Presenter : dr. SteviyaniModerator : Blood coagulation and fibrinolysis: mechanisms of thrombosis*

INTRODUCTIONblood coagulation plays a role in atherothrombosis

blood coagulation in the mechanisms of thrombosis cells, proteins, lipids, and calcium All these elements interplay to stop bleeding the primary task of hemostasis

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Thrombolysis remove intravascular fibrin deposits & restore blood flow

coagulation in a way as it also comprises cells, factors, activators, and inhibitors*

Primary hemostasisoccurs in response to damage of the vascular wall by the exposure of blood to endothelial tissue.leading to a platelet plug, is a complex process involving cells, plasma proteins, receptors, and phospholipids.*

Primary hemostasis*

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Blood coagulation*

Initiation of coagulation

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Amplification of coagulation

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Propagation of coagulation or full thrombin activity

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THROMBINOGRAPH Y*

Regulation of coagulation or the roleof inhibitors

Three main inhibitors are involved: the tissue factor pathway inhibitor (TFPI), the protein Cprotein S system antithrombin*

Tissue factor pathway inhibitor*

ProteinCprotein S system*

AntithrombinInhibit thrombin, factor Xa, as well as other factors.Physiologically heparin-like substances (heparan sulfate) & antithrombin-binding pentasaccharide sequence to render intact endothelium non-thrombogenic, as well as an ecto-ADPase that suppresses amplification of platelet activation by ADP release*

Fibrinolysis*

Mechanisms of thrombosisMost strokes are secondary to arterial thrombosis. however, venous thrombosis can also occur in the brain

Venous thrombosis decrease in inhibitors, or dysregulation of fibrinolysis*

Arterial thrombosis rupture of atherosclerotic plaque exposes thrombogenic material to circulating platelets & blood coagulation factors

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THANKYOU

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