viral inhibition of the anaphase- promoting complex/cyclosome as a mechanism of tumor-specific cell...
TRANSCRIPT
Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a
Mechanism of Tumor-specific Cell Death
Jose G. Teodoro, Ph.DMcGill Cancer Center
Department of BiochemistryMcGill UniversityMontréal, Canada
Viruses as tools in the study of cell transformation and apoptosis
Viruses as tools in the study of cell transformation and apoptosis
Apoptin localizes in a transformation-dependent manner
Apoptin localization is regulated by a factor in transformed cells
Proteomic analysis of Apoptin-associated proteins
Subunit structure of the APC/C
Thornton et al.Genes & Dev (2006)
Apoptin induces destabilization of the APC/C
FPLC analysis
Apoptin colocalizes with APC/C within PML bodies
Apoptin colocalizes with APC/C within PML bodies
Tran et al. J Virol. 2007 Oct 17
Overview and future directions
How does G2/M arrest proceed to apoptosis?Do current chemotherapies rely on APC/C inhibition for efficacy?Can the APC/C be an anti-cancer drug target?
Acknowledgements
McGill University
Isabelle GamacheMohamed MustafaRussell TowersSarah AssadianYiqing LuMichael Hell
U Mass
Michael GreenDestin HeilmanAlbert ParkerJulie Zhou
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Reagents
Frank GrahamCrister Hoog