hjernen gjennom livet · nba fjell et al., 2013, critical ages in the life course of the adult ......

Anders M Fjell Research Group for Lifespan Changes in Brain and Cognition

Department of Psychology Universitetet of Oslo www.oslobrains.no

Hjernen gjennom livet

5. mai, 2014

Fokus: Livsløpsendringer og hjerne og kognisjon

Utvalg: Friske, nyfødt til eldre, ca 1000 over tid Risikofaktorer, sykdom og skader

Metoder: Nevropsykologiske og kognitive tester Hjerneavbildningsmetoder, spesielt Magnetisk Resonans Imaging EEG/ ERP, PET, CSF biomarkører, genetikk, hjerneskadestudier

Behov for TSD

MRI rådata: 1.0 gb

Morfometri

0.5 gb DTI

TBSS

1.0 gb

Tracula

1.0 gb

fMRI

1.3 gb

MRI 1 deltager: ~5.0 gb

Behov for TSD

PET, fMRI,++

rådata: 2.0 gb

MRI rådata: 1.0 gb

Morfometri

0.5 gb DTI

TBSS

1.0 gb

Tracula

1.0 gb

fMRI

1.3 gb

EEG/ ERP rådata: 1.0 gb

MRI 1 deltager: ~5.0 gb, Totalt 8-10 gb per deltager, n=1000 ~10 tb

Behov for TSD

PET, fMRI,++

rådata: 2.0 gb

MRI rådata: 1.0 gb

Morfometri

0.5 gb DTI

TBSS

1.0 gb

Tracula

1.0 gb

fMRI

1.3 gb

EEG/ ERP rådata: 1.0 gb

MRI 1 deltager: ~5.0 gb, Totalt 8-10 gb per deltager, n=1000 10 tb

Regneressurser

60 timer pr deltager

2500 dager for n = 1000

(6.85 år, ikke medregnet

skuddår)

Magnetic Resonance Imaging

i livsløpsstudier

Fjell and Walhovd, 2010, Reviews in the neurosciences. Figure by Inge Amlien.

Fjell and Walhovd, 2010, Reviews in the neurosciences. Figure by Inge Amlien.

Courtesy of Bruce Fischl

Fjell and Walhovd, 2010, Reviews in the neurosciences. Figure by Inge Amlien.

Diffusjons tensor

imaging

Sensitivt til tidlig Alzheimers demens

Amlien et al. Mild cognitive impairment: cerebrospinal fluid tau biomarker pathologic

levels and longitudinal changes in white matter integrity. Radiology, 2013.

Amlien, Fjell. Diffusion tensor imaging of white matter degeneration in Alzheimer’s

Disease and mild cognitive impairment. Neuroscience, in press.

Inge Amlien,

stipendiat

Håkon Grydeland

Livsløpsfokus

Nyberg et al.

Årlig volumdreduksjon i hjernebarken

Fjell,…,Walhovd, 2013, Brain changes in older adults at very low

risk for Alzheimer’s disease. J Neurosci

Årlig volumdreduksjon i hjernebarken

Fjell,…,Walhovd, 2013, Brain changes in older adults at very low

risk for Alzheimer’s disease. J Neurosci

Fjell,…, Walhovd, 2014, Acellerated cortical

thinning: unique to dementia or universal in aging? Cerebral Cortex

Årlig volumreduksjon

Fjell,…, Walhovd, 2014, Acellerated cortical

thinning: unique to dementia or universal in aging? Cerebral Cortex

Walhovd et al., 2011, Consistent neuroanatomical

age-related volume differences across multiple samples. NBA

Fjell et al., 2013, Critical ages in the life course of the adult

brain: nonlinear subcortical changes. NBA

Husket vs. glemt

LCBC

Hjerneaktivitet under innlæring

Sneve et al., in preparation Sneve Amlien Langnes

The Roots of Alzheimers Disease:

Komparativ neuroimaging

Multiple primate species

Marmoset Capuchin Macaque

Super-human Animation by Inge Amlien

Fjell & Walhovd, 2014, What is normal in normal aging? Effects of aging, amyloid

and Alzheimer’s disease on the cerebral cortex and the hippocampus. Progr neurobiol.

Alzheimers sykdom er unikt for mennesker

Fjell,…,Walhovd, in press, The roots of Alzheimer’s disease: Are

high-expanding cortical areas preferentially targeted? Cerebral Cortex

Fjell,…,Walhovd, in press, The roots of Alzheimer’s disease: Are

high-expanding cortical areas preferentially targeted? Cerebral Cortex

Hva kan vi gjøre med det?

?

?

?

?

?

?

?

Hva gjør oss forskjellige

gjennom livet?

Cognition Brain

Genes Socio-

economic

status

Disease/

injury Nutrition

Mental and

physical

activity

Påvirkning på endring

Engvig, …, Walhovd, NeuroImage, 2010, 2012; Human Brain Mapping 2011

Ann-Marie de Lange Glasø &

Anne Cecilie Sjøli Braathen

Prediction of plastic response in

subjective memory impairment (sMCI)

Engvig, …, Walhovd, NeuroImage, 2010, 2012; Human Brain Mapping 2011

Prediction of plastic response in

subjective memory impairment (sMCI)

Engvig, …, Walhovd, in press, Effects of cognitive training in gray matter volumes in memory

clinic patients with subjective memory impairment, J Alzheimers Disease

Walhovd et al., in press, Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity related to longitudinal cortical thinning in normal aging. Neurobiology af Aging

Modifiers of change in aging

Vil du lære mer om hukommelse og ta et bilde av hjernen? E-mail:

hukommelse@psykologi.uio.no

Thanks!

University of Oslo, LCBC

• Anders M Fjell

• Christian K. Tamnes

• Andreas Engvig

• Astrid Bjørnebekk

• Markus Handal Sneve

• Inge Amlien

• Håkon Grydeland

• Andreas Storsve

• Stine K Krogsrud

• Espen Langnes

• Claudia Nyberg

• Ann-Marie de Lange Glasø

• Joy-Loi Chepkoech

• Lia Mork

• Anne Cecilie Sjøli Bråthen

• Hilde Wiede Aaasland

• Knut Eiliv Ødegaard Øverbye

• Stine Bjørlow Dalsøren

University of Oslo

• Christian Drevon et al., nutrition, med. fak

• Ivar Reinvang

• Lars Westlye

• Thomas Espeseth

Oslo University Hospital

• Atle Bjørnerud, MR physics

• Paulina Due-Tønnessen, radiology

• Ellen Ruud, child medicine

• Øyvind Sundseth, dept neuropsychology

• Torgeir Bruun Wyller, memory clinic

UCSD

• Anders M Dale et al

Harvard, MGH

• Bruce Fischl, Doug Greve et al.

Wayne State University

• Naftali Raz

Umeå

Lars Nyberg

Oxford University

Steve Smith et al

Heidi Johansen-Berg et al

UCSF

William Jagust, AD research

Mark D’Esposito, fMRI memory research