zekeriya aktürk, prof. atatürk university medical faculty , class 1 25.10.2010, erzurum
DESCRIPTION
Biostatistics Introduction. Zekeriya Aktürk, Prof. Atatürk University Medical Faculty , Class 1 25.10.2010, Erzurum. http://aile.atauni.edu.tr [email protected]. Aims – Objectives . - PowerPoint PPT PresentationTRANSCRIPT
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Zekeriya Aktürk, Prof.
Atatürk University Medical Faculty, Class 1
25.10.2010, Erzurum
BiostatisticsBiostatisticsIntroductionIntroduction
http://aile.atauni.edu.tr
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Aims – Objectives • At the end of this lecture, the participants should
defend the importance of research and have basic information about research and biostatistics.– Name the steps of research– Formulate an answerable clinical question– Classify types of data– Mention features of a data– Classify different types of studies– Explain cohort, case control, and randomized
controlled studies
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Lets do a study togetherAU Medical Faculty Students and Research
Aktürk Z. Erzurum. October 25, 2009
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Bir literatür
Askew, DA. et al. GPs involvement in and attitudes to research. Med J Aust 2002;177(2):74-77
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Stages of a study
1. Ask a question2. Is the question already answered?3. Formulate hypothesis4. Design the method5. Apply 6. Perform analysis7. Discussion8. Report
Tyler CW, Epidemyology
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Most important: ideaMy research panel
Idea Method Application Report1. Knowledge and use
of the public on herbal remedies
2. Effect of constipation on cognitive functions
3. .
1. Medical specialty training in Turkey
2. .
1. Effect of structured exercise on weight loss
2. .
1. Osteoporosis prevalence among women in Edirne
2. .
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How to gather ideas?
• Clinical practice• Work environment• Ideas from patients• Colleagues• Unexpected health outcomes• …
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Answerable clinical question•Patient/problem Hasta/problem•Intervention Girişim•Comparison Karşılaştırma•Outcomes Sonuç/Çıktı
Is there any difference among a calorie diet and a glycemic diet in decreasing body mass index of obese women?
Centre for EBM http:www.cebm.net/
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Is your question answered?
• Literature search• Teachers• Colleagues• Books• Internet• …
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Formulating a hypothesis
• H0 – There is no difference between a calorie diet and a
glycemic diet in decreasing body mass index of obese women?
• H1 – There is a difference between a calorie diet and a
glycemic diet in decreasing body mass index of obese women?
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Types of studies(How to answer the question?)
• Observation– Case report– Prevalance– Case control– Cohost studies– Qualitative studies
• Intervention– Randomized controlled studies
• Methodologic– Validity– Reliability
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Case control study
Cases Controls
Exposed Not exposed Exposed Not exposedT
IME
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Cohort study
Diseases Healthy
Exposed Not exposed
T I M
EDiseased Healthy
Population
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Randomized controlled study
Sick Improved
A therapy B therapy
T I M
E
Sick Improved
Population
Randomization
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Statistical analysis
• Features of data– Current– Reliable– Correct– Complete– Appropriate to use– Appropriate for aim
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Statistical analysis
• Frequency distribution• Importance tests (hypothesis tests)
– Student t-test– ANOVA– Chi square– Mann-Whitney U test– McNemar test– Wilcoxon – Fisher exact test– …
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Lets do an example
• Stages of a study1. Ask a question2. Is the question already answered?3. Formulate hypothesis4. Design the method5. Apply 6. Perform analysis7. Discussion8. Report
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Ask a question
• Is there any difference in recognizing “thyme” between class 1 and class 6 medical students?
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Was the question answered?
• Aktürk Z ve ark.– Medical students have problems in recognizing
herbs. Class six students are better in recognizing.
Genel Tıp Derg 2003;16(3):101-106
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Hypothesis
• H0: There is no difference in recognizing “thyme” between class 1 and class 6 medical students?
• H1: There is a difference in recognizing “thyme” between class 1 and class 6 medical students?
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Method
• The following picture was shown to students from class 1 and 6 by a data projector
Statistics – Frequency distribution
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Kekik resmini tanýdý mý
115 63,2 63,5 63,566 36,3 36,5 100,0
181 99,5 100,01 ,5
182 100,0
HayýrEvetTotal
Valid
SystemMissingTotal
Frequency Percent Valid PercentCumulative
Percent
SINIF
115 63,2 63,2 63,267 36,8 36,8 100,0
182 100,0 100,0
16Total
ValidFrequency Percent Valid Percent
CumulativePercent
Statistics – hypothesis testing
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SINIF * Kekik resmini tanýdý mý Crosstabulation
101 14 11587,8% 12,2% 100,0%
14 52 6621,2% 78,8% 100,0%
115 66 18163,5% 36,5% 100,0%
Count% within SINIFCount% within SINIFCount% within SINIF
1
6
SINIF
Total
Hayýr Evet
Kekik resmini tanýdýmý
Total
Chi-Square Tests
80,317b 1 ,00077,468 1 ,00084,089 1 ,000
,000 ,00079,874 1 ,000
181
Pearson Chi-SquareContinuity Correctiona
Likelihood RatioFisher's Exact TestLinear-by-LinearAssociationN of Valid Cases
Value dfAsymp. Sig.
(2-sided)Exact Sig.(2-sided)
Exact Sig.(1-sided)
Computed only for a 2x2 tablea. 0 cells (,0%) have expected count less than 5. The minimum expected count is24,07.
b.
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Conclusion
• While 12% of class 1 students correctly recognized thyme, this was 78% in class 6.
• Although class 6 students are better in recognizing thyme, still 22% are not successfull in recognizing.
• There is a significant difference between class 1 and 6 students in recognizing thyme (p<0,001).