tuesday, december 12, 2017 - defense advanced … december 12, 2017 start time is 9:00 a.m. et darpa...

Tuesday, December 12, 2017

Start time is 9:00 a.m. ET

DARPA APT Proposers Day Webcast

Audio

Participants can use their computer's speakers (VoIP).

Questions

Please email [email protected] for program related questions.

Troubleshooting

• If you are having trouble connecting, call GoToWebinar directly at 1-888-646-0014. Press 1, followed by pressing 1, and finally press 0 for live support.

• You may also contact Jenifer Schimmenti at [email protected] if you are experience issues during the webinar.

mailto:[email protected]


Welcome, Introductions & Logistics

Dr. Blake Bextine, Program Manger, DARPA/BTOMs. Renée Besanson, Meeting Planner

December 12, 2017

Approved for Public Release, Distribution Unlimited

APT Proposers Day Logistics

Ms. Renée Besanson, Meeting Planner

Approved for Public Release, Distribution Unlimited 4

• Blake Bextine, BTO Program Manager APT• Peter Donaghue, BTO Contracting Officer• Janine Bruhn, Business Financial SETA• Anaïs Castagnola, Technical SETA• Jamin Dreyer, Technical SETA• Dan Siegal, Technical SETA• David Swan, BAA Coordinator/SETA

• (SETA = Scientific, Engineering and Technical Assistance Personnel)

APT Team

Approved for Public Release, Distribution Unlimited 5

Poster Sessions

• Foyer outside of Ballroom A&B.

Lightning talks

• Limited to 3 min each. Presentation timer is provided.

Teaming Profiles/Attendees List/Presentations

• Will be distributed to all attendees via email. • Presentations will be posted on the DAPRA opportunities web page.

Questions and Answers--Please submit questions during the breaks

• Printed Q&A cards will be collect by the SETA team (Janine, Ana, Jamin and Dan) during breaks and lunch. The APT team will provide answers at the end of the day, time permitting.

• Further technical and programmatic questions can be submitted to [email protected]

• Video recording as well as all presentations and the FAQs from the Proposers Day will be posted on the DARPA Opportunities web page: http://www.darpa.mil/work-with-us/opportunities?tFilter=&oFilter=1&sort=date

Posters, Lightning Talks and Q&A


http://www.darpa.mil/work-with-us/opportunities?tFilter=&oFilter=1&sort=date

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Start End Duration (Hr:Min)

Item

8:00 a.m. 9:00 a.m. 1:00 Registration/continental breakfast8:00 a.m. 9:00 a.m. 1:00 Meet & Greet + Poster Session

9:00 a.m. 9:05 a.m. 0:05Welcome, Introductions and LogisticsDr. Blake Bextine, Program Manager, DARPA/BTOMs. Renee Besanson, Meeting Coordinator

9:05 a.m. 9:15 a.m. 0:10 Remarks from BTO LeadershipDr. Justin Sanchez, Director, DARPA/BTO

9:15 a.m. 10:15 a.m. 1:00 Advanced Plant Technologies (APT) Technical Program OverviewDr. Blake Bextine, Program Manager, DARPA/BTO

10:15 p.m. 10:35 p.m. 0:20 Guest SpeakerDr. Joe Cornelius, Program Director, ARPA-E

10:35 a.m. 10:50 a.m. 0:15 (Bio) Break & Questions collected

10:50 a.m. 11:30 a.m. 0:40Advanced Plant Technologies BAA OverviewDr. Blake Bextine, Program Manager, DARPA/BTOMr. Peter Donaghue, Contracting Officer, DARPA/CMOMr. David Swan, BAA Coordinator/DARPA/BTO

11:30 a.m. 12:15 p.m. 0:45 Working Lunch/Networking/Questions collected by the DARPA team Questions to be answered at the 3pm Question & Answer review session

12:15 p.m. 12:35 p.m. 0:20 Guest SpeakerDr. Troy Olsson, Program Manager, DARPA/MTO

12:35 p.m. 2:00 p.m. 1:25 Lightning Round Talks - Proposer Introductions (25 slots, 3 min. each with two 5 min breaks built in)

2:00 p.m. 3:00 p.m. 1:00 Poster Session and Networking

3:00 p.m. 3:30 p.m. 0:30Question & Answer review (no additional Q&A)Dr. Blake Bextine, Program Manager, DARPA/BTOMr. Peter Donaghue, Contracting Officer, DARPA/CMOMr. Mike Smith, Program Security Officer, DARPA/BTO

3:30 p.m. 3:45 p.m. 0:15 Closing remarks/Meeting unofficially adjourns

3:45 p.m. 4:30 p.m. 0:45 Informal Poster Session and Networking

Agenda (yellow = up from seats)


DARPA’s Biological Technologies Office

Justin C. SanchezOffice Director

Biological Technologies OfficeDefense Advanced Research Projects Agency

Briefing prepared for Advanced Plant Technologies proposers day

December 12, 2017

Distribution F: Distribution authorized to intended briefing attendees only. Further distribution only as directed by DARPA, Biological Technologies Office.

2

DARPA – Breakthrough Technologies for National Security

SATURN F1 Rocket

Engine

Stealth Fighter

Speech Recognition

MicroelectromechanicalSystems (MEMS)

1960 1970 1980 1990 2000 2010

ARPANET

Miniaturized GPS Receivers

Global Hawk

Autonomous Vehicle

Humanoid Robot

Brain-controlled Prosthetic Arm


3

Who we serve

Control complex systemsLearns complex tasks and concepts

Subject to extraordinary injuryUnder extraordinary stress

Learn complex tasks and concepts


Biology as a Technology

4

Biology to solve real-world problems

Proof of Concept

Laboratory Environment

Natural Environment

Basic Biology Biology for National Security

Exploratory Investments

Technological Foundations

Practical Applications


5

Vision: Biological platforms for enhanced biosurveillance

Technologies to leverage multiple organisms for enhanced security

Threats and Emerging Opportunities

Terrestrial Marine

Pre-deployment Monitoringand ISR

Far Forward Urban

Locate targets of interest

Persistent surveillance

of large areas

Real-time detection of

threat agents

� Emergence of novel natural or engineered biological threats

� Unknown providence and prior events of non-state actors

� Undetected littoral activity

+ Provide near real-time, actionable information+ Rapidly develop and deploy countermeasures

to new and emerging threats+ Flexible, low-cost, autonomous platforms+ Operate in natural environments


6

Vulnerabilities of megacities at home and abroad

High population density leads to greater impact

Buildings

Food

Water

Transportation

Global Travel Hubs


www.darpa.mil

7Distribution F: Distribution authorized to intended briefing attendees only. Further distribution only as directed by DARPA, Biological Technologies Office.

12 December 2017

Blake Bextine, Ph.D.

Program Manager, Biological Technologies Office (BTO)

Proposers DaySlides will be available at the registration website shortly


2


Item






10:35 a.m. 10:50 a.m. 0:15 Break & Questions collected











3

APT Program Proposers Day Objectives

• To introduce the science and technology community (industry, academia, and government) to the Advanced Plant Technologies (APT) program vision and goals;

• To explain the logistics of DARPA contract awards as well as the objectives of the APT program;

• To facilitate interaction between investigators that may have capabilities of interest and relevance to APT program goals; and

• To encourage and promote teaming arrangements among organizations that have the necessary expertise, facilities and capabilities to meet research objectives established by the APT program.


4

DARPA Intros: Govt. Team

Michael SmithDARPA

Program Security Officer

Jared AdamsDARPA

Public Affairs Office


Blake BextineDARPA Biological Technologies

Office, Program Manager

Peter DonaghueDARPA

Contracts Management Office

TBDContracting Office

Representative

5

DARPA Intros: Support Team

Janine BruhnDARPA SETA

Business/Financial

Jamin DreyerDARPA SETA

Technical

Anaïs CastagnolaDARPA SETA

Technical

Dan SiegalDARPA SETA

Technical


6

Presentation Outline

6 DEMOS &TIMELINE

5 SECURITY


4PROGRAMPHASING

3 APPROACH

2 RATIONALE

VS.1 VISION

http://www.bing.com/images/search?q=flipping+calendar+clipart&view=detailv2&&id=7E7D44FE943C62D032050EF6F99A541080E690CD&selectedIndex=0&ccid=NOblCSr5&simid=608017630441570938&thid=OIP.M34e6e5092af92bb1056bdbb7e70e2c29o0

7


6 DEMOS &TIMELINE

5 SECURITY


4PROGRAMPHASING

3 APPROACH

2 RATIONALE

VS.1 VISION


8

Improved environmental awareness


Image credit: US Navy

Cultivated

Urban

Rural

Closedenvironment

Remote sensing can already tell us much about plant quantity and quality, but what if we could “ask” the plants to tell us much more about their environment?

9

Goal: Develop a plant platform for biosecurity


10


6 DEMOS &TIMELINE

5 SECURITY


4PROGRAMPHASING

3 APPROACH

1 VISION

2 RATIONALE

VS.


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A need for persistent sensing

1

10

100

1000

10000

0.01 0.1 1 10 100Event Activity (% of sensor lifetime)

Life

time

(day

s)

APT Sensor platform would have…• A deployment lifetime independent of event activity — from rare events to continuous • No requirement for batteries or other energy delivery schemes• Robust to a wide range of environmental conditions

ExpectedAPT capability

Sensor lifespan relative to activity


Existing independentsensors

12

Opportunities for plant enhancement

Standoff Plant Detection

Synthetic Biology

Rapidly advancing gene editing (e.g., CRISPR/Cas9) and introduction technology allows complex traits to be modified• Large numbers of gene edits• Synthetic genetic constructs

Geneeditor

Multiple gene edits

“-omics” Revolution

Fast and inexpensive DNA sequencing allows gene mapping to connect blueprint with characteristics Compare

GENOMES

CompareTRAITS

Stimulus

Sensor Platforms

Unique Spectral Signature

Wavelength

Refle

ctan

ce In

tens

ity


13


6 DEMOS &TIMELINE

5 SECURITY


4PROGRAMPHASING

2 RATIONALE

VS.1 VISION

3 APPROACH


14

Major Objectives

Pathway Modification

ResourceManagement

Robustness inEnvironment

Identify, test, and integrate genetic components for plant sensing and reporting.

Tailor plant resource collection and allocation to support sense-and-report traits.

Ensure long-term sense-and-report capability by engineering plants to be robust in intended environments.


15

Program phases

Proof of Concept 24 Months

Design-build-test 18 Months

Pre-design6 Months


Stand-OffReception

SensorDeployment

StimulusApplication

+Sensor

By the end of the 4-year Advanced Plant Technologies Program:

Plants modified to detect specific environmental stimuli and translate these signals into phenotypes that can be ascertained via remote sensing, while maintaining viability in the environment through optimized resource utilization and ecological interactions.

16


6 DEMOS &TIMELINE

5 SECURITY


3 APPROACH

2 RATIONALE

VS.1 VISION

4PROGRAMPHASING


Resources EcologySensing

17

Phase 1: Identify & validate genetic pathways

• Identify pathways linked to specific stimuli

• Validate genes producing valuable functions

• Map associated gene linkages

• Identify critical resource pathway(s)• Sequence relevant genes• Model outcome of modification

• Identify necessary environmental interactions with other species

• Transgenes expressed in vitro• Model anticipated impact

Proof of ConceptDesign-build-testPre-design

Messengers

Receptor

Receptor

LigandEnergyCapture

WaterUse

NutrientUptake


Animals

Microbes

Plants

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Phase 1: Successful program outcomes


Milestones Metrics Deliverables

• Identify and curate genomic information for desired sense-and-report capability

• Identify and curate genomic information for resource and ecology traits in support of sense-report capability

• Experimentally validate activity/role of identified genes and pathways

• Establish the feasibility of proposed genetic alterations using established or novel molecular methods

• Successful in vitroexpression of 3+ stimulus (sensing) genetic pathways

• Successful induction of 3+ remotely-detectable response signals (reporting) in plant

• Successful induction of 1 enhanced resource management trait to support sense-and-report objectives

• Successful induction of 1 enhanced ecological interaction trait to support sense-and-report objectives

• Comprehensive strategy for developing a robust plant sensor and reporter of DoD-relevant stimuli with laboratory confirmation of feasibility

• Mathematical and/or conceptual model(s) to capture impact of proposed plant resource management strategy and ecological interactions on sense-and-report capability

Phase I report (month 6):

• End-of-phase report documenting model results and chosen genetic elements to be engineered into the plant chassis

Resources EcologySensing

19

Phase 2: Component design-build-test (chassis build)

• Insert or edit target genes• Analyze plant cell physiology, tissues,

and organs• Quantify gene expression &

localization• Production of predicted

stimulus/response capacity

Signaltransduction

• Insert or edit target genes• Assess relevant resource pathways• Analyze plant biomass, quality, and

substrate density• Quantify gene expression & localization• Verify cell physiology for patterns

consistent with optimal resource use

PN

NutrientUptake

LightCapture

WaterVessels

• Add/eliminate plant/environment interaction

• Confirm alterations improve interaction

• Robust plant growth under multiple “pressure tests” (e.g., high pest density)

NutrientUptake

Beneficialinsects

Symbioticbacteria

Neighboringplants


Sensor

Phenotypealteration

Stimulus detection


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• Produce plants with gene network alterations resulting in desired sense-and-report capability

• Produce plants with supportive resource management and ecology traits for sensor role

• Complete DBT cycle(s) for individual functioning sensing, reporting, resource management, and ecology traits

• Sensory trait-related gene expression change >2σ above normalized control

• Verified function with stimulus treatment at minimum target concentration (Table 2 or equivalent)

• Induced plant response trait produces unambiguous quantitative difference from wildtype

• Level of gene expression and production of phenotype matching model predictions

• Genetically-modified plants with individual functioning sensing, reporting, resource management, and ecology traits consistent with program objectives growing in a controlled greenhouse environment

• Annotated genomes of all modified plants

Phase II report (month 24):

• End-of-phase demonstration report documenting the sensing trait and reporting trait functionality

21

Phase 3: System integration

• Deploy integrated sensor components within an enclosed complex environment that mimics natural background climates, conditions, and functional species

• Confirm plant pathway response(s) to realistic threat stimuli (e.g., chemical exposure, biological incursion)

• Refine plant platform response (e.g., ligand specificity, resource use, species interactions) across multiple time points and expected stress conditions

• Receive significant, specific, and relevant stimulus/response outcome(s) detectable by current or anticipated detectors


Resources EcologySensing + +

ResponseRefinement

Stand-OffReception

2 3 4

SensorDeployment

StimulusConfirmation

1


22




• Integration of sensing, response, resource management, and ecology traits into a plant sensor

• Test plant sensors in complex environment challenge to reliably detect performer-defined DoD-relevant stimuli (see Section 1.2)

• Test plant sensors survivability in complex environments

• Expose plant for 1+ sense-and-report use with less than 5% positive/negative occurrence at levels outlined in Table 2 (or equivalent for specific chosen stimulus)

• > 95% of plant sensors survive complex greenhouse simulations for >2 months after growth to mature plant

• Complex environment must consist of multiple organisms accurately representing a plant sensor real-world scenario

Mid-phase report (month 36):

• Present performance outcomes of the sensors during environment simulation(s)

• Present results from sense-and-report exposure(s) for analysis

Final report (month 48):

• End-of-phase demonstration illustrating successful sensing and reporting of DoD-relevant stimuli (see Section 1.2)

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6 DEMOS &TIMELINE


4PROGRAMPHASING

3 APPROACH

2 RATIONALE

VS.1 VISION

5 SECURITY


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Biosafety, Biosecurity, and Data Sharing


GeneticSafeguards

BarrierSafeguards

RegulatoryControls

EPAUSDAFDA

Performers are strongly encouraged to establish the appropriate agreements to enable collaboration and data sharing, including pre-existing data generated through funding by other sources, although this is not a requirement of the program.

All research will be conducted in contained environments and DARPA will not support any proposals that include uncontained environmental release of such organisms.

APT performers are strongly encouraged to proactively engage with all relevant regulatory agencies during the design and implementation of their research program.

Performers are encouraged to include genetic safeguards (e.g. transgene degradation, genetic incompatibility) into their research and implementation program.

DataSharing

25

DoD-relevance & information security


Image credit: US Navy

Controlled Unclassified Information (CUI)To prevent the release of sensitive technical information, certain aspects of proposals may be considered CUI and may require safeguarding or dissemination controls, pursuant to and consistent with applicable law, regulations, and government-wide policies.

The following applied military technical information could be considered Controlled Technical Information (CTI) by DARPA:

Plant Sensing: Performance specifications and data of upper and lower limits of detection for chemical and/or biological agents banned by international treaty (e.g., Biological Weapons Convention) or related to specific national security threats.

Plant Reporting: Performance specifications and data of plant response profiles using commercial or military detection platforms.

Classes of DoD-relevant stimuli include: biological agents (e.g., spores, virus, bacteria, toxins), chemicals (e.g., organic, inorganic), and radiative signals (e.g., EM, RF, particle decay). Substitute stimuli that are similar to but less toxic/dangerous than existing national security threats, and that are equally difficult to detect, are preferred.

26


5 SECURITY


4PROGRAMPHASING

3 APPROACH

2 RATIONALE

VS.1 VISION

6 DEMOS &TIMELINE


Example Milestone Timeline

27Approved for Public Release, Distribution Unlimited

Phase 1Initial Design

Phase 2Design-Build-Test

Cycles

Phase 3Proof-of-Concept

Evaluation

18 FY 2019 FY 2020 FY 2021 FY 2022

Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3

Demo 1

KO Demo 2

Technical integration of

desirable traits

Establish feasibility of gene edits

Supportive model

describing expected outcomes

Alter gene expression in

multiple pathways

Modify plant physiology to meet program

goals

Apply stress conditions to test

robustness

Optimize gene expression across gene edits

Reassess plant phenotype

Test stress conditions against

improved plant

Launch environment simulation A

Assess genotype, trait

quality, and plant

robustness

Expose sensor, validate response, nil false negatives

Launch environment simulation B

State-of-the-art phenotyping: Large-scale, high throughput, remote assessment of holistic

plant traits

Expose sensor, remote detection with

nil false positives

De

mo

3

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Technology Transition


Concept

Basic R&D

AdvancedPrototype

EarlyPrototype

Product

Market Entry

CommercialPartnering

Applied R&DFunding

AP

T P

rog

ram Po

st-

Pro

gra

m

Term Definition

BAA Broad Agency Announcement: Document outlining proposal expectations, similar to RFP (Request for Proposals) from other funding agencies.

BTO Biological Technologies Office. One of six DARPA offices.

CMO DARPA Contract Management Office

CTI/CUI Controlled Technical Information/Controlled Unclassified Information

DARPA Defense Advanced Research Projects Agency

Demonstration/Demo A demonstration, typically at the end of a contract phase, that meets measurables/milestones as outlined in DARPA BAAs

DoD United States Department of Defense

Phase Temporal period of a proposal/contract with specific goals/emphasis

POC Point of Contact

Prime/Lead PI The primary lead/POC in a BAA proposal and subsequent contract

Program Manager DARPA leadership position at the office level. Define their own programs, set milestones, meet with their performers and assiduously track progress.

Proposal Abstract A concise version of the proposal comprising a maximum of 8 pages including all figures, tables, and charts.

Proposer Those submitting a proposal to a DARPA BAA

SETA Scientific Engineering and Technical Assistance: Junior DARPA contract position that acts in professional/expert support to offices and program mangers.

SOW Statement of Work: a detailed task breakdown and their connection to the interim milestones and program metrics.

Sub/Co-PI A subordinate (to the prime) lead/POC in a BAA proposal and subsequent contract

DARPA Acronym Glossary


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Item

















www.darpa.mil


1December 13, 2017

2December 13, 2017

3December 13, 2017

THANK YOU

TERRA High Throughput Above-Ground Phenotyping

ROOTSRoot Phenotyping and Soil Measurement

Advanced Plant Technologies BAAHR001118S0005

Slides will be available at the registration website shortly


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Item


















Full Proposal Review-Awards Process

• No common Statement of Work - Proposals evaluated on individual merit and relevance as it relates to the stated research goals/objectives rather than against each other

• Proposals are not ranked, but evaluated for strengths and weaknesses with respect to the criteriapublished in the BAA:• Overall Scientific and Technical Merit• Potential Contribution and Relevance to the DARPA Mission• Cost Realism• Plans and Capability to Accomplish Technology Transition

• Government reserves the right to select for award all, some (partial selection), or none of the proposals received.

• Government anticipates making multiple awards• Contract negotiation timelines depend on each institution/organization’s response time.• The contracting office will contact the selected performers and begin the contracting process.

Anticipated APT program kick off date is August 2018

See BAA pg. 31-32 for details regarding proposal evaluation

3 Government reviewers

PM recommendation

to SRONotification

APT Program Kick Off

August 2018

4

Cost Proposal Tips

• Read the BAA carefully - Nonconforming proposals may be rejected without review

• There is no page limit to Volume II Cost Proposal• Cost break downs are outlined in the BAA

o By Phase (I, II, & III) by contractor fiscal yearo Total program cost by major tasko Projected funding required by month (account for early equipment needs)o Subcontractor proposals must be prepared at the same level of detail as

that required of the prime.• Don’t forget travel funds for key personnel to attend the Kickoff Meeting and

semi-annual PI Review meetings.


See BAA pg. 22-25 for details regarding the detailed cost proposal guidance


Teaming and Eligibility

DARPA strongly encourages establishing teams to address all technical areas to ensure the expertise and capabilities necessary to meet program goals.

• You must find your collaborators on your own. Specific content, communications, networking, and team formation are the sole responsibility of the proposer teams.

• It is expected that proposals will involve multidisciplinary teams that include expertise from multiple complementary disciplines (e.g., synthetic biology, sensor technology, plant genomics and ecology).

• Your team must submit a single, integrated proposal led by a single Program Integrator/ Manager (Prime contractor) that addresses all program Phases as applicable.

This BAA is open to all responsible sources including educational institutions, government labs, FFRDCs, and/or private companies.

Foreign entities may join a team or submit as the prime contractor (section 3.1.2)

If you are a member of a team, you may join any number of other teams or form your own and submit a proposal as the prime contract.

6

APT Program Proposal Information

BAA Released Nov 21

Proposers Day Dec 12th

Abstracts DueJan 11th

Full Proposals DueFeb 21st

TIPS• Ask questions and check the APT Frequently Asked Questions (FAQ) document

• Email BAA questions to: [email protected]• APT FAQs are posted to the DARPA opportunities web page:

https://www.darpa.mil/work-with-us/opportunities• Formation of complete teams with comprehensive expertise and capabilities is

viewed as critical• Teaming is strongly encouraged• Teams are encouraged to have a program integrator/program manager

Take advantage of today’s opportunities to meet potential teammates



https://www.darpa.mil/work-with-us/opportunities


BAA Inbox and FAQ

Direct ALL questions and communications to the BAA Inbox: [email protected]

Dr. Bextine, any member of his team, or the BAA Inbox cannot provide feedback or guidance on any aspect of your proposal, they can only clarify the content of the Advanced Plant Technologies BAA.

DARPA will update the APT FAQs on a regular basis. FAQs can be found on the DARPA Opportunities web page: https://www.darpa.mil/work-with-us/opportunities

All questions must be submitted at least 15 days prior to the proposal submission deadline.

• FAQ deadline: February 7, 2018

• Full Proposal Due: February 21, 2018


https://www.darpa.mil/work-with-us/opportunities

Q: Does it matter what is being sensed?

A: The target for detection that is selected is performer defined, and the choice must be justified by the approach and goals of the proposed research plan.

Q: My research is not geared specifically to meet the APT program goals. Is there an alternate solicitation that I can respond to?

A: Yes. DARPA/BTO has an office‐wide solicitation (HR001117S0030) for this purpose. Responses are being collected through April 26, 2018.

Q: Is the development of traditional transgenics within the scope of the program?

A: Yes, traditional transgenic development is within the scope of the program.

Q: Is it desirable or undesirable if the plant germline is also transformed?

A: There is no preference.

Example FAQs


9

• Before submitting a question, you should…• Read the BAA

• Understand that you’ll get a clarification, not an idea

• Re-read the BAA

• Understand that you won’t get any information from a competitor

• Study the BAA

• Understand that your question will likely be added to the FAQ

• Memorize the BAA!!!

BAA Inbox – [email protected]



10

• NO submissions via fax/e-mail

• Grants & Cooperative Agreements – Grants.gov

• All other Award Instruments – DARPA BAA Portal (https://baa.darpa.mil)

• Known CUI – Hardcopy/CD-ROM

• Start Today

• Only attach attachments requested in the BAA

Submission Specifics


https://baa.darpa.mil/

11

DARPA BAA Portal


12

Abstract and Full Proposal Tips

Proposal Abstract Tips• Abstracts are strongly encouraged, but optional• Abstracts are limited to 6 pages• DARPA will respond to abstracts with a statement as to whether DARPA is

interested in receiving a full proposal• You may submit a full proposal even if you did not submit an abstract

Full Proposal Tips• Read the BAA carefully - Nonconforming proposals may be rejected without

review• Full Proposal Vol I is limited to 42 pages• Understand the evaluation criteria• SOW template provided• You may submit a full proposal even if a proposal is discouraged in response to

your abstract


Full Proposal – Statement of Work (SOW) approaches


Objective Milestone Metric Deliverable

“Global” goal “Local” goal Quantitative measurement of success

Evidence that metric, and thus milestone, has been achieved

Identify, test, and integrate genetic components for plant sensing and reporting

Experimentally validate activity/role of identified genes and pathways

75% induction of 3+ remotely-detectable response signals (reporting) in plant

End-of-phase report documenting model results and chosen genetic elements to be engineered into the plant chassis

Complex

Simple Initialcondition

Finalcondition

Milestone

Deliverable

Task

Init ialcondition

Finalcondition

Milestone

Deliverable

Task

Sub-Task

Sub-Task

Milestone

Milestone

Milestone

13

14

SOW template and guidance

Uniqueidentification

Exampleformat

Fully descriptive

Clear and specific


15

Proposal evaluation criteria

5.1.1 Evaluation CriteriaProposals will be evaluated using the following criteria, listed in descending order of importance: 1) Overall Scientific and Technical Merit2) Potential Contribution and Relevance to the DARPA Mission, 3) Cost Realism and 4) Plans and Capability to Accomplish Technology Transition

5.1.1. Overall Scientific and Technical MeritThe proposed technical approach is innovative, feasible, achievable, and complete.The proposed technical team has the expertise and experience to accomplish the proposed tasks.Task descriptions and associated technical elements provided are complete and in a logical sequence with all proposed deliverables clearly defined such that a final outcome that achieves the goal can be expected as a result of award. The proposal identifies major technical risks and planned mitigation efforts are clearly defined and feasible. If applicable, the CUI risk mitigation plan effectively presents a strategy for safeguarding controlled unclassified information.

5.1.2. Potential Contribution and Relevance to the DARPA MissionThe potential contributions of the proposed effort are relevant to the national technology base. Specifically, DARPA’s mission is to make pivotal early technology investments that create or prevent strategic surprise for U.S. National Security.

5.1.3. Cost RealismThe proposed costs are realistic for the technical and management approach and accurately reflect the technical goals and objectives of the solicitation. The proposed costs are consistent with the proposer's Statement of Work and reflect a sufficient understanding of the costs and level of effort needed to successfully accomplish the proposed technical approach. The costs for the prime proposer and proposedsubawardees are substantiated by the details provided in the proposal (e.g., the type and number of labor hours proposed per task, the types and quantities of materials, equipment and fabrication costs, travel and any other applicable costs and the basis for the estimates).

5.1.4. Plans and Capability to Accomplish Technology TransitionThe proposer clearly demonstrates its capability to transition the technology to the research, industrial, and/or operational military communities in such a way as to enhance U.S. defense. In addition, the evaluation will take into consideration the extent to which the proposed intellectual property (IP) rights will potentially impact the Government’s ability to transition the technology.


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5.1.1. Overall Scientific and Technical MeritThe proposed technical approach is innovative, feasible, achievable, and complete.The proposed technical team has the expertise and experience to accomplish the proposed tasks.Task descriptions and associated technical elements provided are complete and in a logical sequence with all proposed deliverables clearly defined such that a final outcome that achieves the goal can be expected as a result of award. The proposal identifies major technical risks and planned mitigation efforts are clearly defined and feasible. If applicable, the CUI risk mitigation plan effectively presents a strategy for safeguarding controlled unclassified information.




17




5.1.1. Overall Scientific and Technical MeritThe proposed technical approach is innovative, feasible, achievable, and complete.The proposed technical team has the expertise and experience to accomplish the proposed tasks.Task descriptions and associated technical elements provided are complete and in a logical sequence with all proposed deliverables clearly defined such that a final outcome that achieves the goal can be expected as a result of award. The proposal identifies major technical risks and planned mitigation efforts are clearly defined and feasible. The CUI risk mitigation plan effectively presents a strategy for safeguarding controlled unclassified information.




18




5.1.1. Overall Scientific and Technical MeritThe proposed technical approach is innovative, feasible, achievable, and complete.The proposed technical team has the expertise and experience to accomplish the proposed tasks.Task descriptions and associated technical elements provided are complete and in a logical sequence with all proposed deliverables clearly defined such that a final outcome that achieves the goal can be expected as a result of award. The proposal identifies major technical risks and planned mitigation efforts are clearly defined and feasible. The CUI risk mitigation plan effectively presents a strategy for safeguarding controlled unclassified information.





Technology Transition

5.1.4. Plans and Capability to Accomplish Technology Transition

The proposer clearly demonstrates its capability to transition the technology to the research, industrial, and/or operational military communities in such a way as to enhance U.S. defense. In addition, the evaluation will take into consideration the extent to which the proposed intellectual property (IP) rights will potentially impact the Government’s ability to transition the technology.

1919

Phase I Phase IIIPhase IIPre-award

Phase IIIV/V

Successfulcommercial transition

Formulate Research

Plan

DevelopCommercial relationships

IdentifyTransition partner

Certification & permitting

InitialTransition

groundworkPhase III

IV/V

2019 20222020 20212018


Final bits of advice

Read the BAA over and over again and follow all instructionscarefully.

A conforming proposal addresses all aspects of the BAA

• Pay attention to “must”, “should”, “shall”, and “all” in the BAA

• Nonconforming proposals may not be evaluated

DO NOT try to shoehorn ongoing, but not applicable, work into the BAA

DO NOT submit a rewritten USDA, NIH or NSF proposal

DO NOT propose to do anything that is not directly relevant to the BAA

DO NOT submit an irrelevant or incomplete proposal in the hope we’ll fund it anyway

A proposal abstract is HIGHLY RECOMMENDED

21

DARPA Intros: Govt. Team

Michael SmithDARPA

Program Security Officer

Jared AdamsDARPA

Public Affairs Office


Blake BextineDARPA Biological Technologies

Office, Program Manager

Peter DonaghueDARPA

Contracts Management Office

TBDContracting Office

Representative

22

DARPA Intros: Support Team

Janine BruhnDARPA SETA

Business/Financial

Jamin DreyerDARPA SETA

Technical

Ana CastagnolaDARPA SETA

Technical

Dan SiegalDARPA SETA

Technical


Tabitha EllisDARPA SETA

Security

23

Please submit questions during the break.


24


Item








11:30 a.m. 12:15 p.m. 0:45Working Lunch/Networking/Questions collected by the DARPA team Questions to be answered at the 3pm Question & Answer review session









www.darpa.mil


Challenges in Persistent Sensing

APT Industry DayDec. 12, 2017

Troy Olsson, Ph.D.Defense Advanced Research Projects Agency

Distribution Statement "A" Approved for Public Release, Distribution Unlimited

2

How can we know when relevant data will be present near our sensors or transmitted without consuming power or missing transmissions?

Geophone recording of activity followed by RF transmission

Activity


The Persistent Sensing Challenge

Persistent Sensing Applications

3Distribution Statement "A" Approved for Public Release, Distribution Unlimited

Security Threat, Environmental, Agricultural, and Infrastructure Sensing

Persistent sensing requires new low-energy and long-life communications and sensing technologies

• Sensor nodes must be deployed for long durations at low cost

• Energy consumption is extremely limited

• Data is continuously processed but rarely worthy of communication

• Sensing is often time critical, as the source may only briefly be in proximity of the sensor

• Communication of a sensing event is often time critical

Distribution Statement "A" Approved for Public Release, Distribution Unlimited 4

Power Consumption and Lifetime of Unattended Sensor System Components

10 nW

100 nW

1 µW

10 µW

100 µW

1 mW

10 mW

100 mWUNB Transceiver

Sleeping processors, sleeping radios, 64 kB memory and N-ZERO

Wake-on-sound or motion sensors

Microphone and accelerometer

1 MHz, 32-bit M4 processor

Pow

er C

onsu

mpt

ion

Lifetime from

a 30 mAhr button cell

340 (years)

34 (years)

3.4 (years)

4 (months)

1 (day)

12 (days)

3 (hours)

20 (minutes)

10-year lifetime target

Magnetic field sensor

5

N-ZERO Vision: OFF but ALERT!

Devices are OFF (zero power consumption) yet continually ALERT!

N-ZERO passive sensor wake-up:

• Continuous operation and near-zero power processing• Persistent sensing with greatly extended lifetime and reduced cost

Battery leakage, active processing and

N-ZERO wake-up

Battery drainage by active wake-up

circuitry


6

N-ZERO Concept

• N-ZERO senses the environment 100% of the time at near-zero power • N-ZERO uses energy in the signals to perform signal processing to

detect information while rejecting noise and interference• Detection of an event triggers activation of the COTS module for

further processing and follow-up action

N-ZERO does not replace COTS functionality. N-ZERO will reduce COTS “on” time, thereby dramatically increasing the sensor’s useful lifetime.

InformationInterference and Noise

N-ZERORF Sensor

RF Wake-up

Not N-ZERO: COTS Wireless Unattended Ground Sensor

COTSbattery

COTS Sensor Response

COTS Radio Response

N-ZEROPhysical Sensor Sensor

Wake-up

N-ZERO


7

N-ZERO Metrics

Metrics Phase III

Detected signature

Coded RF Waveform

RF level at sensor input

≤ -100 dBm

Probability of detection

95%

False alarm rate

< 1 per hour

Environmenthigh interference

background

Power Consumption

< 10 nW

Metric Phase III

Items todetect

Generator, car, truck

Distance ≥ 10 m

Probability of detection

95%

False alarm rate

< 1 per hour

Environment Urban

Power Consumption

< 10 nW


Range

Selectivity

Specificity

Persistence

Specificity

RF Sensors Physical Sensors

N-ZERO Acoustic Wake-up Sensor

Wake-up to generator and truck at > 5m with 12 nW of power consumption

S. Jeong, et al. "21.6 A 12nW always-on acoustic sensing and object recognition microsystem using frequency-domain feature extraction and SVM classification." Solid-State Circuits Conference (ISSCC), 2017 IEEE International. IEEE, 2017.


N-ZERO Wake-up Receiver

4.5 nW N-ZERO wake-up receiver with -69 dBm sensitivity

H. Jiang, et al. "24.5 A 4.5 nW wake-up radio with− 69dBm sensitivity." Solid-State Circuits Conference (ISSCC), 2017 IEEE International. IEEE, 2017.



N-ZERO: Zero-Power Sensing Modalities

A. Banerjee, et al. "Picowatt gas sensing and resistance switching in tunneling nano-gap electrodes." IEEE SENSORS Conf., Oct. 2016.

Univ. of Utah: Zero-power ppm gas sensing

Draper: Zero-power acoustic sensing at 5 m standoff (68 dB SPL)

J. Bernstein, et al. “MEMS resonant acoustic wake0up sensor." Acoustical Society of America Conf., June 2017.

Northeastern Univ.: Zero-power IR sensing of vehicles at 15 m

Z. Qian, S. Kang, V. Rajaram, C. Cassella, N. E. McGruerand M. Rinaldi., “Zero-power infrared digitizers based onplasmonically enhanced micromechanicalphotoswitches." NATURE NANOTECHNOLOGY, vol. 12, Oct. 2017.


N-ZERO: Sensing Modalities

Sensor TypeNumber of Approaches

Signature Detected

> 95% POD

Interferencew/ Specificity

Standby Power (nW)

Acceleration 3 Stationary vehicle < 1 m Urban 6

Acoustic 4 Vehicle at 5 m Urban 0 - 12

RF 6 -80 dBm codedwaveform Urban 8

Infrared 1100 nW

wavelengthspecific IR

BroadbandThermal & Other

Wavelengths0

Chemical 1 26 ppm of 1,5-Diaminopentane

Ambient and Pentane 0

Magnetic 0 - - -

Radiation 0 - - -

Biological 0 - - -

APT Addresses Key Challenges in Persistent Sensing


Security Threat, Environmental, Agricultural, and Infrastructure Sensing

Persistent sensing requires new low-energy and long-life communications and sensing technologies

• Plants inherently provide persistence

• Plants provide the opportunity for persistent sensing modalities not presently achievable in inorganic sensors

• How can selectivity and specificity be achieved and tested?

• How can remote interrogation be performed?

• How persistent can the interrogation be?

www.darpa.mil


tuesday, december 12, 2017 - defense advanced … december 12, 2017 start time is 9:00 a.m. et darpa...

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