XI-S+® Lightweight Biologic Mesh Delivering an advancement in crosslinked technology for soft tissue repair

Significantly

stronger

tissue repairs

over time.1

www.co-therapeutics.com

Use of crosslinked biological mesh results

in higher quality Type I collagen host tissue

infiltration and replacement. Gram for gram,

Type I collagen is stronger than steel.2

In contrast, non-crosslinked tissues result

in poorly structured, Type III collagen host

tissue replacement.1

Easy to Use

Supports Angiogenesis

Ultra-thin and Translucent

Undetectable Glutaraldehyde Residuals3 • Proprietary process removes glutaraldehyde3

• Glutaraldehyde residuals below detectable limits (<0.97 ug/mL)3

• Tissue demonstrates angiogenesis and endothelialization3

• Robust angiogenesis demonstrated after 21 days3

Angiography (scale = 100 µm)Fluorescent microspheres indicate areas of microvasculature development.

877.290.0045 (toll-free)

303.469.9459

Colorado Therapeutics LLC 486 South Pierce Avenue, Suite A, Louisville, CO 80027

www.co-therapeutics.com

ORDERING INFORMATION:RECTANGULAR SIZESPRODUCT NUMBER PRODUCT SIZE

XI0508-S+ 5 cm x 8 cmXI0710-S+ 7 cm x 10 cmXI0615-S+ 6 cm x 15 cm

CONTOURED SIZESPRODUCT NUMBER PRODUCT SIZE

XI1014A-S+ 10 cm x 14 cmXI1014B-S+ 10 cm x 14 cm

CONTOURED SIZESPRODUCT NUMBER PRODUCT SIZE

XI1116A-S+ 11 cm x 16 cmXI1116B-S+ 11 cm x 16 cm

Contact your sales representative or Colorado Therapeutics LLC for ordering information, in-service support materials, and technical specifications.

CAUTION: Federal (U.S.A.) law restricts this device to sale by or on the order of a physician. For complete instructions for use, storage, warnings, indications, contraindications, precautions, adverse reactions, and disclaimer of warranties, please refer to the insert accompanying each Colorado Therapeutics Xenograft Implant product.

1/20 © Colorado Therapeutics LLC. All rights reserved. Printed in the U.S.A. MKT002.01

orders@co-therapeutics.com

SQUARE & CIRCLE SIZESPRODUCT NUMBER PRODUCT SIZE

XI0606-S+ 6 cm x 6 cmXI0808-S+ 8 cm x 8 cmXI0909C-S+ 9 cm x 9 cm

• No hydration required • Pliable like native tissue; easy to trim and contour• Suture and tack while visualizing critical organs

and vessels

1 Gemma Pascual, PhD; Marta Rodríguez, PhD; Sandra Sotomayor, PhD; Eduardo Moraleda, MD; Juan M. Bellón, MD, PhD. Effects of collagen pros– thesis cross-linking on long-term tissue regeneration following the repair of an abdominal wall defect. Wound Rep Reg (2012) 20 402–413. 2 H. Lodish, A. Bert, C. Kaiser, M. Krieger, M. Scott, A. Bretscher, H. Ploegh, P. Matsudiara. Molecular Cell Biology. 4th edition. Section 22.3 Collagen: The Fibrous Proteins of the Matrix. 2016.3 Data on file.

0

1,000

2,000

3,000

4,000

5,000

6,000

7,000

8,000

9,000

10,000

XI-S+

FlexH

D

SurgiMend

AlloDerm

(XT)

PHASIX (1

)

AlloMax

Perigard

XenMatrix

Veritas

Stratti

ce (F

irm)

Surgisis

Permaco

l

CollaMend FM

BIO-A Ti

ssue

Stre

ngth

/Uni

t Thi

ckne

ss (N

)

Burst Strength/Unit Thickness by Competitor

0

0.5

1

1.5

2

2.5

AlloDerm

(XT)

XenMatrix

Stratti

ce (F

irm)

BIO-A Ti

ssue

Surgisis

CollaMend FM

AlloMax

FlexH

D

Permaco

l

SurgiMend

Veritas

PHASIX (1

)

Perigard

XI-S+

Thic

knes

s (m

m)

ECM Thickness by Competitor

Strength and DurabilityThrough Tissue Crosslinking • Maintains comparable strength at 6

months to tissues over 9 times as thick3

XI-S+ is the thinnest among competitive products

ECM Thickness by Competitor

CrosslinkedNon-crosslinked

Allograft

Burst Strength/Unit Thicknessby Competitor

CrosslinkedNon-crosslinked

Allograft

XI-S+ is the strongest among competitive products

XI-S+

XI-S+