some stuff about cortical network modelling what i done

Some stuff about cortical network modelling what I done

Richard Tomsett1,2, Miles Whittington3,Mark Cunningham4, Marcus Kaiser2,4

1.Institute of Ageing and Health, Newcastle University2. School of Computing Science, Newcastle University

3. Hull York Medical School, University of York4. Institute of Neuroscience, Newcastle University

OSB Hackathon, UCL, 6th November 2013

OSB Hackathon, UCL, 6th November 2013

Matthew Ainsworth

OSB Hackathon, UCL, 6th November 2013

Matthew Ainsworth

OSB Hackathon, UCL, 6th November 2013

OSB Hackathon, UCL, 6th November 2013

NB: wrong dimensions in Bush & Sejnowski 1993

OSB Hackathon, UCL, 6th November 2013

Thanks to:

-Anna Simon-Mark Cunningham-Marcus Kaiser

-BBSRC, Wellcome Trust

OSB Hackathon, UCL, 6th November 2013

OSB Hackathon, UCL, 6th November 2013

OSB Hackathon, UCL, 6th November 2013

LFP simulation

100um – 1000um

OSB Hackathon, UCL, 6th November 2013

LFP simulation

OSB Hackathon, UCL, 6th November 2013

LFP simulation

100um – 1000um

OSB Hackathon, UCL, 6th November 2013

LFP simulation

Edge Half-way to gamma generating region

OSB Hackathon, UCL, 6th November 2013

LFP simulation

100um – 1000um

OSB Hackathon, UCL, 6th November 2013

LFP simulation

Top Middle Bottom

OSB Hackathon, UCL, 6th November 2013

Kawaguchi & Kondo, 2002

Basket cell

Bitufted cell

Axo-axonic cell

Pyramidal cell

GABAA

GABAA

GABAA

GABAA

GABAA

+GABAB

Neurogliaform cell

“Regular spiking non pyramidal cell”

Slide courtesy of Anna Simon

Basket cell

Other interneurons

Pyramidal cell

GABAA

OSB Hackathon, UCL, 6th November 2013

90% basket cell reduction in central 2mm section, replaced by non-basket interneurons (regular spiking)

OSB Hackathon, UCL, 6th November 2013

Thanks to:

- Matt Ainsworth (York)- Anna Simon (Newcastle)- Mark Cunningham (Newcastle)- Miles Whittington (York)- Marcus Kaiser (Newcastle)

-BBSRC, EPSRC, Wellcome Trust