WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
Graphs to show the effects of Inhibitors on Enzyme Action
3.2
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
1Rat
e o
f re
actio
n
Substrate concentration
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
Explanation
Forward
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
1
2
Rat
e o
f re
actio
n
Substrate concentration
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
ExplanationClose
Every active site is saturated. The rate of the reaction is at its highest.
Forward
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
1
2 3
Rat
e o
f re
actio
n
Substrate concentration
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
nForward
ExampleClose
Every active site is saturated, so there is no increase in the rate of reaction.
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
1
2 3
Competitive Inhibitor
Revise
Rat
e o
f re
actio
n
Substrate concentration
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
1
2
Non-competitive Inhibitor
Revise
Rat
e o
f re
actio
n
Substrate concentration
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
nForward
Close Explanation
A competitive inhibitor binds to the enzyme’s active site, and slows down the process.
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
ExplanationClose
The substrate will soon find an active site. The effect of a competitive inhibitor is to slow down the process.
Forward
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
1
2
Rat
e o
f re
actio
n
Revise
Substrate concentration
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
Close Explanation
The shape of the active site changes because the non-competitive inhibitor has bound to an allosteric site; so preventing an enzyme-substrate complex from forming.
Forward
WJE
C G
CE B
IOLO
GY
Inh
ibit
ors
an
d E
nzy
me A
ctio
n
Close Explanation
The reaction rate cannot reach the same point because the non-competitive inhibitors have changed the shape of some of the active sites.
Forward