3d printing for microfluidics manufacturing · 3d printing as a manufacturing technology december...
TRANSCRIPT
![Page 1: 3D Printing for MicroFluidics Manufacturing · 3D Printing as a Manufacturing Technology December 08, 2015 Jan Eite Bullema MicroFluidics Manufacturing 18 After: P. Neil, Advances](https://reader035.vdocuments.us/reader035/viewer/2022070719/5edebb63ad6a402d666a1388/html5/thumbnails/1.jpg)
3D Printing for MicroFluidics Manufacturing
Innovative Manufacturing of Microfluidics
Jan Eite Bullema, Wijnand Germs, Marc van Kleef, Jelle Rohlfs
![Page 2: 3D Printing for MicroFluidics Manufacturing · 3D Printing as a Manufacturing Technology December 08, 2015 Jan Eite Bullema MicroFluidics Manufacturing 18 After: P. Neil, Advances](https://reader035.vdocuments.us/reader035/viewer/2022070719/5edebb63ad6a402d666a1388/html5/thumbnails/2.jpg)
OUTLINE
• Introduction 3D Printing of Micro Fluidics
• 3D Printing for Microfuidics
• 3D Printing as a Manufacturing Technology
• MFManufacturing Project
• Conclusion
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
2
3D Printing for MicroFluidics Manufacturing
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Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
3
Source Scopus, December 1, 2015
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Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
4
F.P.W. Mechels, Additive Manufacturing of Tissue and Organs, Progress in Polymer Science 37 (2012) 1079-1104
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Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
5
Principle of VAT polymerisation
Glass
(blue) light curable resin
Release layer
Cured
Resin Layers
Product carrier Electronic semi-product
DLP Projector
![Page 6: 3D Printing for MicroFluidics Manufacturing · 3D Printing as a Manufacturing Technology December 08, 2015 Jan Eite Bullema MicroFluidics Manufacturing 18 After: P. Neil, Advances](https://reader035.vdocuments.us/reader035/viewer/2022070719/5edebb63ad6a402d666a1388/html5/thumbnails/6.jpg)
Introduction 3D Printing of Micro Fluidics
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
6
Principle of VAT polymerisation
Glass
(blue) light curable resin
Release layer
Cured
Resin Layers
Product carrier Electronic semi-product
DLP Projector
![Page 7: 3D Printing for MicroFluidics Manufacturing · 3D Printing as a Manufacturing Technology December 08, 2015 Jan Eite Bullema MicroFluidics Manufacturing 18 After: P. Neil, Advances](https://reader035.vdocuments.us/reader035/viewer/2022070719/5edebb63ad6a402d666a1388/html5/thumbnails/7.jpg)
3D Printing for Microfuidics: Printed Stenosis
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
7
Stenosis for Thrombosis on a Chip, BIOC material, Printed By TNO, 2015
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3D Printing for Microfuidics: Printed micro Villi
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
8
3D Printed microVilli for Gut on a Chip in R11 Material, Printed By TNO, 2015
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3D Printing for Microfuidics: Printed micro Villi
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
9
3D Printed microVilli for Gut on a Chip with Coca2 cells , BIOC material, Printed By TNO, 2015
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3D Printing for Microfuidics: Vascular System
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
10
Vascular System for Alzheimer on a Chip, BIOC material, Printed By TNO, 2015
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3D Printing for Microfuidics: Organ on a Chip
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
11
Cancer on a Chip Well Plate, First Prototype, BIOC material, Printed By TNO, 2015
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3D Printing for Microfuidics: Organ on a Chip
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
12
Cancer on a Chip Well Plate, Current Device, BIOC material, Printed By TNO, 2015
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3D Printing for Microfuidics: Serpentine Mixer
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
13
Serpentine Mixer, Printed By TNO, 2015
1
1 ~ 270 micron
2 ~ 450 micron
3 ~ 360 micron
4 ~ 470 micron
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3D Printing for Microfuidics: Serpentine Mixer
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
14
Serpentine Mixer, BIOC material, Printed By TNO, 2015
1
1 ~ 570 micron
2 ~ 450 micron
3 ~ 450 micron
4 ~ 515 micron
4 ~ 415 micron
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3D Printing for Microfuidics: Serpentine Mixer
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
15
Serpentine Mixer, CFD modelling, 2015
1
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3D Printing for Microfuidics: Multiple Functions
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
16
Integrated Serpentine Mixer and Tesla Valve, BIOC material, Printed By TNO, 2015
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3D Printing for Microfuidics: Multiple Functions
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
17
Serpentine Mixer and Tesla Valve as Modular Building Block, BIOC material, Printed By TNO, 2015
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
18
After: P. Neil, Advances in three-dimensional rapid prototyping of microfluidic devices for biological applications, 2015
Company XY (mm) Z (mm) Biocomp. Price($)
EnvisonTEC 16 15 Yes 100.000
Digital Wax - 10 Yes 100.000
FormLabs 300 25 No 2.000
B9 Creator 50 6.35 No 2.400
Rapid Shape 25 25 Yes 25.000
Lepus Next Gen 20 20 Yes Development
VAT Equipment Developed by TNO
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
19
TNO Printvaley Machine , 2012
Printvaley Machine: Third Industrial Revolution
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
20
TNO Hyproline 3D Printing Machine, 2015
Hyproline: Hybrid AM production, Integrated Assembly, cyle time < 60 s
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
21
Carbon 3D: Continuous Liquid Interface Production , 2015
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
22
Carbon 3D: Continuous Liquid Interface Production , 2015
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
23
Nexa3D develops fast LSPc resin NX1 3D printer – prints up to a centimeter per minute, 2015
Nexa 3D: 25 mm in height per 3 minutes
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
24
TNO Lepus Next Gen printer, 2014
Lepus Next Gen: Fast, High Resolution and Large build platform (A4)
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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TNO Lepus Next Gen printer, 2015
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3D Printing as a Manufacturing Technology
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
26
Euromold, Launch of the TNO Lepus Next Gen printer, 2014
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December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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MFManufacturing Project
Build microfluidic demonstrators based upon technology building
blocks that can be supplied by different technology providers
MFManufacturing Project, 2014-2017
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December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
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MFManufacturing Project
To make microfluidic successful, printed or otherwise, we need microfluidic standards !
MFManufacturing Project, 2014
Dimensions and port positions
of the serpentine mixer building
block at standardized positions
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CONCLUSION
• Introduction 3D Printing of Micro Fluidics
• 3D Printing for Microfuidics
• 3D Printing as a Manufacturing Technology
• MFManufacturing Project
• Conclusion
December 08, 2015
Jan Eite Bullema
MicroFluidics Manufacturing
29
3D Printing for MicroFluidics Manufacturing
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MicroFluidicManufacturing