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OviGen – the outputs

Aine.OBrien@teagasc.ie

Áine O’ Brien1, Nóirín McHugh1, Eamon Wall2, Kevin McDermott2, Donagh Berry1

1Teagasc, Moorepark; 2Sheep Ireland, Bandon

OviGen objective

+

Parentage

Genomic predictions

Dagginess

Health traits

Lameness• No = not lame• Yes = any sign of lameness

Mastitis• No = no evidence of mastitis• Yes = evidence of (historic)

mastitis

Sire prevalence - dagginess

0

5

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40

0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75

Nu

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Sire

s

Prevalence (%)

0

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10

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0 5 10 15 20 25 30 35 40 45

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Prevalence (%)

Sire prevalence - lameness

Ewes only

Trait Economic value Relative emphasis (%)

Terminal Replacement

Dagginess -€0.34 (score) 1.15 0.17

Lameness – lamb -€0.08 (%) 0.11 0.02

Lameness - ewe -€0.24 (%) 0.04

Health index

€1.2010% 5%100 ewes

Elsewhere…

Worm FECFacial Eczema

Dagginess

Worm FECWorm FEC

LamenessDagginess

Reducing the cost of genotyping

15,000 – 50,000 DNA variants

50,000 DNA variants = €62.5015,000 DNA variants = €26.50

Currently €24.50 for 50,000 DNA variants

Other genotyping technologies?

Aim: reduce the density of the panel without compromising genotype quality

Conclusion: at least 6,000 DNA variants

required

Imputation

Breed composition

Am I really a Texel?

50% CL : 25% CV : 25% SU

50% CL : 50% SU : 0% SU

50% CL : 0% CV : 50% SU

100% Suffolk

?

100% Cheviot

50% Cheviot 50% Suffolk 100% Charollais

DNA breed compositionAm I really a

Texel?

50% Cheviot 50% Suffolk 100% Charollais

50% Charollais13% Cheviot37% Suffolk

Yes, 97% Texel

• Non consistent across all traits

• Main issue – size of reference population

Genomic predictions

Lots of data –genotypes and

phenotypesYounger animals

OviGen achievements

Health index

Questions?