respi ration medical-2015
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PHYSIOLOGY OF THE RESPIRATORY SYSTEM
Tek intra-alv (tek.intrapulmonalis)
Perubahan volume paru, tekanan alveoli, tekanan pleura dan tekanan transpulmonaris selama pernapasan biasa/tenang
Faktor yang mempengaruhi ventilasi paru
RESPIRATORY MEMBRANE
1. A layer of surfactant2. The alveolar
epithelium3. An epithelial
basement membrane4. Interstitial space5. A capillary basement
membrane 6. The capillary
endothelial membrane
Fig. The respiratory membrane
Oxygen transport in the blood
• 97% of the O2 carried in chemical combination with hemoglobin in red blood cell
• 3% dissolved state in the water of the plasma.
Oxy-Hb reaction – O2 molecule combine loosely
and reversibly with the heme portion of the Hb
– Depend on O2 pressure in the tissue
CO2 Transport in the blood
CO2 Transport
Other factors ………. (cont.)
1. Pain & emotion: hypothalamus2. Voluntary control: partial, (cerebral cortex —
corticospinal tract to respiratory motoric neuron)
3. Pulmonary irritants (irritant receptors in the airways)
4. Lung hyperinflation (Hering Breuer’s reflex)– Stimulated by stretch receptors (in the pleura, smooth
muscles layer in bronchus & bronchioles) to n. vagus
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