uc davis 19 chemical biology retreat...session ii keynote talk a chemical biology toolbox for rna...
TRANSCRIPT
2019
5TH ANNUALUC DAVISCHEMICAL BIOLOGYRETREAT
SEPTEMBER 5 -6 , 2019 • GRANLIBAKKEN TAHOE725 Granlibakken Road, Tahoe City, CA 96145
TABLE OF CONTENTS
FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )
FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF
HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?
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TABLE OFCONTENTS
AGENDA
SESSION DETAILS
NOTED SPEAKERS
POSTER PRESENTERS
MENUS
PAGE 1
PAGE 2
PAGE 3
PAGE 4
PAGE 5
PAGE 6
RETREAT AGENDA
Thursday, September 5 Friday, September 6
BREAKFAST 7:30 A.M. - 9 A.M.GRANHALL
SESSION I 1:10 P.M. - 2:30 P.MMOUNTAIN ROOM
BREAKOUTSESSION I
2:45 P.M. - 3:45 P.MMOUNTAIN ROOM
COFFEE & TEABREAK
2:30 P.M. - 2:45 P.MMOUNTAIN ROOM
SESSION IIKEYNOTE TALK
4:45 P.M. - 5:45 P.MMOUNTAIN ROOM
POSTER SESSION& SOCIAL
7:30 P.M. - 9:00 P.MPAVILION(Heaters will be provided)
HAPPY HOUR 5:45 P.M. - 7:00 P.MGRANHALL
DINNER 6:00 P.M. - 7:15 P.MGRANHALL
LUNCH 12 P.M. - 1 P.M.GRANHALL
WELCOME &INTRODUCTIONS
1:00 P.M. - 1:10 P.MMOUNTAIN ROOM
CAREER PANELW/ Q&A
8:20 A.M. - 9:00 A.M.MOUNTAIN ROOM (Food permitted)
BREAKOUTSESSION II
9:00 A.M. - 10:00 A.M.MOUNTAIN ROOM
COFFEE & TEABREAK/CHECKOUT OF ROOMS
10:00 A.M. - 10:40 A.M.MOUNTAIN ROOM
SESSION III 10:40 A.M. - 12:00 P.M.MOUNTAIN ROOM
CLOSINGREMARKS &PHOTOS
12:00 P.M. - 12:15 P.M.MOUNTAIN ROOM
LUNCH PICK UPAND DEPART!(HIKING/HOME)
12:15 P.M. - 12:30 P.M.SOLARIUM
BREAK/CHECK-IN 3:45 P.M. - 4:45 P.MGRANHALL
FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )
FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF
HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?
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SESSION DETAILS
Thursday, September 5 Friday, September 6
SESSION I1:10 P.M. - 2:30 P.M. MOUNTAIN ROOM
1:10 P.M. - 1:30 P.M. Dr. Patrick Shih1:30 P.M. - 1:50 P.M. Morgan Matson
1:50 P.M. - 2:10 P.M. Ami Rose2:10 P.M. – 2:30 P.M. SeHee Park
CAREER PANEL W/ Q&A8:20 A.M. - 9:00 A.M. MOUNTAIN ROOM
(Food permitted)
Dr. Jennifer HeemstraDr. Maique Weber BivattiDr. Michael J. Stevenson
4:45 P.M. - 5:45 P.M. MOUNTAIN ROOMSESSION II KEYNOTE TALK
A Chemical Biology Toolbox for RNA Post-Transcriptional Modification and Capture
Dr. Jennifer Heemstra
BREAKOUT SESSION I2:45 P.M. - 3:45 P.M. MOUNTAIN ROOM
Elevator Pitches & Audiencesfacilitated by Dr. Sheila David
BREAKOUT SESSION II9:00 A.M. - 10:00 A.M. MOUNTAIN ROOM
Ethics in Chemical Biology Researchfacilitated by Dr. Andrew Fisher
SESSION III10:40 A.M. - 12:00 P.M. MOUNTAIN ROOM
10:40 A.M. – 11:00 A.M. Diedra Shorty11:00 A.M. - 11:20 A.M. Cindy Khuu
11:20 A.M. – 11:40 A.M. Nate Harder11:40 A.M. – 12:00 P.M. Cindy McReynolds
POSTER SESSION & SOCIAL
7:30 P.M. - 9:00 P.M. PAVILION(Heaters will be provided)
Please see page 5 for poster information
FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )
FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF
HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?
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FEATURED SPEAKERSKEYNOTE - Dr. Jennifer HeemstraJen received her B.S. in Chemistry from the University of California, Irvine, in 2000. At Irvine, sheperformed undergraduate research with Prof. James Nowick investigating the folding ofsynthetic beta-sheet mimics, which instilled in her a love of supramolecular chemistry. Jen thenmoved to the University of Illinois, Urbana-Champaign, where she completed her Ph.D. with Prof.Jeffrey Moore in 2005 studying the reactivity of pyridine-functionalized phenylene ethynylenecavitands. After a brief stint in industry as a medicinal chemist, she moved to HarvardUniversity to pursue postdoctoral research with Prof. David Liu exploring mechanisms fortemplated nucleic acid synthesis. In 2010, Jen began her independent career in the Departmentof Chemistry at the University of Utah, and was promoted to Associate Professor with tenure in2016. In 2017, Jen and her research group moved to the Department of Chemistry at EmoryUniversity. Research in the Heemstra lab is focused on harnessing the molecular recognition andself-assembly properties of nucleic acids for applications in biosensing and bioimaging. Outsideof work, Jen enjoys spending time with her husband and two sons, as well as rock climbing,cycling, and running.
Career Panel Q& A - Dr. Maique Weber BiavattiGraduated in Pharmacy from the Federal University of Paraná (1993), Master in Chemistry fromthe Federal University of Paraná (1994) and PhD in Chemistry from the Federal University ofSão Carlos (2001). She is currently a professor at the Federal University of Santa Catarina(UFSC). Editor-in-Chief of the Brazilian Journal of Pharmacognosy (2017 - 2019), Vice-Presidentof the Brazilian Society of Pharmacognosy (2014-2016). Has experience in Pharmacognosy,focusing on Study of Extracts and Substances of species of the Asteraceae family, acting on thefollowing subjects: isolation, characterization and quantification of natural substances. She worksin the postgraduate program in Pharmacy, guiding master and doctorate students in projectsfocused on the research of natural, semi-synthetic and synthetic products with potentialbiological activity. Participates in the Research Network Natural Products against NeglectedDiseases (ResNet NPND), that is a global network of researchers uniting their forces againstND.
Career Panel Q& A - Dr. Michael J. StevensonMichael Stevenson obtained a BS in Biochemistry from the University of Washington in 2009and a PhD in Chemistry from Dartmouth College in 2016 studying the thermodynamics of metalsbinding to proteins. He was a postdoctoral scholar at Ohio State University where he workedwith Professor Hannah Shafaat on designing a light driven artificial hydrogenase mimic. He iscurrently a postdoctoral scholar working with Professor Marie Heffern focusing on the role ofmetal ions in regulating and modulating peptide hormones. After this position, he hopes tobecome a professor at a primarily undergraduate institution where he can build on hisunderstanding of metals in biology.
FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )
FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF
HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?
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POSTERS
MATTHEW ORELLANA,BIO-ORGANIC CHEMISTRYDevelopment of an In Vitro High-ContentImaging Screen for Antidepressants
ERIN DOHERTY, CHEMISTRYIncreasing A to I Editing Efficiency of ADAR2Using Cytidine Analolgs
LEANNA MONTALEONEBIO-ORGANIC CHEMISTRYImproving Editing and Binding to Disease Targetswith Adenosine Deaminase Acting on RNA (ADAR)
PEISHAN HUANG , BIOPHYSICSEvaluating the Relationship Between T50 and TMas well as the Performance of Thermal StabilityPrediction Tools for an Enzyme Mutant Library
HANNAH BRINKMAN, CHEMISTRYDesign and Implementation of a High ThroughputScreen for ADAR gRNAs for Rett Syndrome
ANDREA M. COLEMAN, CHEMISTRYRole of Alpha-Actinin in Surface Localizationof the L-type Ca2+ Channel Cav1.2
RJ TOMBARI, CHEMICAL BIOLOGYEx Vivo Analysis of Tryptophan MetabolismUsing 19F NMR
ANGELA ZHANG, BIO-ORGANIC CHEMISTRYMicrobial Production of Human Milk Oligosaccharides
DR. MICHAEL J. STEVENSON BIO-INORGANIC CHEMISTRY
Analysis of Metal Effects on C-Peptide Structure andInternalization
Co-authors: Ian C. Farran, Kylie S. Uyeda, Jessica A. SanJuan, Marie C. Heffern
ELIZABETH R. LOTSOFCHEMICAL BIOLOGYExcision of oxidatively damaged bases in G-quadruplexes by the DNA glycosylases NEIL1 andNEIL3
SAM HARTANTO, STRUCTURAL BIOLOGYCharacterization of the sulfur assimilation complexCysDNC in Mycobacterium tuberculosis
AGYA KARKI, CHEMISTRYBiochemical Analysis of AdenosineDeaminase Acting on RNA1 XANDER WILCOX , BIOPHYSICAL CHEMISTRY
Expanding the Genome Editing Toolbox: Towards theDevelopment of Targetable Genome Editing withAdenosine Deaminase Acting on RNA (ADARs)
SARAH DISHMAN, CHEMISTRYAsymmetric Synthesis of XanthoneNatural Products by C-H Insertion ofDonor/Donor Rhodium Carbenes
ALEXANDER THUY-BOUNSTRUCTURAL BIOLOGY/BIOCHEMISTRY Structural and Functional investigation of anAdenosine deaminase acting on RNA 2 proteinhomodimer
FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )
FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF
HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?
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RIGOBERTO ARENASSTRUCTURAL BIOLOGYStructural Biology of Anthracyclines Metabolism
ELYS RODRIGUEZ, CHEMISTRYSelectivity and structural understanding ofglycosyltransferases to enable proteindesign efforts towards cardiac glycosides
ALBERT LIU, BMCDBStructurally-Guided RuBisCO EngineeringInspired by Novel Metagenomic Protein
CALVIN LY, CHEMICAL BIOLOGYDevelopment of an In Vitro High-ContentImaging Screen for Antidepressants
XIAOHONG YANG, CHEMISTRY 'A Bacterial Exo-α-N-AcetylglucosaminidaseShows Potential for Heparin/Heparan SulfateStructural Analysis
MENUSThursday, September 5
Friday, September 6
BREAKFAST 7:30 A.M. - 9 A.M. GRANHALL
Build Your Own Chopped Saladand Smoothies Lunch Buffet:
Mango Yogurt Naked Juice SmoothieStrawberry Banana Naked Juice Smoothie
Salad BarNuts: Almonds, Pecans, Pistachios
Telara Rolls, Gluten Free RollsFresh Roasted Cubed Turkey (Dg,Gf)
Sustainable Harvested WhiteAlbacore Tuna Salad:
Contains Mayo, Celery, Relish, Hot Sauce, Red BellPepper, Black Pepper, OnionsGrilled/Blackened CertifiedSustainable Cod (Df, Gf)
Vegan/Gluten Free: Healthy Loaded Sweet PotatoSkins: With Onions, Garlic, Bell Peppers,
Tomatoes, Black Beans, Vegan Yogurt, Vegan Mozzarella
DINNER6:00 P.M. - 7:15 P.M GRANHALL
LUNCH12 P.M. - 1 P.M. GRANHALL
LUNCH PICK UP AND DEPART!(HIKING/HOME)
12:15 P.M. - 12:30 P.M. SOLARIUM
Dinner BuffetStrawberry Salad
Chopped Kale Salad withEdamame, Carrot and Avocado
BBQ Shrimp/Bell Pepper/Onion/MushroomKabobs with a Lime Marinade
BBQ Chicken (GF, DF)Vegan/Gluten Free BBQ Beyond Italian Spicy
Sausages BrochettesOven Roasted Sweet Potatoes
Grilled Corn On the Cob (GF, DF)Fresh Fruits, Lemon Cake
(Contains gluten and dairy) (HT)
Labeled bag lunches with sign up sheet theevening prior to confirm any dietary needs again
with the lodgePiece of fruit
Italian sandwichBag of chipsGranola bar
Chocolate chip cookieWater & napkin
Traditional Breakfast Buffet includes
various proteins (eggs, sausage, etc.)Baked goods
Hot and cold cerealFruit
Cofee, tea juice & more
FOR RETREAT SPECIF IC QUEST IONS PLEASE CONTACT ALEX LOPEZ IN PERSON OR BY PHONE (530 - 754 - 1 249 )
FOR LODGING INQUIR IES PLEASE CONTACT GRANLIBAKKEN STAFF
HAVE A QUESTION OR NEED SUPPORT DURING THE REREAT?
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