancer Therapies 2010, March 4-6. Washington DC, USA.

1. 8th Annual Fellows and Young Investigators Colloquium at Ocean City MD from March 3-5, 2008. Title: DNA Damage induces phosphorylation at Ser81 of the DNA repair enzyme Tyrosyl-DNA phosphodiesterase (TDP1): Exploring its implication in DNA repair

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