west pomeranian university of technology - research … · 2013-03-04 · biodegradation of...
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ZBTM• Polymer Institute • Prof. M. El Fray, PhD, DSc, Eng.,• //www.zbtm.zut.edu.pl
DIVISION OF BIOMATERIALS AND MICROBIOLOGICAL TECHNOLOGIES
RESEARCH ACTIVITIES OF THE DIVISION OF BIOMATERIALS AND
MICROBIOLOGICAL TECHNOLOGIES
Date: 1.03.2013
Head of Division
Prof. Miroslawa El Fray
Elastomeric biomaterials BIOMATERIALS FOR HEART
Project manager:
Prof. Mirosława El Fray
NEW ELASTOMERIC BIOMATERIALS FOR HEART ASSISTING DEVICES
Project financialy supported by the NCBiR
Adjuncts: Agnieszka Piegat, PhD, Eng. Marta Piątek-Hnat, PhD, Eng.
BIOMATERIALS FOR HEART
The aim of the project is to develop innovative biomaterials for heart assisting devices. The technological platform based on PET biomaterials modified with hydrophobic fatty acids and vitamin E will be established. Chemical and biological properties will be evaluated along with mechanial and processing performance.
Elastomeric biomaterials
Material-tissue interactions
Post-Doc: Piotr Sobolewski, PhD, Eng.
Project financed from 7 FP Maria Curie IAPP
UNDERSTANDING INTERACTIONS OF HUMAN TISSUE WITH MEDICAL DEVICES
BIOMATERIAL-TISSUE INTERACTIONS
Work Package Leader:
Prof. Mirosława El Fray
The scientific and technological vision of UNITISS is to meet the needs of today’s healthcare industry and social expectation in reducing patient discomfort and infection. UNITISS aims to develop effective in vitro tests that reliably simulate the in vivo conditions, and to develop device design strategies using improved materials and coatings that minimize the discomfort, irritation, inflammation, infection and tissue damage occurring to patients. This will be possible through developing a greater understanding of the response of human tissue to physical interactions and to new non-invasive methods of tissue monitoring .
Material-tissue interactions BIOMATERIAL-TISSUE INTERACTIONS
Injectable Biomaterials BIOMATERIALS FOR REGENERATIVE MEDICINE
Project manager:
Prof. Mirosława El Fray
NEW INJECTABLE BIOMATERIALS
PhD student:
Jędrzej Skrobot, MSc, Eng.
The project is financially supported by Ministry of Science and Higher Education grant N N507 434734
Injectable Biomaterials BIOMATERIALS FOR REGENERATIVE MEDICINE
The work aims at producing photoreactive macromers with potential applications as injectable biomaterials for soft tissue reconstruction 1. Evaluation of chemical structure and molar masses of macromers containing i.e. urethane and anhydride groups (NMR, FTIR, ESI-MS, GPC) 2. Selecting photoinitiators and photocrosslinking parameters 3. Evaluation of chemical structure of photopolymerized systems (ATR-IR) 4. Evaluation of physico-chemical, thermal and mechanical properties 5. In vitro and in vivo biocompatibility studies
Polymeric Self-assemblies
PhD student: Joanna Gajowy, MSc, Eng.
POLYMERIC SELF-ASSEMBLIES
http://www.york.ac.uk/chemistry/staff/academic/o-s/dsmith/
BIOMATERIALS FOR REGENERATIVE MEDICINE
Project manager:
Prof. Mirosława El Fray
This project is financially suported from NCN 2011/03/B/ST8/06353
The goal of the work is to obtain and characterize polymeric self-
assemblies (PAET) derived from natural compounds, mainly amino
acids (tyrosine) and dicarboxylic acids (including fatty acids).
The PAET amphiphilic copolymers will be designed and used for the formulation of micelles/nanospheres of high efficiency of encapsulation and drug release.
Polymeric self-assemblies based on di- and trifunctional derivatives of fatty acids, amino acids and amines/urea as well as modified by polyethers (PEG) and dendrimers will be characterized.
BIOMATERIALS FOR REGENERATIVE MEDICINE
Polymeric Self-assemblies
Polymeric supports for graphene sensor
This project is financially suported from GRAF-TECH/NCBR/08/06/2013
MULTIFUNCTIONAL BIOSENSOR FOR MEDICAL DIAGNOSTICS
BIOMATERIALS FOR MEDICAL DIAGNOSTICS
Project manager:
Prof. Mirosława El Fray
Project leader:
Prof. Ewa Mijowska
The aim of the project is to develop multifunctional biosensor based on graphene technology, by applying different bio-assays, including bio-FET, Electrochemical Impedance Spectroscopy (EIS) – bioelectrical impedance (BI). A multifunctional graphene biosensor will be developed for effective electrochemical detection of specific DNA microbial targets in biological samples and blood glucose monitoring. Developed technology will allow fabrication of low cost sensing components for point-of-care diagnosis.
Polymeric supports for graphene sensor BIOMATERIALS FOR MEDICAL DIAGNOSTICS
Antimicrobial Coatings
PhD Student: Agata Niemczyk, MSc, Eng.
The project is financially supported by Ministry of Science and Higher Education grant N N507 319440
ANTIMICROBIAL COATINGS ON THERMOPLASTIC ELASTOMERS
BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE
Project manager:
Prof. Mirosława El Fray
Antimicrobial Coatings
The aim of the work is to develop a new group of elastomeric biomaterials with improved antimicrobial properties for the implants, mainly cardiac and urological.
1. Synthesis of polyester thermoplastic elastomers
2. Characterization of physical and chemical properties:
NMR, ATR-FTIR analysis
DSC and DMTA
Mechanical properties , hardness Shore D
3. Synthesis of chitosan- linoleic acid systems in form of nano-particles dispersions
4. Modification of polymers with chitosan- linoleic acid dispersions
5. Investigation of antimicrobial activity of new group of modified polyesters
BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE
Enzymatic synthesis of polymers
PhD student: Bogusława Gradzik, MSc, Eng.
ENZYMATIC SYNTHESIS OF POLY(BUTYLENE SUCCINATE) COPOLYMERS
Project manager:
Prof. Mirosława El Fray
BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE
• Celem pracy jest wykorzystanie enzymów jako naturalnych bio-
katalizatorów dla syntezy bioresorbowalnych i biozgodnych
kopolimerów na podstawie poli(bursztynianu butylenu) (PBS).
• Zostaną zaprojektowane i wykonane syntezy kopolimerów z
wykorzystaniem biodegradowalnych segmentów, tj. oligoterów lub
oligowęglanów.
• Dodatkowo, do takich układów zostaną wprowadzone
nanonapełniacze w postaci naturalnych glinokrzemianów lub
ceramiki w celu uzyskania materiałów bioaktywnych o
potencjalnym wykorzystaniu w technikach medycznych.
BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE
Enzymatic synthesis of polymers
Radiation Modification of Nanocomposites BIOMATERIALS FOR RECONSTRUCTION MEDICINE
PhD student: Michał Rybko, MSc, Eng.
INFLUENCE OF THE RADIATION MODIFICATION ON SELECTE PROPERTIES OF POLYMER
NANOCOMPOSITES
The project is financially supported by Ministry of Science and Higher Education grant N N507 471838
Project manager:
Prof. Mirosława El Fray
The aim of the work is to prepare polymer nanocomposites based on multiblock copolyesters by polycondensation in situ and their radiation modification in order to: 1. improve mechanical properties, especially creep resistances 2. modify the surface by the radiation grafting to achieve hydphilic
properties The work includes: 1. Synthesis of nanocomposites with the use of nanoparticles of
different aspect ratio 2. Evaluation of physicochemical and mechanical properties, before
and after the radiation 3. Modification of the surface by the radiation grafting
BIOMATERIALS FOR RECONSTRUCTION MEDICINE
Radiation Modification of Nanocomposites
Polymeric Nanocomposites
PhD student: Zygmunt Staniszewski, MSc, Eng.
POLESTER NANOCOMPOSITES WITH GRAPHENE AND CARBON NANOTUBES
BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE
Project manager:
Prof. Mirosława El Fray
The aim of the work is to prepere multiblock copolyesters by in-situ polycondensation as biostabile materials for implantology and/or medical equipment.
The main subjects of the work are:
1. Synthesis of nanocomposites with carbon nanoparticles (graphene/graphene oxide) and carbon nanotubes (CNT)
2. Examination of nanostructure of prepered materials
3. Evaluation of physicochemical and mechanical properties
4. Evaluation of in vitro biostability
BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE
Polymer Nanocomposites
Polymer Blends
PhD:
Wojciech Ignaczak. MSc, Eng.
Project financed from 7PR EeB. NMP.2012-5. NMP
MODERN POLYMERIC BLENDS CONTAINING POLYESTERS
POLYMER BLENDS
Work Package Leader:
Prof. Mirosława El Fray
The aim of the project is to develop new polymeric blends based on polyesters and polyolefins which wll be compatibilized by multiblock copolymers. New materials will be used for fabrication of composite materials containing basalt fibres.
POLYMER BLENDS
Polymer Blends
Biodegradable Copolyesters POLYMERS FOR ENCAPSULATION TECHNOLOGY
Project manager :
Agnieszka Kozłowska, PhD, Eng.
SYNTHESIS AND PROPERTIES OF NEW POLYESTER COPOLYMERS FOR ENCAPSULATION TECHNOLOGY
The project is financially supported by Ministry of Science and Higher Education grant N N209216538
Biodegradable aliphatic copolyesters based on dimmerized fatty acid:
– polycondensation of copolymers in the melt ,
– characterization of physical, chemical, mechanical, thermal properties
– hydrolytic and biological degradation,
– application of polymers in microencapsulation technology
Biodegradable Copolyesters POLYMERS FOR ENCAPSULATION TECHNOLOGY
Polymer Elastomeric Networks
ELASTOMERS FROM RENEWABLE RAW MATERIALS
Project manager :
Marta Piątek-Hnat, PhD, Eng.
NEW ESTER ELASTOMERS FROM RENEWABLE RESOURCES
The aim of the work is to develop a three-step process and investigate the elastomeric ester networks of poly (glycerol sebacate) (PGS) and poly (sorbitol sebacate) (PSS) for the potential use in medical application as scaffolds, and drug delivery systems for biologically active materials.
ELASTOMERS FROM RENEWABLE RAW MATERIALS
Polymer Elastomeric Networks
1. Synthesis of elastomers based on glycerol/sorbitol and sebacic acid
2. Chemical structure of elastomers
3. Study of physicochemical , thermal and mechanical properties (dynamic creep and relaxation)
4. Hydrolytic and enzymatic degradation
5. Study of physicochemical and structural polymers after hydrolytic and enzymatic degradation
ELASTOMERS FROM RENEWABLE RAW MATERIALS
Polymer Elastomeric Networks
Multifunctional Initiators RADICAL POLYMERIZATION RESEARCH
Project manager :
Ewa Wiśniewska, PhD, Eng.
Research works are carried out in cooperation with Silesian University of Technology in Gliwice, Faculty of
Chemistry, Department of Chemical Organic Technology and Petrochemistry
CH3
C N
CH3
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CH3
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CH2
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O C CH3
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CH3
4
MULTIFUNCTIONAL INITIATORS
IN RADICAL POLYMERIZATION
Multifunctional Initiators RADICAL POLYMERIZATION RESEARCH
Objectives of the work: Azo-perester initiators of radical polymerization with symmetrical
chemical structure and with asymmetrical chemical structure
H3C
CH3
CH3
C O
O
CO CH24
C N N C
CNCN
CH3 CH3
C
O
OOC CH3
CH3
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CH3
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- Studies of initiator’s thermal decomposition by volumetric and UV-Vis spectroscopic methods;
- Kinetic studies of vinyl monomers polymerization by dilatometry; - Studies of chemical structure of initiators, monomers and polymers; - Determination of the average molecular mass of polymers.
Studies on TiO2 Activity Against Fungal Growth MICROBIOLOGICAL STUDIES
Project manager:
Agata Markowska-Szczupak, PhD, Eng.
(Institute of Chemical and Environment Engineering)
Performer:
Krzysztof Ulfig, PhD, DSc
Assoc. Professor
DETERMINATION OF THE INFLUENCE OF LIGHT-INDUCED TITANIUM DIOXIDE AND WATER ACTIVITY
ON THE GROWTH OF FUNGI OCCURRING IN THE INDOOR ENVIRONMENT
The research project no. N N209 106439
MICROBIOLOGICAL STUDIES
The goal of the study is to receive data enabling determination of
titanium dioxide antifungal activity in environments with
different water activity, especially in indoor environments (flats,
public buildings, offices, schools, kinder gardens, etc.).
As a result of project realization, it is planned to determine the
optimal TiO2 concentrations in emulsion paints in order to receive
high quality products, with simultaneous decrease of chemical
biocide quantities.
Studies on TiO2 Activity Against Fungal Growth
Biodegradation of Polyesters by Fungi MICROBIOLOGICAL STUDIES
Project manager:
Krzysztof Ulfig, PhD, DSc,
Assoc.Professor
in cooperation with:
A. Kozłowska, PhD, Eng.
BIODEGRADATION OF CONDENSATION POLYESTERS BY MICROSCOPIC FUNGI
Biodegradation of Polyesters by Fungi MICROBIOLOGICAL STUDIES
The goal of the study is to evaluate the susceptibility of
condensation copolyesters to biodegradation involving
microscopic fungi. The copolyesters under examination are
composed of succinic or sebacic acid, dimerized fatty acid and
fumaric acid.
The copolyesters are examined for physico-chemical and thermal
properties. Microscopic observations are also performed
regarding the penetration and biodegradation of polyesters by
microscopic fungi.
Fungal Diversity Studies MICROBIOLOGICAL STUDIES
Project manager:
Krzysztof Ulfig, PhD, DSc,
Assoc. Professor
Cooperation with:
A. Markowska-Szczupak, PhD, Eng.
STUDIES OF FUNGAL DIVERSITY IN ENVIRONMENTS CONTAMINATED WITH XENOBIOTICS AND ORGANIC
WASTES
Fungal Diversity Studies MICROBIOLOGICAL STUDIES
Based on archival data, the project aims to determine
fungal diversity changes in environments during
bioremediation and in environments contaminated with
organic wastes (municipal waste, sewage and sewage
sludge). The fungi are tested as ecotoxicological
indicators.