1

Twin-Shime study

2

Twin-Shime study

Small Intestine (1 & 2)

Stomach (1 & 2) Ascending colon (AC), Transverse (TC) and Descending (DC) of product 1 : FIBREGUM

Ascending Colon (AC), Transverse (TC) and Descending (DC) of product 2 : FOS

3

Twin-Shime study

2 weeks 2 weeks 3 weeks

stabilisation phase

Faeces inoculation T=0

Products treatment

T= end

Control w1 Control W2 Fibregum w1 Fibregum w2 Fibregum w3

FOS w1 FOS w2 FOS w3 Control w1 Control W2

•

•

•

4

Twin-Shime study

5

Twin-Shime study

Δ

6

Twin-Shime study

7

Twin-Shime study

8

Twin-Shime study

9

Twin-Shime study

10

Twin-Shime study

11

Twin-Shime study

12

The M-Shime study

13

The M-Shime study

•

•

14

The M-Shime study

•

•

15

The M-Shime study

16

17

18