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WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3. 2

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Page 1: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Graphs to show the effects of Inhibitors on Enzyme Action

3.2

Page 2: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Substrate concentration

Page 3: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Forward

Page 4: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Page 5: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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ExplanationClose

Every active site is saturated. The rate of the reaction is at its highest.

Forward

Page 6: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Page 7: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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ExampleClose

Every active site is saturated, so there is no increase in the rate of reaction.

Page 8: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Competitive Inhibitor

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Substrate concentration

Page 9: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Non-competitive Inhibitor

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Page 10: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Close Explanation

A competitive inhibitor binds to the enzyme’s active site, and slows down the process.

Page 11: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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ExplanationClose

The substrate will soon find an active site. The effect of a competitive inhibitor is to slow down the process.

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Page 12: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Page 13: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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Close Explanation

The shape of the active site changes because the non-competitive inhibitor has bound to an allosteric site; so preventing an enzyme-substrate complex from forming.

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Page 14: WJEC GCE BIOLOGY Inhibitors and Enzyme Action Graphs to show the effects of Inhibitors on Enzyme Action 3.2

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The reaction rate cannot reach the same point because the non-competitive inhibitors have changed the shape of some of the active sites.

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