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Transgenic Animals

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Page 1: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Page 2: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Page 3: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Page 4: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Page 5: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

“Cloning”

Page 6: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Page 7: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Tissue specific Expression

CFTR: Cystic Fibrosis Transmembrane Conductance Regulator

Page 8: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic Animals

Tissue specific Expression

Page 9: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

Transgenic animals as organ supplier

Immunological Barriers

Hyperacute rejectionAcute vascular rejectionCellular rejectionChronic rejection

Porcine endogenous retroviruses

Humanizing the pig:

Introduction of Human Genes

Knock out of pig genes -1.3 galactosyltransferase avoid immunogenic reaction

Page 10: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 11: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 12: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 13: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 14: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 15: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 16: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals
Page 17: Transgenic Animals - ftp. · PDF fileKnock out of pig genes -1.3 galactosyltransferase avoid immunogenic ... Transgenic lines can be established from these founder transgenic animals

PRODUCTION OF THERAPEUTICS FROM TRANSGENIC ANIMALS

Trends Biotechnology 150429 TB13 Transgenic animals 1

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Transgenic Animals - Technology and applications

TRANSGENIC ANIMALS...2005/08/24  · transgenic animals that have been invented, familiarize the reader with the laws governing transgenic animals, and their moral and ethical issues

TRANSGENIC ANIMALS - Worcester Polytechnic Institute

Transgenic animals research ethics

Dolly, BST, and transgenic animals: Cloning around …oregonstate.edu/instruct/bi430-fs430/Documents-2004/8A-ANIMAL...Dolly, BST, and transgenic animals: Cloning around with animals

Transgenic animals

Human antibodies from transgenic animals

Gene Cloning and Transgenic Animals

Transgenic Animals 2

Production of transgenic farm animals

Transgenic animals and its Applications

Transgenic Animals, Knock-Out Mice and Dollystaff.unila.ac.id/.../files/2020/04/Transgenic-Animals-2.pdfTransgenic animals: – Animals which have been genetically engineered to contain

Human Antibodies From Transgenic Animals

Transgenic Animals Jessica Götzfried Methods Seminar 03.12.14

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Schering Foundation Workshop 6 Transgenic Animals …978-3-662-02925-1/1.pdf · Schering Foundation Workshop 6 Transgenic Animals as ... Vol. 6 Transgenic Animals as Model Systems

Transgenic Animals

Transgenic Animals 1

AMPK: Lessons from transgenic and knockout animals

Transgenic animals new

THE USE OF TRANSGENIC ANIMALS IN CLINICAL RESEARCH; …€¦ · transgenic animals was started using sperm mediated gene transfer [9] and in 1980s, the transgenic mice was produced

Transgenic Animals 3

Dolly, BST, and transgenic animals: Cloning around with ... · Transgenic animals • First transgenic mouse produced in 1981 – Human growth hormone inserted into a mouse (Singleton,

Generation of α-1,3-galactosyltransferase knocked-out transgenic … · 2017-08-26 · BRIEF COMMUNICATION Generation of a-1,3-galactosyltransferase knocked-out transgenic cloned

Transgenic Animals Thesis WPI 2005

BLOOD PRODUCTS PRODUCTION FROM TRANSGENIC ANIMALS

Transgenic Animals: Methodology and Applicationsstaff.unila.ac.id/gnugroho/files/2020/04/Transgenic-Animals.pdf · Transgenic Animals: Methodology and Applications •Transgenic mice:

TRANSGENIC ANIMALS - Worcester Polytechnic Institute · TRANSGENIC ANIMALS ... Chapter two describes the applications of transgenic technology. ... rDNA technology is sometimes referred

Transgenic Animals 4