transcription in eucriotes,_procariotes_and_rna_processing 2

TRANSCRIPTION IN EUCRIOTES, PROCARIOTES AND RNA PROCESSING

Michelle Silvera Valera

ID. 000172227

Third Semester

Medicine- UPB

FOLDING

INTRODUCTION

INTRODUCTION

Transcription

DNA single chain

RNA polymerases + promoter + other Maturing RNA

RNA

Introns exons splicing

Age-Related Macular Degeneration: Key Mechanism in Geographic Atrophy Identified, Two Possible Therapies

ScienceDaily (Feb. 7, 2011)

Age-Related Macular Degeneration: Key Mechanism in

Geographic Atrophy Identified, Two Possible Therapies

http://www.sciencedaily.com/releases/2011/02/110206132904.htm

Alu RNA accumulates

in retina

It causes macular

degenaration

and death of retina

cells


Accumulation

due to

decreased levels of

“dicer” enzyme

which

Degradates Alu RNA


Two Possible Solutions were proposed

Increase “dicer” Block Alu RNA

enzyme


STUDENT OBSERVATION

I think that this discovery has not only a relevant implication in the physiopatology of the Geographic Atrophy, it is also important to develop a treatment to heel the condition and even more, to prevent it. This will give a hope to those patients with the illness or to those who are prone to it.

Moreover, this news shows us that is important to investigate about the RNA processing and how can it be related to pathologies.

Advance Could Speed Use of Genetic Material RNA in Nanotechnology

ScienceDaily (Jan. 19, 2011)


A change in the sugar ring

of the RNA, averts the effect

of the enzyme RNAse in this

molecule, making the RNA

more stable

Enzyme RNAse


The RNA stability was proved

introducing a nanomotor of

bacteriophague phi29 in a

bacteria

The nanomotor, based on

modified RNA didn´t got

degraded even in the

presence of RNAse


This modified RNA is useful in

nanotechnology because it is

not easily degraded and it

can adopt a 3D structure.

This discovery can be useful

in the development of

treatments for cancer


STUDENT OBSERVATION

I think that it is amazing that just change in a molecule ( RNA ) can adapt it to be part of a nanostructure, and I think it is even more amazing that the modified RNA through this nanotechnology can be useful in sick people, like in cancer patients.

I also think that this nanotechnology allows the development of a new less invasive therapies due to its small size.

MEDICAL UTILITY

MEDICAL UTILITY

ge-Related Macular Degeneration: Key Mechanism in Geographic

Atrophy Identified, Two Possible Therapies

atients who suffer from Geographic Atrophy can have a hope due to the therapies that can be developed based on this scientific advance.

MEDICAL UTILITY


With this nanotechnolgy,based on RNA, therapies for cancer can be developed.

MEDICAL UTILITY

Both discoveries can be used in the development of a mechanism in which illnesses can be prevented, for example the Geographic Atrophy, Cancer or another.

That prevention will allow a better perspective to those patients prone to suffer that illnesses.

BIBLIOGRAPHY

MARTINEZ SANCHEZ Lina Maria. Libro de Clase Biología Molecular.6 ed.Editorial Universidad Pontificia Bolivariana.2011, pág 85, 95.

• University of Kentucky. "Age-related macular degeneration: Key mechanism in geographic atrophy identified, two possible therapies." ScienceDaily 7 February 2011. 25 February 2011 <http://www.sciencedaily.com- /releases/2011/02/110206132904.htm>.

• University of Cincinnati Academic Health Center. "Advance could speed use of genetic material RNA in nanotechnology." ScienceDaily 19 January 2011. 25 February 2011 <http://www.sciencedaily.com- /releases/2011/01/110119125312.htm>.

THANKS !!!

transcription in eucriotes,_procariotes_and_rna_processing 2

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