hjernen gjennom livet · nba fjell et al., 2013, critical ages in the life course of the adult ......
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Anders M Fjell Research Group for Lifespan Changes in Brain and Cognition
Department of Psychology Universitetet of Oslo www.oslobrains.no
Hjernen gjennom livet
5. mai, 2014
Fokus: Livsløpsendringer og hjerne og kognisjon
Utvalg: Friske, nyfødt til eldre, ca 1000 over tid Risikofaktorer, sykdom og skader
Metoder: Nevropsykologiske og kognitive tester Hjerneavbildningsmetoder, spesielt Magnetisk Resonans Imaging EEG/ ERP, PET, CSF biomarkører, genetikk, hjerneskadestudier
Behov for TSD
MRI rådata: 1.0 gb
Morfometri
0.5 gb DTI
TBSS
1.0 gb
Tracula
1.0 gb
fMRI
1.3 gb
MRI 1 deltager: ~5.0 gb
Behov for TSD
PET, fMRI,++
rådata: 2.0 gb
MRI rådata: 1.0 gb
Morfometri
0.5 gb DTI
TBSS
1.0 gb
Tracula
1.0 gb
fMRI
1.3 gb
EEG/ ERP rådata: 1.0 gb
MRI 1 deltager: ~5.0 gb, Totalt 8-10 gb per deltager, n=1000 ~10 tb
Behov for TSD
PET, fMRI,++
rådata: 2.0 gb
MRI rådata: 1.0 gb
Morfometri
0.5 gb DTI
TBSS
1.0 gb
Tracula
1.0 gb
fMRI
1.3 gb
EEG/ ERP rådata: 1.0 gb
MRI 1 deltager: ~5.0 gb, Totalt 8-10 gb per deltager, n=1000 10 tb
Regneressurser
60 timer pr deltager
2500 dager for n = 1000
(6.85 år, ikke medregnet
skuddår)
Magnetic Resonance Imaging
i livsløpsstudier
Fjell and Walhovd, 2010, Reviews in the neurosciences. Figure by Inge Amlien.
Fjell and Walhovd, 2010, Reviews in the neurosciences. Figure by Inge Amlien.
Courtesy of Bruce Fischl
Fjell and Walhovd, 2010, Reviews in the neurosciences. Figure by Inge Amlien.
Diffusjons tensor
imaging
Sensitivt til tidlig Alzheimers demens
Amlien et al. Mild cognitive impairment: cerebrospinal fluid tau biomarker pathologic
levels and longitudinal changes in white matter integrity. Radiology, 2013.
Amlien, Fjell. Diffusion tensor imaging of white matter degeneration in Alzheimer’s
Disease and mild cognitive impairment. Neuroscience, in press.
Inge Amlien,
stipendiat
Håkon Grydeland
Livsløpsfokus
Nyberg et al.
Årlig volumdreduksjon i hjernebarken
Fjell,…,Walhovd, 2013, Brain changes in older adults at very low
risk for Alzheimer’s disease. J Neurosci
Årlig volumdreduksjon i hjernebarken
Fjell,…,Walhovd, 2013, Brain changes in older adults at very low
risk for Alzheimer’s disease. J Neurosci
Fjell,…, Walhovd, 2014, Acellerated cortical
thinning: unique to dementia or universal in aging? Cerebral Cortex
Årlig volumreduksjon
Fjell,…, Walhovd, 2014, Acellerated cortical
thinning: unique to dementia or universal in aging? Cerebral Cortex
Walhovd et al., 2011, Consistent neuroanatomical
age-related volume differences across multiple samples. NBA
Fjell et al., 2013, Critical ages in the life course of the adult
brain: nonlinear subcortical changes. NBA
Husket vs. glemt
LCBC
Hjerneaktivitet under innlæring
Sneve et al., in preparation Sneve Amlien Langnes
The Roots of Alzheimers Disease:
Komparativ neuroimaging
Multiple primate species
Marmoset Capuchin Macaque
Super-human Animation by Inge Amlien
Fjell & Walhovd, 2014, What is normal in normal aging? Effects of aging, amyloid
and Alzheimer’s disease on the cerebral cortex and the hippocampus. Progr neurobiol.
Alzheimers sykdom er unikt for mennesker
Fjell,…,Walhovd, in press, The roots of Alzheimer’s disease: Are
high-expanding cortical areas preferentially targeted? Cerebral Cortex
Fjell,…,Walhovd, in press, The roots of Alzheimer’s disease: Are
high-expanding cortical areas preferentially targeted? Cerebral Cortex
Hva kan vi gjøre med det?
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?
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Hva gjør oss forskjellige
gjennom livet?
Cognition Brain
Genes Socio-
economic
status
Disease/
injury Nutrition
Mental and
physical
activity
Påvirkning på endring
Engvig, …, Walhovd, NeuroImage, 2010, 2012; Human Brain Mapping 2011
Ann-Marie de Lange Glasø &
Anne Cecilie Sjøli Braathen
Prediction of plastic response in
subjective memory impairment (sMCI)
Engvig, …, Walhovd, NeuroImage, 2010, 2012; Human Brain Mapping 2011
Prediction of plastic response in
subjective memory impairment (sMCI)
Engvig, …, Walhovd, in press, Effects of cognitive training in gray matter volumes in memory
clinic patients with subjective memory impairment, J Alzheimers Disease
Walhovd et al., in press, Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity related to longitudinal cortical thinning in normal aging. Neurobiology af Aging
Modifiers of change in aging
Thanks!
University of Oslo, LCBC
• Anders M Fjell
• Christian K. Tamnes
• Andreas Engvig
• Astrid Bjørnebekk
• Markus Handal Sneve
• Inge Amlien
• Håkon Grydeland
• Andreas Storsve
• Stine K Krogsrud
• Espen Langnes
• Claudia Nyberg
• Ann-Marie de Lange Glasø
• Joy-Loi Chepkoech
• Lia Mork
• Anne Cecilie Sjøli Bråthen
• Hilde Wiede Aaasland
• Knut Eiliv Ødegaard Øverbye
• Stine Bjørlow Dalsøren
University of Oslo
• Christian Drevon et al., nutrition, med. fak
• Ivar Reinvang
• Lars Westlye
• Thomas Espeseth
Oslo University Hospital
• Atle Bjørnerud, MR physics
• Paulina Due-Tønnessen, radiology
• Ellen Ruud, child medicine
• Øyvind Sundseth, dept neuropsychology
• Torgeir Bruun Wyller, memory clinic
UCSD
• Anders M Dale et al
Harvard, MGH
• Bruce Fischl, Doug Greve et al.
Wayne State University
• Naftali Raz
Umeå
Lars Nyberg
Oxford University
Steve Smith et al
Heidi Johansen-Berg et al
UCSF
William Jagust, AD research
Mark D’Esposito, fMRI memory research