You Demand. We Deliver.

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TABLETMANUFACTURING &TROUBLESHOOTING

Basics of

By attending this course you will enhance your knowledge of troubleshooting and maintenance proce-dures for tablet presses and tooling, and increase your understanding of TSM specifications and tooling options, reducing production downtime by minimizing compression problems.

• Tablet shapes & designs• Tablet press setup & operation

• Tooling options• Steel types

• Tool inspection • Tool reworking & polishing

Areas of learning:

SAVETHE DATE

OCTOBER23-25

2018St. Charles, MO 63304

LearningOBJECTIVESParticipants of The Tablet Manufacturing Process will finish with an understanding of fundamental concepts including:

• Basics of tablet shapes and designs

• Tablet press setup and operation:causes and effects

• General background of toolingoptions and steel types

• Formulation and granulation overview

• Tool inspection discussion

• Introduction to Natoli’s TM-II tool inspection system

• Hands-on tool reworking and polishing

This course is designed for anyone in the tablet compression industry including pharmaceutical, veterinary, nutritional, confectionery, and industrial. It will benefit tooling technicians, tablet press opera-tors, tablet press maintenance technicians, QC/QA personnel, research and development, and their supervisors. Attendees will receive invaluable hands-on experience that cannot be learned from textbooks or webinars.

Who ShouldATTEND?

DALE NATOLI PresidentNatoli Engineering Company636.926.8900 • natoli.com

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W Welcome to NATOLI!With well over a decade of training experience, our instructors have taught The Basics of Tablet Manu-facturing & Troubleshooting course both at our own location as well as on site at numerous companies throughout the world. Join our team at our technical training center for an immersive experience to learn the basics of tablet shapes and designs, press setup & operations, tooling options & steel types, tool inspections, and tool reworking & polishing.

Reference books and webinars definitely have their place in keeping current in the industry, but nothing compares to the quality training offered at Natoli Engineering Company’s state of the art facilities that promise to have you actively engaged and learn-ing. This is the type of learning we strive for when we map out each of our extensive training courses.

Also covered is how to overcome a vast array of tableting challenges as well as the best practices found industry wide.

We look forward to welcoming you to our facilities in St. Charles, Missouri and encourage you to register early as space is limited and we anticipate the course to fill up quickly.

CLICK HERE to register online!

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DAY 1 Tuesday, October 23, 2018

DAY 2 Wednesday, October 24, 2018

8:00 am 1:30 pm

2:30 pm

2:45 pm

5:15 pm

Tablet Press Setup, Operationand Maintenance (continued)• Maintenance and mechanics• Factors affecting tablet quality• Operation/troubleshooting• Standard operation procedures• Multi-tip tooling• Achieving optimum performance

Break

Powder Compaction & CompressionMr. Robert Sedlock • Common industry tableting machines• Rotary tablet press process including die filling, compression events, ejection and take off stage• Identifying material deformation characteristics and the impact to the compaction process• Tablet development case studies• Critical scale up parameters and examples• Importance of data normalization

Depart Natoli for Evening EventsComplimentary EventTBD

Arrival / Welcome

Natoli Plant TourBreak

Tablet Press Setup, Operationand MaintenanceMr. Doug Kirsch • History of compression machines• Rotary tablet press• Tablet press setup and common errors• Scale up to production issues• Primary causes for press failures• Cam wear• Proper tooling installation• Feeder setup

Lunch

8:30 am

10:30 am

10:45 am

12:30 pm

8:00 am 1:15 pm

2:45 pm

4:45 pm

Arrival / Refreshments

Group Photo

Tablet Design BasicsMr. Bill Turner • Importance of communication• Product characteristics• Drawing request form• Proper tablet terminology• Tablet shapes• Cup configuration• Tablet size• Establishing compressed density• Logos and common engraving cuts• Bisects

Break

Rotary Tablet Press ToolingMr. Dale Natoli • Tooling basics• Standards• Tool configurations• Die segments• Dwell time• Punch heads• Troubleshooting common compression problems• Picking, sticking, capping, lamination, chipping, etc.• Die wear• Fixtures for tool defect samples

Lunch

Rotary Tablet Press Tooling (continued)• Understanding the TSM specifications• Tooling options

Breakout Hands-On Sessions:Ultra-Sonic Cleaning ProcessMr. Stephen Natoli

Visual InspectionMr. Stephen Natoli

Tablet Press Setup including Tooling InstallationMr. Doug Kirsch

Lubrication and StorageMr. Stephen Natoli

Polishing StationMr. Dave Perry

Compact MeasurementMr. Robert Sedlock

TM-II / LVSMr. Robert Caruso

TabletCADMr. Bill Turner

RD-10A Lab Press DemoMr. Robert Sedlock

Closing Statements in Classroom

8:30 am

8:45 am

10:15 am

10:30 am

12:15 pm

We’re confident your learning experience will be a positive one, expanding your knowledge of tablet manufacturing while gaining

valuable technical experience and skills that will immediately start saving your company time and money. This course is also a

career accelerator, making you the go-to person on your team.

BE THE “GO−TO” PERSON

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DAY 3 Thursday, October 25, 20188:00 am Arrival / Refreshments

Tablet Compression Tooling:Steel Types and CoatingsMr. Dave Holleran • Material recommendations• Steel types• Advantages to electroslag remelting• Steel quality reports• Steel chemistry• Punch coating types• Premium die steels/materials• Tooling options

The Natoli Institute at Long Island UniversityJon Gaik• Understanding industrial pharmacy problems• Sticking and picking investigations• Tablet scale up challenges

Break

Multi-tip ToolingMr. Bill Turner • Increasing tablet production• Typical multi-tip tools• Concerns and considerations• Punch designs• Punch and die steels• Compression and ejection forces• Press setup• Modification to processes and validation

Lunch

Continued Hands-On SessionNatoli Engineering Course Instructors

Closing Statements/End of ProgramNatoli Engineering Course Instructors• Q&A• Certificates• Evaluations completed

8:30 am

10:00 am

10:15 am

9:30 am11:30 am

12:15 pm

2:30 pm

Courses and times are tentative and may need to be subject to change.

Natoli Technical Training Center seminars offer a valuable training experience extending well beyond textbooks and webinars.

These seminars consist of a well-balanced combination of presentations, group discussions, Q & A sessions,

and hands-on exercises, resulting in a much more valuable experience.

TRAINING BEYOND TEXTBOOKS

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Speakers may be subject to change.

DALE NATOLI Mr. Natoli is President of Natoli Engineering Company, Inc., with more than 40 years of

t r o u b l e s h o o t i n g experi-ence in the tablet com-

pression industry. Mr. Natoli has authored numerous technical articles for major pharmaceutical publications as well as chapters in three books, including the Tablet Specification Manual, sponsored by the American Pharmaceutical Association. He presents lectures for universities, phar-maceutical associations and tablet manu-facturers worldwide.

OUG KIRSCHDO Mr.Kirsch is the TechnicalService Manager forthe Tablet Press division at Natoli Engi-

neering Company,n Inc.th more than 50 years Wience in the tablet comof experie -35 of those years at pression industry,as trained press operaNatoli, Mr. Kirsch ha -nce technicians worldtors and maintenan -career wide. He began his c training in the U.K. neswith Manesty machin and then served as a

Representative forTechnical Service sses. He also served asManesty tablet presanager for tablet comthe Maintenance M -

neral Nutrition Corporapression at the Gen -tion.

NATHAN GAIKNJON Mr. Gaik received his B.S. in GGChemistry from theMissouri University of Science and TechnoloS -y. He has worked in gygd oral dosage formulaidsoli -d process development dtion and

in the pharmaceutical and food industries. i th ph rmace tici h h iMr. Gaik has various patent applications forhis work combating the opioid crisis viaabuse-deterrent dosage forms. His currentinterest is driving the development of contin-uous manufacturing and first principlessources of solid oral dosage formulation-re-lated issues during processing. Mr. Gaik is currently co-director of the Natoli Institute for Industrial Pharmacy Research and Develop-ment at the Arnold and Marie Schwartz School of Pharmacy at Long Island Universi-ty.

BILL TURNER Mr. Turner is the TechnicalService Manager forthe Tooling and Tablets division at Natoli Engi-

neering Company, Inc.With over 40 years in the

iindustry, all of it with Natoli, Mr.Turner’s previous positions included tabletT ’ i iti i l d d t bl tdesigner, tool designer, and hob manufac-turing. He served as Engineering Manager for 20 years and a Technical Customer Service Representative for 15 years. Heeducates and trains Natoli sales and service staff and conducts industry trainingseminars regarding tablet design, tool design, and troubleshooting of tablet designs and tooling.

KNOWLEDGE IS POWERDuring the seminar, attendees will have the opportunity to tour the Natoli complex for a closer look at the manufacturing process

of punches and dies from design to completion. Attendees are also able to get hands-on experience with punch inspection and

tool management systems, as well as tool reworking and polishing.

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DAVE HOLLERAN Mr. Holleran is the Directorof Customer Serviceat Natoli Engineering Company, Inc., over-seeing all international

accounts. He has more than 10 years of experi-

ence inence in the tablet compresthe tablet compres-sion industry, including Process EngineeringManager and Quality Assurance Manager. yMr. Holleran conducts training for tablet manufacturers worldwide focusing ontroubleshooting and technical support in tablet design, tool design, tool inspections, as well as steel types and tool coatings.

ROBERT SEDLOCK Mr. Sedlock is the Director of Technical Training and Develop-ment for Natoli Engi-

neering Company. He is a leading expert in the

tablet compression industry with over 18 years of experience and has authored numerous technical articles for Pharmaceutical Technology and American Association of Pharmaceutical Scientists.

Mr. Sedlock is responsible for global solid dosage customer support, training semi-nars, contract compression services and continuous research at the Natoli Institute of Industrial Pharmacy located at the Long Island University AMS College of Pharmacy and Health Sciences in Brooklyn, New York.

B CARUSORO Mr.Caruso graduated from Cthe University of tMissouri with a B.A. in Computer Science and Currentlycu provides ware supportsoftw for Natoling Company, Inc. He’s EEEnEngineerinngineering since 1992,been with Natoli Ennge of areas, including serving in a wide ra

Work Order Production,Customer Service, Wng and Tool Inspection.Accounting, Shippin

overseen the developSince 1998, Rob has -i Tool Management IIment of the Natolind tool control system,(TM-II) inspection aed in a number of relatand has been involve -s, including: softwareed specialty areaspment, installation anddesign and develop

customer support.

VE PERRY Mr. Perry isYan Assistant Plant Manag-er for Natoli Engineering Company, Inc., and hasbeen with the company

or more than 30 years. He ted working at Natoli atof 18 serving in a variety of

capacities: stock polishing, overseeing thecapacities stock pbuffing department, hob production,running various manufacturing equipment and department manager.

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Speakers may be subject to change.

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COURSE REGISTRATION

Space is Limited! Early Registration is Recommended!

Individual Course Fee: $1,095.00 per personGroup Course Discount: $995.00 per person (two or more people from your organization)

October 23-25, 2018 • Natoli Technical Training Center • St. Charles, Missouri 63304

General InformationCancellations/Substitutions: Substitutions will be accepted at any time prior to the course without penalty. To receive a full refund, please notify the training coordinator no laterthan seven business days prior to the course. All cancellations received inside of seven business days will be subject to a $125.00 cancellation fee. No-shows are ineligible for a refund.Course Fees Includes: Course materials, three continental breakfasts, breaks with refreshments, three lunches, reception with food and beverages and course certificate. Course Confirmation: A course confirmation will be e–mailed to participants upon receipt of their reservation. Final course details including a timed agenda and maps will be e–mailed approximately 14 days prior to the event. The course will be conducted in English.Travel Information: Information regarding discounted hotel accommodations, airport transportation, and more, will be sent via email with the course confirmation.Please Note: Natoli Engineering Company does not anticipate any changes to this course, but we reserve the right to alter the program and/or speakers without prior notice. In the unlikely event of course cancellation, Natoli’s liability is limited to refunding only the course registration fee.

Basics ofTablet Manufacturing & Troubleshooting

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Payment Methods Full payment in US currency is due no later than two weeks prior to the event. If payment has not been received, a credit card will be required to secure payment for course attendance.

Invoice Company______________________________________________________________ P.O. Number______________________________________________ Check – Please make check payable to Natoli Engineering Company Credit Card: Mastercard Visa American Express Course Fee:_________________________

Card#:________________________________________________________ Exp. Date:__________________________ Security Code:__________________________

Cardholder’s Name:__________________________________________________ Signature:____________________________________________________________

Mail RegistrationComplete form and mail to:

Natoli Engineering CompanyAttn: Training Coordinator28 Research Park CircleSt. Charles, MO 63304

Phone RegistrationDial 636.926.8900 andask for the trainingcoordinator

Email RegistrationEmail the training coordinator: training@natoli.com

4 Easy Ways to Enroll

Name:_________________________________________________________________________ Job Title:________________________________________________

Company:______________________________________________________________________________________________________________________________

Street Address:_____________________________________________________________________ City:________________________________________________

State/Province:___________________________________ Zip_________________ Country:__________________________________________________________

Phone:___________________________________ Fax_______________________________________________ Email:_____________________________________

Special needs and dietary requests:_________________________________________________________________________________________________________

How did you learn about this course?________________________________________________________________________________________________________

2 3 4Fax RegistrationComplete form andfax to: 636.926.89101

Book Your Room Early! Rooms and Rate are Limited!October 23-25, 2018 • Natoli Technical Training Center • St. Charles, Missouri 63304

Basics ofTablet Manufacturing & Troubleshooting

DRURYPLAZAHOTEL

LAMBERTAIRPORT

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36494

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RESEARCH PARKRESEARCH PARKCIRCLECIRCLERESEARCH PARKCIRCLE

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HOTEL RESERVATION

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Do you have a question orcomment that you would like tobe addressed about this event?Please email Travel and Events

Coordinator attraining@natoli.com

Questions?Comments?

DRURY PLAZA HOTEL355 Chesterfield Center,Chesterfield, MO 63017

To make reservations, guests can call the reservations department at+1.800.325.0720 and request the negotiated rate for Natoli Engineering. You may also make reservations online using: https://tinyurl.com/y9rndg6d

Please make your reservations by Thursday, September 20, 2018 to receive your group rate. Reservations made after this date will be subject to prevailing rate and availability. Please book your room early as rooms avail-able at this rate are limited.