why titan works against restenosis?. introduction the cell model the human the animal model...
TRANSCRIPT
WHY TITAN WORKS AGAINST RESTENOSIS?
INTRODUCTION
THE CELL MODEL
THE HUMAN
THE ANIMAL MODEL
CONCLUSION
WHY TITAN WORKS AGAINST RESTENOSIS ?
Why can we be so confident that
Titanium-Nitride-Oxide is ACTIVE ?
WHY TITAN WORKS AGAINST RESTENOSIS ?
INTRODUCTION
Because the scientific data available at
3 different levels is UNQUESTIONABLE
-The Cell model,
-The Animal model,
-The Human.
INTRODUCTION
WHY TITAN WORKS AGAINST RESTENOSIS ?
1-Titanium-Nitride-Oxide is ACTIVE inhibiting PLATELET ADHESION.« …On the titanium oxide films no platelet aggregation was found, almost no red blood cells were damaged, and almost no fibrin was found on the surface. However, all three characteristics were found on the surface of Carbon… »
Journal of Biomedical material 1998 – page 128
THE CELL MODEL
WHY TITAN WORKS AGAINST RESTENOSIS ?
« …However, all three characteristics were found on the surface of Carbon… »
Beyond pointing out the rationale behind the efficacy of Titanium coating this study, shows that BIOCOMPATIBILITY as such is not a very significanyt factor in reducing restenosis. Carbon a highly biocompatible material widely used in implants has none of the positive effect of Titanium coating. It explains why so many biocompatible coatings have failed to demonstrate any efficacy in the fight against restenosis.
THE CELL MODEL
WHY TITAN WORKS AGAINST RESTENOSIS ?
2 -Titanium-Nitride-Oxide is ACTIVE minimising inflammatory response acting as a BARRIER Against Cr, Co and Ni ions RELEASE
« …Local tissue response to metal implants is closely related to the amount and toxicity of the corrosion product. Minimal fibrosis is typically observed around Titanium alloys, whereas fibrous layers as much as 2 mm thick are encountered with Co-Cr and especially, steel implants… »
Journal of Cardiology 1997 – page 386« …Stainless steel implants can cause inflammatory hypersensitivity reactions and allergic reactions to metal, which lead to a fibroproliferative response around the implant. A fibroproliferative and inflammatory response is also characteristically seen in restenotic tissue within coronary stents… »
The Lancet 2000 – page 1897
THE CELL MODEL
WHY TITAN WORKS AGAINST RESTENOSIS ?
Titanium Nitride Oxide Vs 316L in porcine model
47% reduction of neointimal hyperplasia
REMINDER !Sirolimus (Cypher) in porcine model
50 % reduction of neointimal hyperplasia
THE ANIMAL MODELWHY TITAN WORKS AGAINST RESTENOSIS ?
55%55%
Titanium Nitride Oxide Binary RestenosisCirculation
15
33
TITANIUMNITRIDEOXIDE
BMS
THE HUMAN
WHY TITAN WORKS AGAINST RESTENOSIS ?
55%55%15
33
TITANIUMNITRIDEOXIDE
BMS
THE HUMAN
WHY TITAN WORKS AGAINST RESTENOSIS ?
CONCLUSION
Today the only stents that have proven to be active on restenosis reduction are :
Cypher
Taxus
Titan2
WHY TITAN WORKS AGAINST RESTENOSIS ?
