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Statistical analysis of repeated outcomes of different types

Musoro, Z.J.

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Citation for published version (APA):Musoro, Z. J. (2016). Statistical analysis of repeated outcomes of different types.

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Acknowledgements

First of all, I am grateful to God almighty for the gift of good health and strength

bestowed upon me to complete this work. I wish to express my sincere gratitude to

my promoter Prof. dr. Aeilko H Zwinderman (Koos) and co-promoter Dr. Ronald B

Geskus for their aspiring guidance, constructive criticisms and valuable suggestions

in doing this project. I am especially immensely grateful for the patience and friendly

advice during the project. I also wish to say a big thank you to my co-authors,

especially Dr. Gerben ter Riet, Dr Milo Puhan, Dr Lara Siebeling, Prof. dr. Ameen

Abu-Hanna and Dr Michel Hof [MH] for sharing their illuminating views on issues

related to the projects we collaborated on. And to the members of the doctorate

committee, thank you for accepting to evaluate this thesis.

I would like to express gratitude to all members (past and present) of the KEBB

for their help and support. Annet and Gré, you were both very kind and were always

there to help, especially with the administrative tasks. Thank you so much. Dear

Anja, Rosa, Fleur, Erik, Iris, Teodora, Raha, Parvin, Annefloor, Eleonor, Jérémie,

Sapphire, Wouter and Marit thanks for the nice memories in and out of the KEBB.

To my office mates of J1B-207.1, thank you Shayan and Umesh for the wonderful

conversations we had over the years and for the various interesting "Friday projects".

Dicle and Simona it was a pleasure meeting you and I hope you both enjoy your stay

in J1B-207.1. Dear Nan, thank you for the friendly conversations and for allowing

me to join you during some of your statistical consultancy meetings. It was a great

experience. I would also like to thank MH and Victor Lih for being my paranymphs.

I wish to express my appreciation to my landlady, Dea, for providing me a quiet

and comfortable home throughout my PhD. Thank you for the wonderful care you

showed not only to me but also to Chella and Zerah. Felix Aweh, thanks for the good

times at Dea’s, recounting all those BHS stories, all the laughs and the good food.

A big thank you to members of the Love World Ministry choir (Amsterdam) for the

159



160 Chapter 8. General conclusion

glorious times we shared in songs and in fellowship. I am thankful for the opportunity

and platform you gave to me to grow in "Kingdom music". I also wish to appreciate

Pastor Femi Adenuga and his lovely wife for their prayers and wonderful words of

encouragements over the years. Thank you all.

To the Kanjandas: Collins, Kathy, Nancy, Coleen, and the Tans: Cesar, Nolen,

and Naya, you were part of the reason why Chella and I had a successful "long distance

relationship" for about four years. Thanks for taking good care of Chella while I was

away. Friends as caring and trustworthy as you are a rare breed. Da Sylva, thanks

bro for the words of encouragement and for always being there for us. I would like to

appreciate all my friends and loved ones in the Netherlands, Belgium, the Philippines

and Cameroon for their moral support.

May I also thank my colleagues of the statistics and quality of life departments

at the EORTC HQ. I consider myself fortunate for having a chance to work with

extraordinary colleagues like you. Because of your wonderful personalities, it was

easy to integrate into the team. Looking forward to very productive collaborations.

Special thanks to Dr Andrew Bottomly and Corneel Coens for giving me some time

off work to prepare and defend my thesis.

To my parents Tamaji Musoro J. and Musoro Mary N., and my lovely sisters,

I am aware that the only thing most of you would know about my thesis is that

it involves "statistics" and "patient data". But this did not hinder your continuous

support and unceasing encouragement. I am sincerely grateful for all of that. Darlene,

you answered present each time we needed you. Merci petite sœur.

Tatay, thank you for always asking about the progress of my thesis and for your

constant encouragements. Nanay, thank you for traveling from the Philippines to

Hasselt to help us look after your granddaughter, Zerah, while I rounded up my

thesis. I am so sincerely grateful for your continuous love and support.

Finally to my lovely wife Chella and my pretty daughter Zerah, thank you for

your love, support and attention. Welcome Cale! You are an additional blessing to

our family. Chella, you have always believed in me and have stood by me all along.

It was not easy staying away from each other for such a long time. But now we can

proudly say "WE MADE IT!" Thank you mahal, I love you!



Curriculum Vitae and scientific

publications

Jammbe Z. Musoro was born in 1983 at Ndu, North West region- Cameroon. After

graduating from Baptist High school Buea, Cameroon (2001), Jammbe obtained a

Bachelor of medical laboratory science at the University of Buea, Cameroon (2001-

2005). In 2005-2008 he practiced as a laboratory scientist/research assistant at the

Atlantic Medical Foundation Hospital Mutengene, Cameroon. He later studied at the

University of Hasselt, Belgium (2008-2010) where he obtained a Masters in Statistics:

Epidemiology and public health Methodology with distinction. From December 2010,

Jammbe started working on his PhD thesis under the supervision of Prof. dr. Aeilko H

Zwinderman and Dr. Ronald B Geskus at the Department of Clinical Epidemiology,

Biostatistics and Bioinformatics (KEBB) of the Academic Medical Center (AMC),

University of Amsterdam. Currently (2015), Jammbe is a statistician at the quality

of life and statistics departments of the European Organisation for Research and

Treatment of Cancer (EORTC) head quarters, Brussels-Belgium. He is working on

the Minimum Importance Difference (MID) project, which aims at providing a more

evidence-based approach to interpreting a meaningful change in the health-related

quality of life (HRQOL) scores of the EORTC QLQ-C30 questionnaires.

Andraud M., Lejeune, O., Musoro, J., Ogunjimi, B., Beutels, P., Niel Hens N.

(2012) Living on three time scales: The dynamics of plasma cell and antibody

populations illustrated for hepatitis A virus. PLoS Computational Biology. 8(3)

Musoro, J., Geskus, R., Zwinderman, A. (2014) A joint model for repeated events

of different types and multiple longitudinal outcomes with application to a

follow-up study of patients after kidney transplant. Biometrical Journal. DOI:

161




101002/bmj201300167.

Siebeling, L., Musoro, J., Geskus, R., Zoller, M., Muggensturm, P., Frei, A., Puhan,

M., ter Riet, G. (2014) Prediction of COPD-specific health-related quality of life

in primary care COPD patients. Primary care respiratory journal. 24, Article

number: 14060 doi:10.1038/npjpcrm.2014.60.

Musoro, J., Zwinderman, A., Puhan, M., ter Riet, G., Geskus, R.(2014) Validation

of prediction models based on lasso regression with multiply imputed data. BMC

Medical Research Methodology.14:116 DOI:10.1186/1471-2288-14-116

Musoro, J., Struijk, G.,Geskus, R., ten Berge, J., Zwinderman, A. (2015) Dynamic

prediction of recurrent events by landmarking, with application to a follow-up

study of patients after kidney transplant. Statistical Methods in Medical Research

DOI:10.1177/0962280216643563

Musoro, J., Zwinderman, A., Bosman, R., Abu-Hanna, A., Geskus, R. (2015) Dy-

namic prediction of mortality amongst patients in intensive care using the se-

quential organ failure assessment (SOFA) score: A joint competing risk survival

and longitudinal modelling approach. Statistica Neerlandica (under review)

M.H. Hof, J.Z. Musoro, R.B. Geskus, G.H. Struijk, I.J.M. ten Berge, and A.H.

Zwinderman (2015) Simulated maximum likelihood estimation in joint models

for multiple longitudinal markers and recurrent events of multiple types, in the

presence of a terminal event. Journal of Applied Statistics (under review)



PhD Portfolio

PhD training

Courses year

World of science: Graduate school, University of Amsterdam 2010.

Survival data analysis: University of Hasselt 2010.

Advance course in Biostatistics: Graduate school, University of Amsterdam 2010.

Functional data analysis: ISCB Ottawa, Canada 2010

Analysis of interval-censored survival data: ISCB Bergen, Norway 2012.

Advance R programming: Statistics.com 2013.

Prediction models: ISCB Munich, Germany 2013.

INLA course : National Institute for Public Health and the Environment (RIVM) in Bilthoven, 2013.

the Netherlands

Prediction models: ISCB Munich, Germany 2013.

Unix course: Graduate school, University of Amsterdam 2014.

Extension of frailty models for recurrent or clustered survival data with prediction 2014.

(ISCB Vienna, Austria)

Weekly departmental seminars 2010-2015.

163




Presentations

Conference year

ISCB Utrecht, the Netherlands: Dynamic prediction of recurrent event data by landmarking 2015

with application to a follow-up study of patients after kidney transplant (Oral-Best paper award).

IBS Nijmegen, the Netherlands: Dynamic prediction of mortality amongst patients in 2015

intensive care using the sequential organ failure assessment (SOFA) score (Oral ).

ISCB Vienna, Austria: Validation of prediction models based on lasso regression with 2014

multiply imputed data (Oral).

ISCB Munich, Germany: Validation of prediction models based on penalized regression 2013

with multiply imputed data (Poster).

IBS St Andrews, Scotland: A Bayesian joint model for repeated events of different types 2013

and multiple biomarkers (Oral).

ISCB Bergen, Norway: A simulation study to investigate the performance of random effect 2012

variance estimates in repeated outcome data (Poster).

ISCB Bergen, Norway: Dynamic predictions of repeated events of different types by 2012

landmarking (Oral)

ISCB Ottawa, Canada Methods for analyzing data with multiple-repeated events and 2011

multiple biomarkers (Oral).

Membership

The international society for clinical biostatistics Since 2010

Netherlands society for statistics and operations research Since 2010

Awards

ISCB student conference award 2015

Others

ISCB conference assistant 2015

Organizer of Medical statistic PhD day (Netherlands) 2013



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Statistical analysis of repeatedoutcomes of different types

Statist

icalanaly

sisofrepeated

outcomesofdifferenttypes

JammbeMuso

ro

Jammbe Musoro

Uitnodiging

Voor het bijwonen van deopenbare verdediging van het

proefschrift getiteld

Statistical

analysis of

repeated outcomes

of different typesdoor Jammbe Musoro

op dinsdag 15 november 2016, te10:00 uur in de Agnietenkapel

van de Universiteit vanAmsterdam Oudezijds

Voorburgwal 231 Amsterdam

U bent van harte welkom op dereceptie ter plaatse na afloop van

de promotie

ParanimfenMichel HofVictor Lih

Jammbe MusoroBadderijstraat 10/5

3500 [email protected]

uva-dare (digital academic repository) statistical ... · experience. i would also like to thank mh...

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