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Annex 3, Appendix 3 Aerosol sampling and the bias produced between the true and estimated effective dose for the radionuclides of the 238 U and 232 Th natural decay chains SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 1

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Page 1: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

Annex 3, Appendix 3

Aerosol sampling and the bias produced between the true and estimated effective dose for the radionuclides

of the 238U and 232Th natural decay chains

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 1

Page 2: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

Aerosol sampling and bias in dose estimates In Witschger 2002, four different aerosol sampling situations in the context of bias of dose estimation have been described [1]. These situations are described in the scheme below as far as they pertain to NORM nuclides for which the dose coefficients are AMAD dependent (situation 3 and 4). As is explained in Witschger 2002, the true Activity Median Aerodynamic Diameter (AMAD) and Geometric Standard Deviation (GSD) of an ambient aerosol are rarely well known. Therefore, default AMAD and GSD have to be assumed in the estimates of dose after correction for sampling efficiency to true ambient aerosol concentration. This introduces a bias in the dose estimate, relative to the true dose, the size of which will depend on the true AMAD and GSD values. The bias also depends on the absorption tType of the aerosol (Fast, Moderate or Slow) and on the aerosol sampling convention of the personal air sampler (PAS) on which the dose estimate is based. CEPN has extended the example calculations of relative bias in dose estimates in Witschger 2002 to all relevant NORM nuclides, for default AMADS of 1, 5, 10 and 20 µm; GSD 2.5 and 1.5; and inhalable, thoracic and respirable sampling conventions. This has been done for situation 3 and 4. From the results, those for situation 4 have been reproduced here in figures 1to� 35, assuming that sampling efficiency will always be corrected for. The figures have been limited to GSD 2.5 as this value is recommended by ICRP [2] for AMAD values ≥ 1µm.

No

Situation 1 and 2

N

SSituation 2

Yes

To illustrate the results, the situationradionuclides and chains is summar

Pb-210, absorption Type Slow A Pb-210 particle of absorption Typinhalable convention. The true AMDefault AMAD of 5 µm and GSD 2ambient aerosol concentration is 1.2

SMOPIE ANNEX 3 Appendix 3 Bias

Is the dose coefficientAMAD dependent ?

Yes

Yes o

Is the sampling efficiency known and corrected for?

Are AMAD andGSD known?

ituation 3 not considered

further

No

with respect to seised below.

e S is sampled as aAD and GSD of th.5 are assumed. Th (main text WP4, T

between true and

Are AMAD andGSD known?

Yes

No bias in dose estimate

Situation 4 See bias figures

3-35

No

veral commonly encountered NORM

n aerosol with a PAS according to the e ambient aerosol are not known. e sampling correction factor to true able 5). Figure 33 shows that if the

estimated dose 2

Page 3: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

true AMAD of the ambient aerosol is between 1µm and 5 µm the negative bias introduced by sampling in the dose estimate is less than 20%. If the true AMAD is 20 µm the positive bias (overestimate) is about 100%. Thoracic sampling would have introduced virtually no bias (less than ±11%), independent of the true AMAD of the ambient aerosol. Respirable sampling would have required a correction factor to true ambient aerosol of 2.5 (main text WP4, Table 5) and would have underestimated the dose by 64% at a true AMAD of 20 µm and overestimated the dose by 83% at a true AMAD of 1 µm.

Pb-210, absorption Type Moderate A Pb-210 containing particle of absorption Type M is sampled as an aerosol with a PAS according to the inhalable convention. The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to true ambient aerosol concentration is 1.2 (main text WP4, Table 5). Figure 34 shows that if the true AMAD of the ambient aerosol is between 1 and 5 µm , the negative bias in the dose estimate is less than 18%. If the true AMAD is 20 µm the positive bias (overestimate) is about 100%. Thoracic sampling would have introduced virtually no bias (less than ±11%), independent of the true AMAD of the ambient aerosol. Respirable sampling would have required a correction factor to true ambient aerosol of 2.5 (main text WP4, Table 5) and would have underestimated the dose by about 60% at a true AMAD of 20 µm and overestimated the dose by about 60% at a true AMAD of 1 µm.

Pb-210, absorption Type Fast A Pb-210 containing particle of absorption Type F is sampled as an aerosol with a PAS according to the inhalable convention. The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to true ambient aerosol concentration is 1.2 (main text WP4, Table 5). Figure 35 shows that if the true AMAD of the ambient aerosol is 1µm , the positive bias in the dose estimate is about 40%. Inhalable sampling introduces virtually no bias (positive bias less than 18%), independent of the true AMAD of the ambient aerosol above 2 µm. Respirable sampling would have required a correction factor to true ambient aerosol of 2.5 (main text WP4, Table 5) and would have underestimated the dose by about 80% at a true AMAD of 20 µm and overestimated the dose by about 175% at a true AMAD of 1 µm.

U-238sec, absorption Type Slow A particle of absorption Type S containing U-238sec is sampled as an aerosol with a PAS according to the thoracic convention. The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to true ambient aerosol concentration is 1.4 (main text WP4, Table 5). Figure 3 shows that thoracic sampling introduces virtually no bias (less than ±11%), independent of the true AMAD of the ambient aerosol. Respirable sampling would have required a correction factor to true ambient aerosol of 2.5 (main text WP4, Table 5) and would have underestimated the dose by 60% at a true AMAD of 20 µm and overestimated the dose by 60% at a true AMAD of about 1 µm. Inhalable sampling would have required a sampling correction factor of 1.2 (main text of WP4, Table 5) and would have overestimated the dose by 125% at a true AMAD of 20 µm and underestimated the dose only slightly (by 18%) at a true AMAD of 1 µm.

Th-232sec, absorption Type Slow A particle of absorption Type S containing Th-232sec is sampled as an aerosol with a PAS according to the thoracic convention. The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 3

Page 4: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

factor to true ambient aerosol concentration is 1.4 (main text WP4, Table 5). Figure 12 shows that thoracic sampling introduces virtually no bias (less than ±11%), independent of the true AMAD of the ambient aerosol. Respirable sampling would have required a correction factor to true ambient aerosol of 2.5 (main text WP4, Table 5) and would have underestimated the dose by 60% at a true AMAD of 20 µm and overestimated the dose by 60% at a true AMAD of about 1 µm. Inhalable sampling would have required a sampling correction factor of 1.2 (main text of WP4, Table 5) and would have overestimated the dose by 125% at a true AMAD of 20 µm and underestimated the dose only slightly (by 18%) at a true AMAD of 1 µm.

Recommended sampling fractions and default AMAD value From these calculations it appears that: • a thoracic sampler should be chosen to minimise the bias in effective dose assessment,

whatever the true values of AMAD and GSD are, for naturally radioactive particles of slow and moderate absorption rate (type S and M);

• an inhalable sampler should be chosen to minimise the bias in effective dose assessment, whatever the true values of AMAD and GSD are, for naturally radioactive particles of fast absorption rate (Type F);

• a default AMAD value of 5µm (as recommended by ICRP [IC94], for workers) appears to reasonably minimise the bias in effective dose assessment, whatever the true values of AMAD and GSD, as illustrated in Figure 1 and summarised below for a default GSD value of 2.5.

Absorption Type Slow The choice of a thoracic sampler as well as a 5 µm AMAD default value, together with the application of the appropriate sampling efficiency correction factors will ensure that, for an airborne aerosol with a 2.5 GSD, the derived effective dose of any naturally radioactive aerosol will be no more than 24% above, and no more than 29% below, the true effective dose, whatever the true AMAD of the airborne aerosol. If an inhalable (respirable) sampler was chosen, the bias would be significantly higher and the derived effective dose could be up to 178% (resp. 83%) above and 40% (resp. 64%) below the true effective dose, whatever the true AMAD of the airborne aerosol.

Absorption Type Moderate The choice of a thoracic sampler as well as a 5 µm AMAD default value, together with the application of the appropriate sampling efficiency correction factors will ensure that, for an airborne aerosol with a 2.5 GSD, the derived effective dose of any naturally radioactive aerosol will be no more than 44% above, and no more than 13% below, the true effective dose, whatever the true AMAD of the airborne aerosol. If an inhalable (resp. respirable) sampler was chosen, the bias would be significantly higher and the derived effective dose would be up to 228% (resp. 65%) above and 27% (resp. 62%) below the true effective dose, whatever the true AMAD of the airborne aerosol.

Absorption Type Fast The choice of an inhalable sampler as well as a 5 µm AMAD default value, together with the application of the appropriate collection efficiency correction factors will ensure that, for an airborne aerosol with a 2.5 GSD, the derived effective dose of any naturally radioactive aerosol will be no more than 39% above, and no more than 1% below, the true effective dose, whatever the AMAD of the airborne aerosol. If a thoracic (resp. respirable) sampler was chosen, the bias would be significantly higher and the derived effective dose would be up to

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 4

Page 5: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

66% (resp. 173%) above and 48% (resp. 79%) below the true effective dose, whatever the AMAD of the airborne aerosol.

Small GSD aerosol For an aerosol with a GSD value of 1.5, as can be seen in Figure 2, the same sampling fractions and default AMAD value are recommended. However, one can see clearly from this figure that while the recommended sampling fraction (as a function of the aerosol�s absorption Type) and default AMAD value of 5µm still appear to reasonably minimise the bias in effective dose assessment whatever the true values of AMAD, the choice of a non-recommended sampling convention leads to much higher bias in effective dose assessment than in the case of an aerosol with a GSD value of 2.5. The choice of the �right� sampling fraction is thus all the more critical when the aerosol GSD is small.

References [1] I O. Witschger, Sampling for particulate airborne contaminants; Review and analysis of techniques. Report DPEA/SERAC/LPMA/02-18, IRSN/Département de Prevention et d�Ėtude des Accidents � SERAC, September 2002 (See Appendix 1 in Annex 3 to the SMOPIE Rport) [2] International Commission on Radiological Protection: Human respiratory tract model for radiological protection, ICRP publication 66, Annals of the ICRP Volume 24 Nos 1-3, Pergamon Press, Oxford. 1994

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 5

Page 6: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

List of Figures Figure 1: Maximum positive and negative bias (for a true AMAD between 1 and 20 µm)

between the estimated and true effective dose, for a default AMAD value of 5µm and GSD 2.5 (Situation 4)

Figure 2: Maximum positive and negative bias (for a true AMAD between 1 and 20 µm) between the estimated and true effective dose, for a default AMAD value of 5µm and GSD 1.5 (Situation 4)

Figure 3: U-238 sec Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 4 : U-238 sec Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 5 : U-238 sec Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 6 : U-238 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 7 : U-238 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 8 : U-238 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 9 : U-234 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 10 : U-234 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 11 : U-234 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 12 : Th-232 sec Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 13 : Th-232 sec Moderate ; Bias between the estimated and true effective dose (Situation4 ) Figure 14 : Th-232 sec Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 15 : Th-232 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 16 : Th-232 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 17 : Th-232 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 18 : Th-230 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 19 : Th-230 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 20 : Th-230 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 21 : Th-228 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 22 : Th-228 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 23 : Th-228 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 24 : Ra-228 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 25 : Ra-228 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 26 : Ra-228 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 27 : Ra-226 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 28 : Ra-226 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 29 : Ra-226 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 30 : Po-210 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 31 : Po-210 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 32 : Po-210 Fast ; Bias between the estimated and true effective dose (Situation 4 ) Figure 33 : Pb-210 Slow ; Bias between the estimated and true effective dose (Situation 4 ) Figure 34 : Pb-210 Moderate ; Bias between the estimated and true effective dose (Situation 4 ) Figure 35 : Pb-210 Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 6

Page 7: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

Maximum Bias in Effective dose ; Default AMAD 5 ; GSD 2.5 ; Slow

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Fast

Figure 1: Maximum positive and negative bias (for a true AMAD between 1 and 20 µm) between the estimated and true effective dose, for a default AMAD value of 5µm and GSD 2.5 (Situation

4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 7

Page 8: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

Maximum Bias in Effective dose ; Default AMAD 5 ; GSD 1.5 ; Slow

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Figure 2: Maximum positive and negative bias (for a true AMAD between 1 and 20 µm) between the estimated and true effective dose, for a default AMAD value of 5µm and GSD 1.5 (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 8

Page 9: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

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Figure 3: U-238 sec Slow ; Bias between the estimated and true effective dose (Situation 4 )

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Figure 4: U-238 sec Moderate ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 9

Page 10: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

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Figure 5: U-238 sec Fast ; Bias between the estimated and true effective dose (Situation 4 )

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Figure 6: U-238 Slow ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 10

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Figure 7: U-238 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

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Figure 8: U-238 Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 11

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Figure 9: U-234 Slow ; Bias between the estimated and true effective dose (Situation 4 )

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150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-U234 Moderate-GSD 2.5

Figure 10: U-234 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 12

Page 13: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-U234 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-U234 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-U234 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-U234 Fast-GSD 2.5

Figure 11: U-234 Fast ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Slow rate of absorption-Th232++ Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Slow-GSD 2.5

Figure 12: Th-232 sec Slow ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 13

Page 14: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

sInhalableThoracicRespirable

S4-Moderate rate of absorption-Th232++ Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Moderate-GSD 2.5

Figure 13: Th-232 sec Moderate ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Th232++ Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Th232++ Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232++ Fast-GSD 2.5

Figure 14: Th-232 sec Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 14

Page 15: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Slow rate of absorption-Th232 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Slow-GSD 2.5

Figure 15: Th-232 Slow ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Moderate rate of absorption-Th232 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Moderate-GSD 2.5

Figure 16: Th-232 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 15

Page 16: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Th232 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Th232 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th232 Fast-GSD 2.5

Figure 17: Th-232 Fast ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Slow rate of absorption-Th230 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Slow-GSD 2.5

Figure 18: Th-230 Slow ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 16

Page 17: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Moderate rate of absorption-Th230 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Moderate-GSD 2.5

Figure 19: Th-230 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Th230 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Th230 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th230 Fast-GSD 2.5

Figure 20: Th-230 Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 17

Page 18: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Slow rate of absorption-Th228 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Slow-GSD 2.5

Figure 21: Th-228 Slow ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Moderate rate of absorption-Th228 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Moderate-GSD 2.5

Figure 22: Th-228 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 18

Page 19: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Th228 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Th228 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Th228 Fast-GSD 2.5

Figure 23: Th-228 Fast ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Slow rate of absorption-Ra228 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Slow-GSD 2.5

Figure 24: Ra-228 Slow ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 19

Page 20: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Moderate rate of absorption-Ra228 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Moderate-GSD 2.5

Figure 25: Ra-228 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Ra228 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Ra228 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra228 Fast-GSD 2.5

Figure 26: Ra-228 Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 20

Page 21: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

sInhalableThoracicRespirable

S4-Slow rate of absorption-Ra226 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Slow-GSD 2.5

Figure 27: Ra-226 Slow ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Moderate rate of absorption-Ra226 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Moderate-GSD 2.5

Figure 28: Ra-226 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 21

Page 22: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

sInhalableThoracicRespirable

S4-Fast rate of absorption-Ra226 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Ra226 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Ra226 Fast-GSD 2.5

Figure 29: Ra-226 Fast ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Slow rate of absorption-Po210 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Slow-GSD 2.5

Figure 30: Po-210 Slow ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 22

Page 23: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

sInhalableThoracicRespirable

S4-Moderate rate of absorption-Po210 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Moderate-GSD 2.5

Figure 31 Po-210 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

:

AMADD = 1 µm-150%

-100%

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0%

50%

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0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Po210 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Po210 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Po210 Fast-GSD 2.5

Figure 32: Po-210 Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 23

Page 24: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

sInhalableThoracicRespirable

S4-Slow rate of absorption-Pb210 Slow-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

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150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Slow-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Slow-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Slow-GSD 2.5

Figure 33: Pb-210 Slow ; Bias between the estimated and true effective dose (Situation 4 )

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Moderate rate of absorption-Pb210 Moderate-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Moderate-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Moderate-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Moderate-GSD 2.5

Figure 34: Pb-210 Moderate ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 24

Page 25: Annex 3, Appendix 3 · 2017-06-23 · The true AMAD and GSD of the ambient aerosol are not known. Default AMAD of 5 µm and GSD 2.5 are assumed. The sampling correction factor to

AMADD = 1 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (mm)

Bia

s

InhalableThoracicRespirable

S4-Fast rate of absorption-Pb210 Fast-GSD 2.5

AMADD = 5 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

InhalableThoracicRespirable

S4-Pb210 Fast-GSD 2.5

AMADD = 10 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Fast-GSD 2.5

AMADD = 20 µm-150%

-100%

-50%

0%

50%

100%

150%

0 5 10 15 20

AMAD (µm)

Bia

s

InhalableThoracicRespirable

S4-Pb210 Fast-GSD 2.5

Figure 35: Pb-210 Fast ; Bias between the estimated and true effective dose (Situation 4 )

SMOPIE ANNEX 3 Appendix 3 Bias between true and estimated dose 25