using proteomics tools (dige) to study osteoarthritis...
TRANSCRIPT
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USING PROTEOMICS TOOLS
(DIGE)
TO STUDY OSTEOARTHRITIS
PHYSIOPATOLOGY
Benjamín Fernández-Gutiérrez
Servicio de Reumatología
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DNA GENOMICS
RNA TRANSCRIPTOMICS
PROTEIN PROTEOMICS
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LARGE-SCALE ANALYSIS
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DIGE (Differential In-Gel Electrophoresis)
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DIGE (Differential In-Gel Electrophoresis)
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Aigner et al 2006
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Aigner et al 2006
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E U R O P E A N M U S C U L O S K E L E T A L R E V I E W2009
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KEY POINTS
PROTEOMICS, PARTICULARLY DIGE, IS A USEFUL TOOL TO STUDY RHEUMATIC DISEASES AS OSTEOARTHRITIS
SPECIFIC OR ‘HYPOTHESIS GENERATING’ PROTEOMICS APPROACHESCAN BE USED TO ADDRESS SCIENTIFIC QUESTIONS
COMBINATION OF DIFFERENT TECHNIQUES (PROTEOMICS, GENOMICS, MOLECULAR, BIOLOGICAL AND OTHERS) WILL BE PROBABLY THE GOLD STANDARD TO ACHIEVE VALUABLE RESULTS
DIFFERENT POINT OF VIEWS AND DIFFERENT SPECIALISTS ARE CLEARLY NECESSARIES TO CLARIFY THE PHYSIOPATOLOGY OF COMPLEX DISEASESAS OSTEOARTHRITIS REALLY IS
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CENTRO NACIONAL INVESTIGACIONES CARDIOVASCULARES.
Unidad de Proteómica
HOSPITAL CLÍNICO SAN CARLOS.
Servicio de Reumatología
Servicio de Traumatología
Emilio Camafeita
Enrique Calvo
Juan Antonio López
José Ramón Lamas
Maria Pilar Tornero-Esteban
Luis Rodriguez
Esther Villafuertes
Jose Antonio Hoyas
Fernando Marco