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Determinants of acute and chronic renal allograft injury

Kers, J.

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Citation for published version (APA):Kers, J. (2016). Determinants of acute and chronic renal allograft injury.

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Download date: 24 Jun 2020

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373

Contributions, financial support and financial disclosure

Contributions, financial support and financial disclosureChapter 1Wrote the manuscript: Jesper Kers. Financial support: European Renal Association

- European Dialysis and Transplant Asociation fellowship ALTF 69-2010, European

Union 6th Framework Programme RISET consortium, Nierstichting grant KSBS

09.0024, Nierstichting grant KSBO 12.22, EU ERASMUS grant 7834, The Royal

Netherlands Academy of Arts and Sciences (KNAW) van Walree travel grant.

Financial disclosure: none.

Chapter 2Wrote the manuscript: Jesper Kers, Jaklien C. Leemans, Andreas Linkermann.

Financial support: European Renal Association - European Dialysis and Transplant

Asociation fellowship ALTF 69-2010 (JK), The Netherlands Organization for Scientific

Research grant 91712386 (JCL), German Research Foundation grant EXC306 (AL).

Financial disclosure: none.

Chapter 3Designed experiments: Nicolas Preyat, Oberdan Leo. Performed in vitro experiments: Nicolas Preyat. Performed in vivo experiments: Maxime Rossi,

Jesper Kers. Analyzed experiments: Nicolas Preyat, Jesper Kers, Oberdan Leo.

Contributed materials/methods: Liqiang Chen, John Bertin, Peter J. Gough, Frederic

van Gool, Anthony Rongvaux, Alain le Moine. Wrote the manuscript: Nicolas Preyat,

Oberdan Leo. Supervised research: Oberdan Leo. Financial support: Belgian Poles

of Attraction initiated Science Policy Programming, Belgium (NP, OL), Fonds pour

la formation à la Recherche dan l’Industrie et l’Agriculture (NP, OL), Fédération

Wallonie-Bruxelles (NP, OL), Fonds David et Alice van Buuren (NP, OL), Fonds

Brachet (NP, OL), European Renal Association - European Dialysis and Transplant

Asociation fellowship ALTF 69-2010 (JK). Financial disclosure: filed a patent on

isonicotinamide (NP, OL), employees of GlaxoSmithKline (JB, PJG).

Chapter 4Designed experiments: Mark C. Dessing, Jaklien C. Leemans, Jesper Kers.

Performed experiments: Alessandra Tammaro, Jesper Kers, Diba Emal,

374

Addendum

Tessa Vermeer, Gwendoline Teske, Loes Butter, Nike Claessen, Jeffrey Damman. Analyzed experiments: Alessandra Tammaro, Jesper Kers, Mark C. Dessing.

Contributed materials/methods: Ingrid Stroo, Jeffrey Damman, Marc Derive, Henri

G.D. Leuvenink, Harry van Goor, Bouke G. Hepkema, Harold Snieder, Jacob van

den Born, Martin H. d Borst, Stephan J.L. Bakker, Gerjan J. Navis, Rutger J. Ploeg,

Marc Seelen. Wrote the manuscript: Alessandra Tammaro, Jesper Kers, Mark C.

Dessing. Supervised research: Mark C. Dessing, Jaklien C. Leemans, Sandrine

Florquin. Financial support: ZonMw grant 40-42600-98-096 (MCD, JCL, SF),

Nierstichting grant C06.6023 (JCL, LB), European Union 6th Framework Programme

grant 037697 (GJN, MS). Financial disclosure: none.

Chapter 5Designed experiments: Jesper Kers, Hessel Peters-Sengers, Fréderike J.

Bemelman. Performed experiments: Jesper Kers, Hessel Peters-Sengers.

Analyzed experiments: Jesper Kers, Hessel Peters-Sengers. Contributed materials/methods: Martin B.A. Heemskerk, Stefan P. Berger, Michiel G.H. Betjes, Arjan, D.

van Zuilen, Luuk B. Hilbrands, Johan W. de Fijter, Azam S. Nurmohamad, Maarten

H. Christaans, Fréderike J. Bemelman. Wrote the manuscript: Jesper Kers, Hessel

Peters-Sengers. Supervised research: Fréderike J. Bemelman. Financial support: none. Financial disclosure: none.

Chapter 6Designed experiments: Lionel Lattenist, Joris J.T.H. Roelofs. Performed experiments:

Lionel Lattenist. Analyzed experiments: Lionel Lattenist, Jesper Kers, Joris J.T.H.

Roelofs. Contributed materials/methods: Jesper Kers, Nike Claessen, Ineke J.M.

ten Berge, Fréderike J, Bemelman. Wrote the manuscript: Lionel Lattenst, Jesper

Kers, Joris J.T.H. Roelofs. Supervised research: Joris J.T.H. Roelofs, Sandrine

Florquin. Financial support: Nierstichting grant C09.2287 (JJTHR), European Union

6th Framework Programme RISET consortium (JK, SF), European Renal Association

- European Dialysis and Transplant Asociation fellowship ALTF 69-2010 (JK).

Financial disclosure: none.

375

Contributions, financial support and financial disclosure

Chapter 7Designed experiments: Sandrine Florquin, Joris J.T.H. Roelofs. Performed experiments: Ünsal Yapici. Analyzed experiments: Ünsal Yapici, Jesper Kers.

Contributed materials/methods: Fréderike J. Bemelman, Jaap W. Groothoff,

Karlijn A.M.I. van Donselaar - van der Pant, Chris M. van der Loos, Mirza M. Idu,

Nike Claessen. Wrote the manuscript: Ünsal Yapici, Jesper Kers, Sandrine Florquin.

Supervised research: Sandrine Florquin. Financial support: Nierstichting grant

C09.2287 (JJTHR), European Union 6th Framework Programme RISET consortium,

(JK, SF) Academic Medical Center, Amsterdam (SF). Financial disclosure: none.

Chapter 8Designed experiments: Sandrine Florquin, Jesper Kers. Performed experiments:

Alexis Sentís, Jesper Kers, Ünsal Yapici. Analyzed experiments: Alexis Sentís,

Jesper Kers. Contributed materials/methods: Nike Claessen, Sandrine Florquin,

Ineke J.M. ten Berge, Joris J.T.H. Roelofs. Wrote the manuscript: Alexis Sentís,

Jesper Kers, Sandrine Florquin. Supervised research: Sandrine Florquin. Financial support: European Renal Association - European Dialysis and Transplant Asociation

fellowship ALTF 69-2010 (JK), European Renal Association - European Dialysis

and Transplant Asociation fellowship STF 98.00-2012 (AS), Nierstichting ALLOVIR

consortium CP.0904 (IJMtB, SF), Academic Medical Center, Amsterdam (IJMtB,

SF). Financial disclosure: none.

Chapter 9Designed experiments: Mark C. Dessing, Jesper Kers, Jaklien C. Leemans.

Performed experiments: Mark C. Dessing, Jesper Kers, Jeffrey Damman. Analyzed experiments: Mark C. Dessing, Jesper Kers. Contributed materials/methods:

Henri G.D. Leuvenink, Harry van Goor, Jan-Luuk Hillebrands, Bouke G. Hepkema,

Harold Snieder, Jacob van den Born, Martin H. de Borst, Stephan J. Bakker, Gerjan

J. Navis, Rutger J. Ploeg. Wrote the manuscript: Mark C. Dessing, Jesper Kers.

Supervised research: Mark C. Dessing, Jaklien C. Leemans, Jesper Kers, Sandrine

Florquin. Financial support: Nierstichting grant C06.6023 (JCL), European Union 6th

Framework Programme grant 037697 (GJN, MS). Financial disclosure: none.

376

Addendum

Chapter 10Designed experiments: Sandrine Florquin, Ineke J.M. ten Berge, Luuk B. Hilbrands.

Performed experiments: Ünsal Yapici, Jesper Kers, Ivana Slavujevic-Letic,

Geurt Stokman, Nike Claessen. Analyzed experiments: Jesper Kers. Contributed materials/methods: Joris J.T.H. Roelofs, Michiel C. van Aalderen, Jaap W. Groothoff,

Onno J. de Boer, Karlijn A.M.I. van der Pant, Fréderike J. Bemelman. Wrote the manuscript: Ünsal Yapici, Jesper Kers, Sandrine Florquin. Supervised research:

Sandrine Florquin, Ineke J.M. ten Berge, Luuk B. Hilbrands. Financial support: Nierstichting ALLOVIR consortium CP.0904 (IJMtB, SF, LBH), Academic Medical

Center, Amsterdam (IJMtB, SF), European Renal Association - European Dialysis and

Transplant Asociation fellowship ALTF 69-2010 (JK). Financial disclosure: none.

Chapter 11Designed experiments: Sandrine Florquin, Ineke J.M. ten Berge, Luuk B. Hilbrands.

Performed experiments: Geurt Stokman, Sandrine Florquin, Ünsal Yapici, Joris J.

Hoelbeek, Nike Claessen. Analyzed experiments: Jesper Kers, Geurt Stokman.

Contributed materials/methods: Onno J. de Boer, Mihai G. Netea, Fréderike

J. Bemelman. Wrote the manuscript: Geurt Stokman, Jesper Kers, Sandrine

Florquin. Supervised research: Sandrine Florquin, Ineke J.M. ten Berge, Luuk B.

Hilbrands. Financial support: Nierstichting ALLOVIR consortium CP.0904 (IJMtB,

SF, LBH), European Research Counsil Consolidator grant 310372 (MGN). Financial disclosure: none.

Chapter 12Wrote the manuscript: Jesper Kers, Sandrine Florquin. Supervised research: Sandrine

Florquin. Financial support: European Renal Association - European Dialysis and

Transplant Asociation fellowship ALTF 69-2010 (JK). Financial disclosure: none.

Chapter 13Designed experiments: Sandrine Florquin. Performed experiments: Jesper Kers,

Yi-Chin Xu-Dubois, Sandrine Florquin, Joris J.T.H. Roelofs. Analyzed experiments:

Jesper Kers. Contributed materials/methods: Fréderike J. Bemelman, Ineke

J.M. ten Berge, Mirza M. Idu, Eric Rondeau. Wrote the manuscript: Jesper Kers,

377

Contributions, financial support and financial disclosure

Sandrine Florquin. Supervised research: Sandrine Florquin, Eric Rondeau, Yi-Chun

Xu-Dubois. Financial support: European Union 6th Framework Programme RISET

consortium (JK), Nierstichting grant KSBS 09.0024 (JK), European Union ERASMUS

grant 7834 (JK). Financial disclosure: none.

Chapter 14Designed experiments: Mark C. Dessing, Jesper Kers, Jaklien C. Leemans.

Performed experiments: Mark C. Dessing, Jesper Kers, Jeffrey Damman. Analyzed experiments: Mark C. Dessing, Jesper Kers. Contributed materials/methods: Henri

G.D. Leuvenink, Harry van Goor, Jan-Luuk Hillebrands, Bouke G. Hepkema, Harold

Snieder, Jacob van den Born, Martin H. de Borst, Stephan J.L. Bakker, Gerjan

J. Navis, Rutger J. Ploeg. Wrote the manuscript: Mark C. Dessing, Jesper Kers.

Supervised research: Mark C. Dessing, Jaklien C. Leemans, Jesper Kers, Sandrine

Florquin. Financial support: Nierstichting grant C06.6023 (JCL), European Union 6th

Framework Programme grant 037697 (GJN, MS). Financial disclosure: none.

Chapter 15Designed experiments: Jaap J. Homan van der Heide, Fréderike J. Bemelman,

Johan W. de Fijter, Sandrine Florquin. Performed experiments: Jesper Kers,

Fréderike J. Bemelman, Charlotte Meyer, Karlijn A.M.I. van der Pant, Eltjo F. de

Maar, Aiko P.J. de Vries, Jan-Stephan Sanders, Stefan Berger, Marlies E.J. Reinders,

Ingeborg M. Bajema. Analyzed experiments: Jesper Kers, Fréderike J. Bemelman,

Aiko H. Zwinderman, Dave L. Roelen, Sandrine Florquin, Ingeborg M. Bajema.

Contributed materials/methods: Mirza M. Idu, Christina Krikke, Marcory C, van

Dijk, Jan Ringers, Junior Lardy. Wrote the manuscript: Jesper Kers, Fréderike J.

Bemelman. Supervised research: Jaap J. Homan van der Heide, Sandrine Florquin,

Fréderike J. Bemelman, Johan W. de Fijter. Financial support: Novartis Pharma.

Financial disclosure: Novartis Pharma provided an unrestricted grant: the authors

performed data collection, statistical analysis and writing of the manuscript (no role

for the grant supplier).

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Scientific portfolio

Scientific portfolio

380

Addendum

381

Publication list

Publication list2010Kers J, Xu-Dubois Y-C, Rondeau E, Claessen N, Idu MM, Roelofs JJTH, Bemelman

FJ, ten Berge RJM, Florquin S. Intragraft tubular vimentin and CD44 expression

correlate with long-term renal allograft function and interstitial fibrosis and tubular

atrophy. Transplantation. 2010.

2011Yapici Ü, Kers J, Bemelman FJ, Roelofs JJTH, Groothoff JW, van der Loos CM, van

Donselaar-van der Pant KAMI, Idu MM, Claessen N, ten Berge RJM, Florquin S.

Interleukin-17 positive cells accumulate in renal allografts during acute rejection

and are independent predictors of worse outcome. Transpl Int. 2011.

2013Yuan Q, Hong S, Shi B, Kers J, Li Z, Pei X, Xu L, Wei X, Cai M. CD4+CD25-Nrp1+

T cells synergize with Rapamycin to prevent murine cardiac allorejection in

immunocompetent recipients. PLOS ONE. 2013.

Baas MC, Kers J, Florquin S, de Fijter JW, Homan van der Heide JJ, van den Bergh

Weerman MA, ten Berge RJM, Bemelman FJ. Cyclosporine versus everolimus:

effects on the glomerulus. Clin Transplant. 2013.

Lattenist LCW, Kers J, Claessen N, ten Berge RJM, Bemelman FJ, Florquin S,

Roelofs JJTH. Renal and urinary levels of endothelial protein C receptor correlate

with acute renal allograft rejection. PLOS ONE. 2013.

Kers J, Florquin S. Eosinophil-targeted therapy: not the panacea for antibody-

mediated rejection? Am J Transplant. 2013.

Kers J, Choudhry ZA, Roeleveld TA, Houdijk AP. Hypertension secondary to a

periprostatic paraganglioma: case report and review of the literature. BMC Endocr Disord. 2013.

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2014Li X, Vink A, Niessen HWM, Kers J, de boer OJ, Ploegmakers HJP, Tijssen JGP, de

Winter RJ, van der Wal AC. Total burden of intraplaque hemorrhage throughout the

coronary arteries relates to the use of coumarin-type anticoagulants but not platelet

aggregation inhibitors. Virchows Arch. 2014.

Sherer F, van Simaeys G, Kers J, Yuan Q, Doumont G, Laute M-A, Peleman C,

Egrise D, Lahoutte T, Flamand V, Goldman S. Dynamic molecular imaging for

hepatic function assessment in mice: evaluation in endotoxin-induced and warm

ischemia-reperfusion models of acute liver failure. J Liver. 2014.

2015Kers J, Florquin S. Generation of alloreactive-anergized Tr1 cells from patients

on dialysis for the induction of renal transplant tolerance: are we there yet?

Transplantation. 2015.

Preyat N, Rossi M, Kers J, Liqiang C, Bertin J, Gough PJ, le Moine A, Rongvaux

A, van Gool F, Leo O. Intracellular nicotinamide adenine dinucleotide promotes

TNF-induced necroptosis in a sirtuin-dependent manner. Cell Death Differ. 2015.

Dessing MC, Kers J, Damman J, Leuvenink HGD, van Goor H, Hillebrands J-L,

Hepkema BG, Snieder H, van den Born J, de Borst MH, Bakker SJL, Navis GJ, Ploeg

RJ, Florquin S, Seelen M, Leemans JC. Toll-like Receptor family polymorphisms are

associated with primary renal diseases but not with renal outcomes following kidney

transplantation. PLOS ONE. 2015.

Sentís A, Kers J, Yapici Ü, Claessen N, Roelofs JJTH, Bemelman FJ, ten Berge

RJM, Florquin S. The prognostic significance of glomerular infiltrating leukocytes

during acute renal allograft rejection. Transpl Immunol. 2015.

Yapici Ü, Kers J, Slavujevic-Letic I, Stokman G, Roelofs JJTH, van Aalderen MC,

Groothoff JW, de Boer OJ, van der Pant KAMI, Claessen N, Hilbrands LB, Bemelman

FJ, ten Berge RJM, Florquin S. Intragraft Blood Dendritic Cell Antigen-1-positive

myeloid dendritic cells increase during BK polyomavirus-associated nephropathy.

J Am Soc Nephrol. 2015.

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Publication list

2016Hoelbeek JJ, Duivenvoorden R, de Boer OJ, Claessen N, van den Bergh Weerman

M, Roelofs JJTH, Kers J, ten Berge RJM, Florquin S. Unique renal manifestation of

type I cryoglobulinemia, with massive crystalloid deposits in glomerular histiocytes,

podocytes, and endothelial cells. Am J Clin Pathol. 2016.

Stokman G, Kers J, Yapici Ü, Hoelbeek JJ, Claessen N, de Boer OJ, Netea MG, Hilbrands

LB, Bemelman FJ, ten Berge RJM, Florquin S. Predominant tubular interleukin-18

expression in polyomavirus-associated nephropathy. Transplantation. 2016.