uahs november 2016 townhall v15 re-150 l-js-anno · 2020-01-02 · analytics v cb2 ‘s ’big...

ENHANCING EXCELLENCE


2

Joe G.N. “Skip” Garcia, MDSenior Vice President for Health SciencesDr. Merlin DuVal Professor of Medicine

State of the University of Arizona Health Sciences (UAHS) Three Year Update

November 14, 2016


State of the UAHS September 2014

““Implementing the plan"

State of the UAHS September 2015

"Progress toward Goals"

UAHS Goals and 3 Year Accomplishments (2013-2016)

State of the UAHSDecember 2013

“Setting the stage"

An unprecedented level of successALL THANKS TO YOU!!2016


UAHS Goals and 3 Year Accomplishments (2013-2016)Enhancing Excellence to Make a Difference

v UAHS is comprised of two highly functioning academic health centers (AHCs) on 2 distinct campuses (Phoenix & Tucson)

v Like other AHCs, we share a moral obligation to improve the health of the communities we serve

20 UAHS Centers and Institutes including our NCI-designated UA Cancer Center

AZ has Serious Healthcare Challenges!


AZ Uninsured ChildrenDistribution of AZ’s uninsured children is highest on Native

American reservations

AZ Elderly in PovertyAZ’s elderly below the federal poverty

line as % of the elderly population. Highest on Native American reservations

Addressing AZ’s Healthcare ChallengesGeography, Diversity, Poverty, Aging Population

AZ DiversityAZ’s has exceptional diversity with many counties having either Latino

or Native American majorities


v UA Health Sciences is improving AZ health through dissemination of innovative findings:

v Health outcomes researchv Population health researchv Translational researchv Clinical trials

v UA Health Sciences is improving AZ health through education & training of the next generation of health providers & experts:v Over 35% of AZ physicians v 20% of AZ pharmacists and PharmDsv 10% of AZ RNs and Nurse Practitionersv Over 1000 public health scientists in AZ

Addressing AZ’s Healthcare Challenges


Addressing AZ’s Healthcare Challenges UAHS is Committed to Training a Well-Distributed Health Workforce

v 20-25% of AZ’s population is ruralv 85-90% of AZ MDs, DOs, Dentists, Pharmacists,

PAs, and Nurse Practitioners reside in urban areasv Health workforce shortages exist in 13 of Arizona’s

15 Counties (Health Professions Shortage Areas)v UAHS programs are increasing the # of urban and

rural health professionals caring for the underserved via: v Az Area Health Education Centers (AzAHEC) v Az Center for Rural Healthv Each UAHS College has a Rural Health

Professions Training Program (funded by SVPHS/AzAHEC)

HPSA

American Indian Tribal Land

2016 Health Professional

Shortage Areas


Addressing AZ’s Healthcare ChallengesThe Arizona Telemedicine Program (ATP)

v ATP is a lifeline linking 70 AZ communities providing patients with face-to-face video consultations with primary care and medical specialists

v ATP delivers tele-echocardiography scans from the Neonatal ICU in Yuma Medical Center facilitating life saving air evacuations (>500 screened to date)

v Tele-Radiology in 25 rural communities (>1.3M cases screened to date)

v ATP delivers digital retinal screening for high risk diabetic Latino patients (> 4,000 screened to date)


v Remote monitoring cost-effectively increases “access” to care, monitoring & prediction of disease progression

v These technologies will prove critical for AZ’s rural and urban populations with chronic diseases that require diligent individual participation in their own health management

v The AZ Center for Accelerated Biomedical Innovation and Institute on Place and Wellbeing are developing wearables (“BioStampTM” and “Sweat Patch”) that measure physical/chemical “signatures” of disease

v Wearables and mobile health apps allow home monitoring of heart failure (weight, activity), diabetes(blood glucose), asthma (peak flow) for pre-hospital intervention to reduce hospital admissions, readmissions and healthcare costs.

Addressing AZ’s Healthcare ChallengesWearable Technologies & Mobile Health App Development

“Sweat Patch”Sweat glucose correlates with blood glucose

1 cm


v UA Cancer Center provides thought leadership in clinical trials, offering the latest therapies to the Southwest region

v Addressing cancer burden among AZ’s Native Americans via a $13M NCI award for cancer prevention and training of the Hopi Tribe, Tohono O’odham and Navajo Nations (renewed 2014)

v Recently awarded a Breast Cancer Research Foundation grant designed to increase breast cancer screening in Latina Women

v UACC aggressively has increased skin cancer screening via: i) recruitment of 2 Melanoma physicians, ii) submission of a Skin Cancer PPG, iii) and annual commitment to raise funds via the Melanoma Walk

v Decrease tobacco intake in AZ via Arizona Tobacco Quit Linev Studying cancer mechanisms induced by arsenic in the soil

Addressing AZ’s Healthcare ChallengesUA NCI-Designated Cancer Center


Population Health & Outcomes

Health Disparities

Precision Health Neuroscience

Addressing AZ’s Healthcare ChallengesNew UAHS Centers of Biomedical Excellence to Improve Arizona Health

Population Science and Discovery

Innovation in Brain Science

Disparities in Diabetes, Obesity &Metabolism

Border Health Disparities

Bioinformatics and Biostatistics

Asthma and Airway Disease Research

Applied Genetic & Genomic Medicine


v Comprehensive population health data and data analytics to address disparities and inequities in diseaseprevalence and outcomes.

v The Center accelerates research in:v Demographic-related (age, sex, gender, race,

ethnicity) variables in health and disease processesv Development of population-based registries from

electronic health records (EHR)v Understanding social & environmental determinants

of healthv Centralized repository of public national and state health

data sets for UA faculty, staff, and students: https://cpsddr.uahs.arizona.edu/

Addressing AZ’s Healthcare ChallengesCenter for Population Science and Discovery

Beth Calhoun, PhD, MEdDirector, CPSD

Health Policy

HealthEconomics

CommunityPartnerships

Clinical CareImprovement


Ken Ramos MD, PhDDirector, CAG2M

Addressing AZ’s Healthcare ChallengesCenter for Applied Genetics and Genomic Medicine

v The Center bridges the divide between the genome revolution and precision health by leading translation of research discoveries into personalized precision healthcare

v Training of healthcare professionals in clinical genetics, genomic medicine and genetic counseling

v Promotes research programs that interrogate the influence of race, ethnicity and genetics on disease severity and susceptibility

v Partners with UA Genetics Core in offering state-of-the-art resources & solutions to promote genetic and genomic research

v Engages the broader AZ community to engage as partners in precision health initiatives


Yves A. Lussier, MD Director, CB2

Addressing AZ’s Healthcare ChallengesCenter for Biomedical informatics and Biostatistics (CB2)

Big DataAnalytics

v CB2 ‘s ’Big Data’ expertise makes for big ideas for UAHS data –driven healthcare research designed to improve patient outcomes via: v Data-driven learning health systems that advance precision analytics to promote health equityv Resourcing of the research and clinical enterprise with data science and tools

v CB2 created the BUM-T Clinical Data Warehouse allowing extraction of medical information to advance Precision Health, critical success for our ability to compete for our awarded PMI grant

Genomics,Genetics

BIG DATAINPUTS

Drugs(structure,pathways)

ClinicalTrial

Tele-medicine

Populations,Financial,Economics

Self-Reported

(Social Media)

ClinicalPractice

(EHR, Imaging,Pathology)

PrecisionMedicineInitiatives

OUTPUT:Impactful

R&D,ImprovedHealth

DrugRepurposing

ClinicalTrials

Accrual &MgmtImprove

Health CareQuality While

LoweringCosts

BiomarkersDiscovery

TherapyAnchored onCase-basedReasoning

PredictIndividualized

Therapy


Akinlolu Ojo, MDAVP for Clinical Research and Global Health Initiatives

Addressing AZ’s Healthcare ChallengesNIH Precision Medicine Initiative®

Multiple key UAHS faculty involved in this transformative

award, all new since 2014

Building a research cohort of one million volunteers who will share genetic data, biological

samples, diet and lifestyle information.

UA, Banner Receive Historic $4 million Funding in Precision MedicineThe University of Arizona Health Sciences and Banner Health have been awarded a $4 million grant from the National Institutes of Health to participate in the Precision Medicine Initiative Cohort Program, which aims to enroll 1 million U.S. participants to improve prevention and treatment of disease based on individual differences in lifestyle, environment and genetics.

The award, which totals $43.3 million over five years and is the largest NIH peer-reviewed grant in Arizona history, was announced by the NIH on July 6, 2016.

July2016

B-UMCTB-UMC South

B-UMCPDesertEstrella

BoswellThunderbird

Year 1 Recruitment Sites


Addressing AZ’s Health-care ChallengesThe “All of Us” PMI program will improve the health of AZ communities

Arizona is uniquely positioned to contribute to and benefit from the new knowledge that will result from this landmark initiative:v AZ’s unique populations (Hispanic/Native American) gain early access to precision health

drugs and devices generated by “All of Us” researchv The 150,000+ AZ “All of Us” participants reap understanding of genetic, physiologic, life

style, and behavioral data incorporated into their individualized health carev Reduces the costly and socio-economically debilitating impact of health disparities across

AZ, improving quality of life, and expanding economic opportunities for the State/Regionv All of Us will provide Arizonans access to health care providers trained in precision

approaches to healthv Improves AZ’s position to compete successfully for Biotech/Pharmaceutical partnerships

and start-ups that are focused on precision drug/device development


Fernando Martinez, MDCenter DirectorPI of $27M NIH Clinical Trial grant

Farm dust and endotoxin give protection against asthma

Addressing AZ’s Healthcare ChallengesCenter for Asthma and Airway Disease Research


Addressing AZ’s Healthcare ChallengesCenter for Innovation in Brain Science (CIBS)

UAReceives$10.3MtoHelpUnlocktheMysteryofAlzheimer’sinWomen

October2016

TUCSON,Ariz.– WhydomorewomenthanmengetAlzheimer’sdisease?Intheirquesttofindtheanswer,neuroscientistRobertaDiazBrinton,PhD,andhercolleaguesintheCenterforInnovationinBrainScience attheUniversityofArizonaHealthSciences,havebeenawardeda$10.3millionfive-yearProgramProjectGrant(PPG)fromtheNationalInstituteonAgingattheNationalInstitutesofHealth.

Roberta Diaz Brinton PhDDirector; Professor, Departments of Pharmacology & Neurology

In the 21st Century there is not a single cure for neurodegenerative diseases, CIBS is tackling this grand challenge:v Developing personalized therapeutics aimed at

curing neurologic disease via patient-driven integrated discovery at the bedside and the bench

v Launching clinical trials in Alzheimer’s & Parkinson’s Disease testing regenerative therapies and molecularly designed novel compounds

v Fostering interdisciplinary research & innovation focused on cognitive aging, chronic pain, traumatic brain injury, stroke & aphasia


Lawrence J. Mandarino PhD C-DDOM Director

Thought Leader in diabetes geneticsand diabetes in underserved populations

(Mayo Clinic)

David Marrero PhD C-BORD Director

Thought Leader in diabetes community outreach and primary diabetes prevention

Past President of the American Diabetes Association(Indiana University)

Health Disparities

Population Health & Outcomes

Addressing AZ’s Healthcare ChallengesCenter for Disparities in Diabetes, Obesity & Metabolism (C-DDOM)

Center for Border Health Disparities (C-BORD)


29M Americans have Diabetes

1 out of 4 do not know they have Diabetes

86M Americans have Prediabetes

9 out of 10 do not know they have Prediabetes

v Latinos and American Indians have significantly greater Diabetes risk compared to whites

Why the Double Team on Diabetes in Arizona?Addressing AZ’s Healthcare Challenges


2.8

10.7

5.4

9.6

0

2

4

6

8

10

12

1999 2001 2003 2005 2007 2009 2011 2013

Percentage of Adult Population

AZ

USA

8.2% Annual Growth Rate

in AZ

3.4% AnnualGrowth Rate

in USA

v Annual growth rate for diabetes in AZ (8.2%) is nearly 3 times the national averagev Diabetes is the 7th leading cause of death in AZ (and contributes to the #1 cause - heart disease)v American Indians in AZ are 4 times more likely to die from diabetes than average Arizonan

Why the Double Team on Diabetes in Arizona?Addressing AZ’s Healthcare Challenges


UAHSClinical Research

in AZ Communities

Addressing AZ’s Healthcare Challenges: Partnerships with Federally Qualified Health Centers (FQHCs)

RegionalCenterforBorderHealth

Flagstaff

Phoenix

YumaTucson

NogalesMental Health Cancer

Diabetes


UAHS Goals and 3 Year AccomplishmentsImprove Diversity of UAHS Students, Faculty and Residents

A diverse AZ healthcare workforce is critical to addressing state-wide health disparities

v Minority physicians are more likely to treat minority patients

v Minority physicians are more likely to serve in rural and underserved areas.

v Minority patients prefer health providers of their own race or ethnicity and exhibit improved health outcomes when cared for by minority health providers.

v In the US, the gap between the % of minority physicians and the % US minority population has widened (13% in 1990, 17% in 2012)


1.7% 1.5% 1.3%2.4% 2.9%

0.5% 0.3% 0.5%1.3% 1.8%

9.6%8.8%

10.6%

14.5%

18.9%

0%

5%

10%

15%

20%

2012 2013 2014 2015 2016

Num

ber

of D

octo

rs o

f M

edicine

African AmericanAmerican IndianHispanic

Improve Diversity of UAHS Students, Faculty & ResidentsCollege of Medicine-Tucson

Doctors of Medicine Total 4 years

National URM Average (AA, Latino, NA) = 11.5%

UA COM-T URM = 23.8%

Hispanic National Average (5.0%)


Improve Diversity of UAHS Students, Faculty & ResidentsCollege of Medicine-Tucson



Total Residents in GME Programs

2.5% 2.2% 2.1%3.1% 3.5%

0.4% 0.6% 0.4% 0.3% 0.8%

6.9% 6.3%

8.3%9.4%

10.2%

0%

5%

10%

15%

20%

2012 2013 2014 2015 2016Num

ber

of R

esiden

ts

African American

American Indian

Hispanic

National URM Average -13.5%.2016 is the first year that COM-T

is greater than national average

1.7% 1.5% 1.3%2.4% 2.9%

0.5% 0.3% 0.5%1.3% 1.8%

9.6%8.8%

10.6%

14.5%

18.9%

0%

5%

10%

15%

20%

2012 2013 2014 2015 2016

Num

ber

of D

octo

rs o

f M

edicine




College of Medicine-PhoenixImprove Diversity of UAHS Students, Faculty & Residents


0.4% 0.8% 0.7% 1.0%1.8%

0.1% 0.1% 0.5% 0.5% 0.1%

3.7%4.6% 5.2%

6.3%7.6%

0%

5%

10%

15%

20%

2012 2013 2014 2015 2016

Num

ber

of D

octo

rs o

f M

edicine African American

American IndianHispanic

Total Doctors of PharmacyCollege of Pharmacy

1.5%0.8% 1.3% 1.2%

1.9%

0.0% 0.0% 0.5% 0.5% 0.5%

10.9%

12.8% 12.3%13.7%

15.3%

0%

5%

10%

15%

20%

2012 2013 2014 2015 2016Num

ber

of D

octo

rs o

f Ph

armac

y African AmericanAmerican IndianHispanic



College of NursingImprove Diversity of UAHS Students, Faculty & Residents

Total RNs and Doctors of NursingCollege of Public Health

Total MPHs and PhDs

8.4%

6.6% 6.1%

3.9%

6.2%

1.5% 1.3% 2.0% 2.1% 1.4%

11.3%9.6%

11.6% 11.5%12.6%

0%

5%

10%

15%

20%

2012 2013 2014 2015 2016

Num

ber

of D

octo

rate

s in N

ursing


7.2% 7.6%

3.8%4.5%

3.1%

4.3% 4.5% 3.8% 5.6% 4.2%

13.0%

19.7%

21.8%20.2%

22.9%

0%

5%

10%

15%

20%

25%

2012 2013 2014 2015 2016Num

ber

of M

PHs

and

PhDs


Hispanic National Average (8.1%)Hispanic National Average (8.2%)


Faculty Diversity by CollegePe

rcen

tage

of

Empl

oyee

15%14%13%7%6%5%4%3%2%1%0%

COM-P COM-T CON COP COPH

African American American Indian Hispanic

African American 3.9%American Indian 0.0%Hispanic 5.3%Total URM (US ave) 9.2% (8.61%)

1.7%0.4%6.0%

8.1% (8.61%)

2.9%0.5%5.7%

9.1% (9.8%)

0.0%0.0%3.2%

3.2% (7.6%)

4.9%0.0%14.6%

19.5% (13.5%)

4.5%

3.0%

4.5%

3.0%

4.5%

5.2%

2.9%

5.2%

8.1%

5.2%

Hispanic National AverageAA National Average

Improve Diversity of UAHS Students, Faculty & Residents


PhoenixLas CrucesTucson

El Paso

Flagstaff

Jorge Gomez PhDBLAISER Director

UACC Outreach

Francisco Moreno MD Associate Vice President

for Diversity and Inclusion

UAHS recognizes that poor mentorship & nurturing results in leakage in the URM pipeline:v We have launched a reinvigorated “Hispanic Center of

Excellence” and soon a “Center for Native American Health” v Expanded learning specialists resources to help all Health

Science College students succeedv Expanded and improved the quality of our high school

(Med-Start), undergraduate (Frontera, BLAISER), and medical student (Marlys Witte’s MSRP) programs that target disadvantaged students (from border, rural, low SES, etc.), majority of whom are URMs

v BLAISER: 15 URM students (NAU, ASU, UA, UTEP, NMSU) received research experience and mentoring to increase their interest in translational science research & promote health science program applications.

Improve Diversity of UAHS Students, Faculty & Residents


UAHS Goals and 3 Year AccomplishmentsExpand the Physician Scientist and Translational Scientist Pipeline

8 8

16

10

14

12

32

4

0

5

10

15

20

2013 2014 2015 2016 2017

# UAHS NIH Career Development Submission/Awards(K01, K08, and K23 Awards)

Submitted

AwardedThis remains far too few

K Awards for a top performing

AHC!!!

An internal UAHS-funded Career Development Award program was launched in 2014 to enhance this pipeline


8 UAHS CDA Awardees, July 2014CristineE.Berry,MDMentor:FernandoMartinezMD“TheImpactofEarlyLifeExposuresonLungFunctionTrajectory:ChildhoodOriginsofCOPD”CollegeofMedicine-Tucson

PavaniChalasani,MDMentor:MarkD."Marty''PagelMD“OptimizingAcidoCESTMRIasaNovelMethodforMeasuringTumorpHinBreastCancerPatients”CollegeofMedicine-Tucson

AnkitA.Desai,MDMentor:JoeGNGarciaMD“SuddenDeathandSickleCellDisease– AnElectrophysiologicalandMolecularinvestigation”CollegeofMedicine-Tucson

AmolPatwardhan,MD,PhDMentor:FrankPorrecaPhDIntraoperativeTRPV1antagonistfortreatmentofhypothermiaandpostoperativepainCollegeofMedicine-Tucson

ChristianBime,MDMentor:SairamParthasarathyMD“GeneticandNon-GeneticContributorstoARDSOutcomes”CollegeofMedicine-Tucson

FrancineC.Gachupin,PhDMentor:ScottB.Going,PhD“AmericanIndianYouthWellnessInitiative”CollegeofMedicineTucson

MayKhanna,PhDMentor:ToddVanderah,PhD“DesignerDrugsforChronicPain:IndirectTargetingofNav1.7”CollegeofMedicine-Tucson

KatriTyppo,MDMentor:FayezK.Ghishan,MD“IntestinalBarrierFunctionandPostOperativeEnteralNutritionforChildrenwithCongenitalHeartDisease”CollegeofMedicine-Tucson

R01 funded!2nd R01 submitted

R01 submitted 2016 K01 re-submitted 2016

K01 re-submittedU01 (MPI)/R21 submitted

2016

R01 submittedR21 submitted 2016K23 awarded!

Expand the Physician Scientist and Translational Scientist Pipeline

Anesthesia Society CDA awarded

R01 submitted

ALA Biomedical Research Grant Awarded


ArchitaDesai,MDMentors:ElizabethCalhoun,PhDandThomasBoyer,MD“TheHospitalist-basedHealthcareDeliveryModelinCirrhosis:ClosingtheQualityChasm”CollegeofMedicine-Tucson

OlgaRafikova,MD,PhDMentor:SteveM.Black,PhD/AnkitDesai,MD“HMGB1andgenderdifferenceinpulmonaryarterialhypertension”CollegeofMedicine-Tucson


MichelleKahn-John,PhD,RNMentors:ThaddeusPace,PhD/MarilynMcEwen,PhD/TerryBadger,PhD,RN“DepressioninDiné(Navajo)AdultswhoParticipateintheDinéHóchxóíjí(NavajoEvilWay)Ceremony”CollegeofNursing

MeganSmithey,PhDMentor:JankoNikolich-Zugich,MD,PhD“DefiningImmuneControlofHumanCytomegalovirusovertheLifespan”CollegeofMedicine-Tucson

W-HJennyLo-Ciganic,PhDMentors:KentKwoh,MD/DanielMalone,PhD“UsingMachineLearningtoPredictProblematicOpioidUse”CollegeofPharmacy

JarrodMosier,MDMentors:CharlesCairns,MD“AcuteRespiratoryDistressSyndrome(ARDS)rescuetherapiesandoxidativestress”CollegeofMedicine-Tucson

EyalOren,PhDMentor:LynnGerald,MD,PhD“Assessingtherelationshipbetweenchildhoodstressandasthma”CollegeofPublicHealth

7 UAHS CDA Awardees, July 2015

R01 awarded2016

K23 submitted 2016

R01 submitted 2016

R34 submitted 2016

Am. Pharmacy Assoc. New

Investigator Award

R01 submitted

R03 to be submitted

R15 submitted 2016R34 to be submitted


CharlesDowns,PhDMentors:StephenBlack,JoeGNGarcia“RAGE-inducedchangesintheproteomeofthealveolarepithelium”CollegeofNursing

CraigHeise,MDMentor:RaymondWoosley,MD,PhD“Evaluationofanelectronicmedicalrecordbasedclinicaldecisionsupportsysteminalargehealthcaresystemtoimproveantibioticsafety:Aclusterrandomizedinterventiontrial”CollegeofMedicine-Phoenix

JohnPurdy,PhDMentors:FeliciaGoodrum,PhD“TargetingHostMetabolismduringCytomegalovirusInfection”CollegeofMedicine-Tucson

JasonKarnes,MDMentor:RickKittles,PhDKennethRamos,MD,PhD“WarfarinPharmacogenomicsinLatinoPopulations”CollegeofPharmacy

ElsaReyes-Reyes,PhDMentor:LynnGerald“DefiningL1asamoleculartargetforclinicaltranslationinlungcancerresearch”CollegeofMedicine-Phoenix


R01submitted2016

DavidGarcia,PhDMentors:CynthiaThomson,PhD/KennethRamos,MD,PhD“TheinfluenceofgeneticvariantsandmetaboliteprofilesonresponsestoaweightlossinterventionforHispanicMen”CollegeofPublicHealth

R01submitted(MPI)2016

R21andPewScholarship

submitted,2016

6 UAHS CDA Awardees, July 2016

AHA Scientist Development Grant

Awarded!


2016 MD-PhD Committee

Janis Burt, PhDPhysiology & SurgeryCharles C. Hsu, MD, PhDRadiation Oncology

Rajesh Khanna, PhD,Pharmacology

Lonnie Lybarger, PhDCellular and Molecular Medicine

Christina Laukaitis, MD, PhDMedicine & Medical Genetics

Mohammad Reza Movahed, MD, PhDMedicine

Linda L. Restifo, MD, PhDCellular & Mol Medicine/ Neurology

Jil C. Tardiff, MD, PhDMedicine, Cellular & Molecular Med

Expand the Physician Scientist and Translational Scientist PipelineU COM-Tucson MD-PhD Students

Emmanuel Katsanis, MDPediatrics, Pathology & Immunobiology

Ken Ramos, MD, PhD, PharmBMedicine

83

9684

109115

7 76

11

15

0

4

8

12

16

20

24

0

20

40

60

80

100

120

140

2012 2013 2014 2015 2016

MD/PhD ApplicationsAccepted MD/PhD Students in Program


UAHS Goals and 3 Year Accomplishments (2013-2016)Increase the UAHS Biomedical Research Portfolio

v UA research portfolio (NSF) has been declining since 2007v UAHS research portfolio has not kept pace with peers since 2007v Interactions and synergies between UAHS Colleges and Centers and the rest

of UA Colleges has historically been weak, a major complaint from the other side of Speedway

v Dwindling State support for higher education has limited investment in research (faculty, support staff, facilities)

v Lack of strategic program focus resulted in markedly reduced numbers of large-scale, multidisciplinary grants (e.g., NIH P- and U-series) and funded training programs (e.g., NIH T-series and K-series)

v Major goal articulated in December 2013 was to increase the UAHS research portfolio in a sustainable manner


v Thematically-focused Advisory Councils delivered plans for multidisciplinary strategic research expansion emphasis in: Health Disparities, Population Health and Health Outcomes, Precision Health, and Neuroscience

v New UAHS Centers, residing in both UAHS academic health centers (Phoenix and Tucson), launched to catalyze research

v Thought leadership investment through recruitment of nationally-regarded facultyv A centralized Research Administration Service (RAS) established in full service to faculty

grant, contract, IRB and IACUC submissions and post-award coordinationv UAHS launched multiple internal funding opportunities to kick-start and further sustain

promising research: Career Development Awards, Bridge Funding Awards, Clinical Research Pilot Program Awards, Health Data and Analytics Program Awards, Multidisciplinary Program Feasibility Awards, and Translational Imaging Program Project Stimulus Awards

v Major investment in new facilities, facility improvements, and capital equipment

Increase the UAHS Biomedical Research Portfolio


UAHS submissions over the past 4 years

UAHS Research Administration Services (RAS) Total Proposal Amount across all of UAHS

8721052

276 273

692864

0

200

400

600

800

1000

1200

2013 2014 2015 2016

Prop

osals

Subm

itte

d

UAHS RAS Proposals

$522M

$606M $642M

$944M

$250

$500

$750

$1,000

2013 2014 2015 2016

1137 Total

968 Total ($929Mby RAS)

($506Mby RAS)

Proposal Total$ Amount



5147

68

210 7

15 16**

6 3 5

14

28**

0

10

20

30

40

50

60

70

2013 2014 2015 2016 2017

Num

ber

of P

ropo

sals S

ubmitte

d

UAHS Proposals/Awards greater than $2M, $5M & $10M

Grants Awarded 2013 2014 2015 2016 2017$2M to $5M 7 8 9 9 *2 (**8)$5M to $10M 0 0 0 2 *2 (**8)

Greater than $10M 1 0 2 2 *1 (**4)

Proposal Total Cost 2013 2014 2015 2016 2017$2M to $5M 51 47 68 93 *29 (**116)$5M to $10M 2 10 7 15 *4 (**16)

Greater than $10M 6 3 5 14 *7 (**28)*3 months of FY2017; ** full year projection

78

9 98**

0 0 02

8**

10

2 24**

0

5

10

15

20

2013 2014 2015 2016 2017

Num

ber

of G

rant

s Awa

rded

51 47

68

93116**

40

60

80

100

120

UAHS Proposals UAHS Awards

Increase the UAHS Biomedical Research PortfolioGrant $2M to $5M Grant $5M to $10M Grant Greater than $10M


UAHS Goals and 3 Year Accomplishments (2013-2016)Recruit key UAHS Leadership

College Deans Center Directors

From left: L. Mandarino, Y. Lussier, E. Calhoun, R. Britton, J. Yuan, K. Ramos, A. Kraft. Not shown: A. Ojo, D. Marrero, S. Black, J. Gomez

From left: R. Schnellmann, Pharmacy; K. Ramos, COM-P; C. Cairns, COM-T.


UAHS Department Chairs

UA College of Medicine–Tucson. From left: M. Muramoto, S. Wang, M. Kraft, W. Jacobsen, L. Neumayer. Not shown: T. Vanderah

UA College of Medicine – Phoenix. From left: J. Wolfrey, M. Fallon, J. McLoone, M. Foley, S. Johnson.

UAHS Goals and 3 Year Accomplishments (2013-2016)Recruit key UAHS Leadership

Division Directors

From left: N. Sweitzer; N. Ellis; R. Kittles; J. Yuan; M. Gulati; P. Roy-Chaudhury; B. Lee; E. Connick; J. Bauman. Not shown: G. Hoyme, T. Riall


v Modern learning studios to support interprofessional, team-based education. v Home for Tucson-based components of newly launched UAHS research Centers, UAHS

cutting-edge simulation center, educational facilities

Increase the UAHS Biomedical Research PortfolioHealth Science Innovation Building (HSIB) in Tucson

(Opening July 2018, 9 floors + basement, 227,000 GSF)


v CLIA-certified genetics core facility, informatics, dry and wet lab space, bioinformatics, biomedical engineering, imaging core facilities

v Interdisciplinary, basic and translational research

Increase the UAHS Biomedical Research PortfolioBioScience Research Laboratory Building in Tucson

(Opening July 2018, 4 floors + basement, 150,000 GSF )


v Imaging, informatics, dry and wet lab spacev Focus on interdisciplinary translational and clinical research (vs basic research) v Home for Phoenix-based components of each UAHS Center.

Increase the UAHS Biomedical Research PortfolioBiomedical Sciences Partnership Building in Phoenix

(Opening January 2017, 10 floors 243,000 GSF)


UA’s Dr. Fernando Martinez awarded $27 million by NIH on landmark study on childhood origins of adult airway diseaseTheUniversityofArizona’sDr.FernandoMartinez,willcontinuehisgroundbreakingasthmaresearchafterbeingawardeda$27 millioncooperativeagreementgrantbytheNationalHeart,Lung,andBloodInstitute(NHLBI)attheNationalInstitutesofHealth(NIH)tofurtherinvestigatethechildhoodoriginsofadultairwaydisease.

UA Health Sciences Study of Devastating Lung Disorders in the Critically Ill Receives $11.4 Million BoostFive-yearNationalHeart,LungandBloodInstituteprogramprojectgrantledbyUAVicePresidentforHealthSciencesDr.JoeG.N.“Skip”Garcia.Cutting-edgeresearchinvestigatingthegeneticbasisfordevastatingdisordersinthecriticallyill–acuterespiratorydistresssyndrome(ARDS) and ventilator-inducedlunginjury(VILI) – willreceiveamajorboostthankstoan $11.4million,…

May 2016 July 2016 August 2016

$7 Million NIH Grant to UA College of Medicine – Tucson Aimed at Helping Asthma Sufferers Reduce Severe AttacksAbout25millionpeopleintheU.S.—7millionofthemchildren—sufferfromasthma.Afive-year,$7millionNIHgrant awardedrecentlytoMonicaKraft,MD,aninternationallyrenownedphysician-scientistwhospecializesintranslationalasthmaresearchattheUniversityofArizonaCollegeofMedicine– TucsonandtheUAHealthSciences’AsthmaandAirwayDiseaseResearchCenter…



v July 2013- Failed UACC Director search, alarming exodus of funded faculty,

v UACC’s NCI Cancer Center Support Grant (CCSG) renewal due for submission in September 2014

v July 2013- Anne Cress PhD named Interim UACC Director, instrumental in receiving a year extension before CCSG submission

v September 2014, Andrew Kraft MD began as new UACC Directorv Dr. Kraft quickly revamped the External Advisory Board, hired

key recruits, organized and submitted CCSG renewal in September 2015

v 2016 NCI Review- UACC “Outstanding” with continued Comprehensive status, 37th yr of NCI funding

Recruit a UA Cancer Center Director and Renew UACC’s NCI Award

UA Cancer Center Retains Prestigious NCI Comprehensive Status with $17.6M AwardComprehensivedesignationgivesArizonansaccesstoresearch-driven,highlypersonalized,cancercareandtreatments.TheUACancerCenter,ledbyDr.AndrewKraft,UACCDirector,istheonlyNCI-designatedcomprehensivecancercenterheadquarteredinArizonaandisoneof45inthenation.



v ~50% growth 2013-2017*v $135M in new awards through

the first 8 months of calendar year 2016

v The UAHS 2017* NIH portfolio creates a calculated economic impact of ~1500 jobs, ~$180M in business activity and >$3M in annual AZ tax revenues

NIH Research awards for the five UAHS Health Science Colleges


$71.2M

$65.2M$62.7M

$58.2M

$62.7M$59.5M

$64.6M

$40

$50

$60

$70

$80

$90

2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017

Millions

$66.7M$69.4M

$74.6M

$85.7M

*June 2008 Families USA's Global Health Initiative Report: "In Your Own Backyard: How NIH Funding Helps Your State's Economy"


Metrics FY14 FY15 FY16 FY17 YTDInvention Disclosures 56 70 75 29 (87*)US Patent Filed 58 67 100 56 (168*)US Patent Issued 9 11 12 8 (24*)Total License Agreements 21 20 22 12(36*)Startup Companies 2 5 4 2 (6*)

Asset Development Awards 3 ($135K) awarded) 6 ($271k) awarded) 8 ($366k) awarded) 4-$181k awarded($540k)

UAHS Commercialization Efforts and Opportunities

Rick Silva, PhDExecutive Director,Biomedical Corp Alliances

Marvin J. Slepian, MDDirector, ACABIProf of Med and BioMed Eng


v In Tucson- UAHN (2012-2015) was a severely challenged health system – financially and infra-structurally.

v UAHN operating margin teetered between 0-2% with minimal funds flow (i.e., people/program reinvestment) to College of Medicine and a severely under-capitalized hospital physical plant (circa 1971).

v In FY 2014, UAHN booked $-40M operating loss representing a severe threat to the academic enterprise. In FY 2015, UAHN operating loss was $-2M per month.

v In January 2015, the Banner transaction went into effectv COM-Phoenix now has clinical partners in Banner Health and Dignity St. Joseph

UAHS Goals and 3 Year AccomplishmentsStrengthen linkages and synergies with UAHS health delivery partner


Banner - University Medical Center Tucson

Hospital(opening early 2019, $400

million, 11-story )

v Replaces the 40-year-old portion of B-UMCT (previously UMC)v 689,000-sq-ft patient tower, 336 private patient rooms, 22 operating

rooms, imaging suites etc.

Strengthen Linkage/Synergy with Health Delivery Partner


18

33

57

102

0

20

40

60

80

100

120

2013 2014 2015 2016N

umbe

r of

Kid

ney

Tran

spla

nts

Kidney Transplantationat B-UMCT

v Rebuilding Cancer and Surgical ServicesvRecruitment of top talentvIncreased surgeries along with a focus on OR

efficiencyv Solid Organ Transplant Programs

v Robust Kidney Transplant Programv CMS recertification of Lung Transplant Program

(a month ago)v Investment to rebuild the Heart Failure, VAD

and Heart Transplant Programv Investment

vNew HospitalvNew Ambulatory BuildingvNew Physician Compensation planvNew complete Electronic Medical Record (Cerner)

Strengthen Linkage/Synergy with Health Delivery Partner Clinical Leadership

From left: Robert C. Harland, MD, FACS; Pradeep V. Kadambi, MD, MBA, FASN


v UAHS performance in development (2008-2014) ranked among the lowest of ABOR peers

v Jennifer Flores- hired January 2015, AVP for Development

v Development team underwent remodeling with influx of talented fund raisers.

v Donor contacts increased 106% between FY15 and FY16

UAHS Goals and 3 Year Accomplishments (2013-2016)Increase UA Health Sciences Philanthropic Successes


v FY16: Best fundraising year in 10 years. v FY17 is shaping up to be even better than

$80M target, $32M after 4 months v More than 300% increase in $1M+ gifts

between FY15 and first 4 months of FY17v 63 proposals at the $1M+ level are

planned for FY17v FY17 with largest solicitations ever—1

planned at $100M, 2 at $50M, 2 at $25M (largest prior solicitation: $10M)

v Many UAHS Development-led “Visioning” sessions for colleges and centers to increase likelihood significant philanthropy

Increase UA Health Sciences Philanthropic Successes

…

$51M $59M

$50M

$71M $80M

0

20

40

60

80

100

2013 2014 2015 2016 2017M

illions

*July-September 2017

UA Health Sciences Development

$6.3 $6.0 $5.8

$11.2

$19.6

$0

$10

$20

$30

FY13 FY14 FY15 FY16 FY17*

$1M+ Gifts

Millions


College of Pharmacy 10 year Strategic Visioning Sessions

v $175M visionv $100M derived from philanthropyv $75M in prospects identifiedv $30M in solicitations since July 1, 2016v $4M booked since July, $13.75M in commitments v First step: Renovation of the Skaggs building

$1.6M $2.2M $2.5M$0.72M $0.5M

$14.2M

$0

$5

$10

$15

FY12 FY13 FY14 FY15 FY16 FY17*M

illions

College of Pharmacy Philanthropy

Spring2016VisioningSession

Summer2016NewDeanHired

Fall2016VisionPresentedtoDonors

Fall/Winter2016GiftCommitmentsSecured

Spring 2016Visioning SessionSpring2016

VisioningSessionSummer2016

NewDeanHiredFall2016

VisionPresentedtoDonorsFall/Winter2016

GiftCommitmentsSecured

Summer 2016New Dean HiredSpring2016





Fall 2016Vision Presented to DonorsSpring2016





Fall/Winter 2016Gift Commitments Secured

*July-September 2017

Increase UA Health Sciences Philanthropic Successes


US News Ranking

NIH Funding Ranking

UAHS Goals and 3 Year AccomplishmentsImprove Each College’s National Ranking (NIH, US News)

College 2013 2014 2015 2016 2017 2020 goalCollege of Medicine-T 68 67 67 63 ?? 45College of Nursing 32 32 38 30 ?? 15College of Pharmacy 9 10 10 16 ?? 5College of Public Health 25 23 25 25 ?? 15College of Medicine-P NA NA NA NA NA <100

College 2013 2014 2015 2016* 2017 2020 goalCollege of Medicine-T 60 61 66 57 ?? <50 College of Public Health 32 27 28 28 ?? 20College of Nursing 24 32 37 52 ?? 15College of Pharmacy 26 32 19 31 ?? 10 College of Medicine-P NA NA NA NA NA <100

NIH Rankings from Blue Ridge not available for 2017

* Projected 2016 NIH Rankings from Blue Ridge


v Banner affiliation- stabilized COM Education mission via new funds flow

v UAHS & Dignity St Joseph’s new UA Cancer Center is growingv New UACC Phoenix Deputy Director hired- William Caice MDv Finalists being interviewed for Chair of new Department of

Interdisciplinary Oncologyv Final negotiations for Chair of Dept. of Translational

Neuroscience v New DOM Chair and Divisional recruits in progressv With new Partnership Building, COM-P poised for marked growth

of clinical and translational research v LCME application for “Provisional” to “Full” accreditation to be

submitted November 2017, site visit Feb 2017, final June 2017.

UAHS College of Medicine-Phoenix


v Five Clinical Department Chairs recruited over the past 3 years (including three women chairs), seven Clinical Division Chiefs in Medicine & Surgery

v Charles B. “Chuck” Cairns, MD named COM Dean (April 2016) v Banner Health transaction has stabilized the Collegev New hospital facility in Tucson, opening 2019 v Marked increase in annual funds flow to support UAHS and the

COM’s academic mission (teaching & research) v 20 million in annual Academic Enhancement Funding shared with

COM-Phoenixv 50% increase in research portfolio, #57 NIH rankingv Banner, COM and UAHS are aligned in their vision for the future

of the partnership

UAHS College of Medicine-Tucson


UAHS College of Pharmacyv John Murphy, interim Dean, served admirably since November

2015, retaining key research facultyv Rick Schnellmann recruited to serve as the 7th Dean of the

College, August 2016

v Nathan Cherrington PI and Director of Southwest Toxicology Center, grant up for renewal

v Search-Chair Dept. of Pharmacology/Toxicologyv Recruit efforts in drug discovery, pharmacogeneticsv Phoenix COP expansion critical to success of the College with

expanding student enrollmentv COP received prestigious “Lawrence C Weaver Transformative

Community Service award” from the American Association of Colleges of Pharmacy


UAHS College of Nursing

v Usha Menon recruited in September 2015 as Associate Dean for Research and Global Advances

v UAHS Multi-disciplinary Program Pilot grant to develop UAHS infra-structure around border health equity collaborations.

v Three CON faculty are leading engagement and evaluation efforts on the Precision Medicine Cohort Center award (Koithan, Menon, Szalacha)

v $30M increase in CON total research dollars submitted ($48.3M vs compared to $18.8M in FY15)

v # of federal grants doubled in 2016v CON Global Advances Steering Committee formed- 2 MOUs

signed (Tzu Chi College of Technology, Taiwan, and Liberia)


UAHS Mel & Enid Zuckerman College of Public Health

v 2016 total research portfolio is $19.8M (40% increase vs 2012) v Center for Rural Health- $3.4M to improve the health and

wellness of rural and vulnerable AZ populations. PI: Dan Derksenv $5M NIEHS grant to establish the Center for Indigenous

Environmental Health Research, PI: Jeff Burgessv Dr. Rosales, Associate Dean for COPH Phoenix Campus, awarded

>$2M NHLBI grant to decrease cardiovascular disease/compli-cations in Northern Mexico

v Dr. Rosales- Mobile Unit ($304k) to partner with the U.S. Mexico Border Health Commission to deploy a mobile unit to provide access to health services to vulnerable Latino populations in Maricopa County. “Juntos Por la Salud”


UAHS Three Year Summary and Future Direction v UAHS proactively responded to the challenging US healthcare landscape with strategic

program development, partnership alignment, and heightened organizational performance

v UAHS is the cornerstone for two unique, potentially top-tier Academic Health Centers v UAHS Centers and Health Science Colleges have unprecedented national prominence:

v As high impact leaders in academic medicine v In translation of UAHS Scientific Discovery into improved community health in

the state, the border state region, and the worldv In promoting Academic Diversityv In elimination of Health Disparities

v UAHS is on a sustainable trajectory to continue to have lasting impact toward improving the health of Arizona’s communities


Thank You !

My heartfelt thanks to UAHS faculty and health sciencecommunity for your extraordinary efforts!!

The future ain’t what it used to beYogi Berra

(1935-2015)

uahs november 2016 townhall v15 re-150 l-js-anno · 2020-01-02 · analytics v cb2 ‘s ’big...

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