wax it overview full

Our FocusWe are a preclinical histopathology CRO offering general histology services (paraffin and frozen), immunohistochemistry services (general IHC, antibody testing/validation, cross-reactivity studies), GLP histopathology for preclinical toxicology studies, and resin sectioning for implantable medical devices and bone.

customized solutions for your research

202 - 2386 East Mall | Vancouver, BC Canada V6T 1Z3 | [email protected] | 604.822.1595 | www.waxitinc.com

We operate like an extension of your lab. - Flexible, customized research solutions. - Reach research milestones faster and more efficiently.- Consultative approach to adapt to differing project needs. - Save on infrastructure: access experts when you need them.



Key Markets- Drug Development (Biotech/Pharmaceutical) - Medical Device - Commercial Antibody- Antibody Therapeutics- Academic Institutes- Environmental & Government Organizations



General Histology (Discovery, Preclinical, GLP) - Paraffin and frozen services - grossing, processing, embedding, sectioning , and slide staining (H&E and special stains). - GLP histopathology for preclinical toxicology studies. - Full Pathology reporting (GLP and non GLP). - Digital microscopy imaging, digital whole slide scanning, staining quantification, Pathological scoring/analysis, report generation. - Plant histology for environmental applications.



Resin Histology: Medical Device & Bone- Soft and hard tissues, implanted medical devices, and bone. - Custom protocols.- Imaging and data analysis.- Work with a variety of resins to best match the material/device:

- Methyl Methacrylate (MMA)- Glycol Methacrylate (GMA)- Spurr's Epoxy



Sample Devices- Stents - Artificial muscle- Heart valves- Silk and artificial fibres- Bio-absorptive materials- Sutures- Polymers



Antibody Applications- Standard immunohistochemistry for research applications. - Test/validate commercially available antibodies for use in immunohistochemistry.- Test and validate new antibodies.- Development work for antibody therapeutics.



Immunohistochemistry Expertise- Background literature research and sourcing of optimal antibodies - Antibody optimization - Cross-reactivity studies- Protocol development - Routine IHC staining (manual and automated)- Slide analysis: digital microscopy imaging, digital whole slide scanning, staining quantification, Pathological scoring/analysis, and report generation.



Imaging & Analysis- Digital microscopy imaging.- Digital whole slide scanning: high-resolution imaging permits real-time zoom for regions of interest.- Staining quantification: semi-automated IHC quantification permits data acquisition of area scored, total positive pixels, average positive pixels, total staining intensity, and average staining intensity, all of which are separated amongst weakly and strongly stained.



Imaging & Analysis- Pathological scoring/analysis: our Pathologists work with you to determine an appropriate scoring criteria. - Report generation: quantified data can be collated into a presentation-ready report or PowerPoint presentation, while images can be professionally edited for publication-ready submission.



Our Pathologists- U.S. board certified Pathologists with 35 + years experience in Veterinary Pathology and Toxicologic Pathology.- Experienced in Pathology reporting for NDA filing. - Pathological scoring/analysis: our Pathologists work with you to determine an appropriate scoring criteria. - Report generation: quantified data can be collated into a presentation-ready report or PowerPoint presentation, while images can be professionally edited for publication-ready submission.



In-House Tissue Bank- Collection of tissues from multiple species including mouse, rat, pig, rabbit, and monkey.- Identify proteins of interest in multiple tissues on a single slide for a

truly macroscopic view of protein distribution, and a complete antibody cross-reactivity profile.



In-House Tissue Bank: Applications- Control Tissues - Antibody Testing & Validation - Antibody Optimization - Protocol Development - Testing for newly developed antibodies - Generating IHC images for antibodies



Plant & Environment- Histological analysis for environmental monitoring based on animal/plant species health. - Customized protocols for plant sectioning.- Custom paraffin and frozen sections to preserve plant tissue morphology and integrity at the highest level.- Custom tailored special staining methods for plant tissue, including Safranin Green, PAS, Toluidine Blue, and more.



Get in TouchWebsite: www.waxitinc.com | Phone: 604.822.1595 Tanya [email protected] | Aruna [email protected]



http://www.waxitinc.com/

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wax it overview full

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