world premier international research center initiative...in april 2016, i became chair of the world...
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16Vol.
2020. 8
World Premier InternationalResearch Center Initiative
In April 2016, I became chair of the World Premier Internation-al Research Center Initiative (WPI) Program Committee, succeeding Professor Hiroo Imura.
The WPI Program was launched in 2007 with a mission to cre-ate globally open and appealing centers of research that serve as pivotal hubs for global brain circulation. The Program has four basic objectives: advancing leading-edge research, establishing interna-tional research environments, reforming research organizations, and creating interdisciplinary domains. The year 2016 was the 10th and final year of phase 1 of our Program, which has generated numerous scientific breakthroughs to date, most notable among which were the Nobel Prize in Physiology or Medicine awarded to Professor Shinya Yamanaka (iCeMS) in 2012 and the Nobel Prize in Physics awarded to Professor Takaaki Kajita (Kavli IPMU) in 2015. The WPI Program itself has earned widespread acclaim as one of the world's preeminent research excellence initiatives. Under the Program's next phase, started in 2017, we are pushing ahead with launching new centers, while Japan's Ministry of Education, Culture, Sports, Science and Technology has established the WPI Academy, a new framework intended to take the vanguard in internation-alizing and further renovating Japan's research environment to accelerate and expand the global circulation of the world's best brains. We will take stock of the Program as a whole and evaluate its performance over the first 10 years to expand and intensify its operations and maximize its pool of amassed accomplishments.
The challenge of dealing with problems of global scale, the advancement of transdisciplinary research, and the movement toward open science are among a set of trends that are rapidly reshaping the world of the scientific community. We will properly address these trends in earnest so that the WPI centers continue demonstrating leading-edge research accomplishments into the years ahead. If the scientific community is to boldly tackle new problems and unknown frontiers of knowledge with broad-based perspectives and insight, it is important that it look beyond the lim-its posed by national borders and specific domains to tap into its vast diversity of human talent.
To that end, we will not only promote high-level undertakings in scientific research but also work to strengthen organizations that continually support and lead in the sphere of research, refine and expand mechanisms that facilitate global brain circulation, foster heightened levels of personnel exchange with research centers abroad, support programs of training for young researchers, and enhance our activities in the arena of global outreach. Among steps taken to accommodate and foster international diversity, WPI centers have been promoting the development of a comfort-able environment for foreign researchers both in life and research, for example through the placement of bilingual office staff for research assistance and the provision of living support for visiting foreign researchers and their family members.
I am confident the WPI Program is capable of providing an amazing platform for researchers with future visions and excel-lent potential, and I look forward to the opportunity to collaborate with everyone in building a set of top-level global standards for research.
Message fromProgram Committee ChairWorld Premier International Research Center Initiative
The emblem of WPI adopts the motif of a bird, symbolizing the programâs driving concept of
âupward flight.â Undaunted by todayâs tur-bulent global climate of twisting and turning winds, the bird flies on steady, azure wings through the sky. In its beak, it carries a seed of new innovation. This radiant dot over the âiâ also serves to light the path ahead in pioneering the frontiers of scientific discovery.
Emblem Concept
Message from Program Committee Chair About WPI
Tohoku University: Advanced Institute for Materials Research (AIMR) The University of Tokyo: Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU) Kyoto University: Institute for Integrated Cell-Material Sciences (iCeMS) Osaka University: Immunology Frontier Research Center (IFReC) National Institute for Materials Science: International Center for Materials Nanoarchitectonics (MANA) Kyushu University:International Institute for Carbon-Neutral Energy Research (I²CNER) University of Tsukuba:International Institute for Integrative Sleep Medicine (IIIS) Tokyo Institute of Technology: Earth-Life Science Institute (ELSI) Nagoya University: Institute of Transformative Bio-Molecules (ITbM) The University of Tokyo: International Research Center for Neurointelligence (IRCN) Kanazawa University: Nano Life Science Institute (NanoLSI)
Hokkaido University: Institute for Chemical Reaction Design and Discovery (ICReDD)
Kyoto University: Institute for the Advanced Study of Human Biology (ASHBi)
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Contents
WPI centers
World Prem
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Centers currently receiving fundingWPI Academy
AIMR
IIISMANAKavli IPMU
ITbM
NanoLSI
I²CNER
iCeMSIFReC
IRCNELSI
ICReDD
ASHBi
Two centers adopted in 2018
One center adopted in 2010
Five centers adopted in 2007 Three centers adopted in 2012
Two centers adopted in 2017
P.10
P.12
P.14
P.06 P.18
P.20
P.22
P.16
P.24
P.26
P.08
P.28
P.30
Tohoku University:Advanced Institute for Materials Research (AIMR)
Kyoto University: Institute for Integrated Cell-Material Sciences (iCeMS)
Osaka University: Immunology Frontier Research Center (IFReC)
National Institute for Materials Science: International Center for Materials Nanoarchitectonics (MANA)
The University of Tokyo:Kavli Institute for the Physics and Mathematicsof the Universe (Kavli IPMU)
Hokkaido University:Institute for Chemical ReactionDesign and Discovery (ICReDD)
Kyoto University: Institute for the Advanced Studyof Human Biology (ASHBi)
Kyushu University:International Institute for Carbon-Neutral Energy Research (I2CNER)
University of Tsukuba:International Institute for Integrative Sleep Medicine (IIIS)
Tokyo Institute of Technology: Earth-Life Science Institute (ELSI)
Nagoya University: Institute of Transformative Bio-Molecules (ITbM)
The University of Tokyo:International Research Center for Neurointelligence (IRCN)
Kanazawa University: Nano Life Science Institute (NanoLSIïŒ
Program Contents
Fundingperiod
Projectfunding
Evaluation Each year, a thorough follow-up review is conducted of the centers. A midterm evaluation is conducted in their 5th year and a final evaluation in their 10th year. These reviews are conducted by the Program Committee, comprising Nobel laureates and top-level researchers, and program directors and program officers.
About ¥700 million per fiscal year for each center (up to ¥1.4 billion per year for centers selected in FY 2007 and FY 2010)
10 years(up to 15 years for centers selected in or before FY 2012)
The WPI Academy was launched in FY 2017 for maximizing the effect of the WPI Program by such means as: amplifying the experience and know-how acquired by the WPI centers as they worked toward achieving âWorld Premier Statusâ with regard to their research level; enhancing the profile and brand of the overall WPI Program; promoting global brain circulation; and internationalizing and reforming the scientific environment by networking the activities of WPI centers.
WPI Academy
The Japan Society for the Promotion of Science assists in smoothly and effectively implementing the WPI Program.
WPI WPI centers(total: 13 centers)
Toward Enhancing and Strengthening "Highly Visible Research Centers"
About W
PI
An intensifying global demand for talented researchers is accelerating the need to
circulate good brains among the world's nations. This trend has prompted Japan to
establish new research centers that attract top-notch researchers from around the
world so as to be a hub within global brain circulation.
WPI provides concentrated support for projects to establish and operate research
centers that have at their core a group of very high-level investigators. These
centers are to create a research environment of a sufficiently high standard to
give them a highly visible presence within the global scientific communityâthat
is, to create a vibrant environment that will be of strong incentive to frontline
researchers around the world to want to come and work at these centers.
Challenges in building top-world institutes
â A critical mass of outstanding researchers- 7-10 or more top-level principal investigators (centers
selected in FY 2007 and FY 2010 had 10-20 or more)- With at least 30% of researchers continuously from overseas- Total of 70-100 or more researchers and staff (centers
selected in FY 2007 and FY 2010 had 100-200 or more)
â Attractive research and living environment by top international standards
- Strong leadership by center director- English as the primary language- Strong support functions for researchers Four Missions
Background
Program Summary
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Education (Fostering next generation of researchers)Outreach (Disseminating information to society)
Globalization (Creating international research environments)3
⢠Besides advancing research in each of their fields, WPI centers also contribute to pioneering various new interdisciplinary
domains.
⢠A cascade of fused research achievements is being generated. Examples include an elucidation of the structure of glass
by fusing mathematics and materials science and the discovery of a method for combating the parasitic plant Striga
made by fusing animal/plant biology and synthetic chemistry.
⢠A âflatâ organization with no partitioning between research fields and an open building architecture with no walls
between labs spawn intellectual inspiration and a collaborative atmosphere of friendly rivalry among researchers.
⢠WPI centers act as the nucleus for system innovation within their host universities and research institutions. The
reforms they achieve are shared and applied to their host institutions, elevating system-wide internationalization and
strengthening research capabilities. Some spinoffs of center reforms include:
- Groundbreaking introduction of cross-appointment systems and of merit-based pay systems for researchers
- Introduction of top-down management systems revolving around the center director
- Horizontal development of large-scale funding acquisition know-how
Reform (Innovating research organizations)4Fusion (Generating fused research domains)2
Science (Implementing the world's highest level of research)1⢠English is the working language in WPI centers.
Overseas researchers make up approximately
40% of the center's research staff.
⢠By recruiting internationally for postdoctoral
researchers and taking measures to
promote the employment of overseas
researchers, WPI centers are establishing
highly competitive, internationally attuned
research systems. By establishing systems
to support their life and work in Japan, the
centers are creating environments that
allow the researchers to both independently
and comfortably carry out their work.
⢠Nearly 50% of the papers published by WPI
centers stem from international joint research,
attesting to the posture of the centers within
international research networks.
WPIWPI has continuously produced the world's highest-level achievements in fused research.
WPIWPI has tackled the challenge of creating an excellent world-class environment for advancing research.
WPIWPI centers yield productive ripple effects that improve the operation of their host institutions.
Steadfast results are being achieved as WPI carries out various joint outreach activities with an aim to broaden its visibility within society. WPI is working to create a framework for human resource development aimed at fostering the next generation of
researchers. It includes:⢠WPI Science Symposiums
These symposiums are held to give participants a feeling of familiarity for cutting-edge research by introducing them to WPI programs and their research results. They are attended by students from local junior high and high schools and members of the general public.
⢠âWPI Forumâ websiteKnow-how accumulated by WPI on ways to attract overseas researchers is shared with universities and research institutions seeking to internationalize their operations.
⢠Double mentoring by instructors from diverse research fields whose training enhances the ability of young researchers
to do fused research.
⢠Collaborative relationships with overseas graduate schools.
Annual trend of research impact for the 5 WPI centers launched in FY 2007
- This figure was created by MEXT and JSPS based on data from Clarivate Analytics (collected in May 2019).- Research impact (RI): The sum of all the impact factors of the journals in which papers are published in
a year, used as a proxy variable to show the international visibility and competitiveness of a center.- Relative research impact: Ratio of the average centersâ research impact to the average research impact
of their benchmark institutions. - The vertical axis shows relative research impact while the radius of the circle and the blue numbers in
them indicate the average number of papers published from WPI centers in that year.
ïŒ Benchmark institutions: For each WPI center, five benchmark institutions at a top world level in a similar research domain are set by each center's working group.
Annual transition in the percentage and number of internationallyco-authored papers published by the 5 WPI centers selected in 2007
- The WPI portion of the graph was created by MEXT and JSPS based on data from Clarivate Analytics (collected in May 2019). The Japan average is extracted from NISTEP's âJapanese Science and Technology Indicators 2018.âïŒReference Research Material-274, August 2018ïŒ
- The radius of the circles and blue numbers inside them show the number of internationally co-authored papers.
⢠Since their establishment, the WPI centers
have steadily produced research papers
on a level commensurate with the world's
top-level research institutions.
⢠Two WPI center researchers have won
Nobel Pr izes. Others have gained
international recognition by winning such
prestigious awards as the Canada Gairdner
International Award. Still others have
received top domestic awards such as
Japan's Order of Culture.
⢠Despite their focus on basic research, WPI
centers enjoy high appraisal by society
as seen in the large donations and
investments they receive from foundations,
corporations and other private entities.2007
80%
70%
60%
50%
40%
30%
20%
10%
0%2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018ïŒYearïŒ
Percentage of internationally co-authored papers
Japan AverageïŒ33.4%: 2016)
Japan AverageïŒ24.2%: 2007)
Undersubsidy support
Out ofsubsidy support
583
741 828859 894
941 1017
1009
938
268 44019
2007
1.8
1.6
1.4
1.2
1.0
0.8
0.6
0.4
0.2
02008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018ïŒYearïŒ
158
236
294317
341
334349
329 347316
302
12
Relative research impact the average of the 5 WPI centers
launched in FY 2007
the average of benchmark institutionsïŒ
Undersubsidysupport Out of
subsidysupport
ïŒããarea of the circle: Proportionalto the average number of papers published from 5 WPI centers ïŒ
"WPI Forum" website
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Tohoku University:
Advanced Institute for M
aterials Research (AIM
R)
By designing the molecular structure of hydrogen
clusters (complex ions containing high density
hydrogen), a new hydride that exhibits lithium
superionic conductivity at room temperature was
developed. Using this hydride as a solid electrolyte,
AIMR has also succeeded in demonstrating a lithium
negative-electrode-type all-solid-state battery device
with the world's highest energy density. AIMR is
now conducting research aiming at elucidating the
mechanism of ionic conduction and further improving
superionic conductivity through mathematics and
materials science collaboration.
Tohoku University
Advanced Institute for Materials Research (AIMR)
One practical link that AIMR is forging between
mathematics and materials science is the establishment of
three Advanced Target Projects focusing on âcontrol of local
structure in topological functional materials,ââintegrated
control of bond variation and its time evolution,â and
âimproving self-organization technology and controlling
biological responses.â Through the promotion of these
research projects and expansion of its global network with
three joint laboratories set up in the UK, US, and China,
AIMR intends to create materials based on understanding and controlling atoms and molecules â the smallest units
for materials. AIMR is also actively pursuing global brain circulation by developing researchers who promote research
initiatives worldwide, through methods such as providing outstanding young researchers with their own laboratories.
Bringing Advanced Materials Science to the World through Cooperation with MathematicsAIMR aims to contribute to society by further developing the collaboration between mathematics and materials
science and to contribute to society through materials discovery and development. Based on the results, AIMR will
form a research hub that brings advanced materials science to the world.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Advanced Target Projects & global brain circulation
Reinforcing original scientific foundation based on mathematics-materials science collaboration
A wide array of materials including metals, semiconductors,
ceramics, and polymers contribute to modern technologies in
every field from energy to ICT, medicine, healthcare, and high-
speed transport, and many technological domains have been
improved together with materials discovery and development.
Progress in materials science as the scientific principle will
continue to be essential for the acceleration of materials
discovery and development.
As well as further reinforcing its original scientific foundation
based on mathematics-materials science collaboration, by
developing actual technological fields in concert with cutting-
edge analysis techniques, AIMR will create materials that make
a genuine contribution to society.
In October 2019, I was appointed as AIMR's Director. Working together under one roof, materials
scientists and a wide range of mathematicians spanning pure and applied mathematics have
achieved major successes and established AIMR's identity of the collaboration between mathematics
and materials science. As well as further reinforcing AIMR's unique academic foundations by
developing actual technological fields in concert with cutting-edge technologies in areas such as
measurement, we will create materials that make a genuine contribution to society. AIMR is striving
to bring advanced materials science to the world. I look forward to your continued support for us.
Message from ORIMO Shin-ichi, Director of AIMR
Profile After receiving his PhD from Hiroshima University, Prof. Orimo has held posts as JSPS Research Fellow and Guest Researcher at the Max-Planck Institute for Metal Research, before becoming Professor at the Institute for Materials Research (IMR), Tohoku University in 2009. He became Principal Investigator at AIMR in 2013 and was promoted to Deputy Director in 2018 and to Director in October 2019. Major awards include the Japan Institute of Metals and Materials Meritorious Award (2011), the Award for Science and Technology (Research Category), the Commendation for Science and Technology by MEXT (2012), and the Science of Hydrogen & Energy Award (2015).
AIMR has developed a new-concept spintronics
device that utilizes thermal fluctuation and can operate
at room temperature. Using this device as a pseudo
quantum bit (probabilistic bit, or p-bit), AIMR has
succeeded in demonstrating factorization by applying
a method similar to quantum annealing. The results are
promising to pave an unexplored pathway towards a
new computing paradigm that is particularly well-suited
for certain classes of problems like optimization.
âHydride superionic conductorâ can accelerate developments of all-solid-state batteries
âPoor-manâs q-bitâ based on spintronics can solve quantum problems at room temperature
A schematic illustration showing the all-solid-state batteries using hydride with lithium superionic conductivity including hydrogen cluster
Archive of research results
Director of AIMR / Device and System Group PI Shin-ichi Orimo et al.ïŒNature Communications, 2019ïŒ Device and System Group PI Shunsuke FukamiïŒNature, 2019ïŒ
TOHOKU UNIVERSITY
The structure of a magnetic tunnel junction and the design of the energy barrier for MRAM and p-bit applications. The magnetic tunnel junction consists of ferromagnetic free and fixed layers which sandwich a thin insulating tunnel barrier.
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In the search for new physics, Kavli IPMU has been a
member of the Belle II high-energy physics experiment's
international collaboration since November 2012.
Kavli IPMU was responsible for producing the ladders
on the fourth and outermost layer of the Silicon
Vertex Detector (SVD), which will help researchers
study B meson decay following electron and positron
collisions inside the SuperKEKB collider at Tsukuba. The
ladders were completed in May 2018. By March 2019,
researchers had begun fine-tuning the collider with
the SVD set up inside the Belle II detector. Now the
collaboration will continue to collect and analyze data
from collisions.
The University of Tokyo
Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU)
The University of Tokyo:
Kavli Institute for the Physics and Mathem
atics of the Universe (Kavli IPM
U)
Every day, 280 mathematicians, physicists, and astronomers
who make up Kavli IPMU cross over traditional boundaries of their
disciplines to create new ideas and opportunities.
Principal investigators who are world leaders in their fields carry
out core research activities. But they, and professors, associate
professors, assistant professors, researchers, students, collaborators,
and visitors are all treated as equals.
The institute's daily teatime is a chance for Kavli IPMU members and
visitors to interact, and sparks ideas that lead to new research results.
Kavli IPMU has become a role model for the University of Tokyo in accommodating overseas researchers in Japan.
More than half of its faculty come from overseas, and more than 600 researchers apply for one of the institute's 10 or so
posts every year, 90 percent of whom come from overseas.
The institute values diversity and supports many activities, including stronger women scientist networks.
By supporting different ideas and cultures, and providing a space where these ideas can interact, Kavli IPMU will
continue to generate new insight.
Cross-Disciplinary Research Centerfor Addressing the Origin and Evolution of the Universe Establishing a world-class research center for the most urgent issues in basic science such as dark energy,
dark matter, and unified theories, with close collaboration between mathematics, physics and astronomy.
Galaxies captured by the Hyper Suprime-Cam(Credit: Princeton University/HSC Project)
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Cross-disciplinary research in mathematics, physics, and astronomy
Uncover the origin and evolution of the Universe
Until recently, it had been believed that atoms were the only components of the
Universe. However, new advances in observational cosmology have shown that
galaxies contain invisible âdark matter,â which keeps the stars from dispersing, and that
the Universe is filled with mysterious âdark energy,â which is accelerating the Universe's
expansion. But the true identity of dark matter and dark energy has yet to be revealed.
"Unified theories," such as string theory and quantum gravity, are developing as physics
and mathematics enhance our understanding of the Big Bang and black holes. Recent
advances have led many researchers to speculate that many hidden dimensions exist
beyond the third dimension, and that the origin and evolution of the Universe are closely
related to their geometries. Kavli IPMU delves into these deep mysteries of the Universe.
The Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU) was launched
at the University of Tokyo from scratch back in 2007. Now it boasts about 100 scientists
on site, whose majority comes from outside Japan. It has a comparable impact factor to major
research institutes worldwide. Its scientific objective is to address age-long questions of humanity:
How did the Universe begin, what is its fate, what is it made of, what laws govern it, and why
do we exist in it? Kavli IPMU is poised for major advances using a unique combination of
mathematics, theoretical physics, experimental physics, and astronomy. It received an endowment
in 2012 from The Kavli Foundation, which supports leading universities around the world.
Message from OOGURI Hirosi, Director of Kavli IPMU
Profile After receiving his PhD from the University of Tokyo, Ooguri has held posts at the University of California, Berkeley, and Kyoto University, before becoming Fred Kavli Professor of Theoretical Physics and Mathematics at the California Institute of Technology in 2007. He is also Director of the Walter Burke Institute for Theoretical Physics, and became Director of Kavli IPMU in October 2018. In 2019, he was awarded the Medal of Honor with Purple Ribbon by the Government of Japan.
Kavli IPMU Teatime
Plans are moving forward with the LiteBIRD satellite,
where Kavli IPMU is a member. The project aims to
find a footprint of primordial gravitational waves left in
the cosmic microwave background, in order to test the
inflation theory of the Universe. LiteBIRD was named
an important large-scale research project in the 2020
Master Plan announced by the Science Council of Japan,
and the plan is to launch it into space in the mid-2020s.
Kavli IPMU is responsible for the polarizing modulator
in the telescope system.
Belle II experiment begins first data-taking after upgrade
LiteBIRD satellite planstake a step forward
A partially completed SVD showing ladders assembled together like a lantern (Credit: Belle II Collaboration)
Archive of research results
This project involves Kavli IPMU members including Associate Professor Takeo Higuchi
This project involves Kavli IPMU members including Professor Nobuhiko Katayama and Associate Professor Tomotake Matsumura
Artist's impression of the finished LiteBIRD satellite (Credit: LiteBIRD)
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Kyoto U
niversity: Institute for Integrated Cell-M
aterial Sciences (iCeMS)
Using organized microfibrillation (OM) technology
to precisely form fibrils in polymers, Prof. Easan Sivania
and his colleagues have developed a material that
reflects light of a specific frequency that human eyes
recognize as color. Crazing, which usually appears
randomly as plastic products deteriorate, can be
precisely controlled by using OM technology, and that
made it possible to print on flexible and transparent
materials with a resolution of up to 14,000 dpi. This is
expected to be applied to a variety of technologies,
including the development of inkless color printing
technology and the prevention of counterfeiting of
banknotes.
Kyoto University
Institute for Integrated Cell-Material Sciences (iCeMS)
1) iCeMS has an environment that fosters active discussion and
exchange across disciplines, for example, open offices and laboratories,
and shared lab equipment that researchers from different fields can
use together. Researchers can meet face-to-face regularly, and that
helps to generate ideas for collaborations. 2) It also has the Overseas
Researchers Support Office (ORSO) to provide an environment in
which foreign researchers, who make up about 20% of the total, can
concentrate on research activities. The ORSO provides support for
obtaining a status of residence in Japan, procedures for employment,
and finding housing to help overseas researchers and their families. Furthermore, 3) in order to realize an international
and interdisciplinary research environment, iCeMS holds many international symposia and seminars in Japan and
abroad. 4) iCeMS also has a specialist team called the Research Administration Office (RAO) to reinforce the international
research network and return iCeMS' research results to society. The RAO works to obtain external funds and to accelerate
human resource exchange through industry-academia or academia-academia collaborations, and also works on
outreach activities for brain circulation and the dissemination of research results both domestically and internationally.
Towards the Integration of Materials Science and Cell BiologyiCeMS seeks to illuminate the chemical basis of cells; to create chemical compounds controlling cellular processes
and functional materials inspired by cellular processes; and to ultimately contribute to the fields of industry,
medicine and drug discovery.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
An international and interdisciplinary environment with many young PIs
To understand cellular functions through chemistry and to reproduce and manipulate them with materials
Cells sustain life through self-assembly and cooperative
interactions among great numbers of chemical materials. The
behaviors of those chemicals constantly change in time and space.
To understand this in chemistry, it is necessary to look at molecules
working in a slightly larger mesoscopic region, rather than in the
nanometer region. To this end, iCeMS develops a variety of imaging
and modeling techniques, as well as physics and chemistry methods
to analyze the complex life of cells. In addition, it tries to reproduce cellular functions with materials. The replication of cellular
functions with designed materials should be possible once a full understanding of cellular processes has been achieved. iCeMS
is simultaneously working to advance analysis and synthesis to promote its research.
Challenge, Creativity, Core: We seek to reimagine the international research institution
through a unique environment and system of management. iCeMS could challenge the
world, but only by bringing everyone together into a single core will we have sufficient creativity.
Discovery, Wonder, Passion: It is in our power to unlock mysteries that inspire feelings of
wonder and passion. We must seek out these discoveries in order to turn conventional
wisdom on its head and create new science.
Message from KITAGAWA Susumu, Director of iCeMS
Profile Obtained a PhD in 1979, from the Graduate School of Engineering, Kyoto University. After serving as an Assistant Professor at Kindai University and a Professor at Tokyo Metropolitan University, he became a Professor at the Graduate School of Engineering, Kyoto University in 1998. Then he became a Deputy Director and a Professor of iCeMS in 2007. He has been the Director of iCeMS since 2013, and also a Distinguished Professor of the institute since 2017. Major awards include the Thomson Reuters Citation Laureate (2010), Medal with Purple Ribbon from the Japanese government (2011), Fellow of the Royal Society of Chemistry (2013), Basolo Medal of the American Chemical Society (2016), and Grand Prix of the French House of Chemistry (2019).
Drs. Kenichiro Kamei and Rodi Abdalkader have
developed a small chip device that moves fluids over
corneal cells similarly to the movement of tears over
a blinking eye, using a microfabrication technology.
As a corneal model, it is more functional than the
conventional method. The scientists hope their findings
will help improve ophthalmic drug development and
testing, and will lead to a reduction in animal studies
required for them.
OM technology allows an inkless, large-scale color printing process Eye blinking on-a-chip
The new âcornea-on-a-chipâ device can reproduce the pressure of moving tears inside a blinking eyelid, and can more accurately test the effects of drugs on the human eye. (Illustration by Mindy Takamiya)
A very high-resolution painting of approximately 1 mm can be created without ink.
PI/Professor Easan Sivaniah, Program-Specific Assistant Professor Masateru Ito(Nature, June 2019)
PI / Associate Professor Ken-Ichiro Kamei, Program-Specific Assistant Professor Rodi Abdalkader(Lab on a Chip, December 2019)
Archive of research results
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Osaka U
niversity: Im
munology Frontier Research Center (IFReC)
The human leukocyte antigen (HLA) system is a gene
complex that encodes the major histocompatibility
complex proteins in humans. These cell-surface
proteins are responsible for the regulation of the
immunity of humans.
Yukinori Okada and his research group conducted
next-generation-sequencing-based typing of the 33
HLA genes of 1,120 Japanese, providing the high
resolution allele catalog and linkage disequilibrium
structure of both classical and non-classical HLA genes.
The research group revealed the existence of
different gene variants and their connections with
diseases and other traits in the Japanese population.
Their multiple analyses first revealed the levels of
polymorphism in the HLA genes, then classified the
overall patterns of this polymorphism into 11 distinct
groups across the Japanese population using a machine
learning approach. Using data from medical records
on 106 different phenotypes, including 46 complex
diseases from over 170,000 Japanese individuals, they
clarified that about half of these phenotypes showed
significant associations with the studied genes. Their
findings provide a foundation for future studies on risk
factors associated with this part of the genome.
Osaka University
Immunology Frontier Research Center (IFReC)
To further develop as an international research center, IFReC has
increased its efforts in the study of human immunology, which is
basic research using human cells with the cooperation of the Osaka
University Graduate School of Medicine. Further, by incorporating
the viewpoint of pharmaceutical companies, it is accelerating the
sharing of its basic research with society.
IFReC has concluded international collaboration agreements
mainly with European universities and has actively increased
networking among researchers. Furthermore, nurturing the next
generation of researchers is also an important responsibility of
IFReC. To recruit outstanding young researchers from all over the
world, IFReC has created an advanced postdoc system that offers a competitive salary and generous research budget.
IFReC provides an enticing environment for the next generation of researchers and aims to be an indispensable part
of the career paths of talented international researchers.
Comprehensive Understanding of Immune Reactions and Contribution to SocietyIFReC's important mission is to construct a world-class immunology research center.
Furthermore, in addition to efforts in advanced research on basic immunology, IFReC has been actively engaging
in serving society through the results of its research.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
A world-class research center
Striving to lead the world in interdisciplinary and immunology research
Since its inception in 2007, IFReC has been
advancing interdisciplinary research through a team of
outstanding researchers in the fields of immunology,
bioimaging, and bioinformatics. IFReC's research
encompasses diverse fields extending beyond
traditional immunology. Numerous articles have been
published in many top journals and with an increasing
number of academic awards, IFReC's reputation has
spread far and wide among the world's immunologists.
Since 2017, in addition to basic research, IFReC has
endeavored to create a methodology for developing the results of its basic research into medical applications.
I will strive not only to deepen our basic research into immunology until now but also to make
IFReC a world-class research center with the aim of overcoming immunological disorders
of the future. IFReC has concluded comprehensive collaboration agreements with a number
of pharmaceutical companies thereby creating an industry-academia collaboration system for
advancing free basic research, the first model of its kind in Japan. The future looks promising as
IFReC accelerates world-class basic immunology research and the sharing of its results with society.
Message from TAKEDA Kiyoshi, Director of IFReC
Profile Osaka University, Medical School, MD 1992/PhD 1998. 2003: Professor, Medical Institute of Bioregulation, Kyushu University. 2007-Present: Professor, IFReC/Graduate School of Medicine, Osaka University. July 2019-: Director of IFReC.Japanese Society for Immunology Award (2004). JSPS Prize (2010). Osaka Science Prize (2016). BÀlz Prize (2016). Mochida Memorial Academic Award (2019). Highly Cited Researchers (2014-2017). 2nd place in âWorld Immunologist Ranking by Citations 2014.â (Dr. Shizuo Akira, the former director of IFReC ranked first.)
The intestinal immune cells extend dendrites to
capture antigens, triggering immune responses.
Kiyoshi Takeda group identified GPR31, a protein
residing on the surface of small intestinal macrophages,
as the specific receptor for the two metabolites lactate
and pyruvate. Mice lacking GPR31 showed reduced
dendrite protrusion by CX3CR1+ cells after being
administered pyruvate or lactate. As a result, antibody
production decreased following infection with a non-
pathogenic strain of Salmonella.
Big data provides clues for characterizing immunity in Japanese
Bacterial metabolites have big effects on the intestinal immune response
Hirata et al. (Nature Genetics, 2019)
Morita, Umemoto et al. (Nature, 2019)
Role of bacterial metabolites in intestinal immune response
Returning to Society
â¡Human Immunology Lab at IFReC -Single Cell Analysis -Multi-Parameters Analysis -Bioinformatics
â¡Graduate School of Medicine, Osaka University ã(clinical data)
â¡Pharmaceutical Companies (drug screening)
Basic Research
IFReC advanced postdoctoral fellows from around the world
Archive of research results
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National Institute for M
aterials Science: International Center for M
aterials Nanoarchitectonics (M
AN
A)
Two-dimensional nanomaterials, characterized by
atomic/molecular thickness and lateral size of bulk range,
show attractive properties and superior functions not
found in existing materials. MANA has been successful in
synthesizing a wide variety of two-dimensional materials
based on oxides and hydroxides, using a soft chemical
approach in which layered compounds are osmotically
swollen to such a high extent that they eventually come
apart into single layers. It has developed the technology
to assemble, stack and combine them in a manner
similar to LEGO® blocks.
With this new nanosheet nanoarchitectonics, MANA
has demonstrated various innovative functions to bring
new possibilities to a wide range of application fields.
National Institute for Materials Science
International Center for Materials Nanoarchitectonics (MANA)
In order to create a world premier research center with global visibility,
MANA strongly promotes the following management.
Melting pot environment
MANA provides a âmelting potâ environment for gathering researchers of
different fields, cultures and nationalities in one place. MANA is regarded as one
of the most internationalized research organizations in Japan. MANA promotes
fusion research between various fields for âNano Revolution for the Future.â
Fostering young scientists
Young researchers in MANA are involved in interdisciplinary research in the 3D
system with double-affiliation, double-discipline and double-mentors.
Global network
MANA's international nanotech-network is spreading over the world through
research collaboration with seven Satellite Laboratories and young MANA-
alumni at research institutes in other countries.
"Materials Nanoarchitectonics"- New Paradigm of Materials Development -Nanotechnology is changing our lives.
MANA is pioneering a revolutionary technological system called "nanoarchitectonics" as a new paradigm
for nanotechnology to create new materials and functions.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
International nanotechnology research center driven by challenges and field fusion
Pioneering a new nanotechnology system to create next generation materials
MANA is focusing on a new technology system for materials
development named ânanoarchitectonics.â Various nano-scale structural
units are created and arranged in a designed configuration and
interactions occur among them. Synthesis, fabrication and resulting
functionalities are analyzed and predicted both theoretically and
experimentally. This challenge is tackled by researchers distributed over
three research fields: Nano-Materials, Nano-Systems and Nano-Theory.
Nanoarchitectonics opens a new paradigm of materials development
that can contribute to society in forms such as environment & energy
sustainability, next-generation computation & communication, and
health & security.
For the sustainable development of human society, innovative technologies that are based on
discovery and creation of appropriate materials play a crucial role to solve various problems.
In recent years, nanotechnology has made astonishing progress and become a modern pillar of
materials discovery and development. MANA is pursuing innovation on the basis of our concept
of ânanoarchitectonics,â where new materials and functions are created by rationally integrating
and joining nanoscale parts. We have developed various novel nanomaterials, nanodevices and
nanosystems, and led nanotechnology research in the world.
Message from SASAKI Takayoshi, Director of MANA
Profile 1985: Doctor of Science, The University of Tokyo; 1980: Researcher at NIRIM (National Institute for Researches in Inorganic Materials); 2003: Professor of Graduate School of Pure and Applied Sciences, University of Tsukuba (Collateral office); 2007: Principal Investigator of MANA, NIMS; 2008: Field Coordinator of Nano-Materials Field, MANA; 2009: NIMS Fellow; 2017: Director of MANA.
MANA has developed the world's first "synapse
device" that autonomously reproduces the processes
of remembering and forgetting like the human brain.
This is realized by an "atomic switch" which forms
a conductive path of metal atoms precipitating from
a solid electrolyte depending on input frequency.
This device is expected to contribute to developing
a neuromorphic computer that operates without
preprogramming.
Innovative function design by using two-dimensional nanosheets as building blocks
Atomic switch "synapse device"
Director / Principal Investigator Takayoshi Sasaki Group Leader Renzhi Ma(Advanced Materials, 2014 / ACS Nano, 2018)
Principal Investigator Kazuya Terabe(Nature Materials, 2011 / Nanotechnology, 2013)
MANA administrative office welcomes foreign researchers
Melting Pot Cafe
MANA's three research fields
Archive of research results
â Oxide/graphene composite materials for secondary battery with both high capacity and long cycle life
When an electrical signal is input, metal atoms precipitatefrom the electrode on the right, forming a bridge betweenthe electrodes. Higher input frequency creates a thicker(more stable) bridge.
â Atomic switch with synaptic operation
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Kyushu U
niversity: International Institute for Carbon-N
eutral Energy Research (I²CN
ER)
Profs. Nakashima and Fujigaya developed a novel
electrocatalyst structure for polymer electrolyte fuel
cells (PEFC), in which the carbon supports are wrapped
with polymers prior to the catalyst loading. One of the
powerful advantages of this strategy is that carbon
materials with high crystallinity can be used for catalyst
loading, and thus, high durability of PEFC was realized
(Advantage 1). The team also successfully increased
the utilization efficiency of platinum and realized high
activity of PEFC (Advantage 2).
Kyushu University
International Institute for Carbon-Neutral Energy Research (I²CNER)
This is a unique collaborative project between Kyushu
University and the satellite institute at the University of Illinois at
Urbana-Champaign (UIUC). I²CNER's strength is its young faculty
members who have been encouraged to develop independent
research programs, and who have been intensively working
with our international collaborators. The issue of transitioning
into a carbon-neutral energy society is global and requires
leveraging resources from the international community.
I²CNER provides unique opportunities for bottom-
up research, giving researchers opportunities to create
and establish new research directions. In order to foster
interdisciplinary research, applied math and economics are
integrated into I²CNER's research portfolio. âApplied math and
economics for energyâ is now a new interdisciplinary research
direction, and will be an important component of I²CNER.
Grand Highway for a Carbon-Neutral Energy Fueled WorldI²CNER's mission is to contribute to the creation of a sustainable and environmentally-friendly society by
advancing low-carbon emission and cost-effective energy systems, and improvement of energy efficiency.
Through its mission-driven basic research, I²CNER has defined and produced the development of the science to
dramatically reduce Japan's CO2 emissions.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Collaboration with the UIUC and generating fused disciplines
Creation of basic science for realization of a low-carbon society
The Institute aims at understanding and advancing the science of hydrogen production using artificial photosynthesis;
hydrogen tolerant materials; next-generation fuel cells; catalysis and âgreeningâ of chemical reactions; CO2 capture and
utilization; CO2 geological sequestration; and energy analysis. This broad-based agenda cuts across the boundaries of
chemistry, physics, materials science, mechanics, geoscience, biomimetics, economics, and policy-making. The research in
I2CNER bridges multi-dimensional spatial and temporal scales for various phenomena.
I²CNER's projects are beginning to achieve technology transfer. We have new efforts that fuse
applied math and energy engineering, including modeling the smart electric grid based upon
understanding of how energy generation, demand, and storage interact; and using persistent
homology to characterize the properties of porous materials. We are integrating computational
scientists by leveraging synergism between computation and experiments, which may provide an
accelerated and targeted approach to scientific discovery. We are trying to enhance our impact by
considering the well-to-wheel implementation of carbon-neutral technologies.
Message from Petros Sofronis, Director of I²CNER
Profile Professor, Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign. Professor Sofronis studies solid mechanics, micromechanics and fracture mechanics. He is currently developing a mechanistic understanding of hydrogen embrittlement in pipeline steels to determine whether hydrogen fuel can be safely transported at enormous pressures through existing pipelines. Professor Sofronis has received numerous awards from the US National Science Foundation and the US Department of Energy. Since December 2010, he has served as the Director of I²CNER.
Efficient CO2 capture technologies are indispensable
and urgently needed for carbon-neutral energy
systems. Prof. Fujikawa and his group succeeded to
develop well-defined, free-standing nanomembranes
of 34 nm thickness, which is the highest level of CO2
permeance in the world. This finding expands the
relevance of I2CNER research goals beyond capturing
CO2 from fire-powered plants to the entirely new area
of CO2 capture directly from the atmosphere.
Novel electrocatalyst design based on polymer-wrapping of carbon supports
Creation of ultra-fast CO2 separation nanomembranes and direct air capture
Tsuyohiko Fujigaya et al. (Scientific Reports, 2015)Tsuyohiko Fujigaya et al. (Electrochimica Acta, 2019) Shigenori Fujikawa et al. (Chemistry Letters, 2019)
Archive of research results
Strategic partnership with UIUC
A state-of-the-art research environment
CO2 separation nanomembrane and its gas separation per formance: (a) a free-standing and 150-nm thick nanomembrane (orange O-ring is a frame); (b) gas permeance of CO2 (blue squares), N2 (green triangles), and CO2/N2 selectivity (red crosses) as a function of thickness.
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University of Tsukuba:
International Institute for Integrative Sleep Medicine (IIIS)
Hibernating mammals lower their body temperature
and reduce energy expenditure, although the
regulating mechanism of hibernation is still not well
known.
IIIS has found a population of hypothalamic neurons
that induces a long-lasting hypothermic/hypometabolic
state similar to hibernation (Q neurons). No obvious
tissue/organ damage nor abnormalities in behavior
have been observed after recovery.
This finding opens the door to the development
of the induction of a hibernation-like state on non-
hibernating mammalian species, including humans.
University of Tsukuba
International Institute for Integrative Sleep Medicine (IIIS)
Under the leadership of Prof. Yanagisawa, the researchers at IIIS collaborate
with each other to drive forward innovative sleep research. Based on Prof.
Yanagisawa's 20-plus-year experience as a PI at the University of Texas
Southwestern Medical Center, IIIS has been established as the best and unique
sleep research center in Japan, by learning from the merits of the US-style
academic âdepartment.â IIIS has created a free and vigorous atmosphere
emphasizing: (i) flexible and timely appointments of independent PIs
regardless of their age and career stage, with a necessary start up package (e.g.,
funding, personnel and space); (ii) a flexible and dynamic allocation of floor
space for each laboratory to facilitate free and open communications; and
(iii) sharing of major facilities and capital equipment among laboratories. IIIS
manages the organization so that all researchers and students can vigorously
communicate and maximize their potentials.
Solving the Mysteries of SleepSleep is one of the biggest black boxes of today's neuroscience.
Researchers at IIIS cooperate together aiming to elucidate the fundamental principles of sleep/wake regulation
and develop new strategies to assess and treat sleep disorders.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Open and flat organization to maximize all membersâ capacity
Aiming to realize a society where people can sleep soundly
We spend nearly 1/3 of our lives asleep. The importance of sleep is clear
because the loss of sound sleep lowers daytime performance and physical
and mental health. However, the regulation and function of sleep remain
unclear.
IIIS sets 3 missions to uncover the mystery of sleep and to solve sleep-
related social problems:
1. To elucidate the functions of sleep and the fundamental
mechanisms of sleep/wake regulation
2. To elucidate molecular pathogenesis of sleep disorders and related
diseases
3. To develop preventive measures, diagnostic methods, and
treatments for sleep disorders
Our discovery of the neuropeptide orexin and its prominent role in sleep/wake regulation has
generated a highly active research field in neurobiology of sleep. However, the fundamental
governing principle for the regulation of sleep pressure remains a mystery. Based on my own
experience as a PI in the US, and by learning from the merits of US academia while retaining
the merits of Japanese traditions, IIIS provides a scientific culture and environment that strongly
encourage all members to initiate and continue truly groundbreaking studies.
Message from YANAGISAWA Masashi, Director of IIIS
Profile Received a PhD from the Faculty of Medicine, University of Tsukuba. Assigned as a Professor at the University of Texas and a Researcher at the Howard Hughes Medical Research Institute for 24 years from 1991 to 2010. In 2010, his research project was adopted as FIRST. In 2012, appointed Director and Professor of WPI-IIIS. Received numerous awards and distinctions, including the Medal with Purple Ribbon (2016), the Keio Medical Science Prize (2018), the Person of Cultural Merit (2019), and the Ibaraki Prefecture Honor Award (2019).
While several brain areas including the hypothalamus
are known to be essent ial f or NREM sleep,
comparatively little is known about how the brainstem
controls NREM sleep. Previous work has found that
a subregion of the brainstem, the sublaterodorsal
tegmental nucleus (SubLDT), regulates both REM and
NREM sleep. Researchers at IIIS therefore targeted this
area to identify NREM sleep-promoting neurons, and
found that a wide network of neurotensin-producing
neurons is involved in NREM sleep regulation.
A novel neuronal pathway that induces hibernation-like hypometabolic states
To sleep deeply: the brainstem neurons that regulate non-REM sleep
Archive of research results
Takahashi, Sunagawa, Sakurai et al. (Nature, 2020)ã
Kashiwagi, Hayashi et al. (Current Biology, 2020)
Open floor space
Shared laboratory
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Mantle convection removes heat from our planet's
interior and drives plate tectonics. Geochemical data
suggests ancient domains are preserved >4.4 billion
years in the mantle despite persistent convection and
mixing. To explain this, ELSI established a new model
of mantle material transport. In its simulations, high-
viscosity mantle rock can stabilize unmixed mantle
domains despite whole-mantle flow circulating within
them. Preservation of ancient SiO²-rich domains may
also explain SiO² depletion in the circulating mantle,
relative to the solar system's average composition.
ELSI remains a world-leading research hub following its system reform plans:
Research environment:- Open and flat inclusive research environment- Annual evaluation of researchers - Young researcher start-up funds- Rich external funding, including Astrobiology Program established by private
company donation
Top-notch administration:- One-stop-shop with research-orientated administrative support staff- Close relationship with university- Lab safety lectures, cultural diversity training courses, and harassment
counselling offered in English
Outreach and science communication:- Promote science communication under Communications Director with scientific
and rich international background- Bridge gap between scientists and society- Outreach of an international standard, including press releases and events in English
Initial Conditions (dilute gas)
Viability Filter
Viability Filter
Stellar System
Formation
Geological
Evolution
Biological Evolution
(diversification of
lineages)
Formation of
Chemical
Environments
Coalescence
(LUCA)
Expansion of
the Modern
Biosphere
Diversification+
Filter SelectionDiversification Filter
Selection Diversification FilterSelection
FilterSelectionDiversification
Chemical
Selection
A diverse range of planets is created
Basic habitability requirements
1
2
Diversification of geological processes over time
3
Diverse geochemical contexts with chemically available energy
4Chemical selection results in functional molecules
6
Evolution results in features of modern biology
7Diverse environments create diverse chemical processes and building blocks
5
Increase in biodiversity and establishment of ecosystems
8
Tokyo Institute of Technology: Earth-Life Science Institute (ELSI)
ELSI has demonstrated abiogenic electrochemical
reduction of CO2 to CO under geochemically plausible
conditions. The significance of this result is that abiogenic
CO has long been proposed as a feedstock for complex
organic synthesis; the efficient reduction shows that the
potentials obtained at hydrothermal vents are sufficient to
drive carbon fixation.
Ballmer, M., Houser, C., Hernlund, J., Wentzcovitch, R., Hirose, K. Persistence of strong silica-enriched domains in the Earth's lower mantle. (Nature Geoscience, 2017)
Tokyo Institute of Technology
Earth-Life Science Institute (ELSI)
World-class Interdisciplinary Research Hub Exploringthe Origins of Earth and LifeELSI's Earth/planetary and life scientists study the origins of Earth and life; and possible life forms on solar-
system and extra-solar planets by testing what is unique and universal to Earth's life.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
An open and inclusive interdisciplinary research environment
How did the Earth form, and how did life begin and evolve?
ELSI specifically investigates how the Earth
formed, the emergence of life in the early
environment, co-evolution of the Earth-life
system, and the emergence/occurrence of
life elsewhere in the universe. These domains
are achieved by using the ELSI model as
a theoretical framework and a roadmap
for origins of life research. The ELSI model
captures the idea that the events from the Big
Bang to life were a series of diversifications
followed by selections.
We will promote integrated research in fields related to the early Earth, including Earth's
formation, early Earth environment, the emergence of life on Earth, and the co-evolution of
the Earth-Life system. Through these, ELSI will clarify both unique and universal aspects of the Earth,
from which life emerged and evolved, and try to predict the presence or absence of life on other
planets. In order to immediately apply our research results to search for extraterrestrial life, we will
work in close cooperation with space exploration missions and astronomical observations.
Message from HIROSE Kei, Director of ELSI
Profile A world premier expert on the Earth's interior. In 2004, he and his team made the first discovery of a main mantle mineral in 30 years: "post-perovskite" in a few-100-km thick layer near the mantle's base. This discovery expanded the understanding of what has long been the most enigmatic region inside the Earth. In 2010, his group successfully generated static ultrahigh-pressure and temperature conditions beyond those at the Earth's center and revealed metallic iron's crystal structure in the solid inner core. He received the Japan Academy Prize and Ringwood Medal in 2011, and Fujihara Award in 2016.
Domains of ancient rocks preserved in the Earthâs mantle
Geoelectrochemistry- a new field of study within OoL research
Archive of research results
Kitadai N., Nakamura R., Takai K., Li Y., Gilbert A., Ueno Y., Yoshida N.,and Oono, Y. Geoelectrochemical CO production: Implications for the autotrophic origin of life. (Science Advances, 2018)
ELSI model of the origins of life
Open and flat research structure
Active collaboration between young and senior researchers
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ITbM has discovered GO829, which slows or lengthens
the circadian rhythm in cultured human cells, DHEA, which
treats jet-lag in mice by accelerating the circadian rhythm,
and AMI-331, which slows or lengthens the rhythm in plants.
The circadian clock controls the rhythm of the day such as
sleeping and waking, and, when disrupted, is known to
cause a variety of health problems. Through the elucidation
of the molecular mechanism of the circadian clock in a wide
variety of organisms from mammals to plants, it is expected
that improvements will be made in the treatment of related
diseases such as sleep disorders, depression, obesity and
cancer, and that food production will be increased.
ITbM's research is expected to improve the treatment of diseases such as sleep disorders, depression, obesity and cancer.
Yuichiro Tsuchiya, Daisuke Uraguchi, Takashi Ooi et al.(Science, 2018)
Nagoya U
niversity: Institute of Transform
ative Bio-Molecules (ITbM
)
SPL7 is a ground-breaking molecule developed to
exterminate the parasitic plant Striga, which has dealt
a heavy blow to African cereal production. SPL7 has
very little impact on the biological environment of
cereals and soil bacteria, and promotes the suicidal
germination of Striga at concentrations of as little
as 1/1013-15mol/L. SPL7 boasts a potency equivalent
to natural germination stimulant strigolactone, the
most potent germination stimulant to Striga among
all commercially available compounds. Currently,
ITbM is conducting field testing of SPL7 in Kenya and
continuing its development towards practical use.
Nagoya University
Institute of Transformative Bio-Molecules (ITbM)
At ITbM, top level experts in a variety of fields from both Japan and
abroad occupy the positions of Principal Investigators (PIs). ITbM's
younger specialists take on the role of Co-PIs, cooperating with PIs to
drive forward their research effectively and learn important research
skills and management of her/his laboratory. With most of the post-
doctoral researchers coming from overseas, and 30% of researchers
being women, ITbM is a highly diverse research environment. ITbM
incorporates research spaces and researchers from different fields into
cooperative "Mix Labs" and "Mix Offices" where researchers can conduct
experiments and talk side by side, and promotes collaborative and inter-
disciplinary research within its research groups.
Change the World with Molecules:Where Chemistry, Biology and Theory MeetITbM's dream is to develop âtransformative bio-moleculesâ that can change the way we live.
By merging synthetic/catalytic chemistry, animal/plant biology, and theoretical science, ITbM will take up the
challenges of solving global issues with molecules.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Diverse and interdisciplinary research born from mixed spaces
Interdisciplinary research producing transformative biomolecules
ITbM continues its research into creating innovative bio-functional
molecules that will fundamentally transform life science research -
"transformative biomolecules." Through the dynamic cooperation
of synthetic chemists, plant/animal biologists and theoreticians
and the creation of a new field of research merging biology and
chemistry, ITbM develops transformative biomolecules that will have
a great and positive impact on society. In 2020, ITbM will prioritize
new areas of research as â"ITbM 2.0," using molecules to tackle
worldwide issues such as climate change, food supply and medical
technologies.
Molecules are tiny, but they are an essential part of everything we do in life. I firmly believe that
they hold the power not only to change our scientific techniques, but to change our society
as well. Through the cooperation of chemists, biologists, and theoreticians, molecules with carefully
designed functions are born: SPL7 to help the African food supply problem, DHEA, which is expected to
become a drug to treat jet-lag, and molecular nanocarbons, which will revolutionize carbon materials
science. ITbM will connect molecules, create value, and change the world one molecule at a time.
Message from ITAMI Kenichiro, Director of ITbM
Profile Director Itami received his PhD in synthetic chemistry from Kyoto University in 1998. He became an Associate Professor at Nagoya University's Research Center for Materials Science in 2005, a Professor at the Graduate School of Science in 2008, and ITbM Director in 2012. Founded on the development of fast and accurate synthesis of arene-assembled molecules, his research expands across a number of fields including catalytic chemistry, materials science, medicinal chemistry and nanocarbon chemistry. He has won a number of international awards, and was one of Clarivate Analyticsâ Highly Cited Researchers in 2017, 2018 and 2019.
Exterminating the parasitic menace Striga in Africa
Molecules to treat diseases in mammals and improve food production by modifying the circadian rhythm
Tsuyoshi Hirota et al. (Science Advances, 2019) Takashi Yoshimura et al. (EMBO Molecular Medicine, 2018)Norihito Nakamichi et al. (PNAS, 2019)
SL-like molecules work as inducers of suicidal germination to purge the soil of viable Striga seeds before planting the crop seed.
â Extermination of Striga seeds by suicide germinationâ Modification of the circadian rhythm to treat diseases in
mammals and to improve food production
ITbM's flagship research areas
Researchers and students from different fields work alongside one another in ITbM's Mix Lab and Mix Office
Poster session by students of the Graduate Program of Transformative Chem-Bio Research (GTR)
Archive of research results
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The University of Tokyo:
International Research Center for N
eurointelligence (IRCN
)
Psychosis is a debilitating mental condition observed
in disorders such as schizophrenia. A team led by
IRCN Principal Investigator Haruo Kasai and Affiliated
Faculty Shin Ishii showed that psychosis may be linked
to defective neural signaling in a brain area called
the striatum. Using optogenetic technologies in mice
to perturb neurotransmitter dopamine D2 receptor
signaling, they implicated a behavior called reward
discrimination learning in the emergence of psychosis
and provided novel insights into potential therapies.
The University of Tokyo
International Research Center for Neurointelligence (IRCN)
IRCN is organized into four Research Units (Development, Human/Clinical, Computation,
Technology), whose collective goal is creation of the research field of neurointelligence.
Each unit is asked to produce new synergistic research outcomes through collaborative
research. IRCN also aims to build the world's highest-level research organization by
offering cutting-edge technology and an international environment.
Leading Global Network
Functioning as a research hub in collaboration with 18 key overseas institutions such
as Boston Children's Hospital
Core Facilities for Interdisciplinary Research
Maintaining facilities which provide a platform for enabling researchers to
seamlessly integrate hypothesis and verification cycles for efficient research
Nurturing Young Researchers
Encouraging trainees to exchange views and ideas through Science Salon, Retreat,
and Neuro-Inspired Computation Course, which lead IRCN to new integrated research
Tackling the Ultimate Question â âHow Does Human Intelligence Arise?â IRCN combines life sciences and information sciences to establish the new field, "neurointelligence."
By clarifying the essence of human intelligence, overcoming neural disorders, and developing new A.I.,
it will contribute to a better future society.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Global bridging â Brain development and computational science
To establish the new field of âneurointelligenceâ
Elucidating brain functions is a highly complicated and difficult endeavor,
and this is one of the biggest scientific frontiers on par with identifying the
origins of the universe.
IRCN aims to (1) elucidate fundamental principles of neural circuit
maturation, (2) understand the emergence of psychiatric disorders
underlying impaired human intelligence, and (3) drive the development of
next-generation artificial intelligence (A.I.) based on these principles.
By proceeding with this research, IRCN is establishing the new field of
âneurointelligenceâ and tackling the the ultimate question: "How does
human intelligence arise?â
International Research Center for Neurointelligence was established in 2017 with a 10-year mission:
to create a new discipline at the interface of human and artificial intelligence from the view of
neurodevelopment and its disorders. We seek answers in the underlying principles of neural circuit
development and how it goes awry in psychiatric disorders. This promises new insights for neuro-
inspired A.I. and innovative, computational approaches to understanding the human condition.
Come share our quest, key collaborations, state-of-the-art core facilities and unique culture!
Message from Takao K. Hensch, Director of IRCN
Profile After receiving his PhD from UCSF (1996), Hensch helped to launch the RIKEN BSI before returning to Harvard in 2006. Currently, he is Joint Professor of Neurology and Molecular Cellular Biology, Director of NIMH Silvio Conte Center for Mental Health Research, Director of IRCN, and Co-Director of CIFAR Child Brain Development network.Hensch serves on the editorial board of several prominent journals: Neuron, Frontiers in Neural Circuits (chief editor).He received several honors including the Young Investigator Award in both Japan (Tsukahara Prize, 2001) and the US (2005), and the Mortimer D. Sackler's Prize (2016).
Opening a new window intopsychosis, a major disorder ofhuman intelligence
Archive of research results
Principal Investigator / Professor Haruo KasaiAffiliated Faculty / Professor Shin IshiiIino et al. (Nature, 2020. DOI: 10.1038/s41586-020-2115-1)
Principal Investigator / Professor Takao HenschAffiliated Faculty / Professor Charles NelsonAffiliated Faculty / Associate Professor Michela FagioliniArtoni P et al. (PNAS, 2019. DOI: 10.1073/pnas.1820847116)
Early diagnosis of developing intellectual disabilities
is essential before critical periods of brain plasticity
close. In a study led by IRCN Director Takao Hensch
and Affiliated Faculty Michela Fagiolini and Charles
Nelson of Boston Children's Hospital, a deep machine
learning algorithm based on pupil dilation or heart rate
was established for the detection of pre-symptomatic
autism-like disorders. By first training on genetic
mouse models then transferring learning to patients, a
powerful new translational tool was created.
Microscopic image of a neuron that expresses D2RCredit: © 2020 Iino et al.
A.I. detects emergent disorders of human intelligence Credit: ©Pietro Artoni / Boston Children's Hospital
Researchers from around the world at Imaging Core
IRCN Neuro-Inspired Computation Course
A.I. detects early arousal biomarkers of autism spectrum disorder from mouse to human
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Highlighting the real-time feedback-controlled
dynamic 3D extracellular pH mapping that their tool
allows, and the heterogeneities of cancer cells that it
can detect âlabel-free and at subcellular resolution,â
they conclude, âThis method could help with cancer
diagnosis, prognosis, and in evaluating acidic
extracellular pH targeted therapies.â
Kanazaw
a University:
Nano Life Science Institute (N
anoLSI)
Extracellular pH plays an essential role in cancer cell
progression, invasiveness, and resistance to therapy.
However, despite the growing recognition of the
importance of the pH directly surrounding a cell as
an indicator of cell health, conventional techniques
remain limited in terms of their lower sensitivity and
spatiotemporal resolution in response to a local pH
change.
The researchers developed a nanopipette pH
biosensor that has > 0.01 units sensitivity, 2 ms
response time, and 50 nm spatial resolution.
The researchers incorporated a zwitterionic pH-
sensing membrane in one barrel of a double-
barrel nanopipette, and used another open barrel
as feedback-control for scanning ionic conductance
microscopy (SICM), which enabled simultaneous high-
resolution 3D topographical imaging and pH mapping.
Tests on live cancer cells showed their probe could
sense increases in extracellular pH from invasive
phenotypes of breast cancer cells that had hormonal
therapy-resistance. They could also detect pH changes
from algae exposed to sunlight, caused by the uptake
of inorganic carbon in photosynthesis, as well as
identify heterogeneities in aggressive melanoma cells
from high-resolution pH maps.
Kanazawa University
Nano Life Science Institute (NanoLSI)
NanoLSI organizes regular meetings for ideas to create
new interdisciplinary fields: PI-centric NanoLSI Colloquia;
T-Meetings, for "one-to-one inter-lab" interaction; and
informal "plate-in-hand" NanoLSI Luncheons. Outstanding
ideas from these meetings receive âTransdisciplinary Research
Promotion Grantâ funding for "start-up projects."
Other activities include the Bio-SPM Summer School; Bio-
SPM Collaborative Research; NanoLSI Visiting Fellows Program;
and international symposia held at satellite hubs in the UK
and Canada, with results fed back to young researchers at the
Department of Nano Life Sciences.
New policies introduced by NanoLSI include hiring "research-dedicated" faculty, performance-based salaries, and a tenure
track program. Furthermore, after working at NanoLSI, administrative staff are transferred to departments within Kanazawa
University to share their experience.
Nanoprobe Life Sciences:Exploring "Uncharted Nano World" of Life Sciences
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Comprehensive programs for enhancing creativity and innovation
Nanoscale insights into dynamic mechanisms in life sciences
Countless molecules and cells that make up the body play critical roles
in sustaining human life. However, humans are unable to directly observe
the nanoscale dynamics and interactions of these molecules. This is the
"uncharted nano-world" of life science.
NanoLSI is an interdisciplinary research institute where experts in
nanometrology, life science, supramolecular chemistry, and mathematics
are using cutting-edge scanning probe microscope technology to explore
"unseen nano-cellular worlds." NanoLSI scientists directly observe complex
mechanisms of "nanoscale life-phenomena" through world-class research
and have created the new academic field of ânanoprobe life scienceâ to
advance knowledge in the life sciences.
The origins of all the physical properties and phenomena can be explained by structures and
dynamics of nanoscale (roughly 1/1,000,000,000 of a meter) species, such as atoms and
molecules. We aim to develop new nanoprobe technologies that allow us to directly visualize
nanodynamics in the uncharted nano-realms at the surface and interior of live cells. This will hereby
contribute to dramatic progress in the life science field, and lead to the formation of a new academic
discipline, "nanoprobe life science."
Message from FUKUMA Takeshi, Director of NanoLSI
Profile Prof. Takeshi Fukuma received a PhD in Engineering from Kyoto University in 2003. Since then, he has worked at Kyoto University, Trinity College Dublin, and Kanazawa University. Since 2017, he has been the director of NanoLSI. He developed the world's first in-liquid frequency modulation atomic force microscopy (AFM) that allows observation at atomic scale. He received the Young Scientistsâ Prize from the Ministry of Education, Culture, Sports, Science and Technology (MEXT; 2011) and Japan Society for the Promotion of Science Prize (2018).
Innovative nanopipette probe biosensor offers improved detection of changes in pH surrounding living cells for possible cancer treatment strategies
Archive of research results
NanoLSI PI Yuri Korchev, Associate Professor Yasufumi Takahashi (Nature Communications, 5610, 2019)
The operation of the double-barrel nanoprobe for simultaneous SICM imaging and pH measurementCredit: Nature Communications
Scientists at the Nano Life Science Institute are making nanoscale observations of "life-phenomena" using unique
scanning probe microscopes to demystify this "uncharted nano-world of life science" for the advancement of
science.
An experiment using scanning probe microscope technology
Group photo at the 8th Bio-SPM Summer School
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MANABIYA is a system to foster a new generation of
researchers proficient in the three fields of computational,
information and experimental sciences and to develop the
new interdisciplinary academic field of "chemical reaction
design and discoveryâ (CReDD) worldwide. Within this system,
ICReDD conducts joint research and education, develops human
resources, and discovers new research seeds. Thus, ICReDD
aims to form an academic network, becoming an internationally
recognized research institution. In the academic branch, young
researchers and graduate level students from domestic and
overseas institutions are invited to stay at ICReDD for 2 weeks to 3 months to acquire techniques for developing new
chemical reactions. In the industry branch of the program, ICReDD promotes collaborations between faculty and
corporate researchers in the form of consulting, research collaborations, and consortia.
Hokkaido U
niversity: Institute for Chem
ical Reaction D
esign and Discovery (ICR
eDD
)
Eradication of cancer requires the targeting of cancer
stem cells (CSCs). Recently, ICReDD researchers have
established a novel technique for rapidly and efficiently
inducing CSCs using double network gel (DN gel)
developed by Prof. Gong in ICReDD (JP2017-028833:
PCT/JP2018/005884: US16/487,247). The group has
elucidated the mechanism of induction of CSCs by DN
gel, which is designated as the HARP (hydrogel activated
reprogramming) phenomenon, and succeeded in
selecting an effective drug for CSCs. This is an epoch-
making result that has led to the development of an
innovative method for diagnosis and treatment of CSCs
using hydrogel.
Tsuyoshi Mita, Yu Harabuchi, Satoshi Maeda (Chemical Science, 2020. DOI: 10.1039/D0SC02089C)
To develop a bioisostere of amino acids, ICReDD
researchers planned to synthesize an α,α-difluoroglycine
derivative, which is the most simple α-fluorinated
α-amino acid. The group first retro-synthesized
α,α-difluoroglycine by AFIR, proposing three basic and
simple starting materials such as :CF2 (difluorocarbene),
NR3 (amine), and CO2 (carbon dioxide). After predicting
a difluorocarbene precursor and an amine structure
employed in experiments by further calculations, they
conducted the chemical synthesis of a difluoroglycine
derivative (R = Me). It took only two months to complete
the synthesis.
Hokkaido University
Institute for Chemical Reaction Design and Discovery (ICReDD)
In-depth Understanding and Efficient Development of Chemical ReactionsICReDD aims to establish the scientific field of "chemical reaction design and discovery" through a combination of
computational, information, and experimental sciences to efficiently develop new chemical reactions.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
MANABIYA to foster researchers proficient in three fields
The purposeful and efficient design of chemical reactions
The current trial-and-error approach to the development
of new chemical reactions is time-consuming and
inefficient. ICReDD uses state-of-the-art reaction path
search methods based on quantum chemical calculations
and applies concepts of information science in order to
extract meaningful information for experiments, thus
narrowing down optimal experimental conditions. This
approach considerably shortens the time required to
develop chemical reactions and creates a feedback loop
in which data obtained through experiments is circulated
back to computations through information science.
Reaction development that relies solely on the trial-and-error approach is too time-consuming
to solve current global problems that include pollution as well as the scarcity of energy and
resources. CReDD will revolutionize the traditional approach to developing reactions by fusing
computational, information, and experimental sciences. We strive to spread the benefits of this
approach by establishing a global research center, integrating multiple disciplines. Our sincere hope
is that ICReDD may contribute to a brighter and more prosperous future for all of humanity.
Message from MAEDA Satoshi, Director of ICReDD
Profile After his PhD from Tohoku University, he served as a Postdoc at Emory University and Kyoto University. At 37, full Professor at Hokkaido University; at 39, youngest Director of a WPI center. Recipient of numerous awards, among them the JSPS Prize âto recognize and support young researchers with rich creativity and superlative research abilityâ and the WATOC Dirac Medal for an
âoutstanding theoretical and computational chemist under the age of 40.âDeveloped the "artificial force induced reactionâ (AFIR) method to calculate chemical reaction-path networks and predict unknown reactions.
Difluoroglycine synthesis guidedby quantum chemical calculations
Successful rapid induction of cancer stem cells by hydrogel
Archive of research results
Shinya Tanaka, Jian Ping Gong et al. (Nature Biomedical Engineering, 2020. Accepted.)
The strategy of CReDD
Interdisciplinary discussion among young researchers
Proposed tailored treatment for cancer patients and anti-cancer drug development utilizing cancer stem cells on DN gels
Retrosynthetic analysis of α,α-difluoroglycine by quantum chemical calculations
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Kyoto U
niversity: Institute for the A
dvanced Study of Hum
an Biology (ASH
Bi)
To create advanced studies of human biology, ASHBi strongly
pursues the development of novel principles through fusion of
new ideas in biology, mathematics and ethics provoked by deep
understanding of different disciplines.
âBiology/Mathematics: Mutual learning process of mathematicians
catching up on the latest advancement in genome science and
biologists absorbing the latest mathematical approaches actively takes
place to create essential ideas provoked through interaction.
âBiology/Ethics: Discussions on new ethical issues arising from
scientific advancement in research, and the philosophical meaning of
humanity and life continuously takes place to set ethical frameworks.
âFusion Research Grant: Supporting new collaboration among ASHBi
groups trying to elucidate new scientific principles based on fused
disciplines.
In this study, ASHBi successfully recapitulated the
pathology of human autosomal dominant polycystic
kidney disease (ADPKD), which is one of the most
common hereditary disorders, by genome editing using
CRISPR/Cas9. The cynomolgus monkey ADPKD models
generated in this study confirmed renal cyst formation
from childhood, which was difficult to reproduce in small
animal models, and clarified the earliest manifestations
of pathogenesis, which had been unknown before. The
monkey models generated in this study will serve as a
critical basis for establishing new treatment strategies.
ASHBi Associate Professor Cantas Alev (Nature, 2020. DOI: 10.1038/s41586-020-2144-9)
A team of researchers lead by Dr. Cantas Alev, a PI
at ASHBi, has succeeded to establish an in vitro model
of the human segmentation clock. Utilizing induced
pluripotent stem cells (iPSCs) and mimicking embryonic
development in a dish, Dr. Alev and colleagues
recapitulated and analyzed core molecular and
functional features of the human segmentation clock,
which they found to oscillate with a period of ~5 hours.
Combining patient-like and patient-derived iPSCs with
their in vitro system they also succeeded with modeling
diseases of the human spine, providing novel insights
into human development during health and disease.
Kyoto University
Institute for the Advanced Study of Human Biology (ASHBi)
What Key Biological Traits Make Us "Human," and How Can Knowing these Lead Us to Better Cures for Disease?ASHBi investigates the core concepts of human biology with a particular focus on genome regulation and disease
modeling, creating a foundation of knowledge for developing innovative and unique human-centric therapies.
ãPurpose of the Researchã
ãUnique Features of WPI Centerã
Initiating fusion research through mutual understanding
Creating an advanced study of human biology
ASHBi's goals:
1) Promote the study of human biology, with a sharp focus on genome
regulation
2) Clarify core principles defining differences among species
3) Generate primate models for intractable human diseases
4) Reconstitute key human cell lineages/tissues in vitro
5) Contribute to formalizing an international ethics standard for research on
human biology
Understanding the basic biology of human beings is a fundamental challenge in life sciences.
The knowledge gleaned from model organisms has often been difficult/impossible
to translate to humans due to species differences in the regulations of key basic pathways.
Accordingly, ASHBi will target humans and non-human primates as major research subjects
in an effort to uncover the key principles of human traits and disease states, through a multi-
disciplinary science approach. This takes place in our open and flexible international research
environment, with full support for motivated, early-career investigators.
Message from SAITOU Mitinori, Director of ASHBi
Profile Prof. Saitou has spent decades extensively investigating the genetic and epigenetic mechanisms that determine the development of germ cells, the cells fundamental to all life. Using iPS cells, he has recently succeeded in generating human primordial germ cell-like cells (PGCLCs), which are responsible for producing sperm and oocytes. He is the recipient of numerous prestigious awards including the Imperial Prize, the Japan Academy Prize, the Asahi Prize and the International Society for Stem Cell Research Momentum Award.
Reconstituting the clock of human spine development in a dish
Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
Archive of research results
ASHBi Associate Professor Tomoyuki Tsukiyama, Professor Masatsugu Ema (Nature Communications, 2019. DOI: 10.1038/s41467-019-13398-6)
ASHBi's strategies and aims
Discussion on ethics of human biology
Interdisciplinary discussion is held regularly
Expressions of nephron segment markers in an ADPKD kidney compartment containing multiple cysts (Scale bar: 1 mm)
In vitro model of the human segmentation clock & diseases of the spineSchematic overview of applied strategy and summary of results when assessing features of the segmentation clock in presomitic mesoderm (PSM) derived from iPSCs of healthy controls or isogenic controls (left) and in PSM made in vitro from patient-like or patient-derived iPSCs (right)
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Ballmer, M., Houser, C., Hernlund, J., Wentzcovitch, R., Hirose, K. Persistence of strong silica-enriched domains in the Earth's lower mantle. Nature Geoscience (2017)
Kitadai N, Nakamura R, Takai K, Li Y, Gilbert A, Ueno Y, Yoshida N, and Oono, Y. Geoelectrochemical CO production: Implications for the autotrophic origin of life. Science Advances (2018)
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Tokyo Institute of TechnologyEarth-Life Science Institute (ELSI)
2-12-1-IE-1 Ookayama, Meguro-ku, Tokyo 152-8550, JapanPhone : +81 3 5734 3414 Fax : +81 3 5734 3416Email : [email protected] : www.elsi.jp/en www.facebook.com/ELSIorigins www.twitter.com/ELSI_origins
Nagoya UniversityInstitute of Transformative Bio-Molecules (ITbM)
Furo-cho, Chikusa-ku, Nagoya 464-8601, JapanPhone : +81 52 747 6843 Fax : +81 52 789 3240Email : [email protected] : www.itbm.nagoya-u.ac.jp facebook.com/NagoyaUniv.ITbM twitter.com/NagoyaITbM
The University of TokyoInternational Research Center for Neurointelligence (IRCN)The University of Tokyo Institutes for Advanced Study
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanPhone : +81 3 5841 4861 Fax : +81 3 5841 0738Email : [email protected] : ircn.jp/en
Kanazawa UniversityNano Life Science Institute (NanoLSI)
Kakuma-machi, Kanazawa, Ishikawa 920-1192, JapanPhone : +81 76 234 4550 Fax : +81 76 234 4559Email : [email protected] : nanolsi.kanazawa-u.ac.jp/en
Hokkaido University Institute for Chemical Reaction Design and Discovery (ICReDD)
Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, JapanPhone : +81 11 706 9649 Fax : +81 11 706 9652Email : [email protected] : www.icredd.hokudai.ac.jp
Kyoto UniversityInstitute for the Advanced Study of Human Biology (ASHBi)Kyoto University Institute for Advanced Study
Yoshida Konoe-cho , Sakyo-ku, Kyoto 606-8501, JapanPhone : +81 75 753 9882 Fax : +81 75 753 9768Email : [email protected] : ashbi.kyoto-u.ac.jp
æ±äº¬å·¥æ¥å€§åŠå°ççåœç 究æïŒELSIïŒãšã«ã·ãŒïŒ
ã152-8550ãæ±äº¬éœç®é»åºå€§å²¡å±±2-12-1-IE-1Phone : 03-5734-3414 Fax : 03-5734-3416Email : [email protected] : www.elsi.jp www.facebook.com/ELSIorigins www.twitter.com/ELSI_origins
åå€å±å€§åŠãã©ã³ã¹ãã©ãŒããã£ãçåœååç 究æïŒITbMïŒã¢ã€ãã£ãŒããŒãšã ïŒ
ã464-8601ãåå€å±åžåçš®åºäžèçºPhone : 052-747-6843 Fax : 052-789-3240Email : [email protected] : www.itbm.nagoya-u.ac.jp/index-ja.php facebook.com/NagoyaUniv.ITbM twitter.com/NagoyaITbM
æ±äº¬å€§åŠåœéé«çç 究æ ãã¥ãŒãã€ã³ããªãžã§ã³ã¹åœéç 究æ©æ§ïŒIRCNïŒã¢ã€ã¢ãŒã«ã·ãŒãšãïŒ
ã113-0033ãæ±äº¬éœæ京åºæ¬é· 7-3-1Phone : 03-5841-4861 Fax : 03-5841-0738Email : [email protected] : ircn.jp
é沢倧åŠããçåœç§åŠç 究æïŒNanoLSIïŒãããšã«ãšã¹ã¢ã€ïŒ
ã920-1192ãç³å·çéæ²¢åžè§éçºPhone : 076-234-4550 Fax : 076-234-4559Email : [email protected] : nanolsi.kanazawa-u.ac.jp
åæµ·é倧åŠååŠåå¿åµæç 究æ ç¹ ïŒICReDDïŒã¢ã€ã¯ã¬ããïŒ
ã001-0021ãåæµ·éæå¹åžååºå 21æ¡è¥¿ 10äžç®Phone : 011-706-9649 Fax : 011-706-9652Email : [email protected] : www.icredd.hokudai.ac.jp/ja
京éœå€§åŠé«çç ç©¶é¢ ããçç©åŠé«çç 究æ ç¹ ïŒASHBiïŒã¢ã·ã¥ãã£ïŒ
ã606-8501ã京éœåžå·Šäº¬åºåç°è¿è¡çºPhone : 075-753-9882 Fax : 075-753-9768Email : [email protected] : ashbi.kyoto-u.ac.jp/ja
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æ±å倧åŠææç§åŠé«çç 究æïŒAIMRïŒãšãŒã¢ã€ãšã ã¢ãŒã«ïŒ
ã980-8577ãä»å°åžéèåºçå¹³2-1-1Phone : 022-217-5922 Fax : 022-217-5129Email : [email protected] : www.wpi-aimr.tohoku.ac.jp www.facebook.com/TohokuUniversity.AIMR
æ±äº¬å€§åŠåœéé«çç 究æ ã«ããªæ°ç©é£æºå®å®ç 究æ©æ§ïŒKavli IPMUïŒã«ããªã¢ã€ããŒãšã ãŠãŒïŒ
ã277-8583ãåèçæåžæã®è5-1-5Phone : 04-7136-4940 Fax : 04-7136-4941Email : [email protected] : www.ipmu.jp/ja
京éœå€§åŠé«çç ç©¶é¢ ç©è³ªïŒçŽ°èçµ±åã·ã¹ãã æ ç¹ïŒiCeMSïŒã¢ã€ã»ã ã¹ïŒ
ã606-8501ã京éœåžå·Šäº¬åºåç°çãå®®çºPhone : 075-753-9753 Fax : 075-753-9759Email : [email protected] : www.icems.kyoto-u.ac.jp facebook.com/Kyoto.Univ.iCeMS twitter.com/iCeMS_KU
倧éªå€§åŠå ç«åŠããã³ãã£ã¢ç 究ã»ã³ã¿ãŒïŒIFReCïŒã¢ã€ãã¬ãã¯ïŒ
ã565-0871ã倧éªåºå¹ç°åžå±±ç°äž3-1Phone : 06-6879-4275 Fax : 06-6879-4272Email : [email protected] : www.ifrec.osaka-u.ac.jp
ç©è³ªã»ææç 究æ©æ§åœéããã¢ãŒããã¯ããã¯ã¹ç 究æ ç¹ïŒMANAïŒããïŒ
ã305-0044ãèšåçã€ãã°åžäžŠæš1-1Phone : 029-860-4709 Fax : 029-860-4706Email : [email protected] : www.nims.go.jp/mana/jp
ä¹å·å€§åŠã«ãŒãã³ãã¥ãŒãã©ã«ã»ãšãã«ã®ãŒåœéç 究æïŒI²CNERïŒã¢ã€ã¹ããŒïŒ
ã819-0395ãçŠå²¡åžè¥¿åºå 岡744Phone : 092-802-6932 Fax : 092-802-6939Email : [email protected] : i2cner.kyushu-u.ac.jp/ja
ç波倧åŠåœéçµ±åç¡ç å»ç§åŠç 究æ©æ§ïŒIIISïŒããªãã«ã¢ã€ãšã¹ïŒ
ã305-8575ãèšåçã€ãã°åžå€©çå°1-1-1Phone : 029-853-5857 Fax : 029-853-3782Email : [email protected] : wpi-iiis.tsukuba.ac.jp/japanese
Tohoku UniversityAdvanced Institute for Materials Research (AIMR)
2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, JapanPhone : +81 22 217 5922 Fax : +81 22 217 5129Email : [email protected] : www.wpi-aimr.tohoku.ac.jp www.facebook.com/TohokuUniversity.AIMR
The University of TokyoKavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU)The University of Tokyo Institutes for Advanced Study
5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8583, JapanPhone : +81 4 7136 4940 Fax : +81 4 7136 4941Email : [email protected] : www.ipmu.jp
Kyoto UniversityInstitute for Integrated Cell-Material Sciences (iCeMS)Kyoto University Institute for Advanced Study
Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, JapanPhone : +81 75 753 9753 Fax : +81 75 753 9759Email : [email protected] : www.icems.kyoto-u.ac.jp facebook.com/Kyoto.Univ.iCeMS twitter.com/iCeMS_KU
Osaka UniversityImmunology Frontier Research Center ïŒIFReCïŒ
3-1 Yamadaoka, Suita, Osaka 565-0871, JapanPhone : +81 6 6879 4275 Fax : +81 6 6879 4272Email : [email protected] : www.ifrec.osaka-u.ac.jp/en
National Institute for Materials ScienceInternational Center for Materials Nanoarchitectonics ïŒMANAïŒ
1-1 Namiki, Tsukuba, Ibaraki 305-0044, JapanPhone : +81 29 860 4709 Fax : +81 29 860 4706Email : [email protected] : www.nims.go.jp/mana
Kyushu UniversityInternational Institutefor Carbon-Neutral Energy Research (I²CNER)
744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanPhone : +81 92 802 6932 Fax : +81 92 802 6939Email : [email protected] : i2cner.kyushu-u.ac.jp/en
University of TsukubaInternational Institute for Integrative Sleep Medicine (IIIS)
1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanPhone : +81 29 853 5857 Fax : +81 29 853 3782Email : [email protected] : wpi-iiis.tsukuba.ac.jp
64
MEXT
Basic Research Promotion Division, Research Promotion Bureau
Ministry of Education, Culture, Sports, Science and Technology
3-2-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-8959, Japan
Phone : +81 3 5253 4111 Fax : +81 3 6734 4074
Email : [email protected]
URL : http://www.mext.go.jp/en/policy/science_technology/
researchpromotion/title01/detail01/1374076.htm
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Email : [email protected]
URL : www.mext.go.jp/a_menu/kagaku/toplevel
Contact
JSPS
Center for World Premier International Research Center Initiative
(WPI Program CenterïŒ
Japan Society for the Promotion of Science
5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan
Phone : +81 3 3263 0967
Email : [email protected]
URL : www.jsps.go.jp/j-toplevel
Facebook: https://ja-jp.facebook.com/wpi.japan/
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Facebook: https://ja-jp.facebook.com/wpi.japan/
© 2020 Japan Society for the Promotion of Science