SARKOPENIA

SARKOPENIAFatichati , dr, SpPDSARKOPENIALoss of skeletal muscle mass and strength that occurs in concert with biological aging ( even in healthy elderly) (1) encompasses the effects of altered :central and peripheral nervous system innervation, hormonal status, inflammatory effectscaloric and protein intake Underlying mechanism ?Factors contributing to sarcopenia

How about incidence and prevalence ?Its prevalence is high, from 1024% in 6570-year-olds to over 30% in those over 80 years old.(2)How to detect sarcopenia ?Sarcopenia is characterized by :muscle mass index (MMI) (appendicularskeletal MM [kg]/height2 [m2]) at leasttwo standard deviations lower than the

In older adult MM loss is associated with increased fat mass.

Figure 1:Age-related Changes and Mechanisms Involved in Muscle TissueSarcopenia is associated with muscle tissue changes such as a decrease in the number and atrophy of type II skeletal fibres, while type I fibres are more preserved. Mechanisms involvedin muscle aging include motor unit changes, inactivity, and the dysregulation of muscle protein synthesis and poptosis.

MOTOR UNITMuscle fiber

Increased prevalence of sarcopenia with age

Aetiological factors leading sarcopenia