PROGRAM

19thAnnualYAREMeetinginBerlin,

October06th–08th2017

ConferenceVenueandAccommodation:

HotelAdremaGotzkowskystr.20/2110555Berlinwww.hotel-adrema.dePhone:+49(30)747820-0

AREAMAPImportantaddresses:1. HotelAdrema:Gotzkowskystr.20/21,10555Berlin2. Restaurant“Trofeo”:Wiebestr.36,10553Berlin3. Networking-Dinner on board of “Reederei Winkler”: Charlottenburger

Ufer1,10578Berlin

TheclosestsubwaystationtoHotelAdremaisTurmstraße,U9.DirectionstoHotelAdrema:MainTrainStation(Hauptbahnhof):Take bus 245 (direction S+U Zoologischer Garten) to bus stop Alt-Moabit/Gotzkowskystr.OrtakebusTXL(directionFlughafenTegelAirport)tobusstopTurmstr./Beusselstr.AirportTegel:Take bus TXL (direction S+U Alexanderplatz via Hauptbahnhof) to bus stopTurmstr./Beusselstr.AirportSchönefeld:Take local train S45 (direction S+U Bundesplatz) to stop Bundesplatz. AtBundesplatz,takesubwayU9(directionUOsloerStr.)tostopTurmstraße.

FRIDAY

Until14.00 CONFERENCE REGISTRATION (Rebecca Ölkrug, AnnekathrinKeiler)

14:00 INTRODUCTION(StephanieBurger-Stritt)

14:30–15:45 PITUITARY&NEUROENDOCRINOLOGY(Chairs:StephanieBurger-Stritt,Jana-ThabeaKiehn)

14:30 HuiTang(Berlin):High-fatdiet-inducedobesityandinsulinresistanceare characterizedbydifferential betaoscillatory signalingof the limbiccortico-basalganglialoop

14:45 LisbethHarder(Lübeck):DevelopmentalControlofParvalbuminergicNeurons in the Anterior Hypothalamic Area by Thyroid Hormones inMice

15:00 Denis Ciato (Munich): Targeting the master regulator of stressresponse Heat shock factor 1 (Hsf1): a novel approach for restoringglucocorticoidsensitivityinacellularmodelofcorticotrophadenoma

15:15 RanLi(Munich):Somatostatinreceptor5isexpressedinprolactinomasand suppresses prolactin promoter activity in a cellular model ofmammosomatotrophinoma

15:30 Dorothea Gebert (Munich): De-masking Oxytocin-Deficiency inCraniopharyngiomaandAssessingitsLinkwithAffectiveFunction

15:45–16:30 COFFEEBREAK&HOTELCHECK-IN

16:30–17:30 HORMONETRANSPORTERS(Chairs:RebeccaÖlkrug,SebastianHönes)

16:30 FranziskaLademann(Dresden):ThyroidhormonetransporterMCT8-deficiencycausesopposingeffectsontrabecularvs.corticalboneinmice

16:45 Beate Herrmann (Lübeck): Role of the murine thyroid hormonetransportersMCT8andOATP1C1inthecardiovascularsystem

17:00 Sarah Paisdzior (Berlin): Elucidation of a new approach to treattransportdefectsviaaGPCRinternalizationmechanism

17:15 Anna-Maria Eleftheriadou (Berlin): Quantification of autoantibodiesagainstproteinsinvolvedinthyroidhormonebiosynthesisandtransportinhumanserum

17:30–17:45 ANNOUNCEMENTS(RebeccaÖlkrug)

18:00–18:30 TRANSFERTORESTAURANT“TROFEO”

19:30 DINNERLECTURE(CHAIR:YOSHIYUKIHENNING)

Dr.A.Pechstein(phi360,Berlin):

Biomimicry:FromNaturetoModernTechnology

SATURDAY

9:00–10:30 METABOLISM(Chairs:AnnekathrinKeiler,JuliaKind)

9:00 Kornelia Johann(Lübeck):A reasonwhyoverweightmen shouldnotbetakingViagra®

9:15 Jana-Thabea Kiehn (Lübeck): A role for circadian clocks in leptin-responsiveneuronsinappetiteregulationinmice

9:30 SogolGachkar(Lübeck):Howmiceregulatetheirbodytemperature

9:45 Qian Sun (Berlin): Defects in trace element metabolism as potentialreasonforneuropediatricdiseases

10:00 Weiwei Zhang (Freiburg): Mesenchymal Stem Cell (MSC)-derivedhumoralfactorspromotesurvivalofinsulinproducingpancreaticβ-cellsduringintrinsiccellularstressviaAktandERK1/2signalling

10:15 ChristinaHöber(Lübeck):Timeofthedaymodulatesthehedonicdrivetoeat

10:30–11:00 BREAK&GROUPPICTURE

11:00–12:15 INFLAMMATION(Chairs:RebeccaÖlkrug,DorotheaGebert)

11:00 Julia Kind (Berlin): Environmental changes profoundly affect thedevelopment of obesity-induced insulin resistance and nonalcoholicsteatohepatitis caused by a more physiological “aging” of adaptiveimmunity

11:15 HanjaKramer(Kiel):CorrelationbetweensmalldenseLDL,lipoprotein(a) and the gut microbiome in patients with chronic inflammatorydiseases

11:30 JulianSeelig(Berlin):Adverseeffectsoftraumaticspinalcordinjuryontraceelementhomeostasis

11:45 JulianeSchulz(Kiel):sFRP5– apotentialbiomarker forpatientswithchronicperiodontitis?

12:00 Maria Pangerl (Kiel):Cytokine serumlevels in patients with differentgastroenteropancreatic neuroendocrine neoplasms with and withoutsomatostatinanaloguetreatment–apilot-study

12:15–13:30 LUNCHBREAK

13:30–14:15 THYROIDHORMONES(Chairs:YoshiyukiHenning,LisbethHarder)

13:30 Özlem Vural (Berlin): Approaches to generate a 3D Human Thyroidmodelinvitro

13:45 JuliaBräunig(Berlin): 3-iodothyronamine is an agonist of thehumanserotoninreceptor1b

14:00 Sebastian Nock (Lübeck): Identification of organ specific thyroidhormonebiomarkersasnewdiagnostictools

14:15–15:15 ADRENALS(Chairs:StephanieBurger-Stritt,UlrichDischinger)

14:15 Hanna Remde (Berlin): The cardiovascularmarkers copeptin andhighsensitiveC-reactiveproteindecrease following specific therapy forprimaryaldosteronism

14:30 MilenaDoroszko (Turku): Luteinizing hormone and GATA4 action intheadrenocorticaltumorigenesisofgonadectomizedfemalemice

14:45 VeronikaGörge(Munich):QuantificationOfSodiumUptakeandTastePerceptionofSaltWithPatientsWithPrimaryAldosteronism

15:00 Meghna Jha (Berlin): Role of Androgens and Salt status on renal MRandGRexpressioninorchiectomizedrats

15:15–15:45BREAK

15:45–17:00 TheFutureofYARE(StephanieBurger-Stritt)

15:45 PROF.DR. SVENDIEDERICH (VICE-PRESIDENTDGE,BERLIN):WHAT

DOESTHEGERMANENDOCRINESOCIETYOFFERFORYOUNGSCIENTISTS

16:15 YARESURVEY: CURRENT SITUATION AND FUTURE PERSPECTIVES INYOUNGSCIENTISTSWORKINGINTHEFIELDOFENDOCRINOLOGY

16:30 THEFUTUREOFYARE-DISCUSSION

17:00–17:15 ANNOUNCEMENTS(StephanieBurger-Stritt)

18:00–19:00 TRANSFER

19:00–21:30 NETWORKINGDINNER

SUNDAY

9:30–10:15 INVITEDLECTURE(Chair:AnnekathrinKeiler)

Prof.Dr.ChristianStrasburger(CharitéBerlin): Howaclinicalendocrinologistgetsinvolvedwithdoping

10:15–10:30 BREAK&HOTELCHECK-OUT

10:30–11:45 REPRODUCTION

(Chairs:AnnekathrinKeiler,MilenaDoroszko)

10:30 MP Gastiazoro (Dresden): Disturbance of placental and fetal ratdevelopmentcausedbycafeteriadiet

10:45 LauraHeckmann (Münster): Marker analysis of testicular tissues ofprepubertalandpubertalpatientsatriskforgermcellloss

11:00 AlexanderBusch(Copenhagen):Differential impactofgenetic locionageatthelarcheandmenarcheinhealthygirls

11:15 Anna Hankele (Zurich): Establishing an LC-MS/MS platform todetermineprostaglandinssecretedbytheearlybovineembryo

11:30 Lívia Dias de Queirós (Dresden): Evaluation of estrogenic activity of aglycone-rich biotransformed soy extracts

11:45–12:00 BREAK

12:00–12:45 INVITEDLECTURE(Chair:RebeccaÖlkrug)

Russell Hodge (Max Delbrück Center for MolecularMedicine,Berlin)

GoodScienceWriting

12:45–13:00 CLOSINGREMARKSANDFAREWELL

SAVETHEDATE:NEXTYAREMEETING–MUNICH-05.10.–07.10.2018

YARE would like to thank the following companies for theircontributiontoour19thannualmeeting:

The19thAnnualMeetingofYoungActiveResearchinEndocrinology(YARE)hasbeenendorsedby theEuropeanSocietyofEndocrinologywhohasalsoprovided financial support throughanESESmallMeetingGrant.

SteeringCommitteecontact:

CarolinHöfig(Email:carolin.hoefig@charite.de)InstituteofExperimentalEndocrinology,CharitéUniversitätsmedizinBerlin,AugustenburgerPlatz1,13353Berlin

TinaKienitz(Email:tina.kienitz@charite.de)DepartmentofEndocrinology,DiabetesandNutriton,CharitéUniversitätsmedizinBerlin,Charitéplatz1,10117Berlin

HenrietteUndeutsch(hundeuts@bidmc.harvard.edu)BethIsraelDeaconessMedicalCenter,HarvardUniversity,Boston,USA