access and benefit sharing (abs) in bio prospecting
DESCRIPTION
Satoshi Nimura, President - Nimura Genetic Solutions Co., Ltd. - JapanTRANSCRIPT
Access and Benefit Sharing (ABS) in BioProspecting
27 May, 2010
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CBD Convention on Biological Diversity
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193 countries in CBD (2010)
• Conservation• Sustainable Use• Benefit Sharing (incl. capacity building)
• Resource country’s right
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Bioprospecting
Bioprospecting is an effort to find academic or commercial values from biological diversity
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Biopiracy
Bio prospecting activities without Prior Informed Consent (PIC)
– From authority or community, if necessary– Should include benefit sharing scheme
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Are you from local institute?
Are you from public sector ?
You have proper permission?
Are you from public sector ?
You have proper permission?
You have proper permission?
You have proper permission?
Yes
Yes
Authorised bioprospector
Bio Pirates
No, we are foreigner
No we are from private Yes
NO !YES !
No we are from private
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Keys for good ABS practice
Nimura Principles
1. Keep Biological Resources in Resource Countries2. Practical Technology Transfer3. Sharing Intellectual Properties (IP) with Resource Countries
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Value of Resources: Expectation Gap between owners and users
Med
icin
al V
alu
e of
B
iolo
gica
l Res
ourc
es Expectation of Resource Countries
Expectation of Resource Countries
Reality in User
Countries
Reality in User
Countries
soil samples
isolated
micr
obes
extracts
leads
patent
medici
nes
pre-cli
nical
clinica
l
purified
hit
compoundhit e
xtracts
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Access to resources should be this?
Ideal to user country
Ideal to resource country
Low high
1. From collection to Drug development
in resource country
1. From collection to Drug development
in resource country
2. User establish itslaboratory in
resource country
2. User establish itslaboratory in
resource country
3. Research as much as possible in
resource country
3. Research as much as possible in
resource country
4. Free supply ofBiological material
4. Free supply ofBiological material
Possibility to be accepted by user country
Governmental partners in Malaysia
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Universiti Malaysia SabahUniversiti Malaysia Sabah
Governmental partners in Bhutan
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Royal government of BhutanMinistry of Agriculture and forestryNational Biodiversity Centre
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Resource country NGSNGS client
ABS scheme
• IPR (co-own among 3 parties)• Client has no direct negotiation• Technology transfer is carried out through NGS• Biological Resources will not go out of Resource country, unless any process is impossible to carry out in Resource country.
AgreementRoyalty + Mileston
To NGS
Agreement
Research Result example 1
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CH3
O
O
O
H3C H3C HO
O
OO CH3
CH3
OR1
H3C
R3HOOH
H3CO
CH3CH3OH
O
O O
CH3
OHOH
CH3H3C
R2O
Malaysian application2006/05
PCT application2007/05Japan, US, EU
Novel anti-biotics (Bispolides)
Microbispora sp
Research Result example 2New invention on non-pharmaceuticals
Application of New Firefly Luciferase to Patent Registration officein Malaysia on 25th of Feburary, 2010
Applicant:Olympus CorporationNimura Genetic Solutions Co., Ltd.Perak State Development Corporation
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NGS model
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ResourceCountry X,Y,Z…
ResourceCountry X,Y,Z…BhutanBhutan
MalaysiaMalaysia
NGS(J)SBCSBC
FRIMFRIM
UMSUMS
NGS(M)
ClientsClientsNGS Group
ClientsClients
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Approved and similar
Under negotiation
Future target
Future expanding plan
Conclusion
Bioprospecting is one of most important method of Sustainable Use of Biodiversity
Proper ABS scheme is required Resource Countries’ demands should be
entertained Resource Countries’ support is also
important
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Thank you for your attention
Bioprospecting activity: Bioprospecting activity: Misconstrued for BiopiracyMisconstrued for Biopiracy
Bioprospecting activity: Bioprospecting activity: Misconstrued for BiopiracyMisconstrued for Biopiracy
Chairman NIMURA Satoshi
< National Conference on Agrobiodiversity >
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Contents
1. What is Bioprospecting?• pre CBD and post CBD• Operation example
2 . What is Biopiracy?• Definition
3. How do we do in CBD era?• Expectation gap between resource countries
and user countries• Operation examples
4. Conclusion: For reasonable ABS.
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What is Bioprospecting ?
It was called “Plant Hunting”
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History of Bioprospecting ( PreCBD)
Bioprospecting was a respected adventure as well as a part of expanding policy
European big countries competed for bioresources.
Their quest for spices. Captain Cook
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History of Bioprospecting ( PreCBD)
Big names in plant-hunting
Sir Joseph BanksMost famous British plant hunter in 18 C.
As a Director General of Royal Kew Garden, organized plant hunters to overseas. with Navy assist.
Rosa banksiae was named after his wife.
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History of Bioprospecting ( PreCBD)
Big names in plant-hunting
Philipp Franz von Siebold
Charles R. DarwinDutch biologist stayed in Japan. Introduced Many Japanese indigenousPlant to Europe.
His theory comeThrough his experienceAs onboard biologist.
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Big names in plant-hunting Alfred ・ R. Wallace and Wallace line
History of Bioprospecting ( PreCBD )
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History of Bioprospecting ( PreCBD)
Famous incident Mutiny on the Bounty
The Bounty had a mission to deliver seedlings
Of Bread fruit from Tahiti to East Indies.
No.2 kicked out Captain from the Bounty.
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History of Bioprospecting ( PreCBD)
FAO’s statement ( 1983 ) 「 International Undertaking on Plant Genetic
Resources 」
“Biological Resources belong to all mankind.” “ common treasure”
Still dominant idea for many scientists.
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History of Bioprospecting ( PreCBD )
As a Strategic Resources
Merck & Costa Rica
Access right to bio resources
in Costa Rica(1991)
First Exclusive Access
agreement of its kind
This agreement indicates biological access could be
Strategic resources to fight for, as petroleum.
Costa Rica INBio
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Heat-up discussionsSouthern counters against Northern globalization.Resource countries consider it as great advantage
for protecting their right.
Domestic regulationsPhilippines' president order 247India’s biodiversity lawetc.
CBD arrived
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Definition of Bioprospecting
Bioprospecting is an effort to find academic or commercial values from biological diversity
Common image of prospecting
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Bioprospecting (NGS’s case)
Collection trip
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Bioprospecting (NGS’s case)
Soil collection isolation
collectionCharacterization Genetic analysisfermentation
Extraction Assays
HIT
Structure elucidation
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NGS company profile
Company Neural Genetic Solutions Co., Ltd.Established 26 June, 2000Address 2nd Floor, 1-19-10, Osaki, Shinagawa-ku, Tokyo, 141-0032Management Chairman Satoshi Nimura
President Keiichi KiyotaCapital 410,000,000 yen (about US$3.8 mil)Staff 15 ( 7 PhD. 3 Master, as of Nov. 2006 )Company Nimura Genetic Solutions (M) Sdn. Bhd
Established Dec 2000 ( Oct 2002 Lab start operation )Capital RM 2,030,000 (about US$550,000)Staff 28 ( 1 PhD. 7 Master, 10 Bachelor as of Nov. 2006 )Address Third floor, Chemistry Building,
Forest Research Institute Malaysia (FRIM)
Kepong 52109, Kuala Lumpur, Malaysia
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Biopiracy: definition
Bio prospecting activities without Prior Informed Consent (PIC)
– From authority or community, if necessary– Should include benefit sharing scheme
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Difference between Bioprospecting and Biopiracy
BioprospectingBioprospectingLegal
Bioprospecting
Legal Bioprospecting
Illegal Bioprospecting
Illegal Bioprospecting
Foreigner’s Bioprospecting
Domestic Bioprospecting
academic
academic
CommercialCommercial
Commercial Commercial
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How do we do in CBD era?
Foreign company has to cope with these.
1. Discussion for agreement
2. Operation of collaboration
3. Avoid Speculations
4. Handling of
Intellectual property
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Value of Resources: Expectation Gap between owners and users
Med
icin
al V
alu
e of
B
iolo
gica
l Res
ourc
es Expectation of Resource Countries
Expectation of Resource Countries
Reality in User
Countries
Reality in User
Countries
isolates
identifi
ed st
rains
active i
solateslea
ds
patent
medici
nes
pre-cli
nical
clinica
l
hit extra
cts
purified
hits
extracts
39
Access to resources should be this?
Ideal to user country
Ideal to resource country
Low high
1. From collection to Drug development
in resource country
1. From collection to Drug development
in resource country
2. User establish itslaboratory in
resource country
2. User establish itslaboratory in
resource country
3. Research as much as possible in
resource country
3. Research as much as possible in
resource country
4. Free supply ofBiological material
4. Free supply ofBiological material
Possibility to be accepted by user country
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Business Scheme 1
Extract supply scheme• Controllable• Not beneficial
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Business Scheme 2
Screening contract scheme• improvement• client satisfaction is a problem
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Business Scheme 3
Client visit scheme• more commitment from client• better improvement
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Real Biopiracy or not?
Speculation can kill the company. Rootless rumor is an offence.
Big established companies have proper internal regulation for not committing Biopiracy.
Through our practical observation, academic fields commit more Biopiracy, unconsciously.
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Conclusion
Bioprospecting is not Biopiracy at all, If proper process is taken.
Biopiracy is not always carried out by foreigners and commercial people, by domestic and academic people as well.
Prevent rootless negative speculation or misuse of the word “Biopiracy” is essential for foreign investment into Malaysia.