ygh16 study guide en

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University of Medicine and Pharmacy

„Iuliu Haţieganu” Cluj-Napoca

Faculty of Pharmacy

STUDY GUIDE

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A. The mission assumed by the Faculty of Pharmacy in Cluj-Napoca is to provide

education services for students enrolled in all study programs in pharmaceutical field,

according to the European legislation for the recognition of professional qualifications and

to the principles of the European Higher Education Area, and also to conduct scientifical

research activity, in agreement with the principles of the European Research.Area.

B. The aim of the study program for the licence in pharmacy with 5 year duration is to

form pharmacists as specialists in the field of drugs, with quality university education,

whose competence and performances can be recognised at national and European level.

C. The general objectives of the study program for the licence in pharmacy are: - to ensure the educational frame that allows the student to attain the legal standard of

professional knowledge;

- to ensure the educational frame that allows the student to acquire the professional

intellectual discipline;

- to ensure the educational frame for the ethical formation of the student regarding life and

professional issues;

D. The specific objectives of the study program for the licence in pharmacy are:

- the adequate knowledge of pharmaceutical and auxiliary substances used for the preparation

of medicines;

- the adequate knowledge of pharmaceutical technology and of physical, chemical, biological

and microbiological drug control;

- the adequate knowledge of metabolism and effects of drugs and toxic substances, as well as

the of the use of drugs;

- the adequate knowledge allowing the evaluation of scientifical data regarding drugs, in order

to provide correct informations to patients and collaborators;

- the adequate knowledge of the legal conditions, as well as of other conditions regarding

practicing pharmaceutical activities.

E. The general competences of the graduate of study program for the licence in

pharmacy: - gathering, analysis and qualitative and quantitative interpretation of data and informations

from different alternative sources, from different professional contexts, or from the

literature, respectively in order to formulate arguments or to take correct decisions;

- use of different communication abilities, in writing, orally or even in a foreign language;

- use of information technologies;

- assuming responsibilities in elaborating a personal continuing education program;

- elaboration and performing specific processes in the field of pharmacy.

F. The specific competences of the graduate of study program for the licence in

pharmacy:

- elaboration of pharmaceutical formulations;

- drugs fabrication and control;

- drug control in a drug control laboratory;

- storage, conservation and distribution of drugs;

- preparation, control, storage and delivery of drugs in community pharmacies;

- preparation, control, storage and delivery of drugs in hospital pharmacies;

- delivery of information and consultancy regarding drugs;

- collaboration with the physician in establishing and monitoring drug treatment;

- performing pharmacovigilance activities

- fabrication, control, storage, conservation and distribution of plant products, food

supplements, hygiene-cosmetic products, medical devices, veterinary drugs, pharmaceutical

and auxiliary substances;

- performing analysis in biochemistry, toxicology, food and environment hygiene laboratories;

- performing pharmaceutical marketing and management activities;

- performing teaching and administration activities.

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CHAIR OF GENERAL AND INORGANIC CHEMISTRY

COURSE TITLE – General and inorganic chemistry

COURSE AND PRACTICAL LESSONS OBJECTIVES

To provide to first year students in Faculty of Pharmacy a basic culture in chemistry and the

knowledge needed for following other speciality courses in pharmacy curriculum.

To provide, during practical lessons, the basic knowledge in experimental chemistry and in

laboratory practice.

PREREQUISITE – Elementary knowledge of general chemistry and inorganic chemistry from

high school TEACHING METHODS

Lectures using Power Point presentations;

Applied exercises, computer simulations;

Laboratory practice, experimental proceedings and methods, results evaluation and

interpretation.

EVALUATION METHODS

Tests and oral presentations during the semesters. For the presentations, students are

allowed to choose from a list of topics suggested by the department. Oral presentations

during classes is followed by comments and questions (10% of the final score).

The laboratory practice exam consists in several experiments that have to be performed by

the student and it is followed by a short interview during which students explain the

obtained results. Practical skills and a correct interpretation of the data are evaluated (20%

of the final score). Written exam with short answer questions, problems and exercises. The written exam

evaluates the correct understanding and interpretations of each topic (70% of the final

score).

TEACHING LANGUAGE

Romanian for Romanian section

French for French section

English for English section

NUMBER OF HOURS

Course – 70 hours (28/42)

Practical lessons – 84 hours (42/42)

GENERAL AND INORGANIC CHEMISTRY

COURSE SYLLABUS

1st SEMESTER

1. Elementary Chemistry– A revision 2. Atom structure

Modern concepts of the atomic structure. Atomic orbitals (wave function).

Atomic models. Electron configuration (principles). Atomic nucleus.

3. Periodic system of the elements

Periodicity law. Different forms of the periodic table. Correlation between

physical and chemical properties of elements and their electronic

configuration and position in the periodic table.

4. Chemical bonds

Ionic bond. Covalent bond. Metallic bond. Intermolecular bonding (hydrogen

bonding, van der Waals interactions) – classical theories and quantum

chemistry. Bond type – structure – compound properties correlations.

2 h

3 h

2 h

6 h

4

5. States of matter

Solid. Liquid. Gas. Plasma

6. Crystal structure

Crystal lattice. Types of crystal lattices. Properties of crystal structures –

isomorphism, polymorphism.

7. Electric and magnetic proprieties of compounds

Compounds’ behaviour in an electric or magnetic field. Ionic polarization.

Diamagnetic, Paramagnetic and Ferromagnetic compounds.

8. Principles of thermodynamics, kinetics and equilibrium

Fundamentals of thermodynamics.

Kinetics – Reaction rates – influencing factors. Catalysis.

Chemical equilibrium characteristics, equilibrium constant. Equilibrium in

homogenous and heterogeneous systems. Le Chatelier’s principle.

9. Solutions

General aspects. Qualitative and quantitative expressions of solutions’

concentration. Solution’s properties.

10. Acids and basis

Acid and base theories. Classification. Acid and base strength – parameters of

evaluation. General properties of acid and base.

11. Chemical reaction

Types of inorganic chemical reactions – influencing factors.

Neutralization, hydrolysis, ionic reactions, complex formation reactions.

Oxidation – reduction reactions.

2nd

SEMESTER 1. Coordination chemistry

General principles. Bonding and electronic structure – crystal field and ligand

field theories. Formation and stability of coordination compounds. Isomerism.

Classes of coordinative compounds. Analytical application, importance and

biological role

2. Chemistry of the main group elements: 1, 2, 13, 14, 15, 16, 17, 18 groups of

periodic table General group characterization

Elements and compounds – preparation, structure, physical and chemical

properties, use, biological role, applications in the pharmacy field.

3. Chemistry of the transition metals – 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 – groups of

periodic table General group characterization

Elements and compounds – preparation, structure, physical and chemical

properties, uses, biological role, applications in the pharmacy field.

4. Bioinorganic chemistry – fundamental principles

2 h

2 h

2 h

2 h

1 h

1 h

4 h

9 h

18 h

13 h

2 h

PRACTICAL LESSONS SYLLABUS

1st SEMESTER

1. Security and personal safety in the chemistry laboratory. Fire protection.

First aid procedures in case of accident

2. Presentation of laboratory glassware and materials

3. Laboratory practice of specific techniques and methods. Basic separation

and purification techniques: selective dissolution, sublimation, centrifugation,

filtration, distillation, extraction, chromatographic techniques

4. Purity criteria and evaluation – melting point, molecular weight, chemical

equivalent, water molecules in crystallohydrates

5. Solubility rules. Solutions – concentration units, preparation

2 h

2 h

9 h

3 h

3 h

5

6. Reaction kinetics, reaction rate – influencing factors. Homogeneous and

heterogeneous catalysis

7. Chemical equilibrium. Le Chatelier’s principle – applications

8. Acids and bases. Acid and base strength criteria and evaluation. General

properties of acids and bases

9. Hydrolysis reactions

10. Precipitation reactions. Ionic polarization

11. Redox reactions

2nd

SEMESTER 1. Metal complexes – preparation, stability, specific reactions

Metal complexes preparation: [Cu(NH3)4]SO4, [Ni(NH3)6]SO4, K3[Fe(C2O4)3],

K[PbI3], Cu(glycolate)2.

2. Hydrogen – preparation, properties

3. Group 17 – The halogens

Chlorine, bromide, iodine, hydracids and salts, oxoacids and salts – preparation and

properties.

4. Group 16 – Elements and compounds – preparation and properties

Oxygen, hydrogen peroxide.

Sulphur, sulphur acids: H2S, H2SO3, H2SO4, H2S2O3, H2S2O4, H2S2O8 and salts.

5. Group 15 – Elements and compounds – preparation and properties Nitrogen, phosphorus, arsenic – compounds: ammonia, acids – HNO2, HNO3,

H3PO2, H3PO3, H3PO4, H3AsO3, H3AsO4 – and salts preparation, properties.

Antimony and bismuth – oxides, hydroxides, salts.


Carbon, silicon – oxides, acids and salts – preparation and properties.

Tin and lead – oxides, hydroxides and salts.


Boron – boric acid, borax – preparation and properties

Aluminium – oxide, hydroxide, salts.

8. Groups 1 and 2 – Elements and compounds – preparation and properties

Sodium, potassium, magnesium, calcium, barium – oxides, hydroxides and salts.

9. Chromium and manganese – oxides, hydroxides and salts – preparation and

properties

10. Iron, cobalt, nickel - oxides, hydroxides and salts – preparation and

properties

11. Copper and silver - oxides, hydroxides and salts – preparation and

properties

12. Zinc, cadmium and mercury – oxides, hydroxides and salts – preparation

and properties

3 h

3 h

4 h

3 h

3 h

4 h

6 h

1 h

5 h

6 h

6 h

3 h

3 h

2 h

3 h

3 h

2 h

2 h

References

1. L.Oprean, A. Hangan, A. Bota, Chimie anorganică. Noţiuni teoretice şi aplicaţii practice,

Editura Medicală Universitară “Iuliu Haţieganu”, Cluj-Napoca, 2007.

2. G: Marcu, M. Rusu, V. Coman, Chimie anorganică. Nemetale şi semimetale, Editura

Eikon, Cluj-Napoca, 2004.

3. Victoria Aldea, Valentina Uivaroşi – Chimie anorganică, principii fundamentale, Editura

Medicală, Bucureşti, 2000.

4. Victoria Aldea, Valentina Uivaroşi – Chimie anorganică, elemente şi combinaţii, Editura

Medicală, Bucureşti, 1999.

5. M. Lefort – Les constituents chimiques de la matière, Descriptions des éléments, Ellipses,

Paris, 2003.

6. G. Wulsberg – Théorie et applications, Cours, Traduit de l’américain par G. Boucekkine,

F. Goubard, Dunod, Paris, 2002.

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7. L. Ghizdavu – Chimie bioanorganică, Editura Poliam, Cluj – Napoca, 2000.

8. K. Sommer, K.-H. Wünsch, M. Zettler – Compendiu de chimie, Editura All, Bucureşti,

2000.

9. D.F. Shriver, P.W. Atkins, C.H. Langford – Chimie anorganică (traducere din limba

engleză), Editura Tehnică, Bucureşti, 1998.

10. C.D. Neniţescu – Chimie generală, Editura Didactică şi Pedagogică, Bucureşti, 1985.

11. Grecu, T. Goina – Chimie anorganică, Editura Didactică şi Pedagogică, Bucureşti, 1982.

12. Grecu, M. Neamţu, L. Enescu – Implicaţii biologice şi medicale ale chimie anorganice,

Editura Junimea, Iaşi, 1982.

13. Huheey, Keiter & Keiter - Chimie inorganique, Traduit de l’anglais par André Pousse et

Jean Fischer ; De Boeck & Larcier s.a., 1996.

14. Jacques Barbe - Chimie minerale raisonnée, Editions de Santé, 49 rue Galilée, 75116

Paris, 1996.

15. M. Neamţu, L. Şumălan – Chimie generală şi anorganică, fascicula I, Tipografia UMF,

1994.

16. J.A. Cowan - Inorganic biochemistry –an introduction, Wiley – VCH 1997.

17. Bodie E. Douglas, Darl H. Daniel, John J. Alexander - Concepts and models of inorganics

chemistry, 3d edition - John Wiley & Sons, Inc.

18. Mc. Quarrie / Rock - Chimie générale, 3eme

édition, Traduit de l’anglais par Paul

Depovere ; Révision scientifique de Céline G. Jung ; De Boeck Université; De Boeck

Wesmael, s.a., 1992

19. Site: oprean.xhost.ro/anorganica

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CHAIR OF ANALYTICAL CHEMISTRY AND INSTRUMENTAL

ANALYSIS

COURSE TITLE – Qualitative analytical chemistry


To acquire the principles of qualitative chemical analysis

To perform qualitative analytical reactions, Systematic analysis of unknown samples (inorganic

and organic ions) of pharmaceutical and biomedical interest

PREREQUISITE – basic knowledge of General and inorganic Chemistry, Organic Chemistry

TEACHING METHODES

Lectures with Power Point presentations

Laboratory practical works, workshops on a given subject

EVALUATION METHODES

Periodic oral and written tests

Final practical exam

Final written and oral exam TEACHING LANGUAGE

Romanian, French, English

NUMBER OF HOURS



QUALITATIVE ANALYTICAL CHEMISTRY

COURSE SYLLABUS 1. The object and the importance of analytical chemistry

2. Analytical classification of ions

3. Chemical balances in analyses

4. Water as solvent

5. Analytical reagents

6. Acid-basic reactions in analysis

7. Precipitation reactions

8. Complexing reactions

9. Redox reaction in analysis

2 h

6 h

2 h

2 h

2 h

6 h

4 h

2 h

2 h

PRACTICAL LESSONS SYLLABUS 1. Security safety in the laboratory

2. Preliminary reactions, (Fresenius)

3. Reactions for cations’ identification

4. Analytical classification of anions (Bunsen)

5. Reactions for anion identification

6. Systematic analysis

7. Separation and identification of cations and anions

8. Analysis of unknown salts (7 full analyses of mixtures containing between 2 and

6 inorganic or organic ions)

1 h

5 h

6 h

6 h

24 h

References

1. L.Roman, R.Săndulescu, Chimie Analitică vol 1. – Analiza Chimică Calitativă, E.D.P,

Bucureşti, 1999;

2. R.Săndulescu, R.Oprean, Simona Mirel, Bodoki E., Cecilia Cristea, S.Lotrean, Chimie

analitică calitativă, Ed. Risoprint, Cluj-Napoca, 2007

3. G. Svehla, Vogel's Qualitative Inorganic Analysis, ediţia a 6-a, Longman Scientific &

Technical, Essex, 1991;

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4. M. Guernet, M. Hamon, Abrégé de chimie analytique, tome 1, Chimie des solutions,

Masson, Paris, 1976 ;

5. G. Mahuzier, M. Hamon, D. Ferrier, P. Prognon, Abrégé de chimie analytique, tome 2,

Méthodes de séparation, 3eme

édition, Masson, Paris, 1999 ;

6. R.Sandulescu, Cecilia Cristea, Chimie analytique qualitative, Ed. Risoprint, Cluj-Napoca,

2007;

7. R.Săndulescu, R.Oprean, L.Roman, Analyse Minerale Qualitative, Editura Medicală

Universitară „Iuliu Haţieganu” Cluj-Napoca, 2003.

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CHAIR OF PHYSICAL CHEMISTRY

COURSE TITLE – Physical chemistry


The students should acquire and apply the principles and methods of physical chemistry in

different pharmaceutical disciplines.

PREREQUISITE – knowledge of Physics, Biophysics and General chemistry

TEACHING METHODS

Lectures wit PowerPoint presentations

Practical lessons

EVALUATION METHODS

Written examination and multiple choice questions (75% of the final grade)

Practical exam (75% of the final grade)

TEACHING LANGUAGE

Romanian, French, English

NUMBER OF HOURS



PHYSICAL CHEMISTRY

COURSE SYLLABUS 1. Chemical thermodynamics

Energy, work and heat. The first principle of thermodynamics. Thermochemistry.

Extent of Reaction. Standard States. Measurement of Enthalpy and Internal Energy

Changes. Calorimetry. Relationship between U and H. Temperature Dependence

of Enthalpies of Reaction. Enthalpies of Formation. Bond Enthalpies. The

Calculation of Entropy Changes.

The second principle of thermodynamics. Conditions for Equilibrium. The

Helmholtz and Gibbs energies. Molecular Interpretation. Gibbs Energies of

Formation and Reaction. Thermodynamic Equation of State. The Gibbs-Helmholtz

Equation.

Chemical Equilibrium. Chemical Equilibrium in Solution. Tests for Chemical

Equilibrium. Equilibrium Shift at Constant Temperature. Temperature and Pressure

Dependence of Equilibrium Constants.

Phases and Solutions. Phase Recognition. Vaporization and Vapour Pressure. The

Clapeyron and Clausius-Clapeyron Equations. Enthalpy and Entropy of

Vaporization: Trouton's Rule. Ideal Solutions: Raoult's and Henry's Laws. Partial

Molar Quantities. The Chemical Potential. Thermodynamics of Solutions. No ideal

solutions; Activity and Activity Coefficients. The Colligative Properties. Freezing

Point Depression. Boiling Point Elevation. Osmotic Pressure. Solubility and

Distribution Phenomena. Distribution of Solutes between non-miscible Solvents.

Phase equilibrium. Single-Component Systems. Binary Systems Involving Vapour.

Condensed Binary Systems. Thermal Analysis. Ternary Systems.

2. ELECTROCHEMISTRY

Solutions of Electrolytes. Molar Conductivity. Weak Electrolytes: The Arrhenius

Theory. Ostwald's Dilution Law. Strong Electrolytes. Debey-Hückel Theory. Ionic

Mobilities. Transport Numbers. The Measurement of Transport Numbers. Ion

Conductivies. Ionic Mobilities and Diffusion Coefficients. Activity Coefficients.

Debey-Hückel Laws. Activity Coefficients Measurements. Standard Electrode

Potentials. The Nernst Equation. Applications of standard potentials Measurements.

Electrode Processes.

2 h

2 h

2 h

4 h

2 h

6 h

10

3. CHEMICAL KINETICS

Rate and Order of Reaction. Experimental Techniques. Zero, First and Second Order

Reactions. Analysis of Kinetic Results. Influence of Temperature on Reaction Rates.

Effects of Solvent Polarity, Ionic Strength and Dielectric Constant on Rates.

Reaction Rates and Equilibrium. Consecutive Elementary Reactions. Free-Radical

Reactions. Explosions. Photochemical Reactions. Specific Acid-Base Catalysis.

Collision Theory. Reactions in Solution. Potential Energy Surfaces. Activated

Complex Theory. Degradation and Stabilization of Pharmaceuticals. Accelerated

Stability Analysis.

4. THE ELECTRIC AND MAGNETIC PROPERTIES OF MOLECULES Polarisability. Debye and Clausius-Mossotti Equations. Molar Polarization. Relative

permittivity. Refractive index. Magnetic susceptibility and magnetic moment.

Intermolecular forces. Interactions between dipoles. Repulsive and total interactions.

6 h

4 h

PRACTICAL LESSONS SYLLABUS 1. Quantitative calculations in pharmaceutical practice.

2. Determination of neutralization, mixing and solvation enthalpy using calorimetric

methods.

3. Partial molar volumes

4. Calculation of osmotic and activity coefficients for diluted solutions

5. Calculation of the acidity constant of a weak acid by conductivity measurements

6. Spectrophotometric determination of the acidity constant of a weak acid in presence

of an indicator

7. Electrical properties of molecules. Applications of permittivity measurements.

8. Refraction index measurements applied to structure and purity determination and

quantitative analysis

9. Determination of partition coefficient of a substance between two solvents

10. Cryoscopy and micro cryoscopy.

11. Problems and recapitulation.

12. Practical exam.

6 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

References

1. Peter Atkins, Julio de Paula, Physical Chemistry, Oxford University Press, 2002

2. Alexander T. Florence, David Attwood, Physicochemical Principles of Pharmacy,

Pharmaceutical Press, London, 2004

3. Richard M. Pashley, Marilyn E. Karaman, Applied Colloid and Surface Chemistry, John

Wiley & Sons, Ltd., 2004

4. A. Martin, J. Swarbrick, A. Cammarata, Physical Pharmacy-Physical Chemical Principles

in the Pharmaceutical sciences, Lea & Febiger, Philadelphia, 1983

5. Ludovic Kurunczi, Curs de Chimie Fizică şi Coloidală pentru farmacişti, Editura Mirton,

Timişoara, 2000

6. Emil Făgărăşan, Silvia Imre, Chimie Fizică experimentală, Editura Medicală Universitară

“Iuliu Haţieganu”, Cluj Napoca, 2005

7. Dan Rusu, Iuliu Marian, Chimie Fizică.Elemente de termodinamică şi structură, Editura

Casa Cărţii de Ştiinţă, Cluj Napoca, 2007

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CHAIR OF PHARMACEUTICAL BOTANY

COURSE TITLE – Pharmaceutical botany


Knowledge accumulation regarding: cell organization, structure, ultra structure and

chemical composition; vegetal tissues; organization of vegetative and reproductive

apparatus in plants; some systematic families of plants with pharmaceutical importance.

During practicals, students will learn how to manipulate the microscope, how to recognise

medicinal plants in order to avoid their substitution with other species without

pharmaceutical activity.

PREREQUISITE – General botany knowledge (high school level)

TEACHING METHODS Course: Lecture with Power point presentation, virtual botany (multimedia type)

Practicals: Individual practice: microscopy (vegetal cytology, histology, anatomy), superior

plant determination, medicinal plants from the department collection: study and recognition

EVALUATION METHODS: Evaluation of practical abilities and theoretical knowledge in laboratory (individual practical

activities and written test) at the end of each semester (20% from final score)

Multiple choice questions (MCQ) test at the end of each semester (80% from final score)

TEACHING LANGUAGES: Romanian

French

English

NUMBER OF HOURS



PHARMACEUTICAL BOTANY

COURSE SYLLABUS

1st SEMESTER

1. Vegetal cytology: General organisation of vegetal cell, its chemical composition,

the structure and the ultra structure of cell organelles, their biological role

(hyaloplasma, plasmalemma, endoplasmic reticulum, ribosomes, lysosomes,

Golgi apparatus, plastids, chondriosomes, nucleus). Paraplasmic content.

Elements of cell physiology: permeability and absorption, cell division.

2. Vegetal histology: Definition, differentiation and classification of plant tissues.

Meristems, protection tissues, supporting tissues, parenchyma, conducting tissues,

secretory tissues

3. Morphology and anatomy of vegetative organs: General characteristics of

vegetative organs. Origin, morphology, anatomy, primary and secondary

structures, variations of structure, modified organs, pharmaceutical importance for

root, stem, and leaf.

4. Physiology of the leaf: nutrition types, the photosynthesis, the biosynthesis of

pharmacological substances.

2nd

SEMESTER 1. Plant reproduction: Vegetative, sexual and non sexual multiplication.

Morphology and anatomy of the flower, fruit and seed. The flower, fruit and seed

as medicinal sources

2. Systematic botany: Botanical nomenclature. Systematic units. Subkingdoms

Virobionta, Procariobionta, Phycobionta, Mycobionta, Bryobionta,

Cormobionta. Principal orders, families, genera, species with pharmaceutical

importance of Cormobionta.

15 h

8 h

19 h

6 h

22 h

12


1st SEMESTER

1. The microscope, the microscopy kit. Microscope manipulation. Techniques for

obtaining microscope slides

2. The structure of the vegetal cell. Chloroplasts, chromoplasts, starch grains, micro-

crystals. Cell wall. Cuticula. Cell division (mitosis). Cellular plasmolysis

3. Protection tissues (stomata, trichomes), supporting tissues (collenchyma,

schlerenchyma), fundamental tissues (air spaces, watery tissue), conducting tissue

(xylem, phloem), secretory tissues

4. Primary structure of the root

5. Primary structure of the stem and variations

6. Secondary structure of the root and stem

7. Leaf morphology. Leaf anatomy

2nd

SEMESTER 1. Flower morphology. Inflorescences. Flower anatomy. Fruit morphology and

classification

2. Divisions Pteridophyta and Pinophyta

3. Superior plant determination. Medicinal plants from division Magnoliophyta

3 h

9 h

9 h

3 h

6 h

3 h

9 h

8 h

2 h

18 h

References

1. Tămaş M: Botanică farmaceutică, vol. I (Citologia), Ed. Med. Univ. UMF Cluj-Napoca,

2004

2. Tămaş M: Botanică farmaceutică, vol. II (Histologia) Ed. Med. Univ. UMF Cluj-Napoca,

2002

3. Tămaş M: Botanică farmaceutică, vol. III (Sistematica - Cormobionta), Ed. Med. Univ.

UMF Cluj-Napoca , 1999

4. Guignard J.-L.: Botanique, Ed. Masson Paris, 1998

5. Spichiger R.-E. et al.: Botanique systématique des plantes a fleurs, Pres. Pol. et Univ

Romande, Lausanne, 2002

6. Laberche J.-C.: Biologie végétale, Ed. Dunod Paris, 1999

7. Roland J.-C., Roland Françoise: Biologie végétale. 2. Organisation des plantes à fleurs, Ed.

Dunod Paris, 2001

8. Crişan Gianina, Ştefănescu Cristina: Botanică farmaceutică – Lucrări practice, Ed. Med.

Univ. UMF Cluj-Napoca, 2005

9. M. Tămaş, Crişan Gianina, Stefănescu Cristina, Balica Georgeta: Botanique

pharmaceutique – La systématique, Editura Medicală Universitară “Iuliu Haţieganu” Cluj-

Napoca, 2005

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CHAIR OF PHYSICS-BIOPHYSICS

COURSE TITLE – Pharmaceutical physics


Course: to contribute to the scientific formation of the students in pharmacy by integrating

knowledge and skills acquired in the discipline of Pharmaceutical Physics with the other

basic subjects: Chemistry, Cell Biology and Physiology.

The course also aims to contribute to the formation of a scientific thinking of students by

using models in the description of physical, chemical and biological systems, by establishing

causal links (determinism) between different phenomena and processes, by verification of

theoretical models based on experimental data.

Practical classes aim that students can measure properties and physical constants of

materials: the density of liquids and solids, specific heat, melting point, boiling temperature

surface tension coefficient, viscosity coefficient, refractive index, specific light rotation

angle. Students should acquire skills necessary to use laboratory equipment: electric

equipment, spectroscopes, spectrophotometers, radiation detectors, pH meter, conductivity

meters, Oscilloscopes, polarimeters. Students should be able to perform some simple

medical tests: determination of haematocrit, haemoglobin, plasma proteins, electrophoresis,

and the isoelectric point of protein. Students should acquire specific skills in experimental

measurements: errors calculation, graphic representations, linear interpolation.

PREREQUISITE - Knowledge of physics at high school level

TEACHING METHODS Theoretical course: Plenary Lectures

Practical Lessons: Individual and group experiments

EVALUATION METHODS Theoretical course: Multiple choice or master examination

Practical Classes: performance by the students of a real experiment

TEACHING LANGUAGE Romanian, English, French

NUMBER OF HOURS



PHARMACEUTICAL PHYSICS

COURSE SYLLABUS

1st SEMESTER

I. Mechanics

I.1. Kinematics

Kinematics of uniform accelerated movement. Equation of Galilee.

Kinematics of circular movement.

I.2. Dynamics

The principles of Newtonian dynamics

Forces. Types of forces

Dynamics of circular movement. Centrifugal force. Applications

I.3. Impulsion and kinetic moment.

Impulsion. Conservation of the impulsion.

Kinetic moment. Conservation of kinetic moment.

I.4. Work and mechanic energy.

Work. Power.

Kinetic energy. Potential energy. Conservation of mechanical energy

8 h

14

I.5. Oscillations

Harmonic oscillations.

Equations of oscillatory movement. Forced oscillations.

Composition of oscillations.

I.6. Mechanical waves

Equation of the plane wave. General equation of waves.

Classification of waves. Propagation. Intensity. Reflection and refraction

Interference. Diffraction. Doppler effect.

Dispersion.

Sounds. Infra et ultrasounds.

I.7. Mechanics of solids.

The law of Hooke.

Elastic and plastic deformations.

I.8.Mecanics of fluids.

Static of fluids. The law of Pascal. The principle of Archimedes.

Fluids dynamics. Law of Bernoulli

I.9. Rheology

Law of Newton. Newtonian liquids. Viscosity. Non Newtonian bodies. Viscometers.

I.10.Surface tension.

Surface tension .Capillarity.

Law of Laplace.

Tensioactive substances. The relation of Gibbs.

II. Thermal phenomena

II.1. Thermodynamics

Fundamental notions. Thermodynamic system. Thermodynamic equilibrium.

Transformations. Classifications.

State parameters.

Zero law of thermodynamics.

Gas law. Thermal state equation.

First principle of thermodynamics. Work and heat. Internal energy. Applications.

Calorimetry.

Second principle of thermodynamics. The Carnot cycle. Efficiency.

Entropy. Entropy and probability. Entropy and disorder.

Far from equilibrium systems.

Thermodynamic potentials. Enthalpy. Free energy (Helmholtz). Gibbs free energy.

II.2. Kinetic theory of gases.

Pression formula. State equations.

Specific heat of solids. Dulong-Petit law.

Colligative properties of solutions. Osmosis. Osmotic work.

II.3. Phase transformations.

Vaporisation and boiling.

Clausius Clapeyron equation.

Melting and solidification.

Triple point. Phase rule.

II.4. Transport phenomena. Transport through membranes.

Diffusion. Fick’s equations.

Heat transport. Conduction (Fourier), convection. Radiations’ law.

III. Electricity and magnetism

III.1. Electrostatics

Electric charge. Law of Coulomb.

Electric field. Electric potential. The theorem of Gauss. Applications.

Condensers. Conductors in electric field.

10 h

5 h

15

Electric dipole. Dipole moment. Dipolar electric field.

III.2. Stationary electrical current.

Electric circuit. Electric lead.

Classical conduction theory. Law of Ohm (microscopic form).

The laws of Kirchhoff.

Electric energy. Power.

Electrolysis

III.3. Magnetic field.

Magnetic field of electric currents.

Magnetic induction.

Law of Ampere. Biot-Savart law.

Electromagnetic induction. Law of Faraday.

Electronic magnetic moments. Magneton of Bohr. Spin of the electron. Magnetic

properties of matter. Magnetic resonance. Electrons spin resonance.

NMR- nuclear magnetic resonance. Applications

IV. Optics

IV.1. Geometrical optics. Lenses and mirrors. Optical microscope.

IV.2. Wave optics.

Light as an electromagnetic wave. Maxwell’s equations.

Interference and diffraction.

Polarisation of light. Applications.

IV.3. Photonic optics.

Photoelectric effect. Compton effect. Pair formation.

IV. 4. Light absorption

Photometry

Atomic and molecular spectra.

Lambert Beer law. Spectrophotometry. Colorimetry.

V. Nuclear physics Atomic nucleus. Isotopes.

Nuclear models. Nuclear forces.

Radioactivity. Types of radiations.

Disintegration laws.

Nuclear reaction.

Artificial radioactivity. Applications.

Radiations doses. Protection.

3 h

2 h

PRACTICAL LESSONS SYLLABUS 1. Introduction, physical quantities, units, errors.

2. Balances, characteristics. Weighting methods.

3. Density determinations

4. Viscometers

5. Surface tension.

6. Calorimetry

7. Electricity:

-electrolysis,

-conductometry,

-resistivity,

-variation of resistivity with temperature,

-galvanic cell, concentration cell, pH

8. Optics:

- lenses,

- microscope,

42 h

16

- refractometry,

- polarimetry,

- spectrophotometry, colorimetry

9. Methods of separation

10. Detection of nuclear radiations (activity determinations, gamma photon

absorption)

References

1. Constantin Mihai Lucaciu , Fizica si Elemente de Biofizica, Editura Medicala Universitara

“Iuliu Hatieganu” Cluj-Napoca, 2000

2. F. Gremy, Biophysique, Ed. Flammarion Paris, 1982

3. D., Halliday, R. Resnick, Fizica, Fizica, Ed. Didactica si pedaqgogica, Bucuresti, 1975

4. E. Shottan, K. Ridgway, Physical Pharmaceutics, Clarendon Press Oxford, 1974

5. G. Romto, A Tarjan An introduction to Biophysics with medical orientation, Akademiai

Kiado, Budapest 1994

6. C.M.Lucaciu, Physique et Biophysique experimentales Editura Medicala Universitara

“Iuliu Hatieganu” Cluj-Napoca, 2000

17

CHAIR OF PHYSICS - BIOPHYSICS

COURSE TITLE – Biophysics

COURSE OBJECTIVES

The aim of the course is to contribute to scientific training of students in pharmacy by

integrating knowledge and skills acquired in the discipline of Pharmaceutical Physics to those

acquired in the biological disciplines. Students should be able to explain by the laws of physics

the physiological and pathological processes that occur in biological systems; relationships that

occur between the physical properties and biological role of organic molecules, the effects of

environmental factors on biological systems; the Biophysics aims to contribute to scientific

training pharmacy students in integrating knowledge and skills acquired in the discipline of

Pharmaceutical Sciences with other basic subjects: Chemistry, Cell Biology, Physiology.

PREREQUISITE - Knowledge of physics and biology at high school level

TEACHING METHODS Theoretical course: Plenary Lectures

EVALUATION METHODS Theoretical course: Multiple choices or master examination

TEACHING LANGUAGES Romanian, English, and French

NUMBER OF HOURS


BIOPHYSICS

COURSE SYLABUS 1. Biomechanics

2. Muscle structure. The mechanism of muscle contraction. Dynamic muscle

activity. 3. The structure of cell membranes. Membrane models. Physical properties of

lipids. Membrane proteins. 4. Membrane transport. Passive transport through lipid bilayer.

Transport through oligopeptides and proteins. Active transport. Medical

applications Biophysics methods to study of transport systems. 5. Osmosis. Medical Applications 6. Biophysics of blood circulation 7. Sounds. Infrared and ultrasound. Weber Fechner law. 8. Sensory Biophysics. Human eye. 9. Bioelectricity 10. Transmembrane generating potential. Nernst-Planck equation Resting potential Action Potential Propagation of action potential.

2 h

2 h

3 h

1 h

1 h

1 h

1 h

3 h

References

1. Constantin Mihai Lucaciu “Transportul ionilor prin membranele biologice” Editura

medicala Universitara “Iuliu Hatieganu” Cluj-Napoca, 2005

2. F. Gremy, Biophysique, Ed. Flammarion, Paris 1982

3. A. Bouyyssy, M. Davier, B. Gantz, Physique pour les sciences de la vie, Ed. Belin, Paris,

1988

4. D-G. Margineanu, Energetica lumii vii, Ed. Edimpex-Speranta, Bucuresti 1992

5. D-G Margineanu, M.I.Isac, C.Tarba, Biofizica, Ed. Didactica si Pedagogica, Bucuresti,

1980

18

CHAIR OF MATHEMATICS AND INFORMATICS

COURSE TITLE – Biomathematics and Biostatistics


To acquire the instruments and the mathematical and statistical methods useful for

deterministic and probabilistic modelling of certain problems specific for pharmaceutical

sciences.

To exercise computational methods for implementing mathematical and statistical calculations

related to specific subjects of the course.

PREREQUISITE – knowledge of mathematics at high school level

TEACHING METHODS

Course: Lectures with PowerPoint presentations and demonstrations of computational calculation

Practical lessons: demonstrations in the classroom, implementation of calculations using specialized

programs, Internet site for students: http://www.farma.umfcluj.ro/depts/MI/index.html

EVALUATION METHODS

Continuous assessment based on performances in practical lessons, multiple choice examination,

project based assessment.

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



BIOMATHEMATICS AND BIOSTATISTICS

COURSE SYLLABUS Biological mathematics

1. Notions of algebra 1.1. Lot of numbers and algebraic structures

1.2. Vector spaces. Operations with vectors

1.3. Matrix calculation

1.4. Determinants

1.5. Eigenvalues and eigenvectors

2. Real basic functions

2.1. Real basic common features.

2.2. Limits, continuity, differentiability

2.3. Taylor's formula

2.4. The study of a real function in one real variable

3. Series

3.1. Strings and series

3.2. Numerical series

3.3. Series of functions

3.4. Fourier series

4. Integral calculus

4.1. Primitives

4.2. Fully defined

4.3. Improper integral

5. Differential Equations 5.1. Differential Equations of first order

5.2. Differential equations of higher order

3 h

3 h

4 h

4 h

4 h

http://www.farma.umfcluj.ro/depts/MI/index.html

19

5.3. Differential equations with restrictions

6. Real functions with more than one real variable

6.1. Multidimensional spaces

6.2. Defining the real functions of several real variables

6.3. Expanding notions of limit, continuity, differentiability for functions with

several variables.

6.4. Differentials

6.5. Description of areas by function of several variables

6.6. Applications. The smallest square method. Propagation of errors

7. Numerical Methods

7.1. The approximate calculation of derivatives

7.2. The approximate calculation of defined integrals

7.3. Methods of interpolation

7.4. Numerical solving of equations

8. Mathematical modelling and simulation

8.1. The construction of a mathematical model

8.2. Classical mathematical models

8.3. The relationship model - reality. The accuracy of models

8.4. Simulation

Biostatistics 2

nd SEMESTER

1. Probabilities

1.1. Events. Classical formula of probability

1.2. Total and conditioned probabilities

1.3. Bayes' theorem

1.4. Discrete random variable

1.5. Continuous random variable

2. Laws of random variables distribution

Bernoulli distribution

Binomial distribution

Poisson distribution

Uniform distribution

Normal distribution

3. Sampling

Statistic population and sample

Methods of sampling

The sampling size

Representative samples

4. Descriptive Statistics 4.1. Organization of statistical data

4.2. Indicators of centrality

4.3. Indicators of variation

4.4. Characterization of common distributions

5. Estimates 5.1. Estimator

5.2. Method of maximum likelihood

5.3. Bayesian forecast

5.4. MCMC method (Markov chain Monte-Carlo)

6. Correlation and regression 6.1. Parametric correlation

6.2. Partial correlation

4 h

4 h

2 h

1 h

1 h

2 h

2 h

2 h

2 h

20

6.3. Regression Analysis

6.4. Multiple regression

6.5. Prediction by regression functions

7. Testing of statistical hypothesis

7.1. Tests for comparing a group with the reference values

7.2. Tests for comparing two groups of pairs

7.3. Tests for comparing two independent groups

7.4. Tests for comparing more than two groups

8. Nonparametric methods

8.1. Nonparametric tests for comparing groups pairs

8.2. Nonparametric tests for comparing independent groups

8.3. Nonparametric tests for comparing more than two group

8.4. Nonparametric Correlation

9. Statistical methods for intensive calculation

9.1. Bootstrap re-sampling

9.2. Jackknife re-sampling

9.3. Cross-Validation

2 h

1 h

1 h


1st SEMESTER

Implementation using Excel mathematical functions package of mathematical

problems specific for the following chapters

1. Notions of algebra

2. Real basic functions

3. Series

4. Integral calculus

5. Differential Equations

6. Real functions with more than one real variable

7. Numerical Methods

8. Mathematical modelling and simulation

2nd

SEMESTER Implementation using Excel statistical functions package of statistical calculations

specific for the following chapters

1. Probabilities

2. Laws of random variables distribution

3. Sampling

4. Descriptive Statistics

5. Estimates

6. Correlation and regression

7. Testing of statistical hypothesis

8. Nonparametric methods

9. Statistical methods for intensive calculation

3 h

4 h

4 h

4 h

4 h

3 h

3 h

3 h

3 h

4 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

References

1. R. Trimbitas, Metode Statistice, Presa Universitara Clujeana, 2000

2. S. Benazeth, Biomathematique et Biostatistique, Mason, Paris, 2002

3. R. Cimpean, A. Prodan, Biomatematica, aplicatii in Excel

21

CHAIR OF MATHEMATICS AND INFORMATICS

COURSE TITILE – General informatics


To acquire the essential IT skills for computer use in pharmacy.

PREREQUISITE – general knowledge of informatics at high school level

TEACHING METHODS

PowerPoint presentations, Conversations

Laboratory works, Exercises, Applied experiments, Case studies.

Projects

Computer based modelling and simulation

EVALUATION METHODS

Periodic evaluation

Project evaluation

Electronic portfolios

Final exam

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



GENERAL INFORMATICS

COURSE SYLLABUS

1st SEMESTER

1. Introduction

General information about computers. Hardware and software. Operating

systems and applications. GUI (Graphical User Interface).

Computers network. Internet.

Internet services (e-mail, FTP, World Wide Web, telnet).

Microsoft Office: Word, Excel, PowerPoint, Outlook, FrontPage, Access.

Text Processor for pure text: Notepad. Formatted text.

2. Text Processor Word

Word document. Creation and management.

Character formatting (font, font size, font style, colour, etc.).

Text formatting (alignment, spacing and indentation).

Bullets and numbering.

Arranging a text on columns.

Tab stops.

Tables.

3. Excel

Excel documents. Working with spreadsheets in workbook.

Working with formulae and functions in Excel l.

Relative and absolute addresses

Making graphics associated with spreadsheets.

Databases in Excel

Subtotals in Excel.

Pivot tables and pivot charts.

1 h

2 h

2 h

22

External references in Excel.

Statistical processing in Excel.

4. PowerPoint

Presentations.

Creation and management of a presentation.

Creation of new slides.

Insert images and other objects. Animation.

Print of a presentation.

Visualization of a presentation.

Reordering of the slides in a presentation.

5. Databases in Access

6. FrontPage

Creating a Web page using FrontPage.

Inserting hyperlinks.

Adding images and other objects.

7. Resources on Internet

8. Revision

2 h

2 h

2 h

2 h

1 h


1st SEMESTER

1. General information about computers. Hardware and software. Operating

systems and applications. GUI (Graphical User Interface). Internet services (e-

mail, FTP, World Wide Web, telnet).

2. Text Processor Word

3. Excel

4. PowerPoint

5. Databases in Access

6. FrontPage

7. Resources on Internet

8. Revision

3 h

4 h

4 h

4 h

4 h

3 h

3 h

3 h

References

1. Mihai Prodan, Augustin Prodan – Microsoft Office XP pas cu pas, Editura Albastra

(Microinformatica Group), Cluj-Napoca, 2002, ISBN 973-650-080-2.

2. A. Prodan, F. Gorunescu, M. Gorunescu – Excel, Access si Pagini Web, Editura Albastra

(Microinformatica Group), Cluj-Napoca, 2006, ISBN 973-650-190-6.

3. Mădălina Rusu, Augustin Prodan – Informatică generală pentru studenţii Facultăţii de

Farmacie, Editura Clusium, Cluj-Napoca, 2005, ISBN 973-555-489-5.

4. Remus Câmpean, Augustin Prodan – Biomatematică, Aplicaţii în Excel, Ed. Medicală

Universitară Iuliu Haţieganu, Cluj-Napoca, 2003, ISBN 973-693-016-5.

23

CHAIR OF PHARMACEUTICAL LEGISLATION

COURSE TITILE – Introduction to pharmaceutical technology and legislation (IPhTL)

COURSE OBJECTIVES

The aim of the course is the initiation of the students in the pharmaceutical science, for the first

year practice in pharmacy. The objectives of the course are to teach the students the

introductory pharmaceutical notions and to help them to understand the importance of

pharmaceutical profession.

PREREQUISITE – general high school knowledge

TEACHING METHODS Lectures with PowerPoint presentations

The students receive the course support on the paper or in electronic format.

EVALUATION METHODS

Writing examination: multiple choice questions

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


INTRODUCTION TO PHARMACEUTICAL TECHNOLOGY AND

LEGISLATION (IPHTL) COURSE SYLLABUS

1. Definition of the discipline, objectives, importance for the first year students

2. Definition of pharmacy: profession, societies.

3. Exercise of pharmacy: the law, the code of ethics.

4. Pharmaceutical societies and activities of the pharmacist

5. Medicine: definition, classification, compounds.

6. Prescription: definition, parts, types of medical prescriptions.

7. The relationship between pharmacist and patient: communication, services.

2 h

2 h

2 h

2 h

2 h

2 h

2 h

References

1. Aiache J.M., Initiation à la connaissance du médicament, Lavoisier, 1986, 2001

2. Appelbe G.E, Wingfield J., Pharmacy Law and Ethics, The Pharmaceutical Press, London

1997;

3. Belon J.-P., Conseil à l’officine, Masson, Paris, 2000;

5. Code de la Santé Publique, www.legifrance.gouv.fr;

6. Codul deontologic al farmacistului, Monitorul Oficial al României nr. 490/2009;

4. Kelly W., Pharmacy. What it is and how it Works, CRC Press Pharmacy Education Series,

2002;

7. Legea nr. 95/2006 privind reforma în domeniul sănătăţii, Monitorul Oficial al României nr.

372/2006.

http://www.legifrance.gouv.fr/

24

CHAIR OF MODERN AND APPLIED LANGUAGES

COURSE TITLE – A Practical Course in Romanian (for foreign students) for Pharmacy

COURSE OBJECTIVES

The practical course is aimed at ensuring the acquisition of modern language knowledge and

skills that students may use both in a general as well as in a specialised context related to

their future profession.

The main objective is the development of specific communication skills. Specific objectives

include:

- The development of writing skills through the analysis of text rhetoric (scientific research

articles, summaries, course books, popular science and non-specialist articles), through

employing lexical, morphological and discourse analysis elements as well as through the

identification of text structure and conventional format.

- The development of the other three basic language skills: reading (active and intensive

reading of specialized texts, developing reading speed), oral communication (situational

communication, case presentations, conversation on professional topics, paper and poster

presentations), and listening (understanding and making use of the information in a spoken

text).

Through pair work or group work activities, the practical course also contributes to the

development of the students’ teamwork skills.

PREREQUISITE: none

TEACHING METHODS

Communicative method

Integration of the four basic language skills

EVALUATION METHODS

Written and oral examination (representing 25%+25%=50% of the final mark), class activity,

including portfolio, essay, Curriculum Vitae, formal letters (representing 50% of the final mark)

TEACHING LANGUAGE

English/Romanian

NUMBER OF HOURS

Seminaries – 56 hours (28/28)

ROMANIAN LANGUAGE COURSE SYLLABUS

Reading skills

1. Dividing a text into paragraphs, skimming in order to extract

the main idea(s), scanning for specific information,

summarizing parts of a text

2 hours

2. Skimming for summarizing. Scanning long and difficult texts.

2 hours

3. Rearranging paragraphs according to internal logic

2 hours

Writing skills

1. Completing forms.

2 hours

2. Describing people. Describing objects and their use

2 hours

3. Linking words (Connectors).

2 hours

4. Reconstructing sentences and paragraphs based on discourse logic

6 h

14 h

25

2 hours

5. Presenting pros and cons on a given topic

2 hours

6. Writing formal and informal letters. Writing a Curriculum Vitae (resume)

2 hours

7. Narratives

2 hours

Listening skills

1. Listening for specific information. Listening and information

Transfer (in written form, in diagrams).

2 hours

2. Listening for gist. Understanding a lecture or a conference. Note taking.

2 hours

3. Facts and opinions. Comparing information from different sources.

2 hours

4. Intensive listening.

2 hours

Speaking skills

1. Advantages and disadvantages. Expressing agreement or disagreement;

Explaining.

2 hours

2. Oral presentation skills.

2 hours

3. Giving instructions.

2 hours

4. Structure of the pharmacist-client dialogue.

2 hours

5. Role-play.

2 hours

8 h

14 h

References

1. Bejan, D., Gramatica limbii romane, editia a III-a, Ed. Echinox, Cluj, 2001

2. Brancus, G., Ionescu Adriana, Saramandu Mariana, Limba Romana. Manual pentru

studentii straini, editia a IV-a, Ed. Universitatii din Bucuresti, 1996

3. Pop, Liana, Romana cu sau fara profesor, editia a V-a, Ed. Echinox, Cluj, 2003

4. Dorobat, A., Fotea, M., Limba romana de baza, Ed. Institutul European, Iasi, 1999

26

CHAIR OF SPORT

COURSE TITLE – Sport

COURSE OBJECTIVES

To maintain an optimum physical condition.

To contribute to growing process and to favour a normal physical development.

To develop basic motrice qualities as well as specific qualities necessary for different sports.

To correctly form a development system and motrice principles (basic and used in certain sport

disciplines).

To develop the skills needed to acquire a systematic practice of physical exercises, as a

component of a healthy life-style.

To prevent and correct deficient attitudes and to recover after traumatic sequels following

certain illnesses.

To develop qualities and voluntary and moral characteristics and to stimulate the esthetical

sense and social responsibilities.

PREREQUISITE -

TEACHING METHODS

Physical exercises

EVALUATION METHODS

Practical examination

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS

Practicals: 56 hours (28/28)

SPORT Perform several practical activities necessary for the consolidation of technical and tactical

precepts specific for individual and collective sports.

Perform practical activities necessary for the development of basic motrice qualities.

Perform specific activities necessary for a systematic individual practice of physical activities.

Diversify physical education and sport activities according to students’ choice and to

individual biometric configuration (individual physical condition).

Exercises for the development of motrice qualities: force detente, suppleness, speed,

resistance, coordination skills.

Exercises for the prevention of deficient attitudes or organic deficiencies due to the specificity

of professional activity.

Exercises for learning technical gymnastic and athletisme elements.

Initiation in the practice of a game: basket, badminton, football, volley-ball, tennis, table

tennis.

Massage and self-massage gestures.

Theoretical and practical elements for physical self-education.

Aerobics.

Fitness.

Jogging.

27

CHAIR OF MEDICAL DEVICES

COURSE TITLE – Summer practice for the 1st year students in pharmacy

OBJECTIVES OF THE PRACTICE

initiation work in a pharmacy (community pharmacy, hospital pharmacy)

knowledge of pharmacy organization

understanding the role, responsibility and obligations of the pharmaceutical profession

PREREQUISITE - IPhTL, Botany, Chemistry

TEACHING METHODS

The application of theoretical knowledge acquired during the first year in pharmacy practice, under

the coordination, monitoring and verification of a pharmacist as tutor

Explanations, discussions, analysis on how to solve professional problems

EVALUATION METHODS

Characterization of student’s work by the tutoring pharmacist regarding:

1. Frequency

2. Compliance with internal regulation

3. Involvement in the pharmacy activity

4. The attitude towards the staff in the pharmacy

Filling the practice notebook

Oral exam

TEACHING LANGUAGE

Romanian language

French and English language for foreign students that perform the traineeship in their own

country

NUMNER OF HOURS

30 hours / week - 2 weeks (0/60)

SUMMER PRACTICE FOR THE 1ST

YEAR STUDENTS IN PHARMACY

SYLLABUS 1. Designation of the workplace: location, plan, the destination of each room.

2. Laboratory glassware, tools, packaging: description, use and maintenance.

3. The basic operations of pharmacy practice: weighing, measuring, spraying, homogenization.

4. Performing division of some pharmaceutical specialties.

5. Knowledge of medicinal herbal teas: composition, therapeutic use.

* 30 hours /week – 2 weeks

References

1. Farmacopeea română, Ed. X, Editura Medicală, Bucureşti, 1993

2. Nomenclatorul de medicamente şi produse medicamentoase de uz uman, Agenţia Naţională

a Medicamentului, Bucureşti, 2008

3. Agenda medicală, Editura Medicală, Bucureşti, 2008

4. Memomed, Editura Minesan, Bucureşti, 2008

28


ANALYSIS

COURSE TITLE – Quantitative analytical chemistry


Principles of quantitative analytical chemistry. Errors in quantitative analysis.

Methods of quantitative analysis.

PREREQUISITE - General and inorganic Chemistry, Organic Chemistry, Qualitative analytical

chemistry, Physics, Statistics

TEACHING METHODS



EVALUATION METHODS

Periodical oral and written tests



Romanian language

French language

English language

NUMBER OF HOURS



QUANTITATIVE ANALYTICAL CHEMISTRY

COURSE SYLLABUS 1. Introduction. Quantitative Analysis and Its Problems

2. Taking Samples for Analysis

3. Dissolving the Sample

4. Presenting the Analytical Results

5. General issues in volumetric analysis

6. Acid-Basic Volumetry in Aqueous Medium

7. Acid-Basic Volumetry in Non-Aqueous Medium

8. Redox Volumetry

9. Volumetry by Precipitation Reactions

10. Complexonometry

11. Other methods (Nitritometry, Mercurimetry)

12. Gravimetric Methods

2 h

2 h

2 h

2 h

4 h

2 h

4 h

2 h

1 h

2 h

1 h

4 h


1. Titration exercises; weighing by analytical balance; preparation and titration of

0.1 N volumetric solutions ((NaOH; HCl; KMnO4; Na2S2O3; I2; KBrO3;

K2Cr2O7; AgNO3; NH4SCN; Hg(NO3)2; Complexon III),

2. Protometric methods used for pharmaceutical and biomedical analysis in

aqueous media (strong acids, acetylsalicylic acid, boric acid, glycocol, strong

basis, NH3, NaHCO3 and non aqueous media (medinal with HClO4 in acetic

acid, veronal with sodium methoxide in methanol-benzene)

3. Redoxometric methods for pharmaceutical and biomedical analysis (alkaline

oxalates, reduced Fe, H2O2, alkaline bromates, Cu, ascorbic acid, HIN, thymole,

iodine, Fe(II)

4. Argentometric titration of chloride (Mohr method), bromide (Volhard method)

and iodide (Fajans method)

6 h

6 h

12 h

6 h

29

5. Mercurymetric determination of chloride and iodide (Cl-, I

-).

6. Nitritometric determination of p-aminobenzoic acid.

7. Complexonometric determination of Bi(III), Mg(II), Ca(II), Fe(III) and Ni(II);

determination of water hardness.

8. Complex samples determination without separation of components (Bi; Ca; Mg

– complexonometry, I2; KI – iodometry and argentometry),

9. General principles in gravimetric analysis. Gravimetric determination of Fe2+

from Mohr salt

3 h

3 h

6 h

References

1. L.Roman, R.Săndulescu, Chimie Analitică vol 2. – Analiza Chimică Cantitativă E.D.P,

Bucureşti, 1999;

2. L.Roman, M.Bojiţă, R.Săndulescu, Daniela Muntean, Validarea metodelor analitice,

Editura Medicală, Bucureşti, 2007;


Masson, Paris, 1976;



édition, Masson, Paris, 1999 ;

5. M. Hamon, F. Pellerin, M. Guernet, G. Mahuzier, Abrégé de chimie analytique, tome 3,

Méthodes spectrales et analyse organique, 2eme

édition, Masson, Paris, 1990

30


ANALYSIS

COURSE TITLE – Separation methods and instrumental analysis

COURSE AND PRACTICAL LESSON OBJECTIVES

Separation methods frequently used in chemical analysis, Instrumental methods of analysis,

Method validation

Main separation and instrumental methods applied in pharmaceutical and biomedical analysis

PREREQUISITE – General and inorganic chemistry, Organic chemistry, Qualitative and

quantitative analytical chemistry, Physics, Statistics

TEACHING METHODS



EVALUATION METHODS

Periodical oral and written tests



Romanian language

French language

English language

NUMBER OF HOURS



SEPARATION METHODS AND INSTRUMENTAL ANALYSIS

COURSE SYLLABUS 1. Introduction

2. Problems in Trace Analysis

3. Contamination of Samples and Loosing of Some Components

4. Chromatographic Methods of Analysis

5. Electroanalytical Methods

6. Optical Methods of Analysis

7. Mass Spectrophotometry

8. Nuclear Magnetic Resonance, EPR

9. Hyphenated Methods

10. Validation of Analytical Methods

2 h

2 h

2 h

8 h

4 h

4 h

2 h

1 h

1 h

2 h

PRACTICAL LESSONS SYLLABUS 1. Determination by extraction and TLC of some metallic dithizonates

2. Separation and identification by TLC of some mixtures of anions and indicators

3. Separation and identification by paper chromatography of some mixtures of

cations and thioureea derivatives

4. Separation by ion exchange chromatography on column, at normal pressure of a

cation mixture

5. Electrophoresis separation on paper of some cation mixtures

6. Colorimetric and potentiometric determination of pH

7. Potentiometric determination of strong bases with strong acids

8. Conductometric titration of weak and strong acids with strong bases

9. Conductometric titration of barium by precipitation reactions

10. Voltamperometric determination of ascorbic acid, Ferrous/ferric cyanide system

study by cyclic voltammetry

3 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

31

11. Photocolorimetric determination of Fe (II) with o-phenantroline

12. Spectrophotometric determination in ultraviolet light of ephedrine hydrochloride

13. Spectrophotometric determination in the visible light of some binary mixtures

(KMnO4 and K2Cr2O7)

14. HPLC separation of some caffeine, theobromine and theophylline mixtures

3 h

3 h

3 h

3 h

References

1. L.Roman, R.Săndulescu, Chimie Analitică vol 3. – Analiza Chimică Cantitativă E.D.P,

Bucureşti, 1999;

2. L.Roman, M.Bojiţă, R.Săndulescu, Daniela Muntean, Validarea metodelor analitice,

Editura Medicală, Bucureşti, 2007;


Masson, Paris, 1976;



édition, Masson, Paris, 1999;

5. M. Hamon, F. Pellerin, M. Guernet, G. Mahuzier, Abrégé de chimie analytique, tome 3,

Méthodes spectrales et analyse organique, 2eme

édition, Masson, Paris, 1990

6. Douglas A. Skoog, F. James Holler, Timothy A. Nieman, Principes d'analyse

instrumentale, Ière

Edition, Ed. De Boeck, 2004

32

CHAIR OF ORGANIC CHEMISTRY

COURSE TITLE – Organic chemistry


Course:

Acquiring organic chemistry knowledge necessary for learning and understanding informations

taught in speciality disciplines

Formation for a logical manner of thinking, based on analysis and synthesis

Practical lessons:

Acquiring knowledge and practical skills useful for the activity in other laboratories as well as

for the practical activity of future pharmacists

Understanding the relationship between the structure of a compound and its properties and the

chemical activity

Highlighting the importance of organic synthesis in obtaining bioactive compounds with

pharmaceutical importance.

PREREQUISITE

Theoretical knowledge of organic chemistry form high school regarding the nomenclature,

structure, synthesis methods and properties of the main classes of organic compounds;

Theoretical and practical knowledge acquired during practical lessons and courses during the

first year of faculty.

TEACHING METHODS

Interactive lectures;

Practical activity in the laboratory;

Discussions based on theoretical knowledge with the aim of solving practical problems.

EVALUATION METHODS

Practical exam;

Theoretical exam;

Evaluation of the practical lessons notes;

Evaluation of the theoretical and practical knowledge during the semester

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



ORGANIC CHEMISTRY COURSE SYLLABUS

1st SEMESTER

1. General organic chemistry The aim and the development of organic chemistry as a science and its

importance for pharmacy

Structure of organic compounds: constitutional isomers and stereoisomers

Structure of organic compounds: the influence between atoms in the molecule,

electronic effects.

Acids and bases in organic chemistry

Organic reactions, reaction mechanisms, intermediates of reaction, factors

influencing reaction rates, the role of solvent and catalysts in organic reactions

Relations between structure and physical properties of organic compounds

Nomenclature of organic compounds, nomenclature of compounds of

pharmaceutical interests

9 h

33

2. Saturated, unsaturated and aromatic hydrocarbons

3. Organic compounds with simple functional groups Halogenated compounds

Organometallic compounds

Alcohols, enols, phenols, ethers and inorganic esters

Organic compounds with sulphur

2nd

SEMESTER

1. Organic compounds with simple functional groups Aldehydes and cetones

Carboxylic acids and carboxylic acid derivatives: acyl halides, acid anhydrides,

esters, amides, hydrazides, nitriles

Organic compounds with nitrogen: nitroderivatives, nitrozoderivatives, amines,

hydrazinoderivatives, quaternary ammonium salts, diazoderivatives

2. Organic compounds with mixed functions Halogenoalcohols

Hydroxycarboxylic acids, aldehydoacids and ketoacids

Hydroxyaldehydes and hydroxyketones

Saccharides

Amino alcohols

Amino acids, peptides, proteins

3. Isoprenoids: terpens and terpenoids, carotenoids, steroids

4. Heterocyclic compounds

General, nomenclature

Heterocyclic compounds with five atom rings

Heterocyclic compounds with six and seven atom rings

Heterocyclic compounds. Bicyclic and polycyclic systems

9 h

24 h

21 h

9 h

2 h

10 h


1st SEMESTER

1. Isolations and purification methods for organic liquid and solid

compounds

2. Qualitative and quantitative elemental organic analysis

Qualitative elemental organic analysis

Quantitative elemental organic analysis

3. Synthesis methods and functional analysis for the most important functional

groups

Unsaturated hydrocarbons

Aromatic hydrocarbons

Halogenated compounds

Organic compounds with hydroxylic groups: monohydroxylic and

polyhydroxylic, énols, phenols

Thiols

Aldehydes and ketones

2nd

SEMESTER

1. Synthesis methods and functional analysis for the most important functional

groups

Carboxylic acids and carboxylic derivatives

Amines

Diazonium salts

Organic bifunctional compounds: saccharides, aminoacides

Heterocycles

2. Elemental and functional analysis for some unknown samples

6 h

6 h

30 h

27 h

15 h

34

Observation: The aim of laboratory practice is to introduce functional groups in a

molecule. The compounds obtained are isolated and purified, than they are identified

by chemical reactions and by spectral methods (IR, UV-VIS, NMR, MS). We also

study the identification reactions and characterisation for the most important

functional groups in organic chemistry.

References for the course

1. I. Simiti, Compuşi heterociclici 1984, Litografia U.M.F. Cluj-Napoca

2. C. D. Neniţescu, Chimie organică I şi II Ed. Did. şi Ped. Bucureşti, 1980

3. T.W.G. Solomons, Organic Chemistry, 6th

edition, John Willey and sons, 1996

4. M. Miocque, C. Combet Farnoux, H. Moskowitz, Chimie organique, Tom 1, Masson,

Paris, Milan, Barcelona, 5e édition, 1999

5. M. Miocque, C. Combet Farnoux, H. Moskowitz, Chimie organique, Tom 2, Masson,

Paris, Milan, Barcelona, 3e édition, 1990

6. I. Simiti, V. Zaharia, Produşi naturali, Ed. Dacia, Cluj-Napoca, 1996

7. I. Simiti, V.Zaharia, Ana Mureşan, O. Crişan, Produşi naturali heterociclici, Ed. Dacia,

Cluj-Napoca, 1998

References for practicals

1. V. Zaharia, Chimie organică experimentală, vol. 1, Editura Medicală Universitară „Iuliu

Haţieganu”, Cluj-Napoca, 2003

2. V. Zaharia, Chimie organique expérimentale, vol. 1, Editura Medicală Universitară „Iuliu


3. O. Crişan, Adriana Ignat, Synthèse organique de laboratoire, Editura Medicală

Universitară “Iuliu Haţieganu” Cluj-Napoca, 2007

4. S. Mager, Adriana Donea, I. Hopârtean, A. Benko: Lucrări practice de Chimie organică,

vol. I, Universitatea Babeş-Bolyai, Facultatea de Chimie şi Chimie Industrială, 1990

5. S. Mager, Adriana Donea, I. Hopârtean, A. Benko: Lucrări practice de Chimie organică,

vol. II, Universitatea Babeş-Bolyai, Facultatea de Chimie şi Chimie industrială, 1991

6. S. Mager: Analiza structurală organică, Ed. Stiinţifică şi Enciclopedică, Bucureşti, 1979

7. Margareta Avram, Gh. Mateescu: Spectroscopia în infraroşu. Aplicaţii în Chimia

Organică, Bucureşti, 1966

8. I. Pogany, M. Banciu: Metode fizice în Chimia organică, Ed. Stiinţifică, Bucureşti, 1972

9. Heinz Becker and colab.: Organicum, Berlin, 1978 (Traducere Bucureşti 1982)

10. Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory, Third

Edition, John Witley and Sons, 1994

35

CHAIR OF PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL

LABORATORY

COURSE TITLE – Pharmaceutical biochemistry and clinical laboratory


Accumulation of theoretical and practical knowledge indispensable for the bio-medical

formation of the pharmacist; deciphering of the molecular bases necessary for studying the drug

(action, prospecting, drug-design).

PREREQUISITE - organic and analytical chemistry, anatomy, physiology, cell biology, genetics

TEACHING METHODS

Interactive courses (specially during the 2nd

sem.) based on video projection (animated Power

Point)

EVALUATION METHODS

seminars, essays

Practical and written exams at the end of each term.

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE SYLLABUS

1. Introduction in the study of biochemistry. Object of the discipline, modern

aspects. Significance for pharmaceutical teaching curricula. Chemical

composition of bio-systems.

2. Nucleotides. Nucleosides and nucleotides, structure and role.

3. Vitamins. General aspects. Hydro- and liposoluble vitamins: structure,

sources, absorption, circulation, distribution, bio-transformations, elimination,

biochemical role, antagonists, deficiency characteristics, therapeutic

implications, toxicity.

4. Proteins: structure and function. Amino-acids. Peptides. Structural and

functional diversity of proteins. Isolation, sequence and purification. Primary

structure, methods of study, biological significance. Peptide synthesis by

biotechnology and chemical methods, importance concerning the drug. Three-

dimensional structure: models of secondary and tertiary structure, notion of

domain (levels of structure in protein architecture). Fibrous proteins: collagen

fibrils, structure and biosynthesis. Quaternary structure. Immunoglobulins,

structure, function, utility in immunochemistry. The denaturation phenomenon.

Determinism of three-dimensional structure, functional consequences. Superior

levels of organization.

5. Enzymes. Definition, nomenclature, classification. Structural properties:

catalytic centre. Organic enzymatic cofactors. Role of metals in enzymatic

catalysis. Molecular mechanism of action. Specificity of enzymatic catalysis.

Kinetic properties. Enzyme inhibitors, significance in pharmacotherapy.

Turnover and activity regulation. Allosteric enzymes. Regulation by covalent

modulations. Biomedical importance, enzymatic diagnostic, isoenzymes.

Implications concerning drugs, enzymotherapy.

1 h

2 h

13 h

6 h

6 h

36


1. Preparation of biological material in the view of biochemical analysis. Factors

affecting laboratory results.

2. Methods for identification and quantitative determination of vitamins.

3. Methods for protein purification. Gel-filtration; chromatography of affinity. Ion-

exchange chromatography.

4. Colour and precipitation reactions for amino-acids and proteins in analytical

qualitative and quantitative biochemistry, applications in clinical laboratory. Amino-

acids and proteins as buffer systems.

5. Enzymes. General standards in enzymatic quantitative determinations.

Possibilities to express the enzymatic activity. Determination of specific activity.

Factors that affect the rate of enzymatic reactions. Experimental determination of

kinetic parameters of Michaelian enzymes. Quantitative evaluation of inhibition.

Coupled systems in analytical biochemistry.

6. Enzymatic diagnostic, value and limitations. Isoenzymes.

7. Cellular fractioning, marker components. Drug enzymatic induction.

8. Exam

3 h

6 h

6 h

9 h

9 h

3 h

3 h

3 h

References

1. Cornelia Ţărmure, Biochimie structurală şi metabolică, vol I, Ed. Dacia, Cluj-Napoca,

1996.

2. Ileana Olteanu, Biochimie descriptivă, Ed. Med. Universitară "Iuliu Haţieganu", Cluj-

Napoca, 2001.

3. Ileana Olteanu, Gheorghe Jebeleanu, Biochimie metabolică, Ed. Med. Universitară "Iuliu

Haţieganu", Cluj-Napoca, 2002.

4. Ileana Olteanu, Vitamine şi coenzime, Ed. Med. Universitară "Iuliu Haţieganu", Cluj-

Napoca, 1994.

5. Luminiţa Diaconescu, Cristina Drugan, Gheorghe Jebeleanu, Biochimie metabolică, Ed.

Srima, 2001.

6. Maria Dronca, Enzime, cofactori enzimatici, Ed. Med. Universitară "Iuliu Haţieganu",

Cluj-Napoca, 2002.

7. Mathews, CK, van Holde, KE, Ahren, KG, Biochemistry, 3rd Ed. An Imprint of Addison

Weslez Longman, Inc., Harlow, England, 1999.

8. Zubay, GL., Parson, WW., Vance, DE., Principles of Biochemistry, W.C. Brown

Publishers, Oxford, England, 1995.

9. Christian Moussard, Biochimie structurale et metabolique. Medecine, pharmacie,

sciences, 2eme

edition, DeBoeck, 2002.

10. Ileana Olteanu, Gh. Jebeleanu, Teste biochimie, Ed. Med. Univ. "Iuliu Haţieganu", Cluj-

Napoca, 2000.

11. John W. Baznes, Marek H. Dominiczak, Medical biochemistry, Second edition, Elsevier,

2005.

12. Corina Ionescu, Roxana Lucaciu, Căi fundamentale în metabolismul uman, Ed. Med.

Univ. "Iuliu Haţieganu", Cluj-Napoca, 2008.

13. Roxana Lucaciu, Corina Ionescu, Noţiuni de biochimie clinică, Ed. Risoprint, Cluj-

Napoca, 2008.

14. Niculina Mitrea, Denisa Margina, Andreea Arsene et all, Biochimie: Vitaminele în

procesele metabolice, Ed. Didactică şi Pedagogică S.A., Bucureşti, 2008.

37

CHAIR OF PHYSICAL CHEMISTRY

COURSE TITLE – Physical chemistry


Students should acquire and be able to apply the principles and methods of physical chemistry

in different pharmaceutical disciplines.

PREREQUISITE – Knowledge of Physics, Biophysics and General chemistry

TEACHING METHODS

Lectures with PowerPoint presentations

Practicals

EVALUATION METHODS

Written, oral and practical exam at the end of each semester

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHYSICAL CHEMISTRY COURSE SYLLABUS

1. QUANTUM THEORY AND ATOMIC STRUCTURE The Wave Character of Particles and wave-particle dualism. The Schrödinger

Equation. Translational Motion. The Particle in a Box. Vibration Motion. Rotational

Motion. The Structure and Spectra of Hydrogen Atoms. Angular Momentum and

Magnetic Moment. Spin Quantum Number.

2. CHEMICAL BOND

The valence bond theory. The hydrogen molecule. Homonuclear diatomic

molecules. Polyatomic molecules. Chemical symmetry. Molecular orbitals theory.

3. SPECTROSCOPY

Emission and Absorption Spectra. Atomic Spectra. Pure Rotational Spectra

of Molecules. The Vibrations of Diatomic Molecules. The Vibrations of Polyatomic

Molecules. Vibration-Rotation Spectra. Raman Spectra. Electronic Spectra of

Molecules. Fluorescence and Phosphorescence. Laser Spectroscopy. Photoelectron

Spectroscopy. Photoacustic Spectroscopy. Nuclear Magnetic Resonance

Spectroscopy. Electron Spin Resonance Spectroscopy. Optical Rotatory Dispersion

(ORD) and Circular Dichroism (CD). The Solid State. Crystal Lattices. X-Ray

Crystallography. Experimental Methods. Theories and Models of Solids.

7. TRANSPORT PROPERTIES Viscosity. The measurement of the viscosity. Reology. Diffusion and Fick’s

Laws. Measurement of the diffusion coefficient. Sedimentation. Electrokinetic

Effects. Electroosmose and electrophoresis. Applications.

8. SURFACE CHEMISTRY AND COLLOIDS

Dispersed Systems. Classification of Dispersed Systems. Classification of

Colloidal Systems. Lyophilic, Lyophobic and Association Colloids. Optical

Properties of Colloids. The Faraday-Tyndall Effect. Electron Microscope. Light

Scattering. Kinetic Properties of Colloids. Brownian Motion Diffusion. Osmotic

Pressure. Sedimentation. Viscosity. Solid-Liquid Interfaces. The Electric Double

Layer. Electric Properties of Colloids. Electrokinetic Phenomena. Donnan

Membrane Equilibrium. Stability of Colloid Systems. DLVO Theory. Solubilization.

4 h

2 h

8 h

4 h

10 h

38

Thermodynamics of Solubilization. Micrometrics. Methods for Determining Particle

Size. Methods for Determining Surface Area. Determination of Rheologic

Properties. Suspensions. Interfacial Properties of Suspended Particles. Settling in

Suspensions. Physical Stability of Suspensions. Emulsions. Physical Stability of

Emulsions. Microemulsions. Adsorption. Adsorption Isotherms. Surface Tensions

and Capillarity. Polymers and their pharmaceutical applications.

The Sizes of Macromolecules. Molecular Sizes and Shapes. The Microstructure and

Shapes of Polymer Chains. Physical Properties of Solid Polymers.


1. Kinetic study of sacharosis hydrolysis in acidic medium

2. Kinetic study of tetracycline degradation in acidic medium

3. The hydrolysis of aspirin. Stability profile as a function of pH

4. Viscosity determination of dextran

5. Recognition of emulsions type and their inversion. The isoelectrical point of

proteins

6. Superficial tension and pharachorus. Critical micellar concentration

7. Adsorption isotherms. Acetic acid adsorption on active carbon

8. General aspects of spectroscopic methods

9. Deviations from Lambert-Beer’s law. The solvent effect on n-π* transition in CO

group

10. Application of Lambert-Beer’s law to determination of a binary mixture

11. Spectroscopic titration of I2 with Na2S2O3

12. Qualitative aspects of IR spectroscopy

13. Optical activity measurements

14. Practical exam

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

References

1. Peter Atkins, Julio de Paula, Physical Chemistry, Oxford University Press, 2002

2. Alexander T. Florence, David Attwood, Physicochemical Principles of Pharmacy,

Pharmaceutical Press, London, 2004

3. Richard M. Pashley, Marilyn E. Karaman, Applied Colloid and Surface Chemistry, John

Wiley & Sons, Ltd., 2004

4. A. Martin, J. Swarbrick, A. Cammarata, Physical Pharmacy-Physical Chemical Principles

in the Pharmaceutical sciences, Lea & Febiger, Philadelphia, 1983

5. Ludovic Kurunczi, Curs de Chimie Fizică şi Coloidală pentru farmacişti, Editura Mirton,

Timişoara, 2000

6. Emil Făgărăşan, Silvia Imre, Chimie Fizică experimentală, Editura Medicală Universitară

“Iuliu Haţieganu”, Cluj Napoca, 2005

7. Dan Rusu, Iuliu Marian, Chimie Fizică.Elemente de termodinamică şi structură, Editura

Casa Cărţii de Ştiinţă, Cluj Napoca, 2007

39

CHAIR OF PHARMACOLOGY, PHYSIOLOGY AND

PHYSIOPATHOLOGY

COURSE TITLE – Anatomy and general physiology


To acquire basic knowledge of anatomy and physiology essential for the study of speciality

disciplines, such as structural and functional aspects regarding cells, tissues, organ, system.

PREREQUISITE – high school level anatomy and physiology knowledge

TEACHING METHODS

Lectures and interactive discussions

Practicals

EVALUATION METHODS

Written and practical exam

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



ANATOMY AND GENERAL PHYSIOLOGY

COURSE SYLLABUS 1. Organization of human body. Levels of organization

2. The cell: structure, general and special properties

3. The tissues

4. The blood: composition, roles, haematopoiesis, red blood cells, blood groups,

leucocytes, immunity, platelets. Haemostasis. Coagulation, Fibrinolysis

5. The cardiovascular system.

6. The digestive system

7. The respiratory system

8. The autonomic nervous system: structure and functions

9. The central nervous system: structure and functions

10. The sensory organs

11. The endocrine system: the suprarenal gland-structure and functions

0.5 h

3 h

1 h

7.5 h

4 h

3 h

2 h

1 h

2 h

2 h

2 h


1. Organization of the human body. General presentation of internal organs,

main organ systems. Laboratory animal dissection.

2. The blood. Functional explorations: red blood cells counting, PCV

determination, haemoglobin identification, erythrocyte sedimentation rate

test, determination of blood groups in ABO and Rh system, physiological

haemostasis-bleeding time, coagulation time

3. The cardiovascular system. Functional explorations: determination of blood

pressure. The EKG interpretation

4. The digestive system. Functional explorations: enzymatic activity,

determination of biliary secretion, factors influencing biliary secretion

5. The renal system. Functional explorations: the urine examination, creatinine

clearance

6. The respiratory system. Functional explorations

7. The endocrine system. Functional explorations. Determination of normal

glycemia. The influence of insulin, glucagon and epinephrine on glycemia.

2 h

8 h

4 h

2 h

2 h

2 h

2 h

40

Hypoglycemic coma in laboratory animals

8. The sensory organs

9. The nervous system: structure. Autonomic nervous system. Influence of

adrenaline and acetylcholine on the heart functions

10. Alternative methods for physiology study: computer programs

2 h

2 h

2 h

References

1. Haulică I., Fiziologie umană, Ed. Medicală, Bucureşti, 1997.

2. Niculescu C., Cârmaciu R., Voiculescu B., Sălăvăstru C., Niţă C., Ciornei C., Anatomia şi

fiziologia omului, Ed. Corint, Bucureşti, 2001.

3. Tache S., Structura şi funcţiile organismului uman, Ed. Medicală Universitară «Iuliu

Haţieganu » Cluj-Napoca, 1999.

4. Herve Guenard et colab., Physiologie humaine, deuxieme edition, Ed. Pradel, 1996.

5. Sherwood L., Physiology humaine, Ed. DeBoeck Universite 2000

6. Ader J-L. et colab., Physiologie, Ed. Masson, 2003

7. Schmidt R.F., Physiologie, Ed. De Boeck Université, 1999.

41


PHYSIOPAHTOLOGY

COURSE TITLE – Physiopathology

COURSE OBJECTIVES

Acquiring fundamental concepts of physiopathology: fundamental defence mechanisms,

physiopathology of disease, physiopathology of electrolyte and metabolic disorders

PREREQUISITE – anatomy and physiology knowledge

TEACHING METHODS

Lectures and interactive discussions

EVALUATION METHODS

Written exam

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


PHYSIOPATHOLOGY

COURSE SYLLABUS 1. Fundamental defence mechanisms: inflammation, pain, thermoregulation,

haemostasis

2. Cardiovascular physiopathology: heart failure, arterial hypertension, cardiac

arrhythmias, ischemic heart diseases

3. Respiratory physiopathology: bronchial asthma, obstructive pulmonary diseases

4. Digestive physiopathology: Disorders of digestive secretions and motility

5. The physiopathology of carbohydrate metabolism, lipid metabolism, phosphor

and calcium metabolism, iron metabolism

4 h

4 h

1 h

1 h

4 h

References

1. Pleşca-Manea L., Patofiziologie, Ed. Medicală Universitară « Iuliu Haţieganu » Cluj-

Napoca, 1998.

2. Aramă Ş.S., Fiziopatologie, Ed. Cerma, Bucureşti 1999.

3. Dipiro J.T., Talbert R.L., Yee G.C., Matzke G.R., Wells B.G., Posey L.M.,

Pharmacotherapy, A Pathophysiologic Approach, Ed. Appleton&Lange 1999.

4. Page C.P., Curtis M.J., Sutter M.C., Walker M.J., Hoffman B.B., Pharmacologie intégrée,

Ed. DeBoeck Université, Paris, 1999.

5. Schorderet M., Pharmacologie, Des concepts fondamentaux aux applications

thérapeutiques, Ed. Frison-Roche-Slatkine, 1992, 69-81, 87-94.

42

CHAIR OF MICROBIOLOGY

COURSE TITLE – Microbiology, virology, parasitology


acquiring fundamental knowledge: bacteriology, virology, parasitology, mycology;

the knowledge of the main human pathogen genres and species;

the knowledge of drug contamination.

PREREQUISITE – genetics, biology, biochemistry

TEACHING METHODS

Course: Lectures with visual presentations

Practical works: Interactive programmed education. Microscopy practical individual studies for

isolation and identification of bacterial species, antibacterial testing

EVALUATION METHODS

Written and practical examination

Practical examination (theoretical knowledge and the practical abilities evaluation): the

percentage from the final mark: 20%

Theoretical examination (mcq): the percentage from the final mark, of 80%

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


Practical lessons– 28 hours (0/28)

MICROBIOLOGY, VIROLOGY, PARASITOLOGY COURSE SYLLABUS

1. General bacteriology

2. Bacterial morphology

3. Bacterial physiology

4. Bacterial genetics

5. Disinfectants and antiseptics

6. Chemotherapy

7. Infection and anti-infectious defence

8. Virology

9. Mycology. Parasitology

10. Microbiology of drugs

3 h

6 h

6 h

6 h

2 h

6 h

4 h

6 h

1 h

2 h


1. Isolation and identification of pathogenic bacteria and microorganisms from the

environment (water, air, soil, hospital environment, medical instruments), based

on their properties in culture

2. Laboratory diagnostic in infections produced by the main pathogens for humans

12 h

16 h

References

1. Doina Matinca – Microbiologie pentru studentii Facultatii de Farmacie, 1995

2. Doina Matinca, C. Hodarnau –Lucrari practice de microbiologie pentru studentii Facultatii

de Farmacie, 2003

3. Doina Matinca, Luciana Stanila – Cahier de travaux pratiques a l’usage des etudiants en

Medicine et Pharmacie, 2002

4. Luciana Stănilă – “Bacteriologie generale et virologie – a l’usage des etudiants en medicine,

medicine dentaire et pharmacie”; Ed. Med.Universitară „Iuliu Haţieganu”, Cluj-Napoca

5. Cristian Hodârnău, Cecilia Boboş. Microbiologie, Cahier de traveaux pratiques à l’usage

des étudiants en Pharmacie, Ed. Med. Univ. «Iuliu Haţieganu » 2006, Cluj Napoca,

43


COURSE TITLE – Cell and molecular biology


Accumulating knowledge regarding vegetal and animal cell organization and functions, cell

study methods, cell constituents and their biological role

PREREQUISITE – general biology at high school level

TEACHING METHODS

Course: Lectures with power point presentation

Laboratory: Experimental demonstrations and individual practice

EVALUATION METHODS

Evaluation of practical abilities and capacity of interpreting experimental data (20% from

final score)

Standard or MCQ (multiple choice questions) written exam (80% from final score)

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER FO HOURS



CELL AND MOLECULAR BIOLOGY

COURSE SYLLABUS

1. The importance of cell and molecular biology for the pharmaceutical training.

Recent developments in cell and molecular biology. Cell study techniques:

histological techniques, cytochemical, cytophysical methods, electron

microscopy.

2. Cell membranes: classification, biological and pharmaceutical role. Molecular

organization of biological membranes. Erythrocyte membrane. Lectins and

liposomes

3. Transport through membranes. Carrier and channel proteins. Active and passive

transport. Simple diffusion. Uniport, symport, antiport systems. Exocytosis,

endocytosis, transcytosis.

4. Cell junctions. Cell centre and functions of microtubules. Cytostatic agents.

5. Biological role of the nucleus. Molecular organization of DNA, RNA synthesis

(transcription), synthesis of proteins (translation), antibiotics inhibition. DNA

synthesis (replication)

6. Cell cycle. Antimitotic agents. Tumoral cell biology

4 h

6 h

4 h

4 h

8 h

2 h


1. Histological technique and microscopy slide preparation

2. In vitro cell and tissue culture techniques applied to medicinal plants

3. The analysis of active principles obtained from cell cultures

4. Cytochemical localisation of nuclear acids

5. The effect of colchicine on mitosis. Phytobiological test for cytostatic substances

6. Electron microscopy techniques and interpretation of EM images

4 h

2 h

2 h

2 h

2 h

2 h

References

1. Maillet M.: Biologie cellulaire, Masson Paris, 2000

44


COURSE TITLE – Pharmacogenetics


Accumulating knowledge regarding the molecular basis and techniques used in Technology of

ADN-recombinant and their applications in pharmaceutical industry.

PREREQUISITE – General genetics (high school level), cell biology knowledge

TEACHING METHODS

Course: Lecture with power point presentations (multimedia type)

Laboratory: Individual practice, virtual laboratory

EVALUATION METHODS

Evaluation of practical abilities and theoretical knowledge in laboratory (individual practical

activities and written test) at the end of semester (20% from final score)

Multiple choice questions (MCQ) test at the end of semester (80% from final score)

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACOGENETICS COURSE SYLLABUS

1. Gene

2. Nucleic acids: chemical structure and biological role of DNA

3. Nucleic acids: chemical structure and biological role of ARN

4. Genetic code. DNA replication

5. Technology of DNA-recombinant. Vectors of cloning

6. PCR – technique

7. Nucleic acids- techniques of analyses

8. DNA sequencing.

9. DNA Cloning

10. Restriction enzymes

11. Molecular biology - applications in pharmaceutical industry

12. Transgenic plants

13. Gene therapy

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

2 h


1. DNA structure; genetic code

2. The extraction and isolation of DNA

3. The agarose gel electrophoresis of DNA

4. Polymerase chain reaction (PCR)

5. Notion of Genomics- DNA chip (gene chip)

6. The genetic transformation of plants

7. Genetic disorders; Genetic therapy

2 h

2 h

2 h

2 h

2 h

2 h

2 h

References

1. J. Étienne, Biochimie génétique Biologie moléculaire, 6e édition, Masson, Paris, 2000

2. J.-L. Rossignol, Genetique, 4e édition , Masson, Paris, Milan, Barcelone, 1996

3. Dordea M., Coman N., Crăciunaş C., Andraş C., 2000, Genetică generală şi moleculară -

abordare practică – Ed. Presa Universitară Clujană, Cluj-Napoca, 78 p.

4. Cătană C., 2005, Biotehnologii celulare, Ed. Risoprint, Cluj-Napoca, 234-259.

45


COURSE TITLE – Medical devices

COURSE OBJECTIVES

As a health professional, future pharmacist must know the technical aspects related to medical

products and devices (raw materials: description, mode of use and maintenance), regulatory

issues (classification, labelling, conservation, marking in EU) and medical recommendations.

PREREQUISITE - Knowledge of physics, chemistry, anatomy.

TEACHING METHODS

Interactive lectures with PowerPoint presentations, discussions and explanations

Individual study and documentation

EVALUATION METHODS

Written exam, elaboration and presentation of reports an a given topic.

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


MEDICAL DEVICES

COURSE SYLLABUS

1. Importance of medical devices and products for pharmaceutical care: Legislation

of medical devices. Introduction. Definitions. Classification. Materio- vigilance.

2. Raw materials used for obtaining medical devices and products. Biomaterials.

Biocompatibility.

3. Sterilisation of medical devices and products. The concept and principles of

medical devices and products sterilization. Sterilization processes. Checking

sterility.

4. Devices used for parenteral drug administration. Syringes. Needles for syringes.

Instruments and apparatus for venous drug administration.

5. Medical devices used in surgery. Devices for surgical incision. Devices for

surgical suture.

6. Dressing materials. Skin injuries. Wound healing. Dressing’s characteristics.

Dressing’s classification. Types of dressings. Materials for dressing’s fixation.

7. Protection materials and equipments. Surgery masks. Medical gloves. Surgical

fields.

8. Medical devices for in vitro diagnostic (Self-testing devices). Devices used for

determining the temperature. Devices used to determine blood pressure. Devices

used for the determination of biochemical parameters.

9. Devices for sexual protection and birth control. Contraception through the

barrier methods. The intrauterine device.

10. Neo-natal care products

4 h

2 h

2 h

4 h

2 h

3 h

3 h

4 h

2 h

2 h

References

1. Simona Mirel, Flavius Neag Produse tehnico-medicale, Editura Medicală Universitară

“Iuliu Haţieganu” Cluj-Napoca, (ISBN 978-973-693-278-6), 2008

2. Roşca M. Produse Tehnico-Medicale. Tipografia UMF: Cluj-Napoca; 1996.

3. Roşca M. Produse Tehnico-Medicale. Tipografia UMF: Cluj-Napoca; 2001

4. GALTIER F. La stérilisation. Ed. Arnette Blackwell:Paris; 1996.

5. XXX. Les biomatériaux du futur. Ed. Becton-Dickinson; 1992

6. Blood pressure monitoring. [online] [2003] [citat 2007 iun 20]. Disponibil la: URL:

http://www.medphys.ucl.ac.uk/teaching/undergrad/projects/2003/group_03/index.html

46

CHAIR OF TOXICOLOGY

COURSE TITLE – Pharmaceutical terminology

COURSE AND SEMINARY OBJECTIVES

To acquire knowledge and to practice specific medical terms by activities such as: the correct

analysis of components of medical and pharmaceutical terms, by learning prefixes and suffixes

commonly used and their combinations with basic radicals, by the knowledge of the rules in the

formation of specific terms, the correct correlation between specific terms and their significance

or their medical and pharmaceutical purpose.

To learn the speciality terms in Romanian language and their use.

PREREQUISITE – knowledge of anatomy, physiology from high school, knowledge of analytical

chemistry, physical chemistry, inorganic chemistry, organic chemistry

TEACHING METHODS

Interactive lectures and seminaries

EVALUATION METHODS

Written exam

TEACHING LANGUAGE

English language

NUMBER OF HOURS

Course – 56 hours(28/28)

Seminary – 28 hours (14/14)

PHARMACEUTICAL TERMINOLOGY COURSE SYLLABUS

Istr

SEMESTER – MEDICAL TERMINOLOGY

1. Introduction in pharmaceutical terminology. The parts of a word. The

description of human body in Romanian language.

2. The general organisation of human body. The main radicals for human body.

3. Medical and pharmaceutical specialities.

4. Terms used for cells and tissues.

5. Terms used for locomotor system

6. Terms used in pneumology

7. Terms used in gastro-enterology

8. Terms used in cardiology and angiology

9. The hemato-lympoid system. Terms used in haematology and immunology.

10. Terms used in nephrology and urology.

11. Terms used in neurology and psychiatry.

12. Terms used in endocrinology.

13. Terms used in andrology and obstetrics-gynaecology.

14. Revision

IInd

SEMESTER – PHARMACEUTICAL TERMINOLOGY

1. The radicals, prefixes and suffixes frequently used to form pharmaceutical terms.

Romanian terms used to designate the main glass objects used in the laboratory.

2. Romanian terms used to designate the main porcelain objects, metal/alloy

objects, plastic and rubber objects used in the laboratory.

3. Installations used for the synthesis, extraction and purification of pharmaceutical

substances.

4. The periodical table of elements. Rules for formation of names of chemical

substances in Romanian language.

5. Terms used to describe the relation physician-patient-pharmacist.

6. Terms regarding the organisation of a pharmacy and the pharmaceutical

profession.

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

47

7. Terms used in modern criteria of drug classification. Abbreviations and symbols

used to name the drugs.

8. Terms used in pharmaceutical technology.

9. Terms and abbreviations used to write a prescription.

10. Terms used in industrial pharmaceutical technology. Terms used for the raw

materials of pharmaceutical use.

11. Terms used in biopharmacy and pharmacokinetics. Terms and abbreviations used

to define the main administration routes of drugs.

12. Terms used in biotechnology and in industrial synthesis of drug substances.

13. Terms used in drug analysis.

14. Revision

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

SEMINARY SYLLABUS

Itr SEMESTER – MEDICAL TERMINOLOGY

1. The unities of meaning. The construction of a word based on specifically

defined radicals. The identification of a word’s significance due to the operating

unit.

2. The 5 senses. Learning the main radicals for human body by exercises: word

construction, classification of words with the aid of operating unit, identification

of specific terms in scientific papers and explanation of their meaning.

3. Learning medical and pharmaceutical terms specific for certain medical and

pharmaceutical disciplines by exercises : word construction, classification of

words with the aid of operating unit, identification of specific terms in scientific

papers and explanation of their meaning, crossing words, exercises of

correspondence between the terms and their significance.

IInd

SEMESTER – PHARMACEUTICAL TERMINOLOGY

1. The construction of specific words for pharmacy based on defined radicals. The

identification of a word significance based on the operating unit.

2. Learning pharmaceutical terms specific for certain pharmaceutical specialities

by exercises: word construction, classification of words with the aid of operating

unit, identification of specific terms in scientific papers and explanation of their

meaning.

2 h

2 h

10 h

2 h

12 h

Bibliographie

1. Iuliana Popovici, Lăcrămioara Ochiuz, D. Lupuleasa – Terminologie medicală şi

farmaceutică, Editura Polirom, Bucureşti, 2007

2. J. Thieulle – Pratiques du mot médical. Cahier d’exercices, Editions Lamarre, Rueil-

Malmaison, 2002

3. B. Lacroix – Terminologie médicale. Méthode et activités, Editions Casteilla, Paris, 2000

48

CHAIR OF MODERN AND APPLIED LANGUAGES

COURSE TITLE – A Practical Course in Romanian (for foreign students) for Pharmacy

COURSE OBJECTIVES

The practical course is aimed at ensuring the acquisition of modern language knowledge and

skills that students may use both in a general as well as in a specialised context related to their

future profession.

The main objective is the development of specific communication skills. Specific objectives

include:

- The development of writing skills through the analysis of text rhetoric (scientific research

articles, summaries, course books, popular science and non-specialist articles), through

employing lexical, morphological and discourse analysis elements as well as through the

identification of text structure and conventional format.

- The development of the other three basic language skills: reading (active and intensive

reading of specialized texts, developing reading speed), oral communication (situational

communication, case presentations, conversation on professional topics, paper and poster

presentations), and listening (understanding and making use of the information in a spoken

text).

Through pair work or group work activities, the practical course also contributes to the

development of the students’ teamwork skills.

PREREQUISITE - none

TEACHING METHODS

The communicative method

Integration of the four basic language skills (writing, reading, listening, speaking)

EVALUATION METHODS

Written and oral examination (representing 25%+25%=50% of the final mark), class activity,

including portfolio, essay, Curriculum Vitae, formal letters (representing 50% of the final mark)

TEACHING LANGUAGE

English/ Romanian

NUMBER OF HOURS

Practical seminaries – 42 hours (28/28)

ROMANIAN LANGUAGE COURSE SYLLABUS

Reading skills

1. Tables and diagrams in specialized texts; interpreting information

2. Identifying the structure of various specialized texts.

Drug formula, types of drugs, case presentations

3. Articles of scientific papers: structure, reconstructing articles

according to text structure

4. Abstracts of scientific papers: structure, connectors, verb tenses,

reconstructing paragraphs from separate sentences using connectors

Writing skills

1. Filling in tables and diagrams in specialized texts

2. Drug information leaflets. Prescriptions. Case presentations (illnesses,

medication)

3. Essays on controversial topics (addiction, self-medication, dieting,

alternative medicine); agreeing and disagreeing, expressing personal opinions

4. Abstracts of scientific papers: conventional format, summarizing scientific

articles

2 h

2 h

2 h

4 h

2 h

2 h

2 h

4 h

49

Listening skills

1. Listening for detailed information in a specialized course or lecture

(e.g. vitamins, substance abuse)

2. Listening to a specialized text for taking notes or transferring information

3. Basic pharmaceutical pronunciation

4. Watching films on scientific topics – specific listening tasks

Speaking skills

1. Mechanisms of drug action. Debates on controversial topics (addiction,

self-medication, dieting, alternative medicine); agreeing and disagreeing,

expressing personal opinions

2. Oral presentation skills: preparing for the final project

(poster or PowerPoint presentation) – describing, comparing,

evaluating, explaining data

Final examination

2 h

2 h

2 h

4 h

4 h

4 h

4 h

References

1. Bejan, D., Gramatica limbii romane, editia a III-a, Ed. Echinox, Cluj, 2001

2. Brancus, G., Ionescu Adriana, Saramandu Mariana, Limba Romana. Manual pentru

studentii straini, editia a IV-a, Ed. Universitatii din Bucuresti, 1996

3. Pop, Liana, Romana cu sau fara profesor, editia a V-a, Ed. Echinox, Cluj, 2003

4. Dorobat, A., Fotea, M., Limba romana de baza, Ed. Institutul European, Iasi, 1999

5. Reviste de specialitate: « Farmacia ta », « Hipocrate. Bilunar de informaţie pentru lumea

medicală», « Gazeta Farmaciştilor. Revista colegiului farmaciştilor din România », «Lumea

farmaceutică ».

50

CHAIR OF SPORT

COURSE TITLE – Sport

COURSE OBJECTIVES

To maintain an optimum physical condition.

To contribute to growing process and to favour a normal physical development.

To develop basic motrice qualities as well as specific qualities necessary for different sports.

To correctly form a development system and motrice principles (basic and used in certain sport

disciplines).

To develop the skills needed to acquire a systematic practice of physical exercises, as a

component of a healthy life-style.

To prevent and correct deficient attitudes and to recover after traumatic sequels following

certain illnesses.

To develop qualities and voluntary and moral characteristics and to stimulate the esthetical

sense and social responsibilities.

PREREQUISITE -

TEACHING METHODS

Physical exercises

EVALUATION METHODS


TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS

Practicals: 56 hours (28/28)

SPORT Perform several practical activities necessary for the consolidation of technical and tactical

precepts specific for individual and collective sports.

Perform practical activities necessary for the development of basic motrice qualities.

Perform specific activities necessary for a systematic individual practice of physical activities.

Diversify physical education and sport activities according to students’ choice and to

individual biometric configuration (individual physical condition).

Exercises for the development of motrice qualities: force detente, suppleness, speed,

resistance, coordination skills.

Exercises for the prevention of deficient attitudes or organic deficiencies due to the specificity

of professional activity.

Exercises for learning technical gymnastic and athletisme elements.

Initiation in the practice of a game: basket, badminton, football, volley-ball, tennis, table

tennis.

Massage and self-massage gestures.

Theoretical and practical elements for physical self-education.

Aerobics.

Fitness.

Jogging.

51


COURSE TITLE – Summer practice for the 2nd

year students in pharmacy

OBJECTIVES OF THE PRACTICE

acquiring knowledge on main activities of the practice of pharmaceutical profession

acsuiring knowledge on the properties of pharmaceutical substances

PREREQUISITE - IPhTL, organic chemistry, analytical chemistry, physical chemistry

TEACHING METHODS

The application of theoretical knowledge acquired during the first year in pharmacy practice,

under the coordination, monitoring and verification of a pharmacist as tutor

Explanations, discussions, analysis on how to solve professional problems

EVALUATION METHODS

Characterization of student’s work by the tutoring pharmacist regarding:

1. Frequency

2. Compliance with internal regulation


4. The attitude towards the staff in the pharmacy


Oral exam

TEACHING LANGUAGE

Romanian language

French and English language for foreign students that perform the practice in their own country

NUMNER OF HOURS

30 hours / week - 2 weeks (0/60)

SUMMER PRACTICE FOR THE 2ND

YEAR STUDENTS IN PHARMACY PRACTICE SYLLABUS

1. Designation of the workplace: location, schematic plan, the destination of each room.

2. Knowing Romanian Pharmacopoeia X-edition.

3. Knowledge of drug substances: physical and chemical properties, therapeutic uses.

4. Performing analysis for the identification of drug substances.

5. Performing division of some pharmaceutical specialties.

* 30 hours/week – 2 weeks

References


2. Nomenclatorul de medicamente şi produse medicamentoase de uz uman, Agenţia

Naţională a Medicamentului, Bucureşti, 2008



52

CHAIR OF PHARMACEUTICAL CHEMISTRY

COURSE TITLE – Pharmaceutical chemistry


Objectives of the course – acquiring knowledge on the antiseptics, disinfectants, antiinfectious

chemotherapeutics and antitumoral medication regarding: physico-chemical properties,

nomenclature of compounds, synthesis, essential biological properties, pharmaceutical

presentation, chemical structure-biological activity relationships, optimization of the

biopharmaceutical and pharmacokinetic properties

Objectives of the practical lessons – acquiring knowledge on the physico-chemical properties

of the antiinfectious medical substances, their chemical, chromatographic, spectral identification

and the control of their purity.

PREREQUISITE - knowledge of: Inorganic chemistry, Organic chemistry, Analytical chemistry,

Physical chemistry, Microbiology, Informatics

TEACHING METHODS

Lectures with PowerPoint presentations and video-projections, seminars on up-to-date

problems, elaboration of presentations on a specific subject

EVALUATION METHODS

Written exam

Exam form the laboratory activity

Tests during the semesters

Independent work

The laboratory activity and the tests during the semesters represent 25% of the final score.

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACEUTICAL CHEMISTRY COURSE SYLLABUS

1st SEMESTER

1. Antiseptics and disinfectants

Halogens and halogenated compounds

Oxidants

Compounds of the hard metals

Compounds of the aluminium and tin

Bore compounds

Alcohols

Phenols and phenol derivatives

Carbonylic compounds and their derivatives

Guanidine derivatives

Detergents

Colorants

2. General chemotherapeutics

Nitro furans

Halogenated 8-Hidroxychinolines

Quinolones

14 h

9 h

53

Sulphamides

3. Antiparasitary medication Antimalarics

Antitrichomonasics

Antiamibienes and antilambliasics

Antihelmintics

2nd

SEMESTER

1. Antibacterial antibiotics

Betalactamines

Phosphonates

Lincosamides

Macrolides

Rifamicines

Polypeptides

Glycopeptides

Aminoglicosides

Tetracyclines

Phenicols

Streptogramines

Oxazolidinones

Diverse: fusidanines, cumarines

2. Limited specificity chemotherapeutics

Antituberculosis

Antileprose

Antimicotics

Antiviral

3. Antineoplasic medication

Antineoplasic chemotherapy

Cancer hormonotherapy

Immunotherapy in cancer

New approaches in the therapy of cancer

5 h

20 h

16 h

6 h


1st SEMESTER

1. Security and personal safety in the laboratory. Presentation of the

laboratory. Presentation of FRX.

2. Chemical identification of the inorganic drugs

3. Chemical identification of the organic drugs

3.1. Halogenated derivatives

3.2. Alcohols

3.3. Phenols

3.4. Sulfamides

4. Presentations based on scientific articles

5. Exam

2nd

SEMESTER

1. Chemical identification of antibacterial antibiotics

Betalactamines

Macrolides

Aminoglicosides

Phenicols

Tetracyclines

2. Purity control of the drugs based on FRX requirements

3. Spectral (IR, UV) identification of some antibiotics

3 h

12 h

18 h

6 h

3 h

12 h

15 h

6 h

54

4. Presentations based on scientific articles

5. Exam

6 h

3 h

References

1. O. ONIGA, DOINA GHIRAN, BRINDUŞA TIPERCIUC - Chimie Farmaceutică

Antiseptice, dezinfectante şi chimioterapice generale, Editura Accent Cluj-Napoca, 1999

2. OVIDIU ONIGA, BRINDUŞA TIPERCIUC - Chimie Farmaceutică- Antibiotice

antibacteriene şi chimioterapice cu specificitate limitată, Scheme de curs, Litografia UMF

Iuliu Haţieganu Cluj-Napoca, 2001

3. OVIDIU ONIGA, BRINDUŞA TIPERCIUC - Antibiotice antibacteriene, Editura

Medicală Iuliu Haţieganu Cluj-Napoca, 2003

4. BRINDUSA TIPERCIUC, OVIDIU ONIGA- Medicaţia antiinfectioasă.

Antimicobacteriene, antimicotice, antivirale, Editura Medicală Iuliu Haţieganu Cluj-

Napoca, 2004

5. AFECT - Traite de Chimie Therapeutique. Medicaments antibiotiques (vol 2), Ed.

Medicales Internationales TEC and DOC, 1992

6. AFECT -Traite de Chimie Therapeutique. Principaux antifongiques et antiparasitaires (vol

5, tome 2), Ed. Medicales Internationales TEC and DOC, 1995

7. APPIT- Maladies infectieuses and tropicales, ed. E. Pilly, 17-eme edition, 2000

8. AFECT- Traite de Chimie Therapeutique, Medicaments antitumoraux et perspectives dans

le traitement des cancers, vol.6, Ed. Tec and Doc, 2003

9. RICHARD B. SILVERMAN, The organic Chemistry of Drug Design and Drug Action,

second edition, Elsevier Academic Press, 2004

10. WILSON and GISVOLD’S Textbook of Organic Medicinal and Pharmaceutical

Chemistry, eleven edition, Ed. Lippincott Williams and Wilkins, 2004

11. THOMAS NOGRADY, DONALD F. WEAVER, Medicinal Chemistry, A molecular and

Biochemical Approach, III-rd edition, 2005

12. O. ONIGA, BRINDUSA TIPERCIUC, CRISTINA MOLDOVAN, DOINA GHIRAN,

LAURA COSTEA, Identificarea substanţelor medicamentoase prin metode chimice, Ed.

UMF ,,Iuliu Haţieganu,, Cluj Napoca, 2005.

55

CHAIR OF PHARMACOGNOSY AND PHYTOTHERAPY

COURSE TITLE – Pharmacognosy and phytotherapy


To acquire knowledge regarding the main characteristics of vegetal raw materials used to obtain

herbal drug preparations or other medicinal preparations in pharmacy or in industry. After the

presentation of general terms on this field, natural raw materials are studied, underlining their

origin, harvesting, chemical composition as well as the therapeutical effect of the main active

compounds. The aim of these studies is to consolidate the scientific base for medicinal plant use

in phytotherapy. The classification of natural products is based on the chemical structure of the

main active compounds: sugars, lipids, proteins, alkaloids, aromatic compounds, compounds

with isoprenic structure, essential oils, resins etc. Practical applications present the methods of

qualitative and quantitative analysis of the active principles in medicinal plants.

PREREQUISITE – knowledge of Botany, Organic chemistry, Analytical chemistry

TEACHING METHODS

Course – Lectures with Power Point presentations

Practical lessons - Power Point presentations, reports, seminaries, practical applications

EVALUATION METHODS

Practical and written examination

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACOGNOSY AND PHYTOTHERAPY COURSE SYLLABUS

1st SEMESTER

1. Introduction

2. General Pharmacognosy

3. Natural products containing sugars and derivatives (Verbasci flos, Althaeae

radix, Tiliae flos etc.)

4. Natural products containing lipids (Helianthi oleum, Cacao oleum etc.)

5. Natural products containing protids ( Visci folium)

6. Natural products containing alkaloids:

- piperidine alkaloids (Lobeliae herba, Granati cortex etc.), tropane alkaloids

(Belladonnae radix et folium, Hyoscyami folium, Cocae folium etc.)

- indole alkaloids (Physostigmatis semen, Secale cornutum, Rauwolfiae radix etc.)

- quinoline alkaloids (Cinchonae cortex), isoquinoline alkaloids (Opium, Berberidis

cortex, Chelidonii herba, Fumariae herba, Boldo folium etc.)

- quinolisidine alkaloids (Cytisi semen, Sarothamni herba), purine alkaloids (Coffeae

semen, Cacao semen, Theae folium etc.)

- terpenoid alkaloids (Aconiti tuber), protoalkaloids (Colchici semen, Capsici

fructus), compounds with nitrogen having special structure (Taxus sp., Nivalis

bulbus)

2nd

SEMESTER

1. Natural products containing aromatic compounds:

- aromatic compounds type C6 (Vitis ideae folium, Uvae ursi folium etc.), aromatic

compounds type C6 - C1 (Salicis cortex, Ulmariae flos etc.), aromatic compounds

3 h

6 h

3 h

3 h

3 h

5 h

4 h

5 h

4 h

6 h

3 h

56

type C6 – C3 (Cynarae folium)

- aromatic compounds type C6 – C3 – O: coumarins (Fraxini folium, Meliloti herba

etc.), flavonoides (Crataegi fructus, Sophorae flos, Ginkgo folium, Taraxaci herba

etc.), tannins (Quercus cortex, Hamamelidis folium, Ratanhiae radix etc.)

- aromatic compounds type (C6 – C3)n : lignans (Podophyli rhizome, Silybi mariani

fructus)

- anthracenic derivatives (Rhei rhizoma, Frangulae cortex, Hyperici herba etc.)

2. Natural products containing terpenes compounds:

- atypical monoterpenoids (Valerianae rhizoma cum radicibus, Gentianae radix etc.)

- triterpenoids, steroids: saponosides (Ginseng radix, Primulae rhizoma, Saponariae

radix, Hippocastani semen, Hederae folium etc.), natural steroids, cardiotonic

glycosides (Digitalis folium, Convalariae herba, Adonidis herba etc.)

- carotenoids (Tagetes flos, Calendulae flos, Hippophae fructus etc.)

3. Natural products containing essential oils:

- With monoterpenoids (Lavandulae flos, Carvi fructus, Menthae folium, Thymi

herba, Salviae folium etc.), with sesquiterpenoids (Chamomillae flos, Millefolii flos),

with phenylpropan derivatives (Cinnamomi cortex, Foeniculi fructus, Anisi fructus

etc.)

4. Resins, balms, tars (Balsamum peruvianum, Ichtamolum etc.)

5. Systematical Phytotherapy

6 h

1 h

2 h

3 h

9 h

1 h

9 h

2 h

6 h


1st SEMESTER

l. General pharmacognostical methods

2. Analysis of natural products containing sugars

3. Analysis of natural products containing lipids

4. Analysis of natural products containing alkaloids:

- tropane alkaloids

- indole alkaloids

- quinoline alkaloids

- isoquinoline alkaloids

- purine alkaloids, terpenoid alkaloids

5. Analysis of composed species

2nd

SEMESTER

1. Analysis of natural products containing aromatic compounds:

- phenyl derivatives, phenylpropan derivatives, coumarins

- flavonoids

- tannins

- anthracenic derivatives

2. Analysis of natural products containing terpene compounds:

- monoterpenoids

- saponins

- cardiotonic glycosides, carotenoids

3. Analysis of natural products containing essential oils:

- essential oils containing monoterpenoids

- essential oils containing sesquiterpenoids

- essential oils containing phenylpropan derivatives

4. Isolation and purification technologies. Analysis of composed species

12 h

3 h

3 h

3 h

3 h

3 h

6 h

3 h

6 h

9 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

3 h

6 h

References:

ILIOARA ONIGA - Farmacognozie-Alcaloizi, Ed. Medicală Universitară “Iuliu Haţieganu”

Cluj-Napoca, 2001

DANIELA HANGANU – Farmacognozie – Materii prime naturale cu compuşi aromatici, Ed.

Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca, 2005

57

ILIOARA ONIGA - Farmacognozie. Compuşi terpenici naturali, Editura Medicală

Universitară "Iuliu Haţieganu" Cluj-Napoca, 2007

ILIOARA ONIGA, DANIELA BENEDEC, DANIELA HANGANU - Analiza produselor

naturale medicinale, Ed. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca, 2004

M. TĂMAŞ, ILIOARA ONIGA, DANIELA BENEDEC, S. FLORIAN - Ghid pentru

recunoaşterea şi recoltarea plantelor medicinale. Vol. I Flora spontană, Ed. Dacia Cluj-

Napoca, 2005

ILIOARA ONIGA, M. TĂMAŞ, DANIELA BENEDEC, S. FLORIAN - Ghid pentru

recunoaşterea şi recoltarea plantelor medicinale. Vol. II. Plante din culturi, Ed. Supergraph

Tipo, Cluj-Napoca, 2006

I. Ciulei, E. Grigorescu, U. Stănescu - Plante medicinale, Fitochimie şi Fitoterapie, vol. I -

II, Ed. Medicală, Bucureşti,1993

V. Istudor - Farmacognozie, Fitochimie, Fitoterapie, Ed. Medicală, Bucureşti, vol. I-1998, II-

2001

J. Bruneton – Pharmacognosie, Phytochimie, Plantes médicinales – Ed. Tec et Doc –

Lavoisier, 1993

58

CHAIR OF PHARMACEUTICAL TECHNOLOGY

COURSE TITLE – Pharmaceutical technology


Acquiring knowledge regarding the formulation, preparation and quality control of

pharmaceutical dosage forms.

PREREQUISITE – knowledge of chemistry, physics, physical chemistry, biology

TEACHING METHODS

Lectures with PowerPoint presentations

Practical applications

EVALUATION METHODS

Multiple choice exam

Practical exam

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACEUTICAL TECHNOLOGY COURSE SYLLABUS

1st SEMESTER

1. Drug dosage forms. Definition. Design. Formulation. Preparation. Quality. Good

Manufacturing Practices. Classifications. Pharmaceutical technology. Relations with

other sciences. Specific literature. References.

2. Quality of drug dosage forms. Physical stability of pharmaceutical dosage forms;

physico-chemical stability of drugs. Purity (microbiological, chemical and

mechanical contamination). Relative indocility (dose, dose control, systemic toxicity,

local tolerance). Therapeutic efficiency (controlled clinical trials, bioequivalence

determination).

3. Solutions. Solubility. Solubility thermodynamics. Factors influencing solubility

(pH, temperature). Dissolution of drugs. Vehicles. Rate of dissolution. Factors

influencing the rate of dissolution and their use in drug dosage form preparation

4. Increasing the solubility of drugs with poor solubility. PH changes. Co- solvents.

Complexation. Hydrotropism. Micellar solubilization.

5. Difficulties in the preparation of solutions. Pharmaceutical incompatibilities.

Additives for the preparation of solutions. Sweetening agents, flavours, solubilizing

agents, colours, agents that increase viscosity, antioxidants, and antimicrobial

preservatives.

6. Examples of solutions for internal use, officinal and magistral solutions, industrial

specialties. Syrups. Aromatic waters. Lemonades. Alcoholic and oily solutions.

7. Solutions for external use. Nasal drops. Ear drops. Biopharmaceutical

considerations, local pathology. Drugs, vehicles, additives. Preparation. Examples.

Gargles. Collutoria, mouth washes, washing solutions.

8. Injectable solutions. Biopharmaceutical considerations. Components. Quality of

raw materials, drugs, vehicles, additives, containers, closures. Preparation area.

9. Preparation of injectable solutions. Obtaining the desired solubility. Isotonicity.

Filtration. Distribution in recipients and sealing. Sterilization. Labelling. Packaging.

Quality control. Emulsions for injection. Suspensions and powders for injectable

2 h

2 h

2 h

2 h

2 h

2 h

2 h

4 h

2 h

59

preparations. Radiopharmaceuticals. Injectable solutions and suspensions with

prolonged release.

10. Solutions for intravenous infusions. Preparation, particularities. Large volume

parenterals with electrolytes (hydro-electrolytic and acid-base balance

reequilibration).

11. Infusions with colloidal plasma expanders. Infusions for total parenteral

nutrition. Solutions for peritoneal dialysis and hemodialysis. Quality and quality

control of infusions.

12. Ophthalmic solutions. Biopharmaceutical considerations. Quality conditions

achieved through formulation-preparation. Drugs. Vehicles. Auxiliary substances.

Recipients. Preparation of eye drops.

13. Physical and chemical stability of ophthalmic solutions. Sterility. Isotonicity. pH

value. Conditioning. Ocular baths. Injectable solutions and infusions for ophthalmic

use. Tear substitutes. Accessory lens products. Other ophthalmic solutions.

Therapeutic systems. Quality control of ophthalmic solutions. Examples.

2nd

SEMESTER 1. Aqueous extractive solutions. Raw materials. Vegetal products. Water and alcohol

as extractive solvents. Factors influencing selective extraction and effectiveness of

active principles extraction. Aqueous extractive solutions. Macerations, infusions,

decoctions.

2. Hydroalcoholic extractive solutions. Tinctures. Extracts (fluid, soft, solid). Factors

influencing extraction. Extraction methods. Quality conditions and control.

Examples.

3. Fluid heterogeneous pharmaceutical dispersions. Classification. Colloids.

Emulsions. Suspensions. Factors influencing the physical stability of fluid

heterogeneous dispersions. Interfacial energy. Wetting. The electric charge. Particle

attraction. Viscosity.

4. Colloidal heterogeneous dispersions. Lyophobic colloids. Hydrophilic colloids

(hydrosoluble, macromolecular compounds). Mucilages. Preparation, stability, uses.

Association colloids. Amphiphilic surface active substances with soluble, wetting

properties.

5. Pharmaceutical emulsions. Classification. Emulsifying agents. Classification.

HLB. Manufacture of emulsions. Stability of pharmaceutical emulsions.

Demulsification. Phase inversion. .Quality control. Examples.

6. Pharmaceutical suspensions. Flocculated and deflocculated suspensions. Factors

influencing the stability of suspensions. Auxiliary substances used for preparing

suspensions. Preparation of the suspensions. Quality control. Examples.

7. Pharmaceutical ointments. Classification. Biopharmaceutical considerations.

Excipients used for preparing ointment bases and their role. Hydrocarbon bases.

Emulsifying bases. Water soluble bases. Preparation techniques.

8. Preparation of the pharmaceutical ointments. Solution, emulsion and suspension

ointments; mixed dispersed systems. Gels. Pastes. Quality control. Examples.

9. Suppositories. Biopharmaceutical considerations. Excipients used for

suppositories. Auxiliary substances for the preparation of the suppositories.

10. Suppository preparation techniques. Manual moulding. Melting and casting

moulds. Dislocation factors. Vaginal suppositories. Urethral suppositories. Quality

conditions and control of suppositories. Examples.

11. Pharmaceutical powders. Milling. Sieving-sorting. Powder mixing. Non-divided

powders. Divided powders. Powders for external administration. Quality control.

Examples.

12. Solid oral dosage forms. Compressed tablets. Classification. Excipients for

compressed tablets.

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

1 h

1 h

60

13. Direct compression. Dry granulation. Wet granulation. Excipients, technologies,

equipment. Types of compressed tablets. Characteristics, quality control, examples.

14. Coated compressed tablets. Sugar coating techniques. Coating with polymer

films. Polymers used for coating. Technologies and equipment. Examples.

15. Capsules. Containers, hard gelatine capsules, soft gelatine capsules. Preparation.

Filling. Quality control. Examples.

16. Dosage forms with modified release. Compressed tablets with prolonged or

sustained release. Pharmaceutical systems with controlled release. Formulation

principles. Preparation technologies. Characteristics and quality control. Examples.

2 h

1 h

1 h

2 h


1ST

SEMESTER

1. Solutions. Aqueous solutions of some ionized drugs obtained by dilution,

dissolution and chemical reaction of the components. Aqueous solutions of some

non-ionized drugs.

2. Checking maximum doses. Magistral prescriptions with highly active drugs

(Separanda) and with toxic and narcotic drugs (Venena).

3. Techniques to solubilize poorly soluble drugs. Micellar solubilization. Role of the

pH. Co-solvency. Complexation. Avoiding the physico-chemical interactions in

solution.

4. Syrups. Simple syrup (FR X); Tolu Balm Syrup (FR X); codeine syrup (FR X).

Lemonades. The effervescent solution (FR X); the magnesium citrate solution (FR

X)

5. Solutions for external use.

- Alcoholic solutions: the iodinated iodine alcoholic solution (FR X); the

camphor alcoholic solution (FR X); the anisated ammonium chloride

solution (FR X).

- Nasal drops: nose drops with naphazoline chloral hydrate 0.1% (FR X)

- Aqueous and oily magistral prescriptions.

- Ear drops: magistral prescriptions

- Collutoria: borated glycerine collutorium, zinc chloride collutorium.

- Gargles: magistral prescriptions (phenosallyl).

- Vaginal lavages: with potassium permanganate

6. Injectable preparations.

- Recipients: containers, closures and metal gasket.

- Vehicles: neutralized sunflower oil.

- Injectable procaine chlorhydrate solution (FR X); injectable glucose

solution (FR X); injectable magnesium sulphate solution (FR X). Aseptic

preparations. Injectable methenamine solution. Vials conditioning.

7. Intravenous infusions.

- Expressing infusion drug content.

- The sodium chloride perfusion (FR X); the compound sodium chloride

infusion (FR X); the compound sodium chloride infusion with sodium

lactate (FR X); the sodium bicarbonate infusion (FR X).

8. Ophthalmic preparations.

- Ophthalmic solutions with atropine sulphate (FR X); ophthalmic

solutions with resorcinol (FR X).

- Ear drops with: silver nitrate, with chloramphenicol, with zinc sulphate.

- Magistral prescriptions of medicinal substances with concentrations

below or over 1%. Eye drops- single dose: ophthalmic solutions with

fluorescein.

2nd

SEMESTER

1. Extractive solutions

6 h

6 h

6 h

3 h

6 h

6 h

3 h

6 h

6 h

61

- Macerations

- Infusions from products containing mucilages/ volatile oils/ alkaloids.

- Decoctions

2. Colloidal solutions.

- Lyophobe colloids : colloidal silver salts

- Lyophile colloids: mucilages. Sodium carboxymethylcellulose (FR X);

methylcellulose mucilage (FR X); tragacantha mucilage (FR X)

3. Emulsions.

- Vehicles: oil/water and water/oil emulsions. Wet and dry gum method

- Emulsions for internal use: emulsions with bromoform

- Emulsions for external use: nasal drops emulsions (U/A; A/U)

- Emulsion control: determining the emulsion type

- Ammonium liniments, oleo- limestone liniments.

4. Suspensions.

- Suspensions for internal use: preparing suspensions through dispersion

and condensation. The therpine hydrate suspension. Magistral

prescriptions.

- Suspensions for external use: stirring mixtures.

- Incompatibilities between medicinal substance and suspension agents: the

bismuth nitrate suspension

- Emulsions- suspensions.

5. Ointments.

- Ointment bases: anhydrous fat (simple FR X ointment, emulsifying

ointment FR X); A/U emulsions (hydrated lanolin, FR X); hydrosolubles

and hydrodispersables (ointment with PEG FR X, starch glycerite,

sodium carboxymethylcellulose).

- Medicinal ointments with: clotrimazole (FR X); hydrocortisone acetate

(FR X); phenylbutazone (FR X); zinc oxide (FR X). Magistral

prescriptions.

- Sterile ointments: ophthalmic ointment with pilocarpine (FR X); the

Petrini Paste; ointments with antibiotics (neomycin)

6. Suppositories.

- Rectal suppositories: compression moulding and manual moulding.

Suppositories with metronidazole (FR X). Magistral prescriptions with

toxic and narcotic drugs and with vegetal extracts. Preparation by

moulding: suppositories with polyethylene glycols.

- Vaginal suppositories: the gelatinous mass. Magistral prescriptions

(moulding and shaping).

- Urethral suppositories. Preparation by moulding.

7. Powders.

- Non-divided powders. Opium and ipecacuanhae powder (FR X).

Magistral prescriptions with efflorescent medicinal substances and

oleosacchara.

- Divided powders: the alkaline powder (FR X); the laxative effervescent

powder (FR X). Magistral prescriptions with toxic and narcotic medicinal

substances.

- Powders for external use. Powders with fatty substances. Powders with

eutectic mixtures.

8. Granules. Compressed tablets.

- Calcium glycerophosphate granules. Effervescent granules. Simple

granules.

- Direct compression using the alternative compression machine

6 h

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3 h

6 h

6 h

3 h

6 h

62

References

1. Leucuţa S.E.: Tehnologia formelor farmaceutice. Editura Dacia, Cluj-Napoca, 1995

2. Leucuţa S.E.: Formularea medicamentelor şi a noilor sisteme farmaceutice. Universitatea

L.Pasteur, Strasbourg, 1973

3. Leucuţa S.E., Preda M., Achim M.: Prepararea medicamentelor, Editura Universitară

“Iuliu Haţieganu” Cluj-Napoca, 2000

4. Leucuţa S.E.: Tehnologie farmaceutică industrială, Editura Dacia, Cluj-Napoca, ed. I,

2001, ed.a II-a, 2008 (in editura)

5. Allen L.V., Popovich N.G., Ansel H.C.: Ansel’s Pharmaceutical Dosage Forms and Drug

Delivery Systems; Lippincott, 8th ed.

6. Le Hir A.: Pharmacie galenique. Bonnes Pratiques de Fabrication des medicaments; 7e

edition, Masson, Paris, 1997.

63


LABORATORY

COURSE TITLE – Pharmaceutical Biochemistry and clinical laboratory


Accumulation of theoretical and practical knowledge indispensable for the bio-medical

formation of the pharmacist; deciphering of the molecular bases necessary for studying the drug

(action, prospecting, drug-design).

PREREQUISITE - organic and analytical chemistry, anatomy, physiology, cell biology, genetics

TEACHING METHODS

Interactive lectures based on video projection (animated Power Point)


EVALUATION METHODS

Seminars, essays, practical and written exams at the end of each term

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACEUTICAL BIOCHEMISTRY AND CLINICAL LABORATORY COURSE SYLLABUS

1. Intermediary metabolism: basic concepts and design. General pathways of

biotransformation of fundamental cellular components. Cellular oxidation: citric

acid cycle (amphibolic significance), mitochondrial respiratory chain, oxidative

phosphorylation, microsomial systems (importance concerning drug

metabolism). The cytotoxicity of oxygen, antioxidant mechanisms.

2. Carbohydrates metabolism. Digestion and absorption. Glycolysis. Metabolic

position of pyruvate. Gluconeogenesis. Pentose phosphate pathway, uronic acid

pathway. Metabolism of fructose and galactose. Metabolism of glycogen.

Glycoproteins and proteoglycans.

3. Lipid metabolism. Digestion and absorption. Lipid transport and storage.

Metabolism of saturated and unsaturated fatty acids. Essential fatty acids.

Eicosanoids. Ketogenesis (metabolism of ketone bodies). Metabolism of

acylglycerols and complex lipids. Cholesterol synthesis and biotransformation.

Bile acids. Plasmatic transport, lipoprotein metabolism.

4. Metabolism of proteins and amino acids. Digestion, absorption, distribution,

metabolic directions. Catabolism of amino-acid nitrogen: transamination,

oxidative deamination, formation of ammonia and biosynthesis of urea.

Metabolism of the carbon skeletons of amino acids. Conversion of amino-acids

to specialized products, role and mechanism of action. Hemoglobin: function-

structure relation, heme biosynthesis, porphyrins, catabolism of heme, formation

of bile pigments. Protein biosynthesis, inhibitors, therapeutical significance.

5. Biosynthesis and catabolism of purine and pyrimidine nucleotides.

Observations: treatment of all metabolic pathways contains: presentation,

significance, regulation and metabolic interrelations, pathological aspects, relation

with the drug.

6. Biochemistry of endocrine system. Extra-cellular communication. Molecular

mechanisms of hormone action: transduction systems, intracellular messengers.

Peptidic structure of hormones: pituitary and hypothalamic hormones; hormones of

6 h

10 h

8 h

10 h

2 h

6 h

64

the pancreas, parathyroid hormone, calcitonin, tissular hormones, growth factors.

Steroid sexual hormones and cortico-suprarenal hormones.

Observations: following aspects are treated: structure, biosynthesis, secretion,

circulation, bio-transformations, excretion, biochemical functions, endocrine

dysfunctions, therapeutic implications.


1. Identification and quantitative determination of carbohydrates and some of their

metabolites, applications in clinical laboratory.

2. Exploration of lipid metabolism in clinical laboratory.

3. Blood identification. Hemoglobin and derivatives, absorption spectra and

quantitative determination.

4. Plasma proteins in the laboratory diagnosis. Electrophoresis and dosage of

plasma proteins.

5. Non-proteic nitrogen compounds from blood and urine. Hepato-biliar

biochemical exploration.

6. Biochemical exploration of renal function.

7. Investigation of blood acid-basic equilibrium. Plasma and urine mineral

components.

8. Biochemical analysis of gastric juice and cerebro-spinal liquid.

9. Hormonal explorations.

10. Biochemical tests in molecular diseases. Tumoral markers

11. Exam

6 h

3 h

3 h

6 h

6 h

3 h

3 h

3 h

3 h

3 h

3 h

References

1. Cornelia Ţărmure, Biochimie structurală şi metabolică, vol I, Ed. Dacia, Cluj-Napoca,

1996.

2. Ileana Olteanu, Biochimie descriptivă, Ed. Med. Universitară "Iuliu Haţieganu", Cluj-

Napoca, 2001.

3. Ileana Olteanu, Gheorghe Jebeleanu, Biochimie metabolică, Ed. Med. Universitară "Iuliu

Haţieganu", Cluj-Napoca, 2002.

4. Ileana Olteanu, Vitamine şi coenzime, Ed. Med. Universitară "Iuliu Haţieganu", Cluj-

Napoca, 1994.

5. Luminiţa Diaconescu, Cristina Drugan, Gheorghe Jebeleanu, Biochimie metabolică, Ed.

Srima, 2001.

6. Maria Dronca, Enzime, cofactori enzimatici, Ed. Med. Universitară "Iuliu Haţieganu",

Cluj-Napoca, 2002.

7. Mathews, CK, van Holde, KE, Ahren, KG, Biochemistry, 3rd Ed. An Imprint of Addison

Weslez Longman, Inc., Harlow, England, 1999.

8. Zubay, GL., Parson, WW., Vance, DE., Principles of Biochemistry, W.C. Brown

Publishers, Oxford, England, 1995.

9. Christian Moussard, Biochimie structurale et metabolique. Medecine, pharmacie,

sciences, 2eme

edition, DeBoeck, 2002.

10. Ileana Olteanu, Gh. Jebeleanu, Teste biochimie, Ed. Med. Univ. "Iuliu Haţieganu", Cluj-

Napoca, 2000.

11. John W. Baznes, Marek H. Dominiczak, Medical biochemistry, Second edition, Elsevier,

2005.

12. Corina Ionescu, Roxana Lucaciu, Căi fundamentale în metabolismul uman, Ed. Med.

Univ. "Iuliu Haţieganu", Cluj-Napoca, 2008.

13. Roxana Lucaciu, Corina Ionescu, Noţiuni de biochimie clinică, Ed. Risoprint, Cluj-

Napoca, 2008.

14. Niculina Mitrea, Denisa Margina, Andreea Arsene et all, Biochimie: Vitaminele în

procesele metabolice, Ed. Didactică şi Pedagogică S.A., Bucureşti, 2008.

65

CHAIR OF ENVIRONMENTAL CHEMISTRY AND HYGIENE

COURSE TITLE – Environmental chemistry and hygiene


Course objectives – to acquire knowledge on the environmental factors (air, water, soil, food)

regarding their chemical composition and their impact on human health status and on

environmental pollution.

Practical lessons objectives – to acquire knowledge on the methods used for the analysis of

these environmental factors.

PREREQUISITE – knowledge of analytical chemistry, organic chemistry, inorganic chemistry

TEACHING METHODS



EVALUATION METHODS

Written exam (test and essay)

Practical exam

In-term verifications

Bibliographic research and individual study

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



ENVIRONMENTAL CHEMISTRY AND HYGIENE

COURSE SYLABUS

1. Air as an environmental factor. Air and health status. Sanitary risks due to

common air impurification

2. Water as an environmental factor. The importance of water for the human

body. Clean and residual water. Sanitary norms of potable water. Sanitary

risks due to polluted water. Water pathology.

3. Soil and health status. Human – soil impact.

4. Healthy man nutrition. Food equilibrium and nutrition necessary (energy,

proteins, glucides, lipids, mineral elements, vitamins, fibres).

Energetic requirements of the human body. Energetic food.

Proteins in nutrition. Types of proteins. Biological and nutritional value.

Protein sources. The protein requirement. Inadequate quantities effects.

Carbohydrates in nutrition. Types of carbohydrates. Biological and

nutritional value. Carbohydrate sources. The carbohydrate requirement.

Inadequate quantities effects.

Lipids in nutrition. Types of lipids. Biological and nutritional value. Lipid

sources. The lipid requirement. Inadequate quantities effects.

Mineral elements in nutrition. (Na, K, Ca, Mg, P, Fe, Zn, Cu, I, F, Se, Co).

The biologic and nutritional role. Food sources. Human body requirements

in mineral elements. Inadequate quantities effects.

Vitamins in nutrition. The biologic and nutritional role. Food sources.

Human body requirements in vitamins. Inadequate quantities effects

Fibres in nutrition. The biologic and nutritional role. Food sources. Human

body requirements in fibres. Inadequate quantities effects

5. Food groups

1 h

3 h

0,5 h

1 h

1 h

1 h

1 h

2 h

1 h

1 h

66

Milk and dairy products. Milk – definition, structure and properties.

Chemical composition. Mother and Cow milk comparison. Nutritional value

of milk. Sanitary aspects. Milk derivates: fermented milk products, cheese,

cream, butter. Nutritional value of dairy products. Milk contamination and

alteration. Milk forgeries.

Meat. Meat classification. Structure of muscle tissue. Chemical composition

of meat. Nutritional value of meat. Meat products. Sanitary aspects. Chemical

composition. Modifications after processing. Meat contamination and

alteration.

Fish. Classification. Chemical composition. Sensory aspects of fish: smell,

texture. Nutritional value of fish. Alteration and conservation. Sanitary and

toxicological aspects.

Eggs. Classifications. Chemical composition. Nutritional value of egg.

Chemical composition of egg. Nutritional value of egg. Functional aspects.

Digestibility, altering and contamination. Packing and storing.

Edible fats and oils. Classification. Vegetal fats. Chemical composition of

vegetal fats. Fats obtained from oil seeds. Fruit based fat: olive oil. Animal

fats. Hydrogenate fats: margarine. Other alimentary fats. Nutritional value of

fats. Sanitary aspects. Hygiene and toxicological aspects: alimentary fat

contamination, altering, prevention measures.

Cereals and cereal products. Structure of cereal grain. Chemical

composition. Derivates. Wheat derivates. Other derivates. Nutritional value of

cereals and derivates. Sanitary aspects. Hygiene and toxicological aspects.

Altering and prevention.

Legumes. Definition. Chemical composition. Nutritional value. Sanitary

aspects. Hygiene and toxicological aspects: legumes contamination, altering,

prevention measures. Soybean and soy proteins derivates.

Fruits and vegetables. Fruits. Definition. Chemical composition. Nutritional

value. Sanitary aspects. Hygiene and toxicological aspects: fruit

contamination, altering, storing and prevention measures. Vegetables.

Chemical composition: carbohydrates, nitrogen based compounds. Nutritional

Value. Sanitary aspects. Hygiene and toxicological aspects. Vegetables

contamination, altering and storing.

Sugar and sugar based products. Sugar based products made mostly of

small molecule carbohydrates (refined): sugar, candy, dragées, tablets,

chewing gum, and croquants. Sugar based products made of sugar and fruits:

jam, marmalade, jellies. Sugar based products made of sugar and oil seeds:

chocolate - types, nutritional and caloric value-, marzipan, nougat fillers.

Complex mixtures: ice-cream. Honey. Chemical composition and nutritional

value. Therapeutic effects. Nutritional and energetic value of sugar based

products. Optimal quantities and effects of abuse. Sanitary aspects.

Contamination and altering. Sugar substitute and artificial sweeteners.

Alcoholic and non alcoholic beverages. Alcohols. Classification. Fermented

alcoholic beverages. Sanitary aspects. Distilled alcoholic beverages – spirits.

Chemical composition and nutritional value Effects of abuse. Frauds and

forgeries. Non alcoholic beverages: tea, coffee sodas, refreshments, fruits and

vegetables based beverages. Chemical composition and nutritional value.

Condiments and spices. Classification. Salt. Vinegar and organic acid

condiments, mustard and cocoa. Chemical composition, nutrients and aromatic

substances, nutritional value, properties. Sanitary aspects.

6. The hygiene of pharmaceutical units

2 h

1,5 h

0,5 h

1 h

2 h

2 h

0,5 h

1,5 h

1 h

1 h

0,5 h

2 h

67


1. Security and personal safety in the chemistry laboratory.

2. Chemical-sanitary analysis of water.

Analysis of normal water constituents.

Analysis of water impurifying components.

Disinfection process for potable water.

3. Chemical-sanitary analysis of air. Determination of normal compounds of

common air: O2, CO2

4. Chemical-sanitary analysis of soil

5. Chemical-sanitary analysis of aliments. General aspects. Analysis Methods.

6. Determination of normal composition of aliments:

Protein determination: general methods (Kjeldahl method) and specific

methods: milk casein, flour gluten.

Lipid determinations. General methods (Soxhlet) and specific methods

(Gerber)

Determination of water content of aliments (gravimetric method, distilling

method Dean-Stark, Karl-Fischer)

Determination of carbon hydrates in aliments. Bertrand method, Schoorl

method, iodine method, lactose determination using Ionescu-Matiu method.

Ashes determinations. Minerals determinations.

Determination of vitamins in aliments.

7. Aliment analysis based on their groups, determination of normal compounds,

biological constants, freshness state, forgeries. Determination of polluting

compounds: pesticides heavy metals.

2 h

13 h

1 h

5 h

21 h

References

1. Doina Miere – Chimia şi Igiena alimentelor, vol 1., Ed. Me. Univ. „Iuliu Haţieganu”

Cluj-Napoca, 2002

2. Doina Miere – Chimia şi Igiena alimentelor, vol 2., Ed. Me. Univ. „Iuliu Haţieganu”

Cluj-Napoca, 2007

3. Doina Şendrea, Doina Miere - Ghid de analiză chimico-sanitară a mediului – Litografia

UMF Cluj-Napoca, 1996

4. S. Mănescu, Gh. Tănăsescu, S. Dumitrache, M. Cucu - Igiena, Ed. Medicală, Bucureşti,

1996

5. S. Mănescu, H. Dumitrescu, Zenova Bărduţă, Mona Ligia Diaconescu – Chimia sanitară

a mediului, Ed. Medicală, Bucureşti, 1982

6. E.P.Yufera – Quimica de los alimentos – Editorial Sintesis, Spain, 1998.

7. A. Fouassin, A. Noirfalise – Methodes d’analyse des substances alimentaires 4me

edition, Presses Universitaires de Lieges A.S.B.L.

8. J.R.J. Pare, J.M.R. Belanger – Instrumental methods in food analysis, Ed. Elsevier,

Otawa, Ontario, Canada, 1997

9. H.D. Belitz, W. Grosch – Food Chemistry, Ed. Springer, Berlin, 1999

10. Reinhard Matissek, Frank-M. Schnepel, Gabriele Steiner – Analisis de los alimentos,

Fundamentos, Metodos, Aplicationes, Ad. ACRIBIA, Zaragoza, Spania, 1998

11. J. Mataix Verdu – Tabla de composition de alimentos espanoles, 2a ed. augmentada,

Universidad de Granada, 1995

12. G. Vollmer, G. Josst, D. Schenker, W. Sturm N. Vreden – Elementos de Bromatologia

descriptiva, Ed. ACRIBIA, Zaragoza, Spania, 1999

13. J. G. Gutierrez – Ciencia Bromatologica – Principios generales de los alimentos, Ed.

Diaz de Santos, 2000

68

CHAIR OF SEMIOLOGY AND INTERNAL MEDICINE

– IV MEDICAL CLINIC

COURSE TITLE – Clinical pathology


Course:

To acquire knowledge and understanding of the main diseases with the purpose of a better

understanding of drug therapy.

Practical lessons – to observe, at patient’s bedside, the signs and the para clinical explorations

important for the diagnostic of the disease

PREREQUISITE – knowledge of anatomy, physiology, physiopathology

TEACHING METHODS


Practical demonstrations at patient’s bedside

EVALUATION METHODS

Written exam

Practical exam

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



Clinical pathology COURSE SYLLABUS

1. Basic concepts in general semiology

2. Respiratory semiology

Respiratory semiology - notions

Acute tracheo-bronchitis, chronic tracheo-bronchitis, lung emphysema.

Chronic obstructive bronchopathy

Asthma

Pneumonia. Pulmonary suppuration.

Pleurisy. Lung cancer. Lung thrombo - embolism.

3. Cardiovascular semiology

Cardiovascular semiology - notions

Acute articular rheumatism. Valvulopathies. Endocarditis. Atherosclerosis.

Ischemic cardiopathy

Arterial hypertension

Arrhythmia

Cardiac failure

Choc. Thombophlebites

4. Renal semiology

Acute post-streptococci glomerulo-nephritis. Chronic glomerulo-nephritis.

Nephritic syndrome.

Interstitial nephropathies. Acute pyelonephritis. Chronic pyelonephritis.

Acute renal failure. Chronic renal failure.

5. Digestive semiology

Digestive semiology - notions

Acute gastritis. Chronic gastritis. Gastric and duodenal ulcer. Surgical

9 h

8 h

10 h

3 h

9 h

69

stomach. Tumours of the stomach.

Acute entero colitis. Non specific chronic entheropathy. Malabsorption

syndrome.

Haemorrhagic rectocolite

Chronic hepatitis. Hepatic cirrhosis. Acute and chronic angio-colecistopathies.

Bile lithiasis. Metabolic diseases.

6. Diabetes

7. Collagenosis: LED, Sjogren Syndrome, Scleroderma, Rheumatoid

polyarteritis

8. Haematopoietic system

Anemias. Haemorrhagic diathesis.

Acute leucosis. Chronic leucosis. Medullar failure.

1 h

1 h

2 h


1. Medical semiology notions

2. Respiratory semiology

3. Cardiovascular semiology

4. Renal semiology

5. Digestive semiology

6. Collagenosis

7. Haematopoietic system

4 h

6 h

6 h

2 h

6 h

2 h

2 h

References

1. H.D.Bolosiu, Semiologie Medicala, 1998

2. O. Pascu, Esentialul in Gastroenterolgie si Hepatologie, Editura National, Cluj Napoca,

2005

3. Harrison, Principii de Medicina Interna – volumul 1,2 – editia a 14 – a in limba

romana, 2001

4. R.J.Greene, N.D.Harris, Pathology and Therapeutics for Pharmacists, London, 2000

5. Anton Draghici, Dorel Simpelean, Vasile Negrean, Medicina interna pentru Stomatologi;

Casa Cartii de Stiinta, Cluj Napoca, 2001

6. Mircea Cazacu, Anton Draghici, Vasile Negrean,Urgente Medico-Chirurgicale pentru

Farmacisti; Casa Cartii de Stiinta, Cluj Napoca, 2001

7. Sorin T. Barbu, Ake Andren-Sandberg, Pancreatic Disease in 2008, Casa Cartii de Stiinta,

Cluj Napoca, 2008

70

CHAIR OF IMMUNOPATHOLOGY

COURSE TITLE – Immunology

COURSE AND SEMINARY OBJECTIVES

Course:

To acquire knowledge on the constitutive elements of immune system and the interactions

between them, as well as knowledge on specific defence mechanisms, on mechanisms of

inflammation and on the principles of immunotherapy.

Seminaries:

To understand the immunological and immunogenetic techniques

PREREQUISITE – knowledge of physiology, pathophysiology, cell biology

TEACHING METHODS


Discussions, clinical cases presentation

EVALUATION METHODS

Written exam

TEACHIN LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



IMMUNOLOGY COURSE SYLLABUS

1. Antigens.

2. Defence mechanisms of the organism

3. Lymphoid organs.

4. Specific defence mechanisms

5. Molecular structure of membrane. CD markers and immuno-receptors.

6. Immunoglobulins, antibodies.

7. CMH.

8. Complement system.

9. Cytokines, molecular mediators of immune response.

10. The means of interaction between the elements of immune system. Cellular

cooperation.

11. Inflammation.

12. Immunotherapy

2 h

4 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

4 h

SEMINARIES SYLLABUS

1. Blood cells physiological aspects (H, L, Tr, normal TS), pathological aspects

(pathological TS, anaemia)

2. DNA recombinant technique, transgenic animals, bacteriophages libraries.

3. Immunological techniques.

4. Monoclonal antibodies – definition, properties, clinical applications in

diagnostic and treatment.

5. Hypersensitivity reactions – classification, mechanisms. Case study –

allergology (allergy test)

6. Drug allergies – general presentation, mechanisms, clinical signs. Clinical case

study (beta-lactamines allergy).

7. Auto-immunity – mechanisms, principles of diagnostic, BAI classification

2 h

2 h

1 h

1 h

2 h

2 h

2 h

71

(organ-specific and non specific). Auto-immunity disease - clinical case

presentation.

8. Immunodeficiencies – classification. Clinical case presentation (AIDS).

9. Adverse reactions to biological products.

1 h

1 h

References

1. Cristea V, Crisan M, Imunologie Fundamentala, Ed.Med.Univ.Ìuliu Hatieganu`, Cluj-

Napoca, 2004

2. Cristea V, Crisan M, Esentialul in Imunologie, Ed.Med.Univ. Ìuliu Hatieganu`, Cluj-

Napoca, 2004

3. Cristea V, CrisanM, Imunologie Clinica, Ed.Casa Cartii de Stiinta, 2002

4. Dumitrascu D, Bolile Atopice, Ed. Med.Univ. Ìuliu Hatieganu` Cluj-Napoca, 2002

5. Doru Dejica, Tratat de Imunoterapie, Ed. Mega, Cluj-Napoca, 2006

6. Pichler W J, Drug Hypersensitivity, Ed. Karger, 2007.

72


PHYSIOPATHOLOGY

COURSE TITLE – Pharmacology


Course: Acquiring knowledge of general pharmacology, needed for the understanding of the

pharmacology of the main classes of drugs

Practical lessons: the study of experimental models used for the evaluation of the

pharmacokinetics and pharmacology of drugs.

PREREQUISITE – knowledge of anatomy, physiology, physiopathology, pathology and

biochemistry

TEACHING METHODS

Interactive lectures

Experiments on laboratory animals and computer alternative methods

EVALUATION METHODS

Written exam

Practical exam

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS



PHARMACOLOGY COURSE SYLLABUS

1. Introduction. Phases of drug evolution in the human body. Biopharmaceutical

phase

2. Pharmacokinetic phase. Drug absorption

3. Pharmacokinetic phase. Drug distribution

4. Pharmacokinetic phase. Drug excretion

5. Pharmacodynamic phase. The parameters of pharmacodynamic activity and the

factors influencing pharmacodynamic activity

6. Pharmacodynamic phase. Molecular action of drugs

7. Pharmacotoxicology: tolerance, intolerance, addictions, reactions at drug

treatment discontinuation

8. Pharmacovigilence and pharmacoepidemiology

9. Adrenergic transmission

10. Cholinergic transmission

11. Histaminergic transmission

12. Serotoninergic transmission

13. Glutamate transmission

14. GABAergic transmission

15. Other transmissions

1 h

2 h

2 h

2 h

3 h

3 h

1 h

2 h

1.5 h

1.5 h

2 h

2 h

1.5 h

1.5 h

2 h


1. Introduction, instruments, laboratory animals

2. Cutaneous and ocular drug absorption

3. Pulmonary and digestive drug absorption

4. Parenteral drug absorption. Drug metabolism and excretion

5. Drug-dependent variability factors in pharmacodynamic activity

1 h

2 h

2 h

3 h

2 h

73

6. Organism-dependent variability factors in pharmacodynamic activity

7. Pharmacodynamic antidotism 3 h

1 h

References

1. Aurelia Cristea, Farmacologie generală, Ed. Didactică şi Pedagogică Bucureşti, 1998.

2. Aurelia Cristea, Tratat de Farmacologie, Editura Medicală Bucureşti 2005.

3. Valentin Stroescu, Bazele farmacologice ale practicii medicale, Ediţia a VII-a, Editura

Medicală, 2001.

4. Goodman&Gilman’s, The pharmacological basis of therapeutics, Ed. Mc Graw Hill,

2006.

5. Katzung B.G., Basic and Clinical Pharmacology. Editia a 10-a, Editura McGraw-Hill,

New York 2007.

6. Rang H.P., Dale M.M., Ritter J.M., Pharmacology, Ed. Churchill Livingstone, 2007.

7. Mogoşan Cristina, Abrégé de PHARMACOLOGIE, Editura Medicală Universitară

“Iuliu Haţieganu” Cluj-Napoca, 2005.

8. Cohen Y., Jacquot C., Pharmacologie, Ed. Masson, Paris, 2001.

9. Landry Y., Gies J-P., Pharmacologie, des cibles vers l’indication therapeutique, Ed.

Dunod, 2003.


therapeutiques, Ed. Frison-Roche, Slatkine Geneve 1992.

11. Mogoşan Cristina, Voştinaru Oliviu, Ghibu Steliana, Bazele experimentale ale

farmacologiei, Editura Medicală Universitară „Iuliu Haţieganu” Cluj-Napoca 2005.

74

CHAIR OF TOXICOLOGY

COURSE TITLE – Applied pharmaceutical terminology

SEMINARIES OBJECTIVES

Acquire knowledge of medical and pharmaceutical terminology during activities such as:

correct analysis of components of medical and pharmaceutical terms, analysis of scientific texts

with the purpose of a good comprehension and interpretation.

PREREQUISITE – knowledge of anatomy, physiology, analytical chemistry, physical chemistry,

inorganic chemistry, organic chemistry, 2nd

year pharmaceutical terminology

TEACHING METHODS

Discussions and exercises

EVALUATION METHODS

Written exam

TEACHING LANGUAGE

English language

NUMBER OF HOURS


APPLIED PHARMACEUTICAL TERMINOLOGY SEMINARY SYLLABUS

Ist SEMESTER – APPLIED MEDICAL TERMINOLOGY

1. Learning specific medical and pharmaceutical terms by exercises: word

construction, classification of words with the aid of operating unit,

identification of specific terms in scientific papers and explanation of their

meaning, crossing words, exercises of correspondence between the terms and

their significance.

Terms used in dermatology

Terms used in ophthalmology

Terms used in stomatology

Terms used in ORL

2. The analysis of scientific texts with the purpose of getting the skills of good

comprehension and interpretation of medical and pharmaceutical terms.

IInd

SEMESTER – APPLIED PHARMACEUTICAL TERMINOLOGY

1. Learning specific pharmaceutical terms by exercises: word construction,

classification of words with the aid of operating unit, identification of specific

terms in scientific papers and explanation of their meaning, crossing words,

exercises of correspondence between the terms and their significance.

2. The analysis of scientific texts with the purpose of getting the skills of good

comprehension and interpretation of pharmaceutical terms.

6 h

8 h

6 h

8 h

References

1. Iuliana Popovici, Lăcrămioara Ochiuz, D. Lupuleasa – Terminologie medicală şi

farmaceutică, Editura Polirom, Bucureşti, 2007

2. J. Thieulle – Pratiques du mot médical. Cahier d’exercices, Editions Lamarre, Rueil-

Malmaison, 2002

3. B. Lacroix – Terminologie médicale. Méthode et activités, Editions Casteilla, Paris, 2000

4. Des articles scientifiques de la littérature de spécialité

75


COURSE TITLE – Mycology

COURSE OBJECTIVES

Acquiring knowledge regarding: general characters of domain Mycophyta, pathogen fungal

species, economical importance and use of different fungal species, recognition and

differentiation of edible and toxic mushrooms

PREREQUISITE – high school level general biology

TEACHIN METHODS


EVALUATION METHODS

Written examination (standard type or MCQ – multiple choice questions)

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


MYCOLOGY COURSE SYLLABUS

1. General characters and classification of domain Mycophyta

2. Fungi as human pathogens. Antimycotic substances

3. Edible mushrooms. Recognition criteria and nutritive value. Toxic mushrooms.

Recognition criteria and first aid

4. Yeast – source of proteins, vitamins; economical use. Fungi used in

biotechnologies. Fungi used in pollution control. Fungi as source of

pharmacological active principles

5. Pathogen moulds

6. Phytopathogen mushrooms

1 h

1 h

2 h

4 h

1 h

1 h

References

1. PARVU M.: Botanică sistematică vol.I, Ed.Gloria Cluj Napoca, 2003

2. BOUCHET PH., GUIGNARD J.-L., VILLARD J.: Mycologie fondamentale et appliquée,

Masson Paris, Milan, Barcelone, 1999.

3. CHABASSE D., GUIGUEN CL., CONTET-AUDONNEAU N.: Mycologie médicale,

Masson Paris, 1999.

4. SALAGEANU GH., SALAGEANU A.: Determinator pentru recunoaşterea ciupercilor

comestibile şi otrăvitoare din România, Ed. Ceres Bucureşti, 1985.

5. PARVU M.: Atlas micologic, Ed. Presa Univ. Clujeană Cluj-Napoca, 1999.

6. LUCA MARIANA: Parazitologie şi Micologie medicală, Ed. Medicală Bucureşti, 1997.

7. SLEZEC ANNE-MARIE: Les Champignons, Ed. Liber SA Geneve, 1995.

76


COURSE TITLE – Prosthetic devices

COURSE OBJECTIVES

Acquiring knowledge on prosthetic devices available in pharmacy

PREREQUISITE – knowledge of anatomy, physiology, physiopathology, chemistry, physics

TEACHING METHODS

Interactive lectures, explanations and discussions

Individual study and documentation

EVALUATION METHODS

Written test

Compilation and presentation of papers on a given topic

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


PROSTHETIC DEVICES COURSE SYLLABUS

1. The importance and the role of prosthetic devices in pharmaceutical

practice. Prosthetic devices classification.

2. Supply materials for prosthetic products.

3. Varicosity and their treatment. Prosthetic treatment of varicosity.

4. Various abdominal diseases and their prosthetic treatment.

5. Various vertebral diseases and their prosthetic treatment.

6. Prosthetic devices for hands and legs diseases.

2 h

2 h

2 h

2 h

2 h

2 h

References

1. Rosca M., Produse protetice, Tipografia U.M.F, Cluj-Napoca, 2000

2. Laroche J, Laroche C., Leçons d'orthopedie, Ed. Cooperation Pharmaceutique Francaise,

Paris, 1988.

77


COURSE TITLE – History of pharmacy

COURSE OBJECTIVES

Acquiring knowledge on the evolution of pharmaceutical practice in the context of universal

history and the history of civilisations, art and science

PREREQUISITE - none

TEACHING METHODS


EVALUATION METHODS

Written examination

TEACHING LANGUAGE

Romanian language

French language

English language

NUMBER OF HOURS


HISTORY OF PHARMACY COURSE SYLLABUS

Introduction. The Prehistory

Pharmacy in the Antique Egypt

Pharmacy in Mesopotamia

Pharmacy in India and China. The Antiquity

Pharmacy in the Antique Greece

Pharmacy during the Hellenistic period

Pharmacy during the Roman Empire

Pharmacy during the Medieval Epoch

Pharmacy during the Renaissance

Pharmacy in Modern times

The contemporary history of Pharmacy

The Romanian history of pharmacy

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

References

1. Izsak S.: Farmacia de-a lungul secolelor, Ed. Ştiinţifică şi Enciclopedică, Bucureşti,

1979

2. Cotrău M.: Medicamentul de-a lungul vremii, Ed. Apollonia Iaşi, 1995

3. Cowen D. L., Helfand W. H.: Pharmacy an ilustrated history, Harry H. Abrams, Inc.,

Publishers, New York, 1990

78


COURSE TITLE – Summer practice for the 3nd


COURSE OBJECTIVES

Acquiring knowledge and practical skills on the preparation of pharmaceutical formulations and

filling the documents needed for their preparation and delivery

Acquiring adequate knowledge regarding pharmaceutical substances and pharmaceutical

specialties

Acquiring adequate skills for the communication with patients

PREREQUISITE – knowledge of IPhTL, pharmaceutical technology, pharmaceutical chemistry,

informatics

TEACHING METHODS

The application of theoretical knowledge in pharmacy practice, under the coordination,

monitoring and verification of practice tutors pharmacist

Explanations, discussions, analysis of how to solve real professional problems

EVALUATION METHODS

Characterization of student’s work by the coordinating pharmacist regarding:

1. Frequency

2. Compliance with the internal rules of organization and conduct of work.


4. The attitude towards the staff of the pharmaceutical unit.


Oral exam

TEACHING LANGUAGE

Romanian language

French or English language for foreign students that perform the practice in their own country

NUMBER OF HOURS

30 h / week - 2 weeks (0/60)

SUMMER PRACTICE FOR THE 3ND

YEAR STUDENTS IN PHARMACY PRACTICE SYLLABUS

1. Effective participation in the preparation of pharmaceutical preparations

2. The qualitative, quantitative and value reception of drugs, storage in appropriate

conditions.

3. Knowing pharmaceutical specialties.

4. Tollage and registration of prescriptions, delivering drug formulas and pharmaceutical

specialties.

5. Adequate professional relations with the staff of pharmacy and patients.

* 30 hours/week – 2 weeks

References






79

CHAIR OF THERAPEUTICAL CHEMISTRY

COURSE TITLE – Therapeutical chemistry


The objectives of the course are to acquire knowledge on:

- structural elements important for the therapeutic class

- synthesis and identification of active biological compounds

- physico-chemical properties important for the pharmacodynamic activity and stability

- chemical structure - activity relationships

- metabolic biotransformations influencing therapeutic activity

- main therapeutic effects indications, side effects, chemical and therapeutical interactions,

pharmaceutical products.

The objectives of the practical lessons are as follows:

- application of some chemical methods into the medicinal substances synthesis

- use of chemical and physico-chemical methods for the medicinal substances identification and

assay

- use of certain methods to establish the chemical structure-activity relationships

PREREQUISITE – knowledge of inorganic chemistry, organic chemistry, analytical chemistry,

anatomy, physiology, biochemistry

TEACHING METHODS



Debates on a given subject

Review presentation

EEVALUATION METHODS

Written examination


Periodical verifications

Independent work on a given subject

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



THERAPEUTICAL CHEMISTRY COURSE SYLLABUS

1st SEMESTER

1. The vegetative nervous system Adrenergic agonist drugs

Adrenergic antagonist drugs

Cholinergic agonist drugs

Cholinergic antagonist drugs

2. Neuromuscular blockers

3. The cardiovascular system Antihypertensive drugs

Antianginal drugs

Cerebral and peripheral vasodilators

Antiarrhythmics

Cardiotonics

Normolipemiant drugs

10 h

1 h

13 h

80

4. Diuretics

5. Local anaesthetics

6. The respiratory system Antitussive drugs

Mucolytic and expectorant drugs

Anti-asthmatic drugs

Respiratory analeptical drugs

7. The digestive system Gastric secretion inhibitors

Proton pomp inhibitors

H2 antihistaminic drugs

Antiacide drugs

Cytoprotective drugs

Prokinetic drugs

Antiemetic drugs

Hepatoprotective drugs

Antidiarrheals drugs

Laxative and purgative drugs

2nd

SEMESTER

1. Antiallergic drugs Histamine and antihistamines H1

Inhibitors of histamine release

2. Central nervous system Central myorelaxante drugs

General anesthetic drugs

Sedative and hypnotic drugs

Antianxiety drugs

Antipsychotic drugs

Antidepressants drugs

CNS exciting drugs

Antiepileptic drugs

Antiparkinsonian drugs

Antimigraine drugs

2. Opioid analgesic drugs Morphine

Semi synthetic analogous: agonists and antagonists

Synthetic analogue substances: agonists and antagonists

4. Analgesic, antipyretic and non steroidal anti-inflammatory drugs Analgesics and antipyretics

Non steroidal anti-inflammatory drugs

Slow-acting antirheumatics

Antigout drugs

5. Hormones, semi-synthetic and synthetic analogous Polypeptidic hormones

Insulin and oral antidiabetic drugs

Thyroid hormones and anti-thyroid drugs

Corticosteroid hormones and semi-synthetic and synthetic derivatives

Sexual hormones

6. Antianemic, antithrombotic, haemostatic drugs

7. Substances used for diagnosis

2 h

2 h

6 h

8 h

4 h

14 h

4 h

8 h

8 h

3 h

1 h

81


1st SEMESTER

1. Chemical and physico-chemical characterization of medicinal substances

belonging to the following chemical groups:

Amines

Carboxylic acids, salts and esters

Alcohol acids, phenol acids and their salts

Amides

Amino acids

Alkaloids

1. Synthesis of some medicinal substances, their identification and assay:

Benzocaine

2. Structural modelling

2nd

SEMESTER

1. Chemical and physico-chemical characterization of medicinal substances

belonging to the following chemical groups:

Polyhydroxy aldehide (ketone)

Cyclic ureides

Pyrazolone, pyrazolidindione

Fenothiazines

Benzodiazepines

Alkaloids

Xantines

Vitamins

Hormones

2. Synthesis of some medicinal substances, their identification and assay:

Calcium lactate

3. Structural modelling

9 h

3 h

3 h

3 h

3 h

9 h

6 h

6 h

3 h

3 h

3 h

3 h

3 h

3 h

6 h

3 h

3 h

6 h

6 h

References

1. MICHAELA PITEA, DOINA GHIRAN, ANA MUREŞAN, Medicamente

antiinflamatoare nesteroidiene, Ed. Dacia, Cluj-Napoca, Colecţia “Biblioteca

farmacistului” 1997.

2. I.SIMITI, ZAHARIA VALENTIN, ANA MUREŞAN, OVIDIU CRIŞAN, Produşi

naturali heterociclici, Ed. Dacia, Cluj-Napoca, Colecţia “Biblioteca farmacistului” 1998.

3. MICHAELA PITEA, DOINA GHIRAN, ANA MUREŞAN, MARIANA PALAGE,

Medicaţia în osteoporoză, Ed. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca,

2003.

4. MARIANA PALAGE, ANA MUREŞAN, Medicaţia afecţiunilor sistemului nervos

central, Ed. Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca, 2003.

5. ANA MUREŞAN, MARIANA PALAGE, Medicaţia în bolile cardiovasculare. Ed.

Medicală Universitară “Iuliu Haţieganu” Cluj-Napoca, 2005.

6. JOHN H. BLOCK, JOHN BEALE, Textbook of Organic Medicinal and Pharmaceutical

Chemistry, Eleventh Edition, Lippincott - Williams&Wilkins, Philadelphia, 2004.

7. AFECT-Traité de Chimie Thérapeutique. Ed. Médicales Internationales, Paris, Vol. 1,3,4,

1998.

8. THOMAS L. LEMKE, DAVID A. WILLIAMS, VICTORIA F. ROCHE, WILLIAM S.

ZITO, Foye’s Principles of Medicinal Chemistry, Sixth edition, Lippincott -

Williams&Wilkins, Philadelphia, 2008.

9. RICHARD B. SILVERMAN, The organic Chemistry of drug Designe and Drug Action,

Second Edition, , Elsevier, 2004.

10. THOMAS NOGRADY, DONALD F. WEAVER, Medicinal Chemistry a Molecular and

Biochemical Approach, Oxford University Press 2005.

82


COURSE TITLE – Industrial pharmaceutical technology


Acquiring knowledge on formulation, pharmaceutical technology and quality control of

industrial pharmaceutical dosage forms, with the purpose of registration by the national

regulatory agency and for efficient and safe use in patients


TEACHING METHODS



EVALUATION METHODS

Practical exam

Written exam with multiple choice questions

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



INDUSTRIAL PHARMACEUTICAL TECHNOLOGY COURSE SYLLABUS

1st SEMESTER

1. Drug design. Drug dosage forms. Preclinical and clinical studies. Formulation.

Production. Quality. Good Manufacturing Practices. Quality Control. Validation.

2. Optimization of the formulation and technology of drug dosage forms. Design of

experiments. Methods of optimization. Examples. The importance of optimization in

the preformulation.

3. Drug stability. Chemical kinetics and drug stability. Degradation of drugs,

mechanisms, factors and methods to avoid degradation during preparation of the

dosage form. Shelf life. Accelerated testing of stability and shelf life period.

4. Drug contamination. Microbial, chemical and mechanical contamination. Sources

of contamination. Risks. Methods for avoiding contamination. The relative innocuity

of drugs. Preclinical research of drug toxicity. Local tolerance.

5. Drug efficiency. Phases of clinical drug research. Introducing new drug dosage

forms in therapeutics. Bioavailability and bioequivalence for generic drugs.

6. Solutions. Preparation of solutions, technologies, equipment. Obtaining distilled

water in drug industry.

7. Mixing solutions. Industrial mixing devices. Filtration. Industrial filters. Filling

recipients, methods and equipments. Industrial preparation of syrups and aromatic

waters.

8. Formulation of ophthalmic drugs. Industrial preparation technologies. Equipment.

Formulation of extractive solutions. Physico-chemical factors influencing extraction.

Industrial extraction methods. Equipment. Quality of extractive solutions.

9. Parenteral dosage forms, formulation of injectable solutions and infusions.

Washing, sterilization, depyrogenation of containers and closures; equipment.

10. Sterilization principles. Sterilization methods. Sterilization equipment. Aseptic

preparation. Aseptic (clean) rooms. European guidelines for construction and

functioning of the clean rooms. Validation of sterilization methods. Sterility control.

11. Apyrogeneity. Pyrogens; structure, properties; methods for removal and methods

for pyrogen destruction. Avoiding pyrogenis. Control of pyrogens. The LAL test.

Quality of parenteral dosage forms.

2 h

2 h

2 h

2 h

2 h

2 h

6 h

2 h

2 h

2 h

2 h

83

12. Colloids, emulsions, suspensions. Composition and preparation technologies.

Equipment. Homogenization. Quality control.

13. Topical preparations: ointments, gels: formulation, preparation, quality.

Equipment for industrial preparation of semi solid preparations.

Suppositories: formulation, preparation, quality. Equipment for industrial preparation

of suppositories.

14. Medicinal aerosols: formulation, preparation, quality. Conditioning and

preparation equipment.

2nd

SEMESTER

1. Drying. Psychrometry. Stages in the drying of solids. Drying equipment. Drying

by means of convection, static convection, dynamic convection (tunnel, fluidized

bed); drying by means of conduction (vacuum, tunnel). Drying by means of radiation

(microwaves). Dryers for solutions, suspensions (spray driers, freeze driers).

Lyophilization: theory, equipment, techniques, advantages, applications.

2. Milling. Energy spent for size reduction; laws. Comminution, milling and

micronization equipment. Cutting. Compressing. Impact milling. Friction. Combined

methods. Choosing a method.

3. Particle size analysis. Equivalent diameters. Methods for measuring particle size.

Sieves. Microscopy. The Coulter Counter. Methods for laser beam diffraction.

Sedimentation methods. Separation methods: sieving; airflow separation methods,

elutriation; separation cyclones. Methods of graphic representation for the

distribution of granulometric classes of particles.

4. Powder rheology. The flow-cohesion relationship. The Jenike Cell. The Mohr

Diagram. Indicators of particle cohesion. Shearing force. Angle of repose. Properties

of particles and of powder beds. Porosity. Orifice flow. Building of the feeding

basket. Characteristics of powder flows, density of powder beds, the Carr index, the

Hausner index, the angle of repose. Flow modification in feeders.

5. Mixing. Mixing mechanisms. Measuring of mixing degree. Segregation. Powder

homogeneity. Ordered powders. Industrial mixing: rolling, high speed agitation, etc

6. Compaction and compression. Formulation. Preformulation. Tablet presses. Single

punch press. Rotary press. Granulation. Methods. Wet and Dry granulation.

Mechanisms of particle binding. Mechanisms of granule formation. Granulation

equipment. Planetary and oscillatory mixers, high speed granulation. Spray drying.

Extrusion, spheronization. Dry granulation: slugging, compacting

7. The physics and dynamics of compression. Changes in powder bulk compression.

Forces involved in the compression process. Role of lubricants. Force-displacement

compression diagrams. Tests for compressed tablets quality control, pharmacopoeias

and production quality control.

8. Tablet coating. Sugar coating. Stages. Equipment. Film coating. Polymers,

solvents, plasticizers, colours. Requested film qualities. Coating equipment. Quantity

of coating polymers needed. Film quality control. Disintegration, dissolution.

Compression coating.

9. Capsules. Hard gelatine capsules. Methods of capsule production. Capsule filling.

Powder dosage: screw devices, dosimeters, disk dosimeters. Equipment. Soft

gelatine capsules. Preparation. The Scherer Procedure. Capsule quality, quality

control. Microcapsulation, techniques, utility of microcapsules.

10. Pharmaceutical forms with extended release. Pharmacokinetic principles.

Preparation technologies. Forms of the reservoir type (compressed tablets, pellets).

Forms of the matrix type (hydrophyls, lipophyls, and thermoplastic polymers).

Formation of salts and complexes with poor solubility. Other techniques. Quality

control.

11. Pharmaceutical systems with controlled release. Principles. Characteristics.

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

84

Polymers. Systems with pre-programmed release (therapeutic systems of the matrix

type, reservoir type or with closed microcompartments). Activated systems

(physically activated: osmotic pressure, electro mechanic, hydrodynamic; mechanic

activation, magnetism, iontophoresis, floating, bioadhesive, enzymatic, etc.); systems

with feed-back release. Drug targeting. Microparticles for passive targeting

(liposomes, nanospheres, microspheres). Soluble macromolecular carriers.

Monoclonal antibodies. Endo and transcytosis.

12. Packaging. Packaging materials: glass, plastic materials, metals. Properties. Unit

dose packaging. Industrial equipment. Quality conditions. Uses.

13. Introducing new drug dosage forms on the market. Guidelines. Application files.

14. The concept of quality assurance. Good Manufacturing Practice. Quality Control.

Validation. Good Laboratory Practices. Good Clinical Practices.

2 h

2 h

2 h


1st SEMESTER

1. Aqueous solubility of drugs. Particle size influence on dissolution

2. Influence of the pH and of co solvents on the solubility of weak acidic drugs

(phenobarbital).

3. Preparation of intravenous infusions. Preparation of distilled water; weighting raw

materials, dissolution, flask distribution, sterilization.

4. Quality control of infusions: clarity, pH, concentration, sterility, pyrogens (the

LAL test).

5. Determination of the parameters that characterize the sterilization process:

decimal reduction time, inactivation factor, Z-value, lethality level, F-value,

sterilization value.

6. Alcoholic extractive solutions. Determining the influence of the method used for

extraction (maceration, percolation, turboextraction) and of solvent concentration

(alcohol 50˚, 70˚, 96˚) on the effectiveness of the extraction from vegetal products

(Calendulae flos).

7. Preparation and quality control of deflocculated suspensions. Determination of the

stability of the suspensions according to the viscosity of the dispersion phase, the

presence of an agent for increasing viscosity, the presence of a surface active agent.

Determination of the sedimentation rate.

8. Preparation and quality control of flocculated suspensions. Using the agar- agar

gel as flocculation agent. Determination of the sedimentation rate.

9. Preparing and controlling the stability of emulsions. Preparation of the emulsions

with simple and complex surface active emulsifiers and evaluation of their stability

according to the preparation method, nature and concentration of the emulsifier and

the HLB value of the emulsifying agent. Methods of stability control: determination

of the duration of the separation of phases, centrifugal behaviour; the particle size of

the internal phase, viscosity.

10. Determination of the shelf life of compressed tablets and capsules by applying

accelerated ageing test. 2

nd SEMESTER

1. Preparation and quality control of ointments (control of homogeneity, particle

size, consistency, stretching capacity, structure viscosity).

2. Suppositories- determination of the displacement factor.

3. Preparation of the suppositories by means of moulding and suppositories quality

control (aspect, mass uniformity, mechanic resistance, melting behaviour)

4. Milling of powders. Determination of the granulometric distribution (representing

histograms and the cumulative frequency curve; determining the average particle

diameter). Factors influencing the granulometric distribution (milling device, milling

time).

3 h

3 h

6 h

3 h

3 h

6 h

6 h

3 h

6 h

3 h

3 h

3 h

3 h

6 h

85

5. Mixing powders. Determining the influence of the mixing system; determining the

influence of blending time and particle size on powder homogeneity by statistical

interpretations (D.S.).

6. Powder rheology. Determination of the angle of repose. Studying the kinetics of

bulk density by tapping and determining the apparent density, the porosity, the

Haussner ratio, the Carr index. Determination of real density with the pycnometer.

7. Granule preparation by wet granulation. Following the effect of binding agent

concentration on its properties (granulometric distribution, dissolution time).

8. Filling hard gelatine capsules. Capsule quality control (mass uniformity,

dissolution)

9. Obtaining compressed tablets by means of wet granulation and quality control of

compressed tablets (mass uniformity, dissolution, friability, hardness). Presenting the

single punch press and rotary press and the phases of the compression process.

10. Obtaining solid coated pharmaceutical dosage forms (sugar coated tablets, filmed

coated tablets) and their quality control (mass uniformity, dissolution). Presentation

of coating equipments.

6 h

3 h

6 h

3 h

6 h

3 h

References

1. Leucuţa S.E.: Tehnologia formelor farmaceutice. Editura Dacia, Cluj-Napoca, 1995

2. Leucuţa S.E.: Formularea medicamentelor şi a noilor sisteme farmaceutice. Universitatea

L.Pasteur, Strasbourg, 1973

3. Lachman L., Lieberman H.A., Kanig J.L.: The Theory and Practice of Industrial

Pharmacy, Lea & Febiger, Philadelphia, 1985

4. Aulton M.E.: Pharmaceutics-the science of dosage form design. Churchill Livingstone,

Edinburgh, 2002

5. Leucuţa S.E., Achim M., Tomuta I.: Tehnologie farmaceutică industrială. Procedee de

laborator. . Editura universitara “Iuliu Hatieganu” Cluj-Napoca, 2005

6. Leucuţa S.E., Preda M., Achim M.: Prepararea medicamentelor, Editura Universitară

“Iuliu Haţieganu” Cluj-Napoca, 2000

7. Leucuţa S.E.: Tehnologie farmaceutică industrială, Editura Dacia, Cluj-Napoca, 2001, ed.a

II-a, 2008 (in editura)

86


COURSE TITLE – Biopharmacy and Pharmacokinetics


To acquire knowledge on the biopharmaceutical properties of drugs and dosage forms and on

the pharmacokinetics of drugs in the body: absorption, distribution, metabolism and excretion

phases


TEACHING METHODS



EVALUATION METHODS


Practical exam

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



BIOPHARMACY AND PHARMACOKINETICS COURSE SYLLABUS

1st SEMESTER

1. Biopharmacy and Pharmacokinetics: an introduction.

2. Fundamental pharmacokinetics. The concept of pharmacokinetic compartment.

Kinetics: notions. Kinetic processes of the zero and first order.

3. Pharmacokinetic models. The open one compartment pharmacokinetic model.

Intravenous administration. Elimination rate constant. Biological half life. Volume of

distribution.

4. The excretion of drugs in urine. Rate of urinary excretion. Cumulative excretion.

Renal and metabolic clearance. Total body clearance.

5. Extravascular administration. Absorption rate constant.

6. Constant rate infusion. Concentration in the steady state. Loading dose.

7. The pharmacokinetics of multiple intravenous and extravascular doses. Cmax,

Cmin, Css, loading dose, dosing interval.

8. Two-compartment pharmacokinetic model. Other models. The pharmacokinetics

of the biological response.

9. Clinical pharmacokinetics. Factors influencing pharmacokinetic parameters.

Pharmacokinetics and age. The new born and the elderly.

10. Sex, menstrual cycle and pregnancy: influences on pharmacokinetics.

11. Cardiac insufficiency and pharmacokinetics.

12. Renal failure and pharmacokinetics.

13. Pharmacogenetics, chronopharmacokinetics, patient compliance and

pharmacokinetic implications.

14. Pharmacokinetic interactions.

2nd

SEMESTER

1. Chemical structure and pharmacokinetic parameters.

2. Individualization. Variability in pharmacokinetics. Therapeutic drug monitoring.

3. Dissolution - the limiting step of absorption

4. Absorption of dissolved drugs.

5. Route of administration and bioavailability.

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

1h

87

6. Determining bioavailability of drug dosage forms. Rate and amount of absorption.

Methods.

7. Bioequivalence. Generic drugs and interchangeable dosage forms.

8. Physiological and pharmaceutical factors involved in the bio-availability of drugs.

Drug dosage forms for oral administration. The esophageal transit.

9. The stomach and its role in drug absorption.

10. The small intestine and the absorption of drugs.

11. The large intestine and dosage form administration. Colon therapy. Rectal

administration of dosage forms.

12. Topical administration of dosage forms. Percutaneous absorption. Systemic

transdermic therapy. Pulmonary administration route for medicinal aerosols.

13. Ocular and nasal drug administration for systemic therapy.

14. Importance of biopharmacy and pharmacokinetics in the concept of clinical

pharmacy

1h

1h

1h

1h

1h

1h

1h

1h

1h


1st SEMESTER

1. Description of the “in vitro” experimental pharmacokinetic model used for

determining pharmacokinetic constants and dosing regimens of drug administration.

Equipments. 1st order kinetic simulation using sodium salicylate as model drug.

Calibration curve for salicylic acid, spectrophotometric assay.

2. Pharmacokinetics of the single intravenous dose. Determination of the elimination

rate constant by using blood and urinary data. Determination of the biological half

life in the terminal phase of elimination. Determination of the volume of distribution.

Clearance determination.

3. Pharmacokinetics of the single extravascular dose. Determination of the rate

constant of the absorption process by the method of residuals.

4. Pharmacokinetics of intravenous continuous infusion. Infusion without bolus.

Infusion with a bolus. Loading dose.

5. Pharmacokinetics of multiple doses. Intravenous administration. Determination of

the Cmin and Cmax. Extravascular administration. Accumulation after multiple

doses.

6. Synthesis applications and practical applications using data taken from literature.

7. Biopharmaceutical factors influencing the release of drugs from pharmaceutical

preparations. Influence of the amount of the lubricant on the release and absorption

of salicylic acid from compressed tablets.

2nd

SEMESTER

1. Pharmacokinetics of sodium salicylate from compressed tablets with prolonged

release and from compressed tablets with immediate release.

2. Factors influencing the dissolution rate of drugs from compressed tablets:

temperature, dissolution, medium stirring speed, pH. Use of dissolution equipment

according to USP 23 and FR X, the Erweka model.

3. Influence of ointment base and of salicylic acid incorporation techniques on the in

vitro release.

4. Influence of particle size on absorption (salicylic acid with different but definite

granulometery).

5. Factors influencing the absorption of phenobarbital administered in rats (i.v., i.m.,

oral, s.c. and i.p. routes); pharmaceutical form (solution, suspension, aqueous, oily);

chemical form of the medicinal substance (acid, sodium salt, calcium salt); particle

size (suspensions with particles of different sizes). Measurements of narcotic sleep

induced to rat (rate and duration).

6. Factors influencing the absorption of phenobarbital administered in rats: influence

of adjuvants (polysorbate 80, methylcellulose); influence of the urinary pH

4 h

4 h

4 h

4 h

4 h

4 h

4 h

4 h

8 h

4 h

2 h

4 h

2 h

88

(acidulation with ascorbic acid, alkalinization with sodium bicarbonate,

intraperitoneal use); enzymatic induction and inhibition (rats previously treated with

phenobarbital for 7 days and another group treated with carbon tetrachloride).

7. Determination of the bioavailability of some drugs by using the trapezoidal

method. Data taken from literature. Data taken from our own laboratory research.

8. Using computers for determining pharmacokinetic constants, dosage regimens, for

calculating the bioavailability and bioequivalence of drugs.

2 h

2 h

References

1. Leucuţa S.E.: Introducere în biofarmacie. Editura Dacia, Cluj-Napoca, 1975

2. Leucuţa S.E., R.D.Pop : Farmacocinetica, Editura Dacia, Cluj-Napoca, 1981

3. Leucuţa S.E., Bodea A.: Biofarmacie - Farmacocinetica. Lucrări practice. Lito

U.M.F.Cluj-Napoca, 1986

4. Notari R.E.: Biopharmaceutics and Pharmacokinetics.M.Dekker Inc., New York, 1975

5. Leucuţa S.E.: Farmacocinetica în terapia medicamentoasă, Editura Medicală, Bucureşti,

1989.

6. Leucuta S.E.: Biofarmacie si Farmacocinetica, Editura Dacia, Cluj-Napoca, 2002

89

CHAIR OF TOXICOLOGY

COURSE TITLE – Toxicology


The objective of the course is to provide students basic knowledge of general toxicology,

allowing them to understand the fate of toxic substances in the body, their interaction with cell

components and the main effects at organ level, as well as to provide essential knowledge of

clinical toxicology and toxicological analysis allowing the clinical and laboratory diagnosis of

intoxications and the prevention of toxic effects.

PREREQUISITE - knowledge of inorganic, organic and analytical chemistry, physiology,

pathophysiology, immunology, biochemistry, pharmacology and medicinal chemistry

TEACHING METHODS

Lectures with PowerPoint presentations, case studies

Practical applications in the laboratory

EVALUATION METHODS

Written exam

Practical exam

Evaluation during the semester

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



TOXICOLOGY

COURSE SYLLABUS

1st SEMESTER

GENERAL TOXICOLOGY

1. Introduction in toxicology

Definition and aim

Historic

2. Toxic substances and intoxications Definition and classification of toxic substances

Definition and classification of intoxications

3. Toxicokinetics Mechanisms of transport across biological membranes

Absorption of toxicants

Distribution of toxicants

Accumulation of toxicants

Elimination of toxicants

Metabolism of toxicants. Phase I reactions. Phase II reactions. Consequences of

xenobiotics’ metabolism.

4. Dose – effect relationships in toxicology

5. Factors modulating toxicity Chemical factors

Biological factors

Environmental factors

6. Mechanisms of toxicity Cellular injuries induced by toxicants

Functional effects of toxicants

Genetic toxicity

Chemical carcinogenesis

1 h

1 h

4 h

1 h

3 h

3 h

90

Teratogenesis

Immunotoxicity

7. Target organ toxicity Nervous system toxicity

Pulmonary toxicity

Hepatotoxicity

Nephrotoxicity

Toxicology of the blood

Dermatotoxicology

CLINICAL TOXICOLOGY

1. Treatment and prevention of intoxications

2. Toxicology of air pollutants

Toxicology of carbon monoxide

Toxicology of halogens

Toxicology of ammonia and nitrogen oxides

Toxicology of hydrogen sulphide and sulphur oxides

3. Toxicology of volatile substances Toxicology of petroleum distillates

Toxicology of aromatic hydrocarbons

Toxicology of halogenated hydrocarbons

Toxicology of nitro and amino aromatic derivatives

Toxicology of alcohols and glycols: methanol, ethanol, ethylene glycol

Toxicology of cyanides

Toxicology of carbon sulphide

2nd

SEMESTER

CLINICAL TOXICOLOGY

1. Toxicology of minerals Toxicology of corrosives

Toxicology of metals (lead, cadmium, mercury, chrome, nickel, manganese,

arsenic)

2. Toxicology of drugs Toxicology of hypnotic drugs: barbiturates

Toxicology of minor tranquilizers (meprobamate, benzodiazepines)

Toxicology of antipsychotic drugs

Toxicology of antidepressant drugs (IMAO, tricyclic antidepressants, selective

inhibitors of serotonin reuptake, lithium)

Toxicology of drugs acting on the autonomic nervous system

Toxicology of antihistaminic drugs

Toxicology of anticonvulsants

Toxicology of analgesics-antipyretics

Toxicology of cardiovascular drugs

Toxicology of chemotherapeutic drugs (sulphonamides, antibiotics,

antituberculosis drugs, anticancer drugs)

3. Toxicology of drugs of abuse

Toxicology of opioids

Toxicology of cocaine

Toxicology of natural hallucinogens

Toxicology of designer drugs

Toxicology of inhalants

Toxicology of substances used in doping

Toxicology of nicotine

4. Toxicology of pesticides

3 h

1 h

3 h

8 h

4 h

12 h

8 h

2 h

91

Toxicology of insecticides

Toxicology of fungicides

Toxicology of rodenticides

Toxicology of herbicides

5. Toxins Mycotoxins

Poisonous mushrooms

2 h

PRACTICAL LESSONS

1st SEMESTER

1. Toxicological analysis: classification, phases

2. Methods of systematic toxicological analysis Methods of isolation for gases and vapours

Methods of isolation for mineral toxicants

Methods of isolation for organic toxicants

3. Toxicological evaluation of drugs Assessment of acute toxicity: determination of medium lethal dose

Testing of mutagenicity by micronucleus test

4. Identification of toxicants by chemical methods

5. Identification of toxicants by chromatographic methods

6. Quantitative analysis of toxicants in air and biological samples Toxicological analysis of gases (carbon monoxide, hydrogen sulphide, sulphur

dioxide, nitrogen oxides, chloride) and of biomarkers (carboxyhemoglobin)

Toxicological analysis of volatile substances (ethanol, methanol, ethylene glycol,

phenol, formaldehyde, aniline, cyanide)

Quantification of certain biomarkers of intoxications with volatiles (p-

aminophenol, methemoglobin, thiocyanate, hippuric acid, sulphate index)

2nd

SEMESTER

1. Quantitative analysis of toxicants in air and biological samples Toxicological analysis of drugs in biological samples (barbiturates,

benzodiazepines, phenothiazines, tricyclic antidepressants, izoniazide, aspirin,

acetaminophen)

Toxicological analysis of certain drugs (total morphine in urine, analysis of illicit

powders by TLC)

Toxicological analysis of certain pesticides in biological samples (malathion,

paraquat, DNOC)

Quantification of biomarkers of pesticide intoxication (total p-nitro-phenol in

urine, cholinesterase activity in blood)

2. Analysis of clinical cases of intoxications

3. Applications of toxicological analysis in the diagnostic of certain cases of

intoxications

3 h

9 h

6 h

3 h

3 h

18 h

33 h

6 h

3 h

References

1. Loghin F., Toxicologie generală, Editura Medicală Universitară „Iuliu Haţieganu”, Cluj-

Napoca, 2002

2. Loghin F., Popa D., Kiss B., Anton R., Analize şi evaluări toxicologice, Editura Medicală

Universitară „Iuliu Haţieganu”, Cluj-Napoca, 2003

3. Loghin. F., Popa D., Kiss B., Analyses et evaluations toxicologiques, Editura Medicală

Universitară „Iuliu Haţieganu”, Cluj-Napoca, 2004

4. Flanagan R.J., Braithwaite R.A., Brown S.S., Widdop B., Wolff F.A., Elements de

toxicologie analytique, Organisation Mondiale de la Sante, Geneve, 1997

5. Viala A.,Botta A., Toxicologie, ed. 2, Edition TEC & DOC Lavoisier, Paris, 2005

6. Bismuth C., Baud F., Conso F., Dally S., Ferejaville J., Toxicologie clinique (ed.5),

Medécine Science Flammarion, Paris, 2000

92

CHAIR OF DRUG ANALYSIS

COURSE TITLE – Biological drugs and biological drug control


To provide students informations regarding biological drugs obtained either by traditional

techniques of extraction (from animal bodies), or by genetic engineering.

Practical works have as objective to familiarise the students with the analytical techniques used

on biological matrices and also with the methodology of calculation and interpretation of the

results.

PREREQUISITE - knowledge of immunology, microbiology, physiology, pathology,

pharmaceutical technology

TEACHING METHODS

Plenary lectures assisted by multimedia support.

The students carry out practical works and introduce the results in the personal book (in a

bulletin), which contains the necessary information for the performing of each activity.

EVALUATION METHODS

Written exam (multiple choice questions) at the end of each term

Practical exam (evaluation of theoretical and practical skills) at the end of the term

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



BIOLOGICAL DRUGS AND BIOLOGICAL DRUG CONTROL COURSE SYLLABUS

1. 1. Biological drugs. Obtention methods – Extractive methods

– Genetic engineering

Recombinant DNA technology

Transgenic animal, phage display technology

2. The blood and blood derivatives. Hemotherapy

– General information

Physical and chemical properties of blood

Blood collection and securisation

Blood fractioning

– Labile blood derivatives

– Stable blood derivatives

– Biological drugs interfering in the coagulation cascade: coagulation factors,

anticoagulant therapy, fibrinolytics

Biological drugs interfering in the haematopoiesis

3. Biological drugs used in immunoprophylaxis

– The immune system

– Therapy with immunoglobulins

Polyclonal antibodies

Homologous sera: human immunoglobulins - normal and specific

Heterologous sera

Monoclonal antibodies

– Vaccino-prophylaxis

National Vaccination Plan (vaccination schedule)

Obligatory vaccines

4 h

6 h

14 h

93

Recommended vaccines

Vaccines for travellers

4. Biological drugs obtained by extraction from animal organs and/or

biotechnology

– Enzymes with therapeutic value

– Hypophyseal hormones obtained by biotechnologies

– Biological drugs obtained from the intestinal membrane

– Biological drugs obtained from the pancreas

– Biological drugs obtained from the liver

4 h

PRACTICAL LESSON SYLLABUS

1. Biological methods for quantitative analysis :

– Microbiological quantitative determination of antibacterial drugs

– Radio Immuno Assay (RIA)

– Enzyme-Linked ImmunoSorbent Assay (ELISA)

2. Quantitative analysis of pancreatin conditioned in pharmaceutical forms

3. Quantitative analysis of penicillin’s conditioned in pharmaceutical forms

4. Quantitative analysis of streptomycin conditioned in pharmaceutical forms

5. Quantitative analysis of the pepsin conditioned in pharmaceutical forms

4 h

2 h

2 h

2 h

2 h

References

1. Desai MA. Downstream Processing of Proteins. Methods and Protocols, Humana Press

Inc., 2000

2. Hatti-Kaul R, Mattiasson B. Isolation and Purification of Proteins, Ed. Marcel Dekker,

2003

3. Cutler P. Methods in Molecular Biology. Protein Purification Protocols, Ed. Humana Press

Inc., 2nd edition, 2003

4. Colman RW, Clowes AW, Goldhaber SZ, Marder VJ, George JN. Hemostasis and

Thrombosis: Basic Principles and Clinical Practice, Ed. Lippincott Williams & Wilkins,

5th edition, 2006.

5. World Health Organization, The Clinical Use of Blood Handbook 2001.

http://www.who.int/bloodsafety/clinical_use/en/Handbook_EN.pdf

6. Galley HF, Blood and Blood Transfusion, BMJ Publishing Group, 2002

7. Kern W. PDQ Hematology, Ed. Decker Inc., 2002

8. Spiess BD, Spence RK, Shander A. Perioperative Transfusion Medicine, Ed. Lippincott

Williams & Wilkins, 2nd edition, 2006.

9. Nezlin R. The Immunoglobulins: Structure and Function, Ed. Academic Pr., 1998

10. Plotkin SA, Orenstein WA, Offit PA. Vaccines: Expert Consult, Ed. Saunders, 5th edition,

2008

11. Brumboiu MI, Bocşan IS. Vaccinuri şi Vaccinări în practica medicală, Ed. Medicală

Universitară “Iuliu Haţieganu”, 2005

12. Direction générale de la santé, Comité technique des vaccinations. Guide des vaccinations

2006. http://www.inpes.sante.fr/CFESBases/catalogue/pdf/927.pdf

13. Immunisation against infectious disease - the Green Book, February 2008,

www.dh.gov.uk/greenbook

14. Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/

15. ANM. Nomenclator. http://www.anm.ro

16. European Medicines Agency, http://www.emea.europa.eu

17. Walsh G. Pharmaceutical Biotechnology. Concepts and Applications, Ed. John Wiley &

Sons Ltd, 2007

18. ***, Martindale 35: The Complete Drug Reference, The Pharmaceutical Press, CD-ROM

edition 2007

http://www.cdc.gov/vaccines/

http://www.anm.ro/

94


PHYSIOPATHOLOGY

COURSE TITLE – Pharmacology


Course: Acquiring knowledge of general pharmacology, needed for the understanding of the

pharmacology of the main classes of drugs

Practical lessons: the study of experimental models used for the evaluation of the

pharmacokinetics and pharmacology of drugs.

PREREQUISITE – knowledge of anatomy, physiology, physiopathology, pathology, biochemistry

TEACHING METHODS

Interactive lectures

Experiments on laboratory animals and computer alternative methods

EVALUATION METHODS

Written exam

Practical exam

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



PHARMACOLOGY COURSE SYLLABUS

1st SEMESTER

1. Autonomic pharmacology. Adrenergic pharmacology. Adrenomimetics

2. Autonomic pharmacology. Adrenergic pharmacology. Alpha-blockers

3. Autonomic pharmacology. Adrenergic pharmacology. Beta-blockers

4. Autonomic pharmacology. Cholinergic pharmacology. Cholinomimetic drugs

5. Autonomic pharmacology. Cholinergic pharmacology. Anticholinergic drugs

6. Nicotinic pharmacology. Ganglioplegics. Central and peripheral muscle relaxants

7. Pharmacology of histamine. H1 antihistaminic drugs

8. H2 antihistaminic drugs

9. Pharmacology of steroidal anti-inflammatory drugs

10. Pharmacology of NSAID's

11. Pharmacology of analgesics-antipyretics

12. Pharmacology of opioid analgesics

13. Pharmacology of local anesthetics

14. Pharmacology of general anesthetics

15. Pharmacology of sedatives-hypnotics-tranquilizers

16. Pharmacology of anticonvulsive drugs

17. Pharmacology of antidepressant drugs

18. Pharmacology of antipsychotic drugs

19. Pharmacology of antiparkinsonian drugs

20. Pharmacology of CNS stimulants. Neurotonic drugs

21. Pharmacology of anti-Alzheimer drugs

22. Pharmacology of anti-migraine drugs

2nd

SEMESTER

1. Cardiovascular pharmacology. Cardiotonic drugs

2. Cardiovascular pharmacology. Antiarrhytmic drugs

3. Cardiovascular pharmacology. Antihypertensive drugs

3 h

1 h

3 h

2 h

2 h

2 h

2 h

1 h

2 h

3 h

1 h

2 h

2 h

2 h

3 h

2 h

2 h

2 h

1 h

1 h

2 h

1 h

2 h

1 h

3 h

95

4. Cardiovascular pharmacology. Diuretic drugs

5. Cardiovascular pharmacology. Antianginal drugs. Antihypotensives

6. Cardiovascular pharmacology. Peripheral vasodilators. Venoactive drugs

7. Pharmacology of the blood. Anticoagulant drugs. Antiplatelet drugs.

Fibrinolytics. Hemostatic drugs

8. Pharmacology of the blood. Antianemic drugs

9. Respiratory pharmacology. Cough-suppressive agents. Expectorants.

Antiasthmatic drugs

10. Pharmacology of digestive system. Antiulcerous drugs

11. Pharmacology of digestive system. Emetics, antiemetic drugs, gastric and

pancreatic secretion replacements

12. Pharmacology of digestive system. Laxatives-purgatives. Antidiarrheic drugs.

Spasmolytic drugs

13. Pharmacology of metabolic disease. Hypolipemic drugs

14. Pharmacology of metabolic disease. Antidiabetic drugs

15. Pharmacology of metabolic disease. Gout pharmacology

16. The endocrine medication. The thyroid medication

17. The endocrine medication. The sexual hormones

18. Pharmacology of antibiotic and chimiotherapic drugs

19. Pharmacology of antimycotic, antiparasitary and antiviral drugs

20. Pharmacology of antitumoral drugs

2 h

2 h

1 h

3 h

1 h

3 h

2 h

1 h

2 h

1.5 h

2 h

1 h

1 h

2,5 h

6 h

3 h

2 h


1st SEMESTER

1. Pharmacology of adrenergic system

2. Pharmacology of adrenergic system

3. Pharmacology of cholinergic system

4. Pharmacology of cholinergic system

5. Pharmacology of the peripheral muscle relaxants. Nicotinomimetic drugs

6. Pharmacology oh H1 antihistaminic drugs. Pharmacology of NSAID's

7. Pharmacology of analgesic drugs

8. Pharmacology of local and general anesthetics

9. Pharmacology of tranquilizers-sedatives-hypnotics

10. Pharmacology of anticonvulsive drugs

11. Pharmacology of antipsychotic drugs

12. Pharmacology of antiparkinsonian drugs

13. Pharmacology of antidepressant drugs

14. Pharmacology of CNS stimulants

2nd

SEMESTER

1. Cardiovascular pharmacology

2. Pharmacology of the blood

3. Renal pharmacology

4. Digestive system pharmacology

5. Respiratory system pharmacology

6. Metabolic pharmacology

7. Endocrine system pharmacology

8. Pharmacology of antibiotic and chimiotherapic drugs

9. Pharmacology of antimycotic, antiparasitary and antiviral drugs

10. Pharmacology of antitumoral drugs

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

9 h

6 h

3 h

3 h

3 h

3 h

3 h

6 h

3 h

3 h

References

1. Aurelia Cristea, Farmacologie generală, Ed. Didactică şi Pedagogică Bucureşti, 1998.

2. Aurelia Cristea, Tratat de Farmacologie, Editura Medicală Bucureşti 2005.

3. Valentin Stroescu, Bazele farmacologice ale practicii medicale, Ediţia a VII-a, Editura

96

Medicală, 2001.

4. Goodman&Gilman’s, The pharmacological basis of therapeutics, Ed. Mc Graw Hill, 2006.

5. Katzung B.G., Basic and Clinical Pharmacology. Editia a 10-a, Editura McGraw-Hill, New

York 2007.

6. Rang H.P., Dale M.M., Ritter J.M., Pharmacology, Ed. Churchill Livingstone, 2007.

7. Mogoşan Cristina, Abrégé de PHARMACOLOGIE, Editura Medicală Universitară “Iuliu

Haţieganu” Cluj-Napoca, 2005.

8. Cohen Y., Jacquot C., Pharmacologie, Ed. Masson, Paris, 2001.

9. Landry Y., Gies J-P., Pharmacologie, des cibles vers l’indication therapeutique, Ed.

Dunod, 2003.


therapeutiques, Ed. Frison-Roche, Slatkine Geneve 1992.

11. Mogoşan Cristina, Voştinaru Oliviu, Ghibu Steliana, Bazele experimentale ale

farmacologiei, Editura Medicală Universitară „Iuliu Haţieganu” Cluj-Napoca 2005.

97


COURSE TITLE – Research methodology


Course: studying and understanding of the research process, witting a research proposal,

collecting and processing data, writing a research report.

During the tutorial class, students are trained to perform statistical evaluation on the

experimental data and interpretation of the results. Also, they are trained to recognise a valid

source for bibliographic documentation and to realise an appropriate presentation of the results.

PREREQUISITE – knowledge of pharmaceutical terminology, informatics, statistics

TEACHING METHODS

Plenary lectures assisted by multimedia support

Tutorial class: Lecture assisted by power point presentation, followed by individual practice.

EVALUATION METHODS

Multiple choice questions (MCQ) test at the end of semester (50% of the final score).

Evaluation of practical abilities and theoretical knowledge: questions and computer applications

(50% of the final score)

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



RESEARCH METHODOLOGY COURSE SYLLABUS

1. The research process:

1. Formulating a research problem

2. Conceptualisation of a research design

3. Constructing an instrument for data collection

4. Selecting a sample

5. Writing a research proposal

6. Collecting data

7. Processing data

8. Writing a research report.

2. Basic statistics and pharmaceutical statistical applications.

3. Modalities to write a scientific paper (article, review). Recommendations

4. Modalities to perform a scientific presentation. Recommendations

5 h

4 h

4 h

1 h

TUTORIAL CLASS SYLLABUS

1. Statistical evaluation of experimental data. Statistical tests (t student,

ANOVA, Wilcoxon)

2. Writing a scientific paper (article, scientific report). Practical approach.

3. To realize and perform a presentation. Practical approach.

4. Bibliographic documentation on the internet, databases and journals

6 h

6 h

6 h

10 h

References

1. James E. De Muth – Basic Statistics and Pharmaceutical Statistical Applications, Marcel

Dekker Inc., New York, 1999.

2. Bolton S.- Pharmaceutical Statistics: Practical and Clinical Applications, Marcel Dekker,

Inc. New York, 1997 444-489.

3. Kachigan S.K – Multivariate Statistical Analysis, second edition, Radius Press, New York,

1991, 89-90.

4. D.Dumitraşcu, D.L Dumitraşcu – Introducere în cercetarea ştiinţifică, Editura Dacia, 2007

98

5. Andrei Achimaş Cadariu – Metodologia Cercetării ştiinţifice, Editura Medicală

Universitară “Iuliu Haţieganu”, Cluj-Napoca, 1999

6. Mary Helen Briscoe – Preparing Scientific Illustrations, second edition, Springer, 1996

7. Roger Benichoux – Guide de communication medicale et scientifique, Sauramps Editions,

1997

8. Kumar R. Research Methodology, a step-by-step guide for beginners, Sage Publications,

London, 1999.

99


LABORATORY

COURSE TITLE – Drug metabolism

COURSE OBJECTIVES

The aim of the present course is to offer basic informations concerning drugs biotransformation,

complex process with impact on both main and secondary actions of drugs. We want to underlie

the importance of understanding the phenomena at molecular level, with the purpose of

optimising the therapeutic act by increasing the efficacy and lowering the risk of adverse

reactions and interactions.

PREREQUISITE – knowledge of organic chemistry, pharmaceutical chemistry, biochemistry,

pharmacology, toxicology

TEACHING METHODS Interactive course based on video projection Power Point (animated) presentations

EVALUATION METHODS

Discussions during the course and final oral examination.

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


DRUG METABOLISM COURSE SYLLABUS

1. Molecular aspects of the preliminary processes of drugs biotransformation:

membrane crossing and binding to plasma proteins.

2. Metabolic pathways of biotransformation: phase I (oxidations, reductions, and

hydrolysis processes) and phase II reactions (conjugations).

3. Enzymatical systems involved and molecular mechanisms of biotransformation.

4. Factors that influence drugs biotransformation.

5. Pharmacological and toxicological consequences of drugs biotransformation.

6. Induction and inhibition of drug-metabolising enzymatic systems. Consecutive

drugs interactions.

7. The pharmacogenetics and pharmacogenomic concepts.

1 h

2 h

2 h

2 h

2 h

2 h

1 h

References

1. Testa B, The Metabolism of Drugs and Other Xenobiotics. Biochemistry of Redox

Reactions. Testa B., Well J., editors. London : Academic Press, Harcourt Brace and

Company Publishers, 1995.

2. Gordon GG, Skett P., Introduction to Drug Metabolism. London : Blackie Academic &

Professional, An Imprint of Chapman & Hall, 1997.

3. Woolf TF., Handbook of Drug Metabolism, New York : Marcel Dekker, Inc. 1999.

4. Corina Ionescu, Biotransformarea medicamentelor, Editura Medicală Universitară "I.

Haţieganu" Cluj-Napoca, 2001.

5. Oniga O, Corina Ionescu, Reacţii adverse şi interacţiuni medicamentoase, Editura

Medicală Universitară "I. Haţieganu", Cluj-Napoca, 2004.

6. Corina Ionescu, Mino R. Caira, Current concepts in Drug Metabolism, Springer,

Dordrecht, The Netherlands, 2005.

100


COURSE TITLE – Toxic plants

COURSE OBJECTIVES

Acquiring information regarding medicinal plants with toxicological and allergenic potential

from botanical and toxicological point of view

PREREQUISITE – knowledge of botany and pharmacognosy

TEACHING METHODS


EVALUATION METHODS

Written Exam

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


TOXIC PLANTS

COURSE SYLLABUS 1. Toxic plants of the wild flora

2. Cultivated toxic plants

3. Poisonous ornamental plants

4. Plants causing dermatitis

5. Plants containing toxalbumins

6. Plants causing allergies

7. Photosensitising plants

8. Toxicity of aromatic plants

9. Alimentary risks

10. Considerations upon the toxic plants of the Romanian flora

11. Plants in judicial toxicology

12. Recommended conduct in intoxications

13. Hallucinogens of vegetal origin

14. Legislation of toxic plants in Romania and all over the world

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

References

1. Daniela Hanganu, H. Popescu – Plante toxice – Ed. Medicală Universitară "Iuliu

Hatieganu", Cluj-Napoca, 2002

2. J. Bruneton – Plantes toxiques. Vegetaux dangereux pour l′homme et les animaux, Edition

TEC& DOC, Londrs, Paris, New Cork, 1996

101

CHAIR OF ENVIRONMENTAL CHEMISTRY AND HYGIENE

COURSE TITLE – Nutrition and dietotherapy

COURSE OBJECTIVES

To acquire knowledge on nutrition and the healthy human body necessities during its life cycle,

but also regarding the diet conduct required by a health individual in order to prevent nutritional

unbalances. An aim is also to provide future pharmacists an adequate tool to competently advise

the patients regarding the diet therapy elements as a complement of prescribed drug treatment.

PREREQUISITE – knowledge of environmental chemistry and hygiene, pathology

TEACHING METHODS


EVALUATION METHODS

Written exam

Bibliographic research on a given subject

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


NUTRITION AND DIETOTHERAPY

COURSE SYLABUS :

1. Nutrition during life cycle. Nutrition during pregnancy and lactation. New born

and small child nutrition. Nutrition in childhood. Nutrition in adolescence.

Nutrition in the adult age. Nutrition in aging.

2. Alimentary balance and dietetics – treatment per se or complement in various

pathologies.

3. Nutrition for weight management. Nutrition and obesity. Nutritional

recommendations.

4. Nutrition and diabetes. Nutritional recommendations.

5. Nutrition and dyslipidemia. Nutritional recommendations.

6. Nutrition and cardiovascular disease. Nutritional recommendations.

7. Nutrition and hypertension. Nutritional recommendations.

8. Nutrition and renal disorders. Nutritional recommendations.

9. Nutrition and gastrointestinal tract disorders. Nutrition and hepatic, pancreatic,

biliary disorders. Nutritional recommendations

10. Medical nutrition therapy for Cancer prevention, treatment and recovery.

11. Food allergies and intolerance. Nutritional recommendations.

12. Medical nutrition therapy for anemia.

13. Enteral and parenteral nutrition support. Pharmaceutical implications.

14. Drug-food interactions.

15. Dietetic products.

2 h

1 h

1 h

1 h

0,5 h

1 h

1 h

0,5 h

1 h

1 h

1 h

0,5 h

0,5 h

1 h

1 h

References

1. Mahan LK, Escot-Stump S – Krause2s Food, Nutrition & Diet Therapy, ed. Elsevier

(USA), 2004.

2. Basdevant A, Laville M, Lerebours E. / Traite de nutrition clinique de l’adulte, Ed.

Flammarion Medecine-Sciences (France) 2001

3. Mann J, Stewart Truswell A. – Essentials of human nutrition, Second edition, Ed. Oxford

University Press, 2003

4. Dupin H. et col. - Alimentation et Nutrition Humaines, ESF editeur, Paris, 1992

5. Cervera R, Clapes J, Rigolfas R. – Alimentacion y dietoterapia, 3a Edicion, Mc. Graw-Hill

Interamericana, 1998

6. Sendrea. D- Nutritie si dietoterapie, Ed. Printek Cluj-Napoca, 1996

102


COURSE TITLE – Summer practice for the 4th


PRACTICE OBJECTIVES

Acquiring knowledge on other work places where pharmacists can be employed:

pharmaceutical industry, laboratories (biochemistry, toxicology, and environmental chemistry),

and drug warehouses.

PREREQUISITE – knowledge of biochemistry, toxicology, analytical chemistry, environmental

chemistry, medicinal chemistry, pharmaceutical technology, informatics.

The application of theoretical knowledge in pharmacy practice, under the coordination,

monitoring and verification of practice tutors pharmacist

Explanations, discussions, analysis of how to solve real professional problems

EVALUATION METHODS

Characterization of student’s work by the coordinating pharmacist regarding:

1. Frequency

2. Compliance with the internal rules of organization and conduct of work.


4. The attitude towards the staff of the pharmaceutical unit.


Oral exam

TEACHING LANGUAGE

Romanian language

French or English language for foreign students that perform the practice in their own country

NUMBER OF HOURS

120 hours: 4 weeks – 30 hours / week

SUMMER PRACTICE FOR THE 4TH

YEAR STUDENTS IN PHARMACY SYLLABUS

1. Knowing the specific of practice's place.

2. Knowledge of principles, methods of work, acquiring some practical skills and commenting

results.

3. Knowledge of pharmaceutical legislation.

References






103

CHAIR OF DRUG INDUSTRY AND PHARMACEUTICAL

BIOTECHNOLOGY

COURSE TITLE – Drug industry and pharmaceutical biotechnology


Acquiring theoretical knowledge regarding industrial preparation of pharmaceutical substances

via chemical synthesis and biotechnology

Applying theoretical knowledge to the synthesis of pharmaceutical substances using industrial

methods...

PREREQUISITE – knowledge of organic chemistry, genetics

TEACHING METHODS

Lectures

Practical applications in the laboratory, presentations on given subjects

EVALUATION METHODS

Written exam (multiple choice questions)

Practical exam

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



DRUG INDUSTRY AND PHARMACEUTICAL BIOTECHNOLOGY

COURSE SYLLABUS

1. General notions

The subject of the discipline drug industry and pharmaceutical

biotechnologies

The development of drug industry in the world and in our country

General notions of chemical technology of drugs

Industrial devices for the drug synthesis

2. The main chemical processes with their applications in drug synthesis and

examples Oxidation

Reduction

Halogenation

Nitration

Condensation

Transposition

3. Applications of biotechnology in pharmaceutical industry

General notions

Biosynthesis technological processes

First and second generation biotechnology

Antibiotics

Vitamins

Organic acids

Proteins

Steroids

Third generation biotechnology

DNA recombinant technology: steps, applications

Human recombinant insulin

Recombinant human growth hormone and recombinant somatostatin

2 h

10 h

16 h

104

Recombinant interferons

Rt-PA

Interleukins

Recombinant vaccines


1. Work protection in the drug factories. The organization of a drug factory

2. Synthesis of some drugs and some intermediate substances in the lab, based on

reactions of: oxidation, reduction, condensation, nitration, izonitrosation, acylation,

hydrolysis

3h

39 h

References

1. Coman Mioara, Bota Cristina – „Farmacobiotehnologie”, Editura Srima, Cluj Napoca,

2000;

2. Coman Mioara, Bota Cristina, Pop Carmen – „Biotehnologii farmaceutice”, Editura

Medicală Universitară „Iuliu Haţieganu”, Cluj Napoca, 2004.

3. Coman Mioara, Bota Cristina, Pop Carmen – „Industria medicamentului. Baze teoretice şi

aplicaţii”, Ed. Srima, Cluj Napoca, 2003;

4. Cristea I. – „Reacţii şi mecanisme de reacţie în chimia organică”, Editura Risporint, Cluj

Napoca, 2000;

5. Crommelin D.J.A., Sindelar R.D. - „Pharmaceutical Biotechnology”, Harwood Academic

Publishers, Australia, 1997;

6. Dăescu, C. – „Chimia şi tehnologia medicamentelor”, Editura Didactică şi Pedagogică,

Bucureşti, 1994;

7. Dăescu, C. – „Industria medicamentelor”, Editura Uni-Press, Bucureşti, 1998;

8. Dăescu C. - „Produse de bio- şi semisinteză”, Litografia Institutului Politehnic, Timişoara,

1982;

9. Jurcoane Ştefana – „Fundamente, Biorectoare, Enzime”, Editura Tehnică, Bucureşti, 2000;

10. Jugrestan F. - „Tehnologia produselor farmaceutice”, Partea I, Litografia Universităţii din

Cluj-Napoca, Facultatea de Tehnologie Chimică, 1987;

11. Mitrea Vasilescu Niculina, Lupuleasa D., Andrieş A. A., Enoiu M. – „Biotehnologii

utilizate în prepararea medicamentelor”, vol. I, Editura Medicală Bucureşti, 2001;

12. Oniscu, C. – „Chimia şi tehnologia medicamentelor”, Editura Tehnică, Bucureşti, 1988;

13. Proinov L. - „Curs de industria medicamentului”, Litografia I.M.F. Cluj-Napoca, 1984;

14. Soran V., Rakosy Tican L., Ardelean A. - „Elemente de Biotehnologie”, Tipografia

Mirton, Timişoara, 1993;

15. Viesturs U., Viesturs I.A. X, A.V. Zilevica (traducere din limba rusă):„Biotehnologie”, Ed.

Ceres, Bucureşti, 1991;

105


COURSE TITLE – Pharmaceutical legislation


To acquire adequate knowledge of the legal framework for practicing pharmacy.

The objectives of the course of Pharmaceutical legislation are to study and to understand the

legal injunctions concerning the pharmacist profession and the activities regarding

pharmaceuticals, in order to be able to interpret them and to apply them in practice.

The objectives of the practical lessons are to learn and to understand the correct organization

and practice of the pharmacy activities, the correct use of professional documents and the

software for pharmaceutical administration.

PREREQUISITE – knowledge of all speciality disciplines in the curriculum of the 3rd

and 4th year

of pharmacy curriculum

TEACHING METHODS


Practical lessons: computer applications

EVALUATION METHODS

Written exam: multiple choice questions

Practical lesson: questions and computer applications

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



PHARMACEUTICAL LEGISLATION COURSE SYLLABUS

1. Pharmaceutical legislation: objectives, structure, importance for the pharmacist’s

activity.

2. The national system of health care: public health care, public health authorities,

pharmaceutical societies.

3. The national system of social policy: principles, public authorities, the role of the


4. The profession of pharmacy: conditions for practice, the representative body of

practitioners, the pharmaceutical ethics.

5. The medicine: definition, activities, responsibility.

6. Medicines with special legal status: drugs, drugs precursors, doping products.

7. The pharmaceutical inspection: the surveillance and the control of pharmaceutical

societies.

2 h

4 h

4 h

6 h

6 h

4 h

2 h

PRACTICAL LESSONS SYLLABUS 1. The creation of a pharmacy: the file and the building organization. Application:

documents and the pharmacy plan.

2. The provisioning of the pharmacy. Computer application.

3. The checking of medicines’ delivery. Computer application.

4. The arrangement and the storage of medicines. Computer application.

5. The activity of preparing in pharmacy: magisterial and officinal medicines.

Computer application.

6. The prescribing and the supply of the medicines in pharmacy. Computer

application.

7. The supply of the medicines in the social security system. Computer application.

8. The administration of the pharmacy and pharmacy records. Computer application

2 h

2 h

4 h

2 h

4 h

2 h

4 h

2 h

106

9. The control of the administration, the inventory in pharmacy. Computer

application.

10. The work security in pharmacy. Application: documents.

11. Recapitulation of pharmacy activities.

2 h

2 h

2 h

References

1. Appelbe G.E., Wingfield J., Pharmacy Law and Ethics, The Pharmaceutical Press, London

1997;

2. Benaiche L., Godefroy M.-L., Droit pénal des produits de santé, Litec, Paris, 2002;

3. Crişan O., Profesiunea de farmacist – probleme de legislaţie, Editura Medicală

Universitară “Iuliu Haţieganu”, Cluj-Napoca, 2007;

4. Fouassier É., La responsabilité juridique du pharmacien, Masson, Paris, 2002;

5. Marché, création et gestion d’une pharmacie, Arcane Institut, 2002;

6. Polinicencu C., Crişan O., Boboia A., Activitatea din farmacie – Ghid pentru lucrări

practice de legislaţie farmaceutică, Editura Medicală Universitară “Iuliu Haţieganu”, Cluj-

Napoca, ediţia anuală;

7. Pharmaceutical legislation in force.

107


COURSE TITLE – Drug analysis


Studying and understanding the official regulations and analytical methodology in

pharmaceutical field, applied for quality assurance of pharmaceutical dosage forms.

Practical training offers the skills needed to perform a complete quality control check of a

pharmaceutical dosage form, filling the quality certificate and results interpretation.

PREREQUISITE – knowledge of physical chemistry, organic chemistry, inorganic chemistry,

analytical chemistry, pharmaceutical technology

TEACHING METHODS

Plenary lectures assisted by multimedia support

Practical lessons: The students apply analytical methods to quantify drugs in all types of

pharmaceutical dosage forms. They calculate and interpret of the results and fill in the analysis

certificate.

EVALUATION METHODS

Multiple choice questions (MCQ) test at the end of semester. (50% of the final score)

Evaluation of practical abilities and theoretical knowledge in laboratory (individual practical

activities and written test) at the end of semester (50% of the final score)

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS

Course –42 hours (42/0)


DRUG ANALYSIS COURSE SYLLABUS

1. Romanian National Agency of Drugs – regulatory body of pharmaceuticals

quality control. Good laboratory practice (GLP).

2. Control of errors in analysis. Method validation – definitions and methodology.

Standard operating procedures for the assay (SOP).

3. Basic calculation in pharmaceutical analysis.

4. Physical and chemical properties of drug molecules.

5. Stereochemistry of drugs. Polarimetry. Applications

6. Drug stability

7. Extraction method in pharmaceutical analysis.

8. Titrimetric and chemical analysis method. Applications for pharmaceuticals

9. Ultraviolet and visible spectroscopy. Fluorescence spectroscopy. Applications

for pharmaceuticals

10. Infrared spectroscopy. Applications for pharmaceuticals.

11. Mass spectrometry. Applications for pharmaceuticals.

12. Chromatographic methods – TLC, GC, HPLC. Applications for pharmaceuticals

13. High performance capillary electrophoresis. Applications for pharmaceuticals

14. Thermal analysis – TGA, DSC. Applications for pharmaceuticals

2 h

2 h

2 h

2 h

1 h

5 h

1 h

9 h

5 h

1 h

1 h

9 h

1 h

2 h


1. Qualitative and quantitative analysis of solutions.

2. Qualitative and quantitative analysis of syrups.

3. Qualitative and quantitative analysis of suspensions and emulsions.

4. Qualitative and quantitative analysis of ointments.

5. Qualitative and quantitative analysis of suppositories.

6. Qualitative and quantitative analysis of powders, tablets and capsules.

9 h

3 h

6 h

6 h

6 h

12 h

108

References

1. M. Bojiţă, L. Roman, R. Sandulescu, R. Oprean - Analiza si controlul medicamentelor.

Volumul 1 Bazele teoretice si practice, Ed. Intelcredo, Deva, 2002

2. M. Bojiţă, L. Roman, R. Sandulescu, R. Oprean -Analiza si controlul medicamentelor.

Volumul 2 Metode instrumentale in analiza si controlul medicamentelor, Ed. Intelcredo,

Deva, 2003

3. D. Pradeau - L'analyse practique du medicament, Ed. Medicales Internationales, Paris,

1992

4. L. Roman, M. Bojită, R. Săndulescu, D.L. Muntean – Validarea Metodelor analitice,

Editura Medicală, Bucureşti, 2007.

5. *** - Farmacopeea Romana ed. a X-a, Ed. Medicala, 1993

6. *** - Farmacopeea Romana ed. a X-a, Supliment 2000, Ed. Medicala,2000.




10. *** - Farmacopeea Europeana, ed. a VI-a, 2007

11. *** - USP XXV, 2007

12. M. Hamon, F. Pellerin, M. Guermet, G. Mahuzier - Chimie analitique, vol.III, 2 edition,

Masson, 1990

13. David G. Watson – Pharmaceutical Analysis, A textbook for pharmacy students and

pharmaceutical chemists, second edition, Elsevier, 2005.

14. B. A. Bidlingmeyer - Practical HPLC methodology and applications, John Wiley and Sons

Inc., 1992

15. J. Swarbrick, J.C. Boylan - Encyclopedia of Pharmaceutical Technology, Marcel Dekker

Inc., 1988

109

CHAIR OF CLINICAL PHARMACY

COURSE TITLE – Clinical pharmacy - Pharmacotherapy


To understand the principles of clinical pharmacy practice.

To integrate knowledge about disease and medicine and to apply them with the aim to optimize

patient’s pharmacotherapy.

PREREQUISITE – knowledge of pharmacology, biopharmacy, semiology, pathophysiology,

clinical biochemistry

TEACHING METHODS


Clinical cases analyses

Problems solving

EVALUATION METHODS

Written examination – Multiple choice questions

Practical/oral examination – Clinical case resolution

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



CLINICAL PHARMACY - PHARMACOTHERAPY COURSE SYLLABUS

1. Introduction

Definitions. Clinical pharmacy practice development. Outcomes of clinical

pharmacist interventions in hospital and community pharmacy.

2. Risk reduction

Clinical pharmacist role in reduction of the impact of adverse drug reactions and

drug interactions.

3. Pharmacotherapy in particularly cases: children, elderly, pregnancy, renal failure

4. Patient adherence to therapy

Defining adherence. Risk factors for medication nonadherence. Methods to

improve adherence. Adherence to long term therapy (hypertension, diabetes

mellitus, asthma)

5. Hypertension pharmacotherapy

Introduction (etiology, epidemiology, diagnostic consideration).

Pharmacotherapy principles. Drug therapy optimization (strategies, drug

interactions, adverse drug reactions managing). Pharmacist’s involvement in

patient care.

6. Ischemic heart disease pharmacotherapy

Introduction. Pharmacotherapy principles. Drug therapy optimization.

Pharmacist’s involvement in patient care.

7. Heart failure pharmacotherapy



8. Dyslipidemias pharmacotherapy



9. Asthma pharmacotherapy


4 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

110


10. Peptic ulcer disease pharmacotherapy



11. Liver disease pharmacotherapy



12. Diabetes mellitus pharmacotherapy



13. Principles of antimicrobial use

Elements of pharmacology. Clinical use of antimicrobials. Pharmacist’s

involvement in patient care.

2 h

2 h

2 h

2 h


1. Patient –centred case studies with the aim to optimize patient’s drug therapy. A

rational decision making process is used: drug therapy analysis, patient specific

information assessment, drug therapy problems identification, care plan

development, including interventions designed to resolve or prevent drug therapy

problems.

2. Clinical activities (pediatrics hospital)

33 h

9 h

References

1. Koda-Kimble M.A, Young L. L - Applied Therapeutics: The clinical use of drugs, 8th

ed,

Lippincott Williams&Wilkins, 2005

2. Dipiro J T et al – Pharmacotherapy, a pathophysiologic approach, 6th

ed, McGraw-Hill,

2005

3. Walker R, Edwards C – Clinical Pharmacie and Therapeutics, 3d ed, Churchill Livingstone,

2003

4. Gimenez F et al – Pharmacie clinique et therapeutique, 3e ed, Masson, 2008

5. Fauci et al – Harrison. Principii de medicină internă, ed 15, Editura Stiintelor Medicale

6. ESCP – Pharmacie clinique. Stratégies et communications, Editions Médicales

Internationales, 1990

111

CHAIR OF DERMOPHARMACY

COURSE TITLE – Dermopharmacy and cosmetology


Study of the most frequently occurring skin diseases and the study of the preparations used for

their prophylaxis and treatment. Theoretical and practical study of preparation and utilization of

cosmetics: learning about skin care essentials, about type of cosmetic products, their

composition and formulation; learning about preparation, characterization and evaluation of

cosmetic products.

PREREQUISITE – knowledge of botany, anatomy, physiology, chemistry, biochemistry, physics,


TEACHING METHODS


Practical applications in the lab

EVALUATION METHODS

Written examination: multiple choice questions and/or questions with a short answer (70% of

the final score)

Practical examination: managing a specific situation presented during the practical activities

and/or questions with a short answer (30% of the final score)

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



DERMOPHARMACY AND COSMETOLOGY COURSE SYLLABUS

1. Introduction. Terminology, legislation of cosmetics. Anatomy, histology and

physiology of skin.

2. Primary and secondary skin lesion. Pharmaceutical dosage forms for topical

use. Principles of treatment in topical medication.

3. Bacterial, fungal and viral skin infections.

4. Ectoparasite skin infections.

5. Plaque psoriasis (causes, treatment, patient counselling).

6. Pathology of sebaceous gland: seborrheic dermatitis (causes, manifestations,

treatment, patient counselling); acne (causes, lesions, treatment, patient

counselling).

7. Cosmetology: Different skin types and their characteristics. Cosmetic care for

each skin condition.

8. Skin cleansing cosmetics – soaps, lotions, emulsions, creams. Exfoliating

cosmetics.

9. Antiperspirants and deodorants.

10. Skin care cosmetics: skin hydration and hydrating cosmetics. Skin aging and

anti-aging cosmetics.

11. Skin care for men: shaving cosmetics.

12. Hand and nail care cosmetics.

13. Pigmentation: mechanism, melanin types, pigmentation troubles.

Photoprotection: natural and artificial protection.

14. Hair removal cosmetics: formulation, tolerance, methods.

15. Hair care cosmetics. Hair loosing cosmetics.

16. Oral pathology. Oral health products. Composition, formulation.

2 h

2 h

2 h

2 h

2 h

3 h

1 h

2 h

1 h

2 h

1 h

1 h

2 h

1 h

2 h

2 h

112

PRACTICAL ACTIVITIES

1. Cleansing cosmetics. Influence of soap type on hydration, skin pH and skin barrier

function.

2. Make-up removers. Preparation and characterization of make-up removers and

toner. Choosing cleansing cosmetics for different skin type.

3. Cosmetic masks: preparation and characterization

4. Face scrubs. Evaluation of scrub effect on skin appearance.

5. Water/oil emulsions and creams. Preparation and characterization of water/oil

disperse systems. Dermopreparations for protection. Evaluation of hydrating and

protective effect.

6. Oil/water emulsions and creams. Preparation and characterization of oil/water

disperse systems. Dermopreparations for protection. Evaluation of hydrating effect.

7. Acneic and seborrheic skin care: personal hygiene products, lotions, creams.

Therapeutic strategy for acne patient. Presentation of some clinical cases.

8. Skin care products counselling. Skin type classification. Recognition of skin type

and product counselling according to the skin type.

9. Sunscreens and suntan products: preparation and characterization. In vitro

determination of solar protection factor from suntan cosmetics.

10. Counselling about sun protection cosmetics. Determination of skin phototype.

11. Oral care products: toothpaste, mouth rinse.

12. Preparation and evaluation of shampoo.

3h

2h

2h

1h

3h

3h

3h

3h

2h

2h

2h

2h

References

1. Moldovan M. – Dermatofarmacie şi Cosmetologie. Aplicaţii practice, Ed.Medicală

Universitară „Iuliu Haţieganu”, Cluj-Napoca, 2007.

2. Martini M.C. – Introduction à la dermopharmacie et à la cosmétologie, Ed. Lavoisier Tec

& Doc, Paris, 2006.

3. Dubertret L.– Thérapeutique Dermatologique, Ed.Flammarion, Médicine-Sciences, Paris,

2001.

4. Maier N. – Patologie Cutanată, Ed. Casa Cărţii de Ştiinţă, vol. III, Cluj-Napoca, 2000

5. Mitsui T. – New Cosmetic Science, Ed. Elsevier, Amsterdam, 499p., 1998

6. Farmacopeea Română Ed. a X-a, Editura Medicală, Bucureşti, 1993

7. Farmacopeea Europeană ed. a V-a

8. http://dermatlas.med.jhmi.edu/derm/

113

CHAIR OF DERMOPHARMACY

COURSE TITLE– Technology of homeopathic remedies and of veterinary drugs


The aim of this course is to describe the basic of homeopathy and veterinary pharmacy.

Preparation of homoeopathic and veterinary drugs.

PREREQUISITE – knowledge of botany, anatomy, physiology, chemistry, biochemistry, physics,


TEACHING METHODS


Practical applications in the lab

EVALUATION METHODS

Written examination with multiple choice questions and/or questions with a short answer (60%

of the final score)

Practical examination: managing a specific situation presented during the practical activities

and/or questions with a short answer (40% of the final score)

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



TECHNOLOGY OF HOMEOPATHIC REMEDIES

AND OF VETERINARY DRUGS COURSE SYLLABUS

TECHNOLOGY OF HOMEOPATHIC MEDICINES

1. Homeopathic definitions. Pathogenesis of the medicines. Boundaries and

indications of homeopathy.

2. Models for explaining the action of homeopathic doses.

3. Homeopathic principles.

4. Homeopathy and the human terrain. Homeopathic diathesis.

5. Nature of homeopathic remedies (vegetal, animal, mineral remedies).

6. Preparation of homeopathic medicines.

7. Homeopathic pharmaceutical dosage forms.

8. Homeopathic prescription.

9. Homeopathic therapy.

VETERINARY DRUGS

1. Veterinary pharmacy: definition, legislation. Dispensing veterinary drugs.

2. Veterinary pharmaceutical dosage forms.

3. Routes of veterinary drug administration.

4. Doses of veterinary drugs.

5. Most common veterinary pathologies: internal and external parasites, skin

pathology, digestive pathology.

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h

1 h


1. Good manufacturing practice for homeopathic laboratory.

2. Preparation of mother tinctures from vegetal materials: methods and control.

3. Preparation of mother tinctures from chemical source: methods.

4. Preparation of liquid homeopathic dilutions.

5. Preparation of solid homeopathic dilutions.

6. Preparation of inert homeopathic granules and globules.

7. Impregnation of liquid dilution on the inert supports.

1 h

1 h

1 h

1 h

1 h

1 h

1 h

114

8. Counselling the patient who takes homeopathic medicines.

9. Study of the pathogenesis of a homeopathic medicine.

10. Homeopathic medicines frequently used in homeopathy.

11. Visit at the industrial laboratory of homeopathic medicines.

1 h

1 h

1 h

4 h

References

1. Moldovan M. – Compendiu de homeopatie, Editura Medicală Universitară „Iuliu


2. S. Kayne – Homoeopathic Pharmacy, Ed. Churchill Livingstone, 1997

3. Boiron M., Payre-Ficot A. – Homéopathie. Le conseil au quotidien, Ed. Boiron, France,

1996

4. J.Jouanny - Notions essentielles de Matière Médicale Homéopathique, Ed. Boiron, Lyon,

1981

5. Desachy F. - Conseil vétérinaire à l'officine pour les animaux de compagnie, 2ème édition,

Ed. PRO-OFFICINA, 2007

6. G. Suciu – Forme farmaceutice de uz veterinar, Ed,. Dacia, Cluj-Napoca, 1990

7. Farmacopeea Europeană ed. a V-a

115


COURSE TITLE – Management and marketing

COURSE OBJECTIVES

The aim of the course is that students acquire adequate knowledge of pharmaceutical

management and marketing.

The objectives of the course of Management are the study and understanding of the notions of

management, the problems of pharmaceutical management, so that the pharmacist is able to

practice as a manager in the pharmaceutical field.

The objectives of the course of Marketing are the understanding of the general notions of

marketing, their use and application in the field of the medicine, for the profitableness of the


PREREQUISITE - knowledge of all speciality disciplines in the curriculum of the 3rd

and 4th year


TEACHING METHODS


Case study

Discussions on given subjects

EVALUATION METHODS

Writing examination: MCQ, synthesis themes, independent themes

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


MANAGEMENT AND MARKETING COURSE SYLLABUS

1. The pharmaceutical management and the manager: definition.

2. The manager: necessary qualities, knowledge, working style.

3. The structure and the process of building a business; the specificity of the

pharmaceutical field.

4. The managerial process: planning, structure, taking decisions, stimulating people,

control and assessment of the activities.

5. Systems, methods and techniques of management.

6. The managerial communication.

7. The management of the personnel.

8. The concept of marketing: definition of marketing and of pharmaceutical

marketing, functions and objectives of marketing, social responsibility and ethics of

the activity of marketing.

9. The marketing environment.

10. The market: general notions, evaluation, segments.

11. The behaviour of habitual and organizational consumer.

12. The pharmaceutical market: purveyors, consumers, specific features.

13. The methods for market study.

14. The mix of marketing: concept and general notions, the policy of the product, the

policy of the price, the policy of the distribution, the policy of the promotion.

15. The management of the marketing: strategies of marketing, the business plan and

the marketing plan.

2 h

2 h

2 h

2 h

2 h

2 h

2 h

2 h

1 h

2 h

2 h

2 h

1 h

2 h

2 h

References

1. Marché, création et gestion d’une pharmacie, Arcane Institut, 2002;

2. Mintzberg H., Le management – Voyage au centre des organisations, Éditions

116

d’Organisation, Paris, 1998;

3. Ribierre D., Comment manager son équipe, Masson, Paris, 2002 ;

4. Zambrowski J.J., Théorie et pratique de l’économie de la santé, Masson, Paris, 2001;

5. Bucurescu S.T., Cuparencu B., Ponoran V., Marketing pentru industria farmaceutică, Ed.

Dacia, Cluj-Napoca, 1999;

6. Chatain R., Marketing pharmaceutique, vol. I et II, Technique et Documentation –

Lavoisier, Paris, 1986;

7. Giampietri R., Farmacia & Marketing, Ed. Giornalidea, 1992;

8. Harboun Ch., Le marketing pharmaceutique, Ed. ESKA, Paris, 1995;

9. Kotler P., Armstrong G., Saunders J., Wong Veronica, Principiile marketingului, Ed.

Teora, Bucureşti, 1998;

10. Kotler P., Managementul marketingului, Ed. Teora, Bucureşti, 1997;

11. Voitcu M., Cărăuşu E.-M., Marketingul medicamentelor, Ed. Gr. T. Popa, Iaşi, 2004.

117


COURSE TITLE – Pharmaceutical actualities

TYPE OF COURSE – Integrative course

COURSE OBJECTIVES

To present updates on sexual hormones dysfunctions and their consequences: menopause,

osteoporosis, and erectile dysfunction

PREREQUISITE - knowledge of all speciality disciplines in the curriculum of the 3rd

and 4th year


TEACHING METHODS


EVALUATION METHODS


TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


PHARMACEUTICAL ACTUALITIES COURSE SYLLABUS

1. Elements of physiopathology

2. Pharmacology of drugs used in postmenopausal hormone replacement

therapy, in osteoporosis and erectile dysfunction

3. Chemical structure-biological activity relationship of drugs used in

postmenopausal hormone replacement therapy, in osteoporosis and erectile

dysfunction

4. Pharmacotherapy

5. Phytotherapy

6. Nutritional therapy

7. Pharmaceutical dosage forms containing sex hormones

8. Toxicology of sex hormones

3 h

2 h

2 h

3 h

1 h

1 h

1 h

1 h

118


COURSE TITLE – Pharmaceutical care

COURSE OBJECTIVES

To familiarize the students with Pharmaceutical care philosophy

To increase knowledge on drugs with application to patient care

To develop skills needs, to identify, solve and prevent actual or potential drug-related problems

PREREQUISITE - Pharmacotherapy

TEACHING METHODS


Clinical cases analyses

Discussions

Role playing

EVALUATION METHODS

Written exam

Practical/oral examination – Presentation of Pharmaceutical care patient chart for one patient to

whom the student provided pharmaceutical care

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS



PHARMACEUTICAL CARE COURSE SYLLABUS

1. Introduction. Pharmaceutical care definition. Pharmaceutical care evolution.

2. Clinical and economical impact of pharmaceutical care practice

3. The practitioner’s responsibilities. The standards for professional behaviour

4. The pharmacist – patient relationship. The therapeutic relationship defined. The

patient involvement in decision-making process. The patient’s rights and

responsibilities. Assessment of drug related needs

5. Drug therapy problems: categories, causes

6. The pharmacotherapy workup. Collection of patient specific information

concerning clinical condition and drugs used. Pharmacotherapy assessment:

appropriateness of the indication, effectiveness, safety, patient compliance. Drug

therapy problems identification. Development of care plan to resolve or prevent

drug therapy problems. Evaluation of effectiveness and safety of drug therapy.

Documenting the information and interventions; the pharmaceutical care patient

chart

7. Ethical considerations in Pharmaceutical care practice

8. Pharmaceutical care practice implementation. Knowledge, skills, attitude, and

resources needed to practice. Barriers to implementation of Pharmaceutical care

practice

1 h

1 h

2 h

1 h

2 h

4 h

1 h

2 h


1. Activities and responsibilities in the patient care process

2. Self-care and non-prescription pharmacotherapy. The pharmacist’s role. The

assessment of the patient’s condition. The formulation of care plan. The use of

treatment algorithms; practical exercises (role plays).

Examples of situations which may require additional information or

physician referral

Situations when the pharmacist must select self-treatment and advise the

1 h

9 h

119

patient for specific conditions

3. Prescription analysis. Prescriptions examples for specific diseases: infections,

cardiovascular disorders, gastrointestinal disorders, respiratory disorders,

neurological and psychological disorders, rheumatic disorders , skin disorders

4. Communication skills of the pharmacist

5. Providing of pharmaceutical care patient chart

4 h

6 h

4 h

References

1. Cipolle RJ, Strand LM, Morley PC. Pharmaceutical care practice. The clinician’s guide. 2nd

Edition, McGraw-Hill, 2004

2. Rovers JP, Currie JD, Hagel HP, McDonough RP, Sobotca JL. A practical guide to

Pharmaceutical care, 2nd

Edition, American Pharmaceutical Association, 2003

3. Sexton J, Nickless G, Green C. Pharmaceutical care made easy. Pharmaceutical Press, 2006

4. Tietze KJ. Clinical skills for pharmacists. A patient-focused approach, Mosby, 1997

120

CHAIR OF PHARMACEUTICAL CHEMISTRY

COURSE TITLE – Pharmacovigilance

COURSE OBJECTIVES

To acquire knowledge on the importance of the activity of pharmacovigilance in monitoring the

adverse reactions of drugs and on the methods used for adverse reactions’ identification and

reporting

To improving the knowledge on the adverse reactions: mechanism, prevention, monitoring

PREREQUISITE – knowledge of pharmacology, pathology, immunology

TEACHING METHODS

Course with Power Point presentations

EVALUATION METHODS

Written exam

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


PHARMACOVIGILANCE COURSE SYLLABUS

1. General aspects on pharmacovigilance: objectives, organisation, the place of

pharmacovigilance in drug research, the role of the reglementation agencies

2. View over the adverse reactions: classification, mechanism, prevention,

monitoring, validation

3. Aspects of pharmacovigilance in the use of oral contraceptives

4. Aspects of pharmacovigilance in pregnancy

5. Aspects of pharmacovigilance in using drugs in paediatrics

3 h

3 h

1 h

2 h

3 h

References

1. O. Oniga, Corina Ionescu, Reacţii adverse şi interacţiuni medicamentoase, Ed. UMF Iuliu

Haţieganu Cluj Napoca, 2004

2. Benichou C., Guide pratique de la farmacovigilance, 2-eme edition, Ed. Pradel, Paris, 1996

3. Edwards I.R., The management of adverse drug reactions: From diagnosis to signal,

Therapie, 56, 2001, 727-733

121


COURSE TITLE – Pharmacy as business

COURSE OBJECTIVES

The aim of the course is that students acquire adequate knowledge of the pharmacist’ role in the

management of the pharmacy business.

The objectives of the course are to exercise and to reflect to the aptitudes necessary for the

management of pharmacy business, in order to make it profitable, by the identification of

patients’ needs and by satisfying these needs by offering quality services and products.

PREREQUISITE – knowledge of legislation, marketing, management

TEACHING METHODS


Exercises and case study evaluated in working groups.

EVALUATION METHODS

Written examination: MCQ

Individual and group work

Final projects in work group

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


PHARMACY AS BUSINESS COURSE SYLLABUS

1. The pharmacy in the market economy.

2. The pharmacist – owner, manager, employee. Relations between functions.

3. The business – efficiency, development, profit. The pharmacist’ role.

4. The role of the relationship pharmacist – patient in the business:

communication, sale, marketing.

3 hours

3 hours

4 hours

4 hours

References

1. Junior Achievement România, GlaxoSmithKline, Farmacia – mod de administrare,

Manualul trainerului, Junior Achievement România, Bucureşti, ediţia anuală;

2. Junior Achievement România, GlaxoSmithKline, Farmacia – mod de administrare,

Manualul studentului, Junior Achievement România, Bucureşti, ediţia anuală.

122

CHAIR OF SEMIOLOGY AND INTERNAL MEDICINE – IV MEDICAL

CLINIC

COURSE TITLE – Medical emergencies

COURSE OBJECTIVES

To acquire knowledge regarding the firs-aid measures to be given in a pharmacy

PREREQUISITE – knowledge of pathology, physiology, pathophysiology

TEACHING METHODS

Lectures with interactive presentations

EVALUATION METHODS

Written exam (multiple choice questions)

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS


MEDICAL EMERGENCIES COURSE SYLLABUS

1. Respiratory emergencies: Acute respiratory failure. Acute asthma attack.

Pneumothorax

2. Cardiovascular emergencies. Syncope, lipothymia. Cardiogenic choc. Acute

lung oedema. Hypertension crisis. Acute arterial embolia.

3. Digestive emergencies. Intestinal-mesenteric infarct. Acute abdominal pain.

4. Kidney and urinary emergencies. Nephritic colic. Renal failure.

5. Metabolic emergencies. Hypoglycaemic coma. Hyperglycaemic coma.

6. Pain in the limbs. Lombosciatic. Polyneurophaties

7. Acute intoxications

2h

2h

2h

2h

2h

2h

2h

Bibliographie

1. Negrean Vasile, Urgente medico-chirurgicale pentru farmacisti, editura Casa Cartii de

Stiinta, 2006

123


COURSE TITLE – In service training

TRAINING OBJECTIVES

To acquire knowledge regarding the organization of the activity in a pharmacy (community of

hospital pharmacy)

To participate effectively in all specific activities of the profession, under the coordination,

monitoring and verification of practice guiding pharmacist

To acquire knowledge and practice regarding the role, responsibility and obligations of the

pharmacy profession

PREREQUISITE – knowledge of pharmaceutical legislation and organization, pharmacology,

clinical pharmacy, pharmaceutical technology, medicinal chemistry, toxicology, cosmetology,

medical devices, etc.

TEACHING METHODS

The application of theoretical knowledge acquired during faculty in pharmacy practice, under

the coordination, monitoring and verification of practice guiding pharmacist

Explanations, discussions, analysis of how to solve professional problems encountered

Practicing communication techniques with the patient

EVALUATION METHODS

Characterization of student’s work by the coordinating pharmacist regarding the:

Frequency

Compliance with the internal rules of organization and conduct of work

Involvement in the pharmacy activity

The attitude towards the staff of the pharmaceutical unit


Oral exam (interview) with the examination commission (teachers at the Faculty of Pharmacy

and instructors pharmacists nominated by the College of Pharmacists Cluj-Napoca)

TEACHING LANGUAGE

Romanian language

NUMBER OF HOURS

35 hours/ week, 26 weeks

IN SERVICE TRAINING CONTENTS

1) The reception of drugs

The qualitative, quantitative and value reception of drugs

Documents elaboration: reception note, registration of products with special status

Ensuring the conditions of conservation

2) Analysis of pharmaceutical substances

Identification reactions

Fact sheets analysis of pharmaceutical substances

Ensuring the conditions of conservation

3) Preparation of medicines and officinal formulas

Technical elaboration of the formulation

Packaging, labelling, conservation

Documents elaboration: registration of medicines and officinal formulas

4) Dispensing drugs

Dispensing prescription drugs

Documents elaboration for CAS: summaries, invoices

Prescription processing computer program

Dispensing OTC medicines

124

Dispensing homeopathic medicines

Dispensing phytotherapeutic medicines

Dispensing biological medicines

Counselling / health education of patients

5) Dispensing other pharmaceutical products

Dispensing food supplements

Dispensing cosmetic products

Dispensing medical devices

6) Filling other documents used in pharmacy: cashbook, daily management report,

inventory lists

7) Resolving the problems from the Practice Guide

8) Integration into the pharmacy activity

References

1. Ghid de practică pentru studenţii anului V, Editura Medicală Universitară “Iuliu

Haţieganu” Cluj-Napoca 2005, (ISBN 973-693-092-0), reeditare în ediţie revizuită 2008






6. Supplementary bibliography recommended during the 5 year curriculum

ygh16 study guide en

Documents

control drug control

delivery of drugs

field of drugs

field of pharmacy

use of drugs

effects of drugs

distribution of drugs

drugs collaboration